Investigation of the Vps10p-family proteins and its sorting disorders in life-style-related diseases
| Project/Area Number |
25293074
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
Kanzaki Makoto 東北大学, 医工学研究科, 准教授 (10272262)
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| Co-Investigator(Renkei-kenkyūsha) |
HATAKEYAMA HIROYASHU 東北大学, 学際科学フロンティア研究所, 助教 (00619067)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2015: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
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| Keywords | 生活習慣病 / ソーティング障害 / インスリン反応性 / 糖尿病 / 骨格筋 / ソーティング / 小胞輸送 / GLUT4 / インスリン / インスリン抵抗性 / 細胞内小胞輸送系 / 脂肪細胞 / マイオカイン / アディポカイン |
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| Outline of Final Research Achievements |
Physiological relevance of the Tripartite Complex Assembly composed of Vps10p/soluble ligands/GLUT4 was revealed by several experimental approaches including the single-molecule imaging analysis. Live-imaging analysis allowed us to visualize the transient formation of tripartite complex in a living cell and this approach successfully demonstrated that intracellular dynamics of the tripartite complex containing GLUT4 is tightly regulated by Tbc1d-family RabGAPs (AS160 and Tbc1d1).
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Report
(4 results)
Research Products
(47 results)
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[Journal Article] Single quantum dot tracking reveals that an individual multivalent 2 HIV-1 Tat-protein transduction domain can activate machinery for 3 lateral transport and endocytosis2013
Author(s)
3.Yasuhiro Suzuki*, Chandra Nath Roy, Warunya Promjunyaku, Hiroyasu Hatakeyama, Kohsuke Gonda, Junji Imamura, Biju Vasudevan Pillai, Noriaki Ohuchi, Makoto Kanzaki , Hideo Higuchi, and Mitsuo Kaku
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Journal Title
Mol. Cell Biol.
Volume: 33
Issue: 15
Pages: 3039-3049
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] The Human Satellite Cells can Form the Myotube Even in the Atrophic Fatty Muscle of Rotator Cuff Tear2016
Author(s)
Koide M, Hagiwara Y, Ando A, Yabe Y, Kanazawa K, Sekiguchi T, Itaya N, Yoshida S, Itoi E, Kanzaki M, Hatakeyama H, Tsuchiya M
Organizer
Orthopaedic Research Society 2016 Annual Meeting
Place of Presentation
Orland, Florida, USA
Year and Date
2016-03-05
Related Report
Int'l Joint Research
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[Presentation] Free Fatty Acids and Exercise Effects on Muscle Fiber Type Conversion Revealed by the “in Vitro Exercise Model”2013
Author(s)
Uda, Y., Nakagaito, Y., Fuse, H., Mori, M., and Kanzaki, M.
Organizer
2013 Annual Meeting of the American Society for Cell Biology
Place of Presentation
The New Orleans Ernest N. Morial Convention Center, USA
Related Report
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