microRNA controls Src-induced cancer progression
Project/Area Number |
25293077
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Pathological medical chemistry
|
Research Institution | Aichi Cancer Center Research Institute (2015) Osaka University |
Principal Investigator |
Oneyama Chitose 愛知県がんセンター(研究所), 感染腫瘍学部, 部長 (90373208)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2015: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
|
Keywords | Src / がん / microRNA |
Outline of Final Research Achievements |
c-Src is frequently upregulated in various human cancers and believed to play a pivotal role on malignant behavior of cancer cells. However, the molecular mechanism underlying c-Src-mediated tumor progression remains unclear. To address the molecular mechanisms underlying c-Src-mediated tumor progression through the regulation of gene expression, we examined the involvement of miRNAs in the c-Src-mediated cell transformation. Microarray profiling revealed that c-Src activation causes aberrant expression of a limited set of miRNAs. We investigated the function of these miRNAs and uncovered the miRNA-mediated regulation of c-Src oncogenic signaling and interplay between Src signaling and other oncogenic signaling, such as mTOR and focal adhesion-related pathways. Signaling molecules in such pathways are linked to each other, not only via phosphorylation and protein-protein interactions but also via translational regulation by miRNAs.
|
Report
(4 results)
Research Products
(46 results)
-
-
-
-
-
-
-
-
-
[Journal Article] MiR-424/503-mediated Rictor upregulation promotes tumor progression2013
Author(s)
Oneyama C, Kito Y, Asai R, Ikeda J, Yoshida T, Okuzaki D, Kokuda R, Kakumoto K, Takayama K, Inoue S, Morii E, Okada M.
-
Journal Title
PLos ONE 2013
Volume: 8(11)
Issue: 11
Pages: e80300-e80300
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] がんシグナル研究の新機軸2014
Author(s)
小根山千歳
Organizer
愛知県がんセンター研究所招聘セミナー
Place of Presentation
愛知県がんセンター研究所(名古屋)
Year and Date
2014-11-04
Related Report
Invited
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-