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Development of the molecular targeted therapy for allergic dermatitis

Research Project

Project/Area Number 25293091
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Experimental pathology
Research InstitutionUniversity of Tsukuba

Principal Investigator

SHIBUYA Kazuko  筑波大学, 医学医療系, 准教授 (00302406)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2013: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Keywords免疫系受容体 / アレルギー性皮膚炎 / costimulatory 分子 / ヘルパーT細胞分化 / 分子標的療法 / 免疫学 / 皮膚 / ヘルパーT細胞
Outline of Final Research Achievements

Although Th1 and Th2 cells are known to be involved in allergic inflammatory diseases, the molecular mechanisms underlying their differentiation are incompletely understood. Here, we identified CD155 as a costimulatory molecule on CD4+ T cells. CD155-mediated signaling induced Th1 development. Mice treated with anti-CD155 antibody exhibited attenuated Th1-type contact hypersensitivity. Thus, CD155 plays an important regulatory role in helper T-cell differentiation and allergic diseases.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (49 results)

All 2016 2015 2014 2013 Other

All Journal Article (12 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 12 results,  Open Access: 9 results,  Acknowledgement Compliant: 1 results) Presentation (29 results) (of which Int'l Joint