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Analysis of activation pathways and functional heterogeneity of macrophages - beyond M1/M2 paradigm

Research Project

Project/Area Number 25293089
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Human pathology
Research InstitutionKumamoto University

Principal Investigator

TAKEYA MOTOHIRO  熊本大学, 大学院生命科学研究部, 教授 (90155052)

Co-Investigator(Kenkyū-buntansha) KOMOHARA YOSHIHIRO  熊本大学, 大学院生命科学研究部, 准教授 (40449921)
OHNISHI KOJI  熊本大学, 大学院生命科学研究部, 助教 (40613378)
FUJIWARA YUKIO  熊本大学, 大学院生命科学研究部, 講師 (70452886)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2015: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
KeywordsM1/M2マクロファージ / 腫瘍随伴マクロファージ / ヒト悪性腫瘍 / がん幹細胞 / CD163 / CD204 / Stat3 / corosolic acid / M2マクロファージ / 患者予後 / 腫瘍増殖 / CD169 / 天然化合物 / onionin A / マクロファージ / オルタナティブ活性化
Outline of Final Research Achievements

Tumor-associated macrophages of M2-type (M2-TAM) were considered to play an important role in the maintenance of stemness in a human clear cell renal cell carcinoma. In adult T cell leukemia/lymphoma, density of CD163-positive M2-TAM was associated with poor prognosis of patients, whereas CD204-positive M2-TAM was not, indicating the functional difference of CD163-positive TAMs and CD204-positive TAMs.
Increased number of CD169-positive sinus macrophages in the regional lymph nodes of colon cancer and malignant melanoma was associated with favorable prognosis of the patients. Since it is positively correlated with the number of CD8-positive T cells in tumor tissues, CD169-positive sinus macrophages were considered to be involved in the establishment of anti-tumor immunity.
It was found that corosolic acid, a natural compound that suppresses M2-macrophage differentiation, inhibits tumor cell growth via suppressing the Stat3 activation of both tumor cells and macrophages.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (135 results)

All 2016 2015 2014 2013 Other

All Journal Article (43 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 37 results,  Open Access: 24 results,  Acknowledgement Compliant: 12 results) Presentation (90 results) (of which Int'l Joint Research: 4 results,  Invited: 13 results) Remarks (2 results)

  • [Journal Article] Infiltration of tumor-associated macrophages is involved in CD44 expression in clear cell renal cell carcinoma.2016

    • Author(s)
      Ma C, Komohara Y, Ohnishi K, Shimoji T, Kuwahara N, Sakumura Y, Matsuishi K, Fujiwara Y, Motoshima T, Takahashi W, Yamada S, Kitada S, Fujimoto N, Nakayama T, Eto M, Takeya M.
    • Journal Title

      Cancer Sci.

      Volume: Epub Issue: 5 Pages: 700-707

    • DOI

      10.1111/cas.12917

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prognostic significance of CD169-positive lymph node sinus macrophages in patients with endometrial carcinoma.2016

    • Author(s)
      Ohnishi K, Yamaguchi M, Erdenebaatar C, Saito F, Tashiro H, Katabuchi H, Takeya M, Komohara Y.
    • Journal Title

      Cancer Sci

      Volume: - Issue: 6 Pages: 846-852

    • DOI

      10.1111/cas.12929

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] TIM-3 expression in lymphoma cells predicts chemoresistance in patients with adult T-cell leukemia/lymphoma (ATLL).2016

    • Author(s)
      Horlad H, Ohnishi K, Ma C, Fujiwara Y, Niino D, Ohshima K, Jinushi M, Matsuoka M, Takeya M, Komohara Y.
    • Journal Title

      Oncol Lett

      Volume: -

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Contribution of Macrophage Polarization to Metabolic Diseases2016

    • Author(s)
      Yoshihiro Komohara, Yukio Fujiwara, Koji Ohnishi, Daisuke Shiraishi, Motohiro Takeya
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 23 Issue: 1 Pages: 10-17

    • DOI

      10.5551/jat.32359

    • NAID

      130005118655

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] CXCL10 and CCL2 mRNA expression in monocytes is inversely correlated with the HLA-DR lower fraction of monocytes in patients with renal cell carcinoma.2016

    • Author(s)
      Motoshima T, Komohara Y, Horlad H, Tsukamoto H, Fujita M, Saito Y, Tanoue K, Kasejima Y, Sugiyama Y, Kawano Y, Nishimura Y, Takeya M, Eto M.
    • Journal Title

      Oncol Lett

      Volume: 11 Pages: 1911-1916

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 血液系腫瘍におけるマクロファージの役割(Role of macrophages in hematological malignancies)2016

    • Author(s)
      菰原義弘、竹屋元裕
    • Journal Title

      血液内科

      Volume: 72 Pages: 85-89

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 特集:慢性炎症とがん 総論:がんと慢性炎症の密接な関係2016

    • Author(s)
      竹屋元裕
    • Journal Title

      別冊BIO Clinica

      Volume: 5 Pages: 10-11

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 特集:慢性炎症とがん 病理アトラス 悪性腫瘍:その組織学的特徴と微小環境2016

    • Author(s)
      菰原義弘
    • Journal Title

      別冊BIO Clinica

      Volume: 5

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 特集:慢性炎症とがん マクロファージの活性化制御によるがん治療2016

    • Author(s)
      藤原章雄、菰原義弘、大西紘二、竹屋元裕
    • Journal Title

      別冊BIO Clinica

      Volume: 5 Pages: 112-117

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 特集:慢性炎症とがん リンパ節洞マクロファージとがん免疫2016

    • Author(s)
      大西紘二、菰原義弘、竹屋元裕
    • Journal Title

      別冊BIO Clinica

      Volume: 5 Pages: 94-99

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Tumor-associated macrophages: Potential therapeutic targets for anti-cancer therapy.2015

    • Author(s)
      Yoshihiro Komohara, Yukio Fujiwara, Koji Ohnishi, Motohiro Takeya
    • Journal Title

      Advanced drug delivery reviews

      Volume: 24 Pages: 180-185

    • DOI

      10.1016/j.addr.2015.11.009

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Inhibitors for cholesterol ester accumulation in macrophages from Chinese cabbage.2015

    • Author(s)
      Takamoto H, Eguchi K, Kawabata T, Fujiwara Y, Takeya M, Tsukamoto S.
    • Journal Title

      Bioscience, Biotechnology Biochemistry

      Volume: 79 Issue: 8 Pages: 1315-1319

    • DOI

      10.1080/09168451.2015.1023247

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Prognostic Significance of CD169+ Lymph Node Sinus Macrophages in Patients with Malignant Melanoma.2015

    • Author(s)
      Saito Y, Ohnishi K, Miyashita A, Nakahara S, Fujiwara Y, Horlad H, Motoshima T, Fukushima S, Jinnin M, Ihn H, Takeya M, Komohara Y.
    • Journal Title

      Cancer Immunol Res.

