Multi-step carcinogenesis due to non-coding repetitive RNA expression
| Project/Area Number |
25293076
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IJICHI Hideaki 東京大学, 医学部附属病院, 講師 (70463841)
MAEDA Shin 横浜市立大学, 医学系研究科, 教授 (40415956)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | 分子腫瘍学 / 非コードRNA / ミトコンドリア / 非コードＲＮＡ / 癌 / ＹＢ－１ / 膵癌 / YB-1 |
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| Outline of Final Research Achievements |
While oncogenesis is a process with multi-step mutations of oncogenes and tumor suppressor genes, the molecular mechanisms why and how such mutations accumulate during the carcinogenesis steps. In this stuudy, it was revealed that non-coding repetitive RNA, which express at the early phase of carcinogenesis, binds to YB-1, a repair gene, and suppresses its function. Due to this, mutations of genomic DNA and mitochondrial DNA accumulate and the intracellualr circumstances are disturbed, which leads to carcinogenesis. Based on these results, intervention to inhibit the binding between reprtitive RNA and YB1 may be useful for the supression of carcinogenesis steps.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] ROCK inhibition enhances microRNA function by promoting deadenylation of targeted mRNAs via increasing PAIP2 expression2015
Author(s)
Yoshikawa, T. Wu, J. Otsuka, M. Kishikawa, T. Ohno, M. Shibata, C. Takata, A. Han, F. Kang, Y. J. Chen, C. A. Shyu, A. B. Han, J. Koike, K
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Journal Title
Nucleic Acids Res
Volume: 43(15)
Issue: 15
Pages: 7577-89
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Decreased miR122 in hepatocellular carcinoma leads to chemoresistance with increased arginine.2015
Author(s)
Kishikawa T, Otsuka M, Tan PS, Ohno M, Sun X, Yoshikawa T, Shibata C, Takata A, Kojima K, Takehana K, Ohishi M, Ota S, Noyama T, Kondo Y, Sato M, Soga T, Hoshida Y, Koike K.
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Journal Title
Oncotarget.
Volume: 6
Pages: 8339-8352
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Decreased miR122 in hepatocellular carcinoma leads to chemoresistance with increased arginine.2015
Author(s)
2.Kishikawa T, #Otsuka M, Poh Seng T, Ohno M, Sun X, Yoshikawa T, Shibata C, Takata A, Kojima K, TakehanaK, Ohishi M, Ota S, Noyama T, Kondo Y, Sato M, Soga T, Hoshida Y, Koike K.
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Journal Title
Oncotarget
Volume: in press
Related Report
Peer Reviewed / Open Access
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[Journal Article] The flavonoid apigenin improves glucose tolerance through inhibition of microRNA maturation in miRNA103 transgenic mice.2013
Author(s)
Ohno M, Shibata C, Kishikawa T, Yoshikawa T, Takata A, Kojima K, Akanuma M, Kang YJ, Yoshida H, Otsuka M, Koike K.
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Journal Title
Sci Rep.
Volume: 3
Issue: 1
Pages: 2553-2553
DOI
Related Report
Peer Reviewed
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