| Project/Area Number |
25293090
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Aichi Cancer Center Research Institute |
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Principal Investigator |
Yatabe Yasushi 愛知県がんセンター(研究所), 分子腫瘍学部, 研究員 (90280809)
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| Co-Investigator(Kenkyū-buntansha) |
SAKAO YUKINORI 愛知県がんセンター(研究所), 分子腫瘍学部, 研究員 (00274605)
樋田 豊明 愛知県がんセンター(研究所), 分子腫瘍学部, 研究員 (80250249)
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| Co-Investigator(Renkei-kenkyūsha) |
HIDA TOYOAKI 愛知県がんセンター(研究所), 分子腫瘍学部, 研究員 (80250249)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Keywords | 肺癌 / 分子病理学 / 腺癌 / EGFR / KRAS / 腫瘍進展 / 遺伝子変異 / 染色体破砕 / 肺癌発がんモデル / 肺腺癌 / 発がん機序 / 肺癌分類 / 腺扁平上皮癌 / HNF4α / 浸潤性粘液癌 |
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| Outline of Final Research Achievements |
We focused on the following four themes in this study.
1) A novel model of signal transduction according to transcripts: We found HNF4a functioned as a master regulator for invasive mucinous adenocarcinoma. Also, a novel fusion involving NRG1 was identified in this subtype. 2) Non-stepwise model of lung adenocarcinoma development: We had some findings that supported no-stepwise progression using preinvasive lesions. 3) Genetic heterogeneity of cancer: We analyzed discordant results between protein expression and gene rearrangement of a driver gene for the lung, ALK. 4) Diagnostic application of molecular findings: We contributed to generate guidelines for molecular testing and formulation of basic data for primary-unknown cancers.
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