      Volume: 3 Issue: 12 Pages: 1356-1363

    • DOI

      10.1158/2326-6066.cir-14-0180

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sorafenib enhances the anti-tumor effect of anti-CTLA-4 antibody by inhibiting myeloid-derived suppressor cells.2015

    • Author(s)
      Motoshima T, Komohara Y, Horlad H, Takeuchi A, Maeda Y, Tanoue K, Kawano Y, Harada M, Takeya M, Eto M
    • Journal Title

      Oncol Rep

      Volume: - Issue: 6 Pages: 2947-2953

    • DOI

      10.3892/or.2015.3893

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bastadins, brominated-tyrosine derivatives, suppress accumulation of cholesterol ester in macrophages.2015

    • Author(s)
      Eguchi K, Kato H, Fujiwara Y, Losung F, Mangindaan RE, de Voogd NJ, Takeya M, Tsukamoto S.
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 25 Issue: 22 Pages: 5389-5392

    • DOI

      10.1016/j.bmcl.2015.09.024

    • NAID

      120006897982

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Soyasapogenols contained in soybeans suppress tumour progression by regulating macrophage differentiation into the protumoural phenotype.2015

    • Author(s)
      Fujiwara Y, Shiraishi D, Yoshitomi M, Ikeda T, Mizuta H, Takeya M, Komohara Y.
    • Journal Title

      J Funct Foods

      Volume: 19 Pages: 594-605

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] がん病態におけるマクロファージの重要性─標的細胞としての可能性─2015

    • Author(s)
      菰原義弘、竹屋元裕
    • Journal Title

      細胞

      Volume: 47 Pages: 294-297

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Role of HIC-5 in the formation of microvilli-like structures and the monocyte-endotherial interaction that accelerates atherosclerosis2015

    • Author(s)
      Shigeko Arita-Okubo, et al
    • Journal Title

      Cardiovasc Res

      Volume: 105 Issue: 3 Pages: 361-371

    • DOI

      10.1093/cvr/cvv003

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tumor-associated macrophages as an emerging target against tumors: Creating a new path from bench to bedside.2015

    • Author(s)
      Jinushi M, Komohara Y
    • Journal Title

      Biochim Biophys Acta.

      Volume: 1855 Issue: 2 Pages: 123-130

    • DOI

      10.1016/j.bbcan.2015.01.002

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Cyclic Sulfoxides-Garlicnins K<sub>1</sub>, K<sub>2</sub>, and H<sub>1</sub>-Extracted from <i>Allium sativum</i>2015

    • Author(s)
      Nohara T, Fujiwara Y, Komota Y, Kondo Y, Saku T, Yamaguchi K, Komohara Y, Takeya M
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 63 Issue: 2 Pages: 117-121

    • DOI

      10.1248/cpb.c14-00538

    • NAID

      130004803765

    • ISSN
      0009-2363, 1347-5223
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of tumor-associated macrophages in hematological malignancies. (Review)2015

    • Author(s)
      Komohara Y, Niino D, Ohnishi K, Ohshima K, Takeya M
    • Journal Title

      Pathol Int

      Volume: 65 Issue: 4 Pages: 170-176

    • DOI

      10.1111/pin.12259

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Inhibitors for cholesterol ester accumulation in macrophages from Chinese cabbage.2015

    • Author(s)
      Takamoto H, Eguchi K, Kawabata T, Fujiwara Y, Takeya M, Tsukamoto S
    • Journal Title

      Biosci Biotechnol Biochem

      Volume: -

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The coordinated actions of TIM-3 on cancer and myeloid cells in the regulation of tumorigenicity and clinical prognosis in clear cell renal cell carcinomas.2015

    • Author(s)
      Komohara Y, Morita T, Annan DA, Horlad H, Ohnishi K, Yamada S, Nakayama T, Kitada S, Suzu S, Kinoshita I, Dosaka-Akita H, Akashi K, Takeya M, Jinushi M
    • Journal Title

      Cancer Immunol Res

      Volume: -

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Macrophage-derived reactive oxygen species suppress miR-328 targeting CD44 in cancer cells and promote redox adaptation2014

    • Author(s)
      Ishimoto T, Sugihara H, Watanabe M, Sawayama H, Iwatsuki M, Baba Y, Okabe H, Hidaka K, Yokoyama N, Miyake K, Yoshikawa M, Nagano O, Komohara Y, Takeya M, Saya H, Baba H.
    • Journal Title

      Carcinogenesis

      Volume: 35(5) Issue: 5 Pages: 1003-11

    • DOI

      10.1093/carcin/bgt402

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Novel Strategy for Inducing the Antitumor Effects of Triterpenoid Compounds: Blocking the Protumoral Functions of Tumor-Associated Macrophages via STAT3 Inhibition.2014

    • Author(s)
      Fujiwara Y, Takeya M, Komohara Y
    • Journal Title

      Biomed Res Int

      Volume: 2014 Pages: 348539-348539

    • DOI

      10.1155/2014/348539

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Promotion of atherosclerosis by Helicobacter cinaedi infection that involves macrophage-driven proinflammatory responses.2014

    • Author(s)
      Khan S, Rahman H N A, Okamoto T, Matsunaga T, Fujiwara Y, Sawa T, Yoshitake J, Ono K, Ahmed K A, Rahaman M d M, Oyama K, Takeya M, Ida T, Kitamura Y, Fujii S, Akaike T.
    • Journal Title

      Sci. Rep.

      Volume: (印刷中) Issue: 1 Pages: 4680-4680

    • DOI

      10.1038/srep04680

    • NAID

      120005649608

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Conversion of tomato saponins to pregnane derivatives.2014

    • Author(s)
      Nohara T, Manabe H, Fujiwara Y, Ikeda T, Ono M, Murakami K, Nakano D, Kinjo J, Kajimoto T
    • Journal Title

      Chem Pharm Bull (Tokyo)

      Volume: 62 Pages: 483-487

    • NAID

      130004053795

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Acyclic Sulfides, Garlicnins L-1-L-4, E, and F, from Allium sativum.2014

    • Author(s)
      Nohara T, Fujiwara Y, Ikeda T, Yamaguchi K, Manabe H, Murakami K, Ono M, Nakano D, Kinjo J
    • Journal Title

      Chem Pharm Bull (Tokyo)

      Volume: 62 Pages: 477-482

    • NAID

      40020048679

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Acantholactam and pre-neo-kauluamine, manzamine-related alkaloids, from the Indonesian marine sponges, Acanthostrongylophora ingens.2014

    • Author(s)
      A. H. El-Desoky, H. Kato, K. Eguchi, T. Kawabata, Y. Fujiwara, F. Losung, R. E. P. Mangindaan, N. J. de Voogd, M. Takeya, H. Yokosawa, S. Tsukamoto
    • Journal Title

      J. Nat. Prod.

      Volume: 77 Issue: 6 Pages: 1536-1540

    • DOI

      10.1021/np500290a

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Role of CD204-positive tumor associated macrophages in adult T-cell leukemia/lymphoma.2014

    • Author(s)
      Saito Y, Komohara Y, Niino D, Horlad H, Ohnishi K, Takeya H, Kawaguchi H, Shimizu H, Ohshima K, Takeya M
    • Journal Title

      J Clin Exp Hematopathol

      Volume: 54 Pages: 59-65

    • NAID

      130004886477

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Triterpenoids from the Fruits and Leaves of the Blackberry (Rubus allegheniensis) and Their Inhibitory Activities on Foam Cell Formation in Human Monocyte-Derived Macrophage2014

    • Author(s)
      M. Ono, S. Yasuda, H. Komatsu, Y. Fujiwara, M. Takeya, T. Nohara
    • Journal Title

      Nat. Prod. Res.

