| Project/Area Number |
25293076
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IJICHI Hideaki 東京大学, 医学部附属病院, 講師 (70463841)
MAEDA Shin 横浜市立大学, 医学系研究科, 教授 (40415956)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | 分子腫瘍学 / 非コードRNA / ミトコンドリア / 非コードＲＮＡ / 癌 / ＹＢ－１ / 膵癌 / YB-1 |
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| Outline of Final Research Achievements |
While oncogenesis is a process with multi-step mutations of oncogenes and tumor suppressor genes, the molecular mechanisms why and how such mutations accumulate during the carcinogenesis steps. In this stuudy, it was revealed that non-coding repetitive RNA, which express at the early phase of carcinogenesis, binds to YB-1, a repair gene, and suppresses its function. Due to this, mutations of genomic DNA and mitochondrial DNA accumulate and the intracellualr circumstances are disturbed, which leads to carcinogenesis. Based on these results, intervention to inhibit the binding between reprtitive RNA and YB1 may be useful for the supression of carcinogenesis steps.
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