| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2015: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
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| Outline of Final Research Achievements |
c-Src is frequently upregulated in various human cancers and believed to play a pivotal role on malignant behavior of cancer cells. However, the molecular mechanism underlying c-Src-mediated tumor progression remains unclear. To address the molecular mechanisms underlying c-Src-mediated tumor progression through the regulation of gene expression, we examined the involvement of miRNAs in the c-Src-mediated cell transformation. Microarray profiling revealed that c-Src activation causes aberrant expression of a limited set of miRNAs. We investigated the function of these miRNAs and uncovered the miRNA-mediated regulation of c-Src oncogenic signaling and interplay between Src signaling and other oncogenic signaling, such as mTOR and focal adhesion-related pathways. Signaling molecules in such pathways are linked to each other, not only via phosphorylation and protein-protein interactions but also via translational regulation by miRNAs.
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