      Volume: 28 Issue: 24 Pages: 839-844

    • DOI

      10.1080/14786419.2014.939087

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Isolation and Characterization of New Onionins A2 and A3 from Allium cepa, and of Onionins A1, A2, and A3 from Allium fistulosum.2014

    • Author(s)
      Nohara T, Fujiwara Y, Kudo R, Yamaguchi K, Ikeda T, Murakami K, Ono M, Kajimoto T, Takeya M
    • Journal Title

      Chem Pharm Bull (Tokyo)

      Volume: 62 Pages: 1141-1145

    • NAID

      130004712906

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Overexpression of CD163, CD204 and CD206 on alveolar macrophages in the lungs of patients with severe chronic obstructive pulmonary disease.2014

    • Author(s)
      Kaku Y, Imaoka H, Morimatsu Y, Komohara Y, Ohnishi K, Oda H, Takenaka S, Matsuoka M, Kawayama T, Takeya M, Hoshino T
    • Journal Title

      PLoS One

      Volume: 30 Issue: 1 Pages: e87400-e87400

    • DOI

      10.1371/journal.pone.0087400

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical significance of macrophage heterogeneity in human malignant tumors.2014

    • Author(s)
      Komohara Y, Jinushi M, Takeya M
    • Journal Title

      Cancer Science

      Volume: 105 Issue: 1 Pages: 1-8

    • DOI

      10.1111/cas.12314

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Corosolic acid impairs tumor development and lung metastasis by inhibiting the immunosuppressive activity of myeloid-derived suppressor cells2013

    • Author(s)
      Horlad Hasita, Fujiwara Yukio, Takemura Kenichi, Ohnishi Koji, Ikeda Tsuyoshi, Tsukamoto Hirotake, Mizuta Hiroshi, Nishimura Yasuharu, Takeya Motohiro, Komohara Yoshihiro
    • Journal Title

      Mol. Nutri. Food Res

      Volume: 57 (6) Issue: 6 Pages: 1-9

    • DOI

      10.1002/mnfr.201200610

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Possible involvement of signal transducer and activator of transcription-3 in cell-cell interactions of peritoneal macrophages and endometrial stromal cells in human endometriosis.2013

    • Author(s)
      Itoh F, Komohara Y, Takaishi K, Honda R, Tashiro H, Kyo S, Katabuchi H, Takeya M
    • Journal Title

      Fertil Steril

      Volume: 99 Issue: 6 Pages: 1705-1713

    • DOI

      10.1016/j.fertnstert.2013.01.133

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD169-positive macrophages in regional lymph nodes are associated with a favorable prognosis in patients with colorectal carcinoma.2013

    • Author(s)
      Ohnishi K, Komohara Y, Saito Y, Miyamoto Y, Watanabe M, Baba H, Takeya M
    • Journal Title

      Cancer Sci

      Volume: 104 Issue: 9 Pages: 1237-1244

    • DOI

      10.1111/cas.12212

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Corosolic acid enhances the antitumor effects of chemotherapy on epithelial ovarian cancer by inhibiting signal transducer and activator of transcription 3 signaling.2013

    • Author(s)
      Fujiwara Y, Takaishi K, Nakao J, Ikeda T, Katabuchi H, Takeya M, Komohara Y
    • Journal Title

      Oncol Lett

      Volume: 6 Pages: 1619-1623

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of miR-30e*regulation of Bmi1 expression mediated by tumor-assocated macrophages in gastrointestinal cancer.2013

    • Author(s)
      117 Sugihara H, Ishimoto T., Watanabe M., Sawayama H., Iwatsuki M., Baba Y., Kamohara Y., Takeya M., Baba H
    • Journal Title

      PLoS One

      Volume: 8 Issue: 11 Pages: e81839-e81839

    • DOI

      10.1371/journal.pone.0081839

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TIM-4 glycoprotein-mediated degradation of dying tumor cells by autophagy leads to reduced antigen presentation and increased immune tolerance.2013

    • Author(s)
      Baghdadi M, Yoneda A, Yamashina T, Nagao H, Komohara Y, Nagai S, Akiba H, Foretz M, Yoshiyama H, Kinoshita I, Dosaka-Akita H, Takeya M, Viollet B, Yagita H, Jinushi M
    • Journal Title

      Immunity

      Volume: 39 Issue: 6 Pages: 1070-1081

    • DOI

      10.1016/j.immuni.2013.09.014

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical significance of CD163+ tumor-associated macrophages in patients with adult T-cell leukemia/lymphoma.2013

    • Author(s)
      Komohara Y, Niino D, Saito Y, Ohnishi K, Horlad H, Ohshima K, Takeya M.
    • Journal Title

      Cancer Sci

      Volume: in press Issue: 7 Pages: 945-951

    • DOI

      10.1111/cas.12167

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Manzamine A, a marine-derived alkaloid, inhibits accumulation of cholesterol ester in macrophages and suppresses hyperlipidemia and atherosclerosis in vivo2013

    • Author(s)
      K.Eguchi, R.E.P.Mangindaan, S.Tsukamoto
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 21 Issue: 13 Pages: 3831-3838

    • DOI

      10.1016/j.bmc.2013.04.025

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of Stat3 activation in cell-cell interaction between B-cell lymphoma and macrophages: the in vitro study.2013

    • Author(s)
      Bai B, Horlad H, Saito Y, Ohnishi K, Fujiwara Y, Takeya M, Komohara Y.
    • Journal Title

      J Clin Exp Hematop

      Volume: 53 Pages: 127-133

    • NAID

      10031194234

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] 低分子硫黄含有化合物であるONAはガン微小環境におけるSTAT3の不活性化を介して卵巣癌の進展を抑制する2015

    • Author(s)
      藤原章雄、中尾純子、西東洋一、片渕秀隆、竹屋元裕、菰原義弘
    • Organizer
      第88回 日本生化学会大会
    • Place of Presentation
      ポートアイランド(神戸)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 婦人科疾患における腹腔マクロファージの役割. シンポジウム2015

    • Author(s)
      菰原義弘
    • Organizer
      第30回 日本生殖免疫学会総会
    • Place of Presentation
      くまもと県民交流館パレア(熊本)
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] CD169+ macrophages in regional lymph nodes involved in the tumor immunity and prognosis in patients with colorectal cancer, melanoma and endometrial cancer.2015

    • Author(s)
      OHNISHI Koji, KOMOHARA Yoshihiro, SAITO Yoichi, TAKEYA Motohiro
    • Organizer
      第44回 日本免疫学会学術集会
    • Place of Presentation
      札幌コンベンションセンター(札幌)
    • Year and Date
      2015-11-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Infiltration of tumor-associated macrophages is involved in CD44 expression in clear cell renal cell carcinoma.2015

    • Author(s)
      Chaoya Ma, Yoshihiro Komohara, Koji Ohnishi, Sohsuke Yamada, Toshiyuki Nakayama, Shohei Kitada, Masatoshi Eto, Motohiro Takeya.
    • Organizer
      第61回 日本病理学会秋期特別総会
    • Place of Presentation
      東京大学安田講堂(東京)
    • Year and Date
      2015-11-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] STAT3 経路の活性化を抑制するタマネギ成分ONA の抗腫瘍効果の検討2015

    • Author(s)
      藤原章雄、中尾純子、菰原義弘、野原稔弘、池田剛、片渕秀隆、竹屋元裕
    • Organizer
      第6回 食品薬学シンポジウム
    • Place of Presentation
      岡山大学(岡山)
    • Year and Date
      2015-10-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] 腫瘍随伴マクロファージは腎細胞癌のCD44発現に関与する2015

    • Author(s)
      菰原義弘、Horlad Hasita、元島崇信、山田壮亮、中山敏幸、江藤正俊
    • Organizer
      第74回 日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] Macrophages induced activation of STAT3 on small-cell lung cancer cells.2015

    • Author(s)
      Toyohisa Iriki, Koji Ohnishi, Yoshihiro Komohara, Yukio Fujiwara, Hirotsugu Kohrogi, Motohiro Takeya.
    • Organizer
      第74回 日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] 人工関節からの摩耗粉がマクロファージの活動と炎症性サイトカイン産生量に与える影響2015

    • Author(s)
      近浦裕斗、西真生、吉岡陸、政岡晴行、中島雄太、藤原章雄、菰原義弘、竹屋元裕、水田博志、日垣秀彦、中西義孝
    • Organizer
      第26回 バイオフロンティア講演会
    • Place of Presentation
      九州大学(福岡)
    • Year and Date
      2015-10-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] 人工関節軸受部の表面テクスチャが生体反応因子に与える影響2015

    • Author(s)
      中西義孝、西真生、近浦裕斗、中島雄太、藤原章雄、菰原義弘、竹屋元裕、水田博志、三浦博正、岩本幸秀、日垣秀彦
    • Organizer
      2015年度 日本機械学会年次大会
    • Place of Presentation
      北海道大学(札幌)
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] 人工関節摺動面から発生する磨耗粉がマクロファージの免疫機能に与える影響2015

    • Author(s)
      中島雄太、近浦裕斗、西真生、藤原章雄、菰原 義弘、竹屋元裕、中西義孝
    • Organizer
      2015年度 日本機械学会年次大会
    • Place of Presentation
      北海道大学(札幌)
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] マクロファージの分化・活性化に関する最近の話題と疾患への関与. 招待講演2015

    • Author(s)
      菰原義弘
    • Organizer
      第16回 Atherosclerosis and Biolipid Conference
    • Place of Presentation
      ホテル日航東京(東京)
    • Year and Date
      2015-08-01
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 乳癌患者におけるリンパ節CD169陽性マクロファージの臨床病理学的研究2015

    • Author(s)
      塩田拓也、宮里祐子、大西絋二、菰原義弘、指宿睦子、岩瀬弘敬、竹屋元裕
    • Organizer
      第12回 日本病理学会カンファレンス
    • Place of Presentation
      六甲山ホテル(神戸)
    • Year and Date
      2015-07-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] 乳癌においてCD204陽性マクロファージ浸潤密度は予後予測因子となる2015

    • Author(s)
      宮里祐子、塩田拓也、大西紘二、指宿睦子、山本豊、岩瀬弘敬、竹屋元裕、菰原義弘
    • Organizer
      第12回 日本病理学会カンファレンス
    • Place of Presentation
      六甲山ホテル(神戸)
    • Year and Date
      2015-07-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] 腎細胞癌患者における末梢血抑制性ミエロイド細胞の解析2015

    • Author(s)
      元島崇信、菰原義弘、哈斯塔、塚本博丈、西東洋一、鹿瀬島裕、河野吉昭、西村泰治、竹屋元裕、江藤正俊
    • Organizer
      第46回 腎癌研究会
    • Place of Presentation
      品川インターシティホール(東京)
    • Year and Date
      2015-07-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] ヒト悪性腫瘍におけるマクロファージの役割と標的細胞としての可能性. シンポジウム2015

    • Author(s)
      菰原義弘、竹屋元裕
    • Organizer
      第25回 日本樹状細胞研究会
    • Place of Presentation
      岡山コンペンションセンター(岡山)
    • Year and Date
      2015-07-10
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 脂質代謝とCD163 陽性マクロファージとの関連について. 奨励賞受賞2015

    • Author(s)
      西東洋一、藤原章雄、白石大偉輔、哈斯塔、菰原義弘、竹屋元裕
    • Organizer
      第25回 日本樹状細胞研究会
    • Place of Presentation
      第25回 日本樹状細胞研究会
    • Year and Date
      2015-07-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] Onionin A inhibits ovarian cancer progression via STAT3 pathway inactivation of ovarian cancer cells and macrophages in cancer microenvironment.2015

    • Author(s)
      Junko Tsuboki, Yukio Fujiwara, Hasita Horlad, Hidetaka Katabuchi, Yoshihiro Komohara, Motohiro Takeya.
    • Organizer
      International Conference of Cancer Immunology and Macrophages 2015 (がん免疫療法・マクロファージ国際会議2015)
    • Place of Presentation
      The University of Tokyo(東京)
    • Year and Date
      2015-07-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The significance of tumor-associated macrophages in small cell lung cancer.2015

    • Author(s)
      Toyohisa Iriki, Koji Ohnishi, Yoshihiro Komohara, Yukio Fujiwara, Hirotsugu Kohrogi, Motohiro Takeya
    • Organizer
      International Conference of Cancer Immunology and Macrophages 2015 (がん免疫療法・マクロファージ国際会議2015)
    • Place of Presentation
      The University of Tokyo(東京)
    • Year and Date
      2015-07-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clinicopathological study of CD169-positive lymph node macrophage in patients with breast cancer.2015

    • Author(s)
      Takuya Shiota, Yuko Miyasato, Koji Ohnishi, Mutsuko Ibusuki, Hironori Iwase, Motohiro Takeya, Yoshihiro Komohara.
    • Organizer
      International Conference of Cancer Immunology and Macrophages 2015 (がん免疫療法・マクロファージ国際会議2015)
    • Place of Presentation
      The University of Tokyo(東京)
    • Year and Date
      2015-07-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The density of CD204-positive macrophages predicts clinical prognosis in patients with breast cancer.2015

    • Author(s)
      Yuko Miyasato, Takuya Shiota, Koji Ohnishi, Mutsuko Ibusuki, Hirotaka Iwase, Motohiro Takeya, Yoshihiro Komohara.
    • Organizer
      International Conference of Cancer Immunology and Macrophages 2015 (がん免疫療法・マクロファージ国際会議2015)
    • Place of Presentation
      The University of Tokyo(東京)
    • Year and Date
      2015-07-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] マクロファージスカベンジャー受容体であるCD163の腫瘍増殖における機能性2015

    • Author(s)
      藤原章雄、白石大偉輔、HORLAD Hasita、菰原義弘、水田博志、竹屋元裕
    • Organizer
      第55回 日本リンパ網内系学会総会
    • Place of Presentation
      岡山コンペンションセンター
    • Year and Date
      2015-07-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 腫瘍関連マクロファージに取り込まれるマグネタイトナノ粒子の作製2015

    • Author(s)
      牧山恵里香、松山順次、木田徹也、菰原義弘、竹屋元裕、新留琢郎
    • Organizer
      第31回 日本DDS学会学術集会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2015-07-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] がんにおけるマクロファージの役割 (The significance of tumor-associated macrophages (TAMs) in human malignant tumors).  シンポジウム2015

    • Author(s)
      菰原義弘、藤原章雄、大西紘二、竹屋元裕
    • Organizer
      第104回 日本病理学会総会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2015-04-30
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 悪性腫瘍におけるCD169陽性リンパ節マクロファージの臨床的意義2015

    • Author(s)
      藤原章雄、白石大偉輔、HASITA Horlad、菰原義弘、水田博志、竹屋元裕
    • Organizer
      第104回 日本病理学会総会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2015-04-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] 悪性腫瘍におけるCD169陽性リンパ節マクロファージの臨床病理学的意義の解明. 学術奨励賞受賞講演2015

    • Author(s)
      大西紘二
    • Organizer
      第104回 日本病理学会総会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2015-04-30
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] TIM3 expression in lymphoma cells is involved in chemo-resistance in patients with adult T-cell leukemia/lymphoma (ATLL).2015

    • Author(s)
      Horlad Hasita, Yoshihiro Komohara, Daisuke Niino, Koichi Ohshima, Motohiro Takeya.
    • Organizer
      第104回 日本病理学会総会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2015-04-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] 悪性黒色腫における所属リンパ節内CD169陽性洞マクロファージを用いた予後予測の有用性-CD169陽性細胞数は生命予後と相関する-. 100周年記念 病理学研究新人賞受賞2015

    • Author(s)
      西東洋一
    • Organizer
      第104回 日本病理学会総会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2015-04-30
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] STAT3 経路の活性を抑制する天然化合物 Onionin A のマウスにおける抗腫瘍効果についての検討2015

    • Author(s)
      中尾純子、藤原章雄、菰原義弘、片渕秀隆、竹屋元裕
    • Organizer
      第104回 日本病理学会総会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2015-04-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] 小細胞肺癌における腫瘍随伴マクロファージの重要性.2015

    • Author(s)
      入來豊久、大西紘二、菰原義弘、藤原章雄、興梠博次、竹屋元裕.
    • Organizer
      第104回 日本病理学会総会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2015-04-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] Infiltration of tumor-associated macrophages is involved in CD44 expression in clear cell renal cell carcinoma.2015

    • Author(s)
      Chaoya Ma, Yoshihiro Komohara, Takanobu Motoshima, Sousuke Yamada, Toshiyuki Nakayama, Motohiro Takeya.
    • Organizer
      第104回 日本病理学会総会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2015-04-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] 腎細胞癌患者における抹消血抑制性ミエロイド細胞の解析2015

    • Author(s)
      元島崇信、菰原義弘、哈斯塔、塚本博丈、藤田貢、西東洋一、鹿瀬島裕、河野吉昭、西村泰治、竹屋元裕、江藤正俊
    • Organizer
      第103回 日本泌尿器科学会総会
    • Place of Presentation
      ANAクラウンプラザホテル金沢(金沢)
    • Year and Date
      2015-04-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] CD169-positive lymph node sinus macrophages are correlated with a favorable prognosis in patients with endometrial carcinoma.2015

    • Author(s)
      Yoshihiro Komohara, Koji Ohnishi, Motohiro Takeya
    • Organizer
      Keystone Symposia on Molecular and Cellular Biology
    • Place of Presentation
      Fairmont The Queen Elizabeth, Montreal, QC, Canada
    • Year and Date
      2015-03-08 – 2015-03-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] CD163 (hemoglobin scavenger receptor) expressed on macrophages is involved in tumorgenesis in murine sarcoma model.2015

    • Author(s)
      Daisuke Shiraishi, Yukio Fujiwara, Hasita Horlad, Hiroshi Mizuta, Motohiro Takeya Yoshihiro Komohara
    • Organizer
      Keystone Symposia on Molecular and Cellular Biology
    • Place of Presentation
      Fairmont The Queen Elizabeth, Montreal, QC, Canada
    • Year and Date
      2015-03-08 – 2015-03-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] マクロファージにおけるCD163の発現を抑制する化合物のスクリーニングとその応用2014

    • Author(s)
      藤原章雄
    • Organizer
      生薬若手懇話会 第13回勉強会
    • Place of Presentation
      京都、京都大学
    • Year and Date
      2014-12-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] ミエロイド細胞の制御を介したOnionin A の抗腫瘍薬としての可能性(生薬天然物部会奨励研究賞受賞講演)2014

    • Author(s)
      藤原章雄
    • Organizer
      第20回 天然薬物の開発と応用シンポジウム
    • Place of Presentation
      東京、東京大学弥生キャンパス
    • Year and Date
      2014-11-05 – 2014-11-06
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] トマトサポニンの薬理作用抗動脈硬化, 抗アトピー性様皮膚炎, ならびに抗腫瘍作用について2014

    • Author(s)
      野原稔弘、藤原章雄、周建融、木村善行、池田剛、小野政輝
    • Organizer
      第20回 天然薬物の開発と応用シンポジウム
    • Place of Presentation
      東京、東京大学弥生キャンパス
    • Year and Date
      2014-11-05 – 2014-11-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヘモグロビンスカベンジャー受容体(CD163)は炎症を抑制することで敗血症マウスの生存率を改善する2014

    • Author(s)
      藤原章雄、大西紘二、西東洋一、菰原義弘、竹屋元裕
    • Organizer
      第87回 日本生化学会大会
    • Place of Presentation
      京都、国立京都国際会館
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 悪性黒色腫における所属リンパ節内CD169陽性マクロファージ数は生命予後と相関する2014

    • Author(s)
      西東洋一、大西紘二、宮下梓、中原智史、藤原章雄、福島聡、神人正寿、尹浩信、竹屋元裕、菰原義弘.
    • Organizer
      第87回 日本生化学会大会
    • Place of Presentation
      京都、国立京都国際会館
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Enhanced anti-tumor effects of anti-CTLA-4 antibody and anti-PD-1 antibody to kidney cancer model in mice.2014

    • Author(s)
      Takanobu Motoshima, Yoshihiro Komohara, Horlad Hasita, Yoshiaki Kawano, Motohiro Takeya, Masatoshi Eto
    • Organizer
      The 31st Japan-Korea Urological Congress
    • Place of Presentation
      Roppongi Academy Hills 49, Tokyo, Japan
    • Year and Date
      2014-09-27 – 2014-09-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 成人T細胞白血病/リンパ腫(ATLL)におけるTim-3発現は化学療法への耐性に関与する, Tim-3 expression in lymphoma cells is involved in chemo-resistance in patients with adult T-cell leukemia/lymphoma (ATLL).2014

    • Author(s)
      菰原義弘、Horlad Hasita, 地主将久,松岡雅雄、新野大介、大島孝一、竹屋元裕
    • Organizer
      第73回 日本癌学会学術総会
    • Place of Presentation
      横浜、パシフィコ横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] CD163 is correlated with tumor proliferation in MCA205 sarcoma bearing mice.2014

    • Author(s)
      Yukio Fujiwara, Daisuke Shiraishi, Hasita Horlad, Yoichi Saito, Motohiro Takeya, Yoshihiro Komohara
    • Organizer
      第73回 日本癌学会学術総会
    • Place of Presentation
      横浜、パシフィコ横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] LPS誘導性炎症に対するヘモグロビンスカベンジャー受容体(CD163)の抑制作用について2014

    • Author(s)
      藤原章雄、大西紘二、西東洋一、菰原義弘、竹屋元裕
    • Organizer
      第67回 日本酸化ストレス学会学術集会
    • Place of Presentation
      京都、同志社大学
    • Year and Date
      2014-09-04 – 2014-09-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 子宮体癌患者における予後予測因子としてのCD169陽性リンパ節マクロファージの重要性2014

    • Author(s)
      菰原義弘、大西紘二、西東洋一、竹屋元裕
    • Organizer
      第18回 日本がん免疫学会総会
    • Place of Presentation
      松山、びめぎんホール
    • Year and Date
      2014-07-30 – 2014-08-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] 悪性黒色腫における所属リンパ節内CD169陽性マクロファージ数は生命予後と相関する2014

    • Author(s)
      西東洋一、大西紘二、菰原義弘、竹屋元裕
    • Organizer
      第18回 日本がん免疫学会総会
    • Place of Presentation
      松山、びめぎんホール
    • Year and Date
      2014-07-30 – 2014-08-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヒト固形癌におけるマクロファージの役割と標的細胞としての可能性2014

    • Author(s)
      菰原義弘
    • Organizer
      第24回 日本樹状細胞研究会
    • Place of Presentation
      山形、山形国際ホテル
    • Year and Date
      2014-06-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 悪性黒色腫における所属リンパ節内CD169陽性マクロファージ数は生命予後と相関する(日本樹状細胞研究会奨励賞受賞)2014

    • Author(s)
      西東洋一、大西紘二、菰原義弘、竹屋元裕
    • Organizer
      第24回 日本樹状細胞研究会
    • Place of Presentation
      山形、山形国際ホテル
    • Year and Date
      2014-06-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] マクロファージの活性化を制御する硫黄含有化合物の抗腫瘍薬としての可能性2014

    • Author(s)
      藤原章雄、菰原義弘、竹屋元裕
    • Organizer
      第54回 日本リンパ網内系学会総会
    • Place of Presentation
      山形、山形国際ホテル
    • Year and Date
      2014-06-19 – 2014-06-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] 悪性黒色腫における所属リンパ節のマクロファージ亜群と予後との関連-CD169の予後予測マーカーとしての有用性2014

    • Author(s)
      西東洋一、大西紘二、菰原義弘、竹屋元裕
    • Organizer
      第54回 日本リンパ網内系学会総会
    • Place of Presentation
      山形、山形国際ホテル
    • Year and Date
      2014-06-19 – 2014-06-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] Significance of Macrophage Infiltration in Human Malignancies.2014

    • Author(s)
      Motohiro Takeya
    • Organizer
      The 22nd International Symposium on Molecular Cell Biology of Macrophages
    • Place of Presentation
      Kobe Chamber of Commerce and Industry, Kobe, Japan
    • Year and Date
      2014-06-02 – 2014-06-03
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] CD163 impair the excessive inflammatory responses in murine model of endotoxin shock.2014

    • Author(s)
      Yukio Fujiwara, Koji Ohnishi, Yoich Saito, Daisuke Shiraishi, Motohiro Takeya, Yoshihiro Komohara
    • Organizer
      The 22nd International Symposium on Molecular Cell Biology of Macrophages
    • Place of Presentation
      Kobe Chamber of Commerce and Industry, Kobe, Japan
    • Year and Date
      2014-06-02 – 2014-06-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] CD169-positive macrophages in regional lymph nodes involved in the tumor immunity and prognosis in patients with colorectal cancer, melanoma and endometrial cancer.2014

    • Author(s)
      Koji Ohnishi, Yoshihiro Komohara, Yoichi Saito, Motohiro Takeya
    • Organizer
      The 22nd International Symposium on Molecular Cell Biology of Macrophages
    • Place of Presentation
      Kobe Chamber of Commerce and Industry, Kobe, Japan
    • Year and Date
      2014-06-02 – 2014-06-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] Clinical significance of CD169-positive lymph node macrophages in human malignant tumors.2014

    • Author(s)
      Koji Ohnishi, Yoichi Saito, Yoshihiro Komohara, Yuji Miyamoto, Satoshi Fukushima, Munekage Yamaguchi, Hideo Baba, Hironobu Ihn, Hidetaka Katabuchi, Motohiro Takeya
    • Organizer
      2014 ASCO Annual Meeting
    • Place of Presentation
      McCormick Place Chicago, Illinois, USA
    • Year and Date
      2014-05-30 – 2014-06-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] マクロファージの活性化と病態( 宿題報告)2014

    • Author(s)
      竹屋元裕
    • Organizer
      第103回 日本病理学会総会
    • Place of Presentation
      広島、広島国際会議場
    • Year and Date
      2014-04-24 – 2014-04-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 成人T細胞白血病/リンパ腫におけるCD163陽性マクロファージの重要性2014

    • Author(s)
      菰原義弘、新野大介、大西紘二、大島孝一、竹屋元裕
    • Organizer
      第103回 日本病理学会総会
    • Place of Presentation
      広島、広島国際会議場
    • Year and Date
      2014-04-24 – 2014-04-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] マクロファージの活性化を制御する低分子化合物ONAの抗腫瘍薬としての可能性2014

    • Author(s)
      藤原章雄、菰原義弘、池田剛、野原稔弘、竹屋元裕
    • Organizer
      第103回 日本病理学会総会
    • Place of Presentation
      広島、広島国際会議場
    • Year and Date
      2014-04-24 – 2014-04-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 大腸癌患者における予後予測因子としてのCD169陽性リンパ節マクロファージの重要性2014

    • Author(s)
      大西紘二、菰原義弘、西東洋一、竹屋元裕
    • Organizer
      第103回 日本病理学会総会
    • Place of Presentation
      広島、広島国際会議場
    • Year and Date
      2014-04-24 – 2014-04-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 未分化肉腫(悪性線維性組織球腫)における腫瘍関連マクロファージの役割2014

    • Author(s)
      上川将史、菰原義弘、岡部英俊、竹屋元裕
    • Organizer
      第103回 日本病理学会総会
    • Place of Presentation
      広島、広島国際会議場
    • Year and Date
      2014-04-24 – 2014-04-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 線維肉腫MCA205移植モデルマウスを用いた腫瘍増殖におけるマクロファージヘモグロビンスカベンジャー受容体(CD163)の機能解析2014

    • Author(s)
      白石大偉輔、藤原章雄、Horlad Hasita、菰原義弘、大西紘二、水田博志、竹屋元裕
    • Organizer
      第103回 日本病理学会総会
    • Place of Presentation
      広島、広島国際会議場
    • Year and Date
      2014-04-24 – 2014-04-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 悪性黒色腫における所属リンパ節内CD169陽性マクロファージ数は生命予後と相関する2014

    • Author(s)
      西東洋一、大西紘二、菰原義弘、竹屋元裕
    • Organizer
      第103回 日本病理学会総会
    • Place of Presentation
      広島、広島国際会議場
    • Year and Date
      2014-04-24 – 2014-04-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Onionin Aの卵巣癌細胞における細胞増殖とSTAT3の活性化に対する作用の検討2014

    • Author(s)
      中尾純子、藤原章雄、菰原義弘、片渕秀隆、竹屋元裕
    • Organizer
      第103回 日本病理学会総会
    • Place of Presentation
      広島、広島国際会議場
    • Year and Date
      2014-04-24 – 2014-04-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 淡明細胞型腎細胞癌における腫瘍随伴マクロファージと癌幹細胞の関連性(学生ポスター)2014

    • Author(s)
      下地徹、朔太樹、桑原奈歩、作村恭央、松石梢、山田壮亮、菰原義弘、竹屋元裕
    • Organizer
      第103回 日本病理学会総会
    • Place of Presentation
      広島、広島国際会議場
    • Year and Date
      2014-04-24 – 2014-04-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 宿題報告2:マクロファージの活性化と病態2014

    • Author(s)
      竹屋元裕
    • Organizer
      第103回日本病理学会総会
    • Place of Presentation
      広島国際会議場、広島
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Clinical significance of CD163-positive tumor-associated macrophages in adult T-cell leukemia/lymphoma (ATLL).2013

    • Author(s)
      Yoshihiro Komohara, Yoichi Saitoh, Koji Onishi, Motohiro Takeya
    • Organizer
      21th International Synposium on Molecular Cell Biology of Macrophages
    • Place of Presentation
      Toshi Center Hotel、Tokyo, Japan
    • Related Report
      2013 Annual Research Report
  • [Presentation] Onionin A regulates macrophage activation and suppresses tumor development by inhibiting stat3 activation.2013

    • Author(s)
      Yukio Fujiwara, Yoshihiro Komohara, Hasita Horlad, Daisuke Shiraishi, Koji Ohnishi, Motohiro Takeya
    • Organizer
      21th International Synposium on Molecular Cell Biology of Macrophages
    • Place of Presentation
      Toshi Center Hotel、Tokyo, Japan
    • Related Report
      2013 Annual Research Report
  • [Presentation] Glucagon-like peptide-1 (GLP-1) induces M2 polarization of human macrophages via STAT3 activation2013

    • Author(s)
      Daisuke Shiraishi, Yukio Fujiwara, Yoshihiro Komohara, Hiroshi Mizuta, Motohiro Takeya
    • Organizer
      21th International Synposium on Molecular Cell Biology of Macrophages
    • Place of Presentation
      Toshi Center Hotel、Tokyo, Japan
    • Related Report
      2013 Annual Research Report
  • [Presentation] CD169-positive macrophages in regional lymph nodes are associated with good survival in patients with colorectal cancer.2013

    • Author(s)
      Yoichi Saito, Koji Ohnishi, Yoshihiro Komohara, Motohiro Takeya
    • Organizer
      21th International Synposium on Molecular Cell Biology of Macrophages
    • Place of Presentation
      Toshi Center Hotel、Tokyo, Japan
    • Related Report
      2013 Annual Research Report
  • [Presentation] 大腸癌における抗腫瘍免疫と所属リンパ節のCD169陽性マクロファージの関連性2013

    • Author(s)
      菰原義弘、大西紘二、西東洋一、竹屋元裕
    • Organizer
      第23回 日本樹状細胞研究会
    • Place of Presentation
      国立京都国際会館,京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 成人T細胞白血病/リンパ腫におけるCD163陽性マクロファージの重要性2013

    • Author(s)
      菰原義弘、新野大介、西東洋一、大西紘二、大島孝一、竹屋元裕
    • Organizer
      第23回 日本樹状細胞研究会
    • Place of Presentation
      国立京都国際会館,京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 大腸癌における所属リンパ節のCD169陽性マクロファージはTリンパ球の腫瘍組織内浸潤に関与し、臨床予後と相関する2013

    • Author(s)
      大西紘二、菰原義弘、西東洋一、林田唯、中川雄伸、竹屋元裕
    • Organizer
      第23回 日本樹状細胞研究会
    • Place of Presentation
      国立京都国際会館,京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 新しい概念によるがん治療:標的細胞としての腫瘍内浸潤マクロファージ2013

    • Author(s)
      菰原義弘、竹屋元裕
    • Organizer
      第1回 熊本大学医工連携フォーラム
    • Place of Presentation
      熊本大学、熊本
    • Related Report
      2013 Annual Research Report
  • [Presentation] CD163は抗炎症性作用を有し、LPS誘導性敗血症マウスにおける死亡率を低下させる2013

    • Author(s)
      大西紘二、藤原章雄、菰原義弘、竹屋元裕
    • Organizer
      第102回 日本病理学会総会
    • Place of Presentation
      ホテルさっぽろ芸文館、札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] 悪性線維性組織球腫における腫瘍関連マクロファージの役割2013

    • Author(s)
      上川将史、菰原義弘、竹屋元裕
    • Organizer
      第102回 日本病理学会総会
    • Place of Presentation
      ホテルさっぽろ芸文館、札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] ヘモグロビンスカベンジャー受容体(CD163)の線維肉腫MCA205の増殖に対する役割の解析2013

    • Author(s)
      白石大偉輔、藤原章雄、Horlad Hasita、菰原義弘、大西紘二、水田博志、竹屋元裕
    • Organizer
      第102回 日本病理学会総会
    • Place of Presentation
      ホテルさっぽろ芸文館、札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] 腎細胞癌の腫瘍随伴マクロファージにおけるCD206発現の意義2013

    • Author(s)
      元島崇信、菰原義弘、西東洋一、大西紘二、竹屋元裕
    • Organizer
      第102回 日本病理学会総会
    • Place of Presentation
      ホテルさっぽろ芸文館、札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] マクロファージの活性化を制御する低分子硫黄化合物の抗腫瘍薬としての応用2013

    • Author(s)
      藤原章雄、菰原義弘、池田剛、野原稔弘、竹屋元裕
    • Organizer
      日本ケミカルバイオロジー学会 第8回年会
    • Place of Presentation
      東京医科歯科大学、東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 免疫抑制性ミエロイド細胞を制御する化合物の探索2013

    • Author(s)
      菰原義弘、藤原章雄、Hasita Horlad、粟井博丈、西村泰治、竹屋元裕
    • Organizer
      第17回 日本がん免疫学会総会
    • Place of Presentation
      ANAクラウンプラザホテル宇部、宇部
    • Related Report
      2013 Annual Research Report
  • [Presentation] 大腸癌における所属リンパ節のCD169陽性マクロファージはCD8陽性Tリンパ球の腫瘍組織内浸潤に関与し、新しい予後因子となる2013

    • Author(s)
      大西紘二、菰原義弘、西東洋一、竹屋元裕
    • Organizer
      第17回 日本がん免疫学会総会
    • Place of Presentation
      ANAクラウンプラザホテル宇部、宇部
    • Related Report
      2013 Annual Research Report
  • [Presentation] レクチャー3:腫瘍関連マクロファージの役割とその制御2013

    • Author(s)
      竹屋元裕
    • Organizer
      第10回 日本病理学会カンファレンス2013六甲山
    • Place of Presentation
      六甲山ホテル、神戸
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 成人T細胞白血病/リンパ腫におけるCD163陽性マクロファージの重要性2013

    • Author(s)
      菰原義弘、新野大介、西東洋一、大西紘二、大島孝一、竹屋元裕
    • Organizer
      第10回 日本病理学会カンファレンス2013六甲山
    • Place of Presentation
      六甲山ホテル、神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] ガン治療への応用を目指した免疫抑制性ミエロイド細胞を制御する化合物の探索2013

    • Author(s)
      藤原章雄、菰原義弘、Hasita Horlad、竹屋元裕
    • Organizer
      第10回 日本病理学会カンファレンス2013六甲山
    • Place of Presentation
      六甲山ホテル、神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] 大腸癌における所属リンパ節のCD169陽性マクロファージはCD8陽性Tリンパ球の腫瘍組織内浸潤に関与し、新しい予後因子となる2013

    • Author(s)
      大西紘二、菰原義弘、西東洋一、竹屋元裕
    • Organizer
      第10回 日本病理学会カンファレンス2013六甲山
    • Place of Presentation
      六甲山ホテル、神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] 子宮内膜症の発生・進展における腹腔M2マクロファージと子宮内膜間質細胞の細胞間相互作用2013

    • Author(s)
      伊藤史子、菰原義弘、高石清美、本田律生、田代浩徳、竹屋元裕、片渕秀隆
    • Organizer
      第45回 日本臨床分子形態学会総会・学術集会
    • Place of Presentation
      アクロス福岡、福岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] 免疫抑制性ミエロイド細胞を制御する化合物の探索とコロソリン酸の抗腫瘍効果2013

    • Author(s)
      菰原義弘、藤原章雄、Hasita Horlad、竹屋元裕
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] マクロファージの活性化を制御する天然化合物ONAの骨肉腫モデルマウスにおける抗腫瘍作用2013

    • Author(s)
      藤原章雄、Hasita Horlad、白石大偉輔、菰原義弘、竹屋元裕
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] 悪性黒色腫における所属リンパ節内CD169陽性マクロファージ数は予後と相関する2013

    • Author(s)
      西東洋一、大西紘二、菰原義弘、竹屋元裕
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] 腫瘍内に浸潤したM2マクロファージは悪性線維性組織球腫の増大に関与する2013

    • Author(s)
      上川将史、菰原義弘、竹屋元裕、水田博志
    • Organizer
      第28回 日本整形外科学会基礎学術集会
    • Place of Presentation
      幕張メッセ、千葉
    • Related Report
      2013 Annual Research Report
  • [Presentation] ヘモグロビンスカベンジャー受容体(CD163)の線維肉腫MCA205の増殖に対する役割の解析2013

    • Author(s)
      白石大偉輔、藤原章雄、Horlad Hasita、菰原義弘、大西紘二、竹屋元裕、水田博志
    • Organizer
      第28回 日本整形外科学会基礎学術集会
    • Place of Presentation
      幕張メッセ、千葉
    • Related Report
      2013 Annual Research Report
  • [Presentation] A演説:ヒト悪性腫瘍おける腫瘍随伴マクロファージに関する病理学的解析とその役割について2013

    • Author(s)
      菰原義弘
    • Organizer
      第59回 日本病理学会秋期特別総会
    • Place of Presentation
      甲府富士屋ホテル,甲府
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 悪性黒色腫における所属リンパ節内CD169陽性マクロファージ数は予後と相関する2013

    • Author(s)
      西東洋一、大西紘二、藤原章雄、菰原義弘、竹屋元裕
    • Organizer
      第36回 日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド、神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] High expression of CD169 in lymph node sinus macrophages is a new prognostic factor that reflects CD8+ T cell-mediated anti-tumor immunity in human malignant melanoma.2013

    • Author(s)
      Koji Ohnishi, Yoichi Saito, Yoshihiro Komohara, Motohiro Takeya
    • Organizer
      第42回 日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ、千葉
    • Related Report
      2013 Annual Research Report
  • [Remarks] 熊本大学大学院生命科学研究部細胞病理学分野

    • URL

      http://www.medic.kumamoto-u.ac.jp/dept/patho2/patho2.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 熊本大学大学院生命科学研究部細胞病理学分野

    • URL

      http://srv02.medic.kumamoto-u.ac.jp/dept/patho2/patho2.html

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2013-05-21   Modified: 2019-07-29  

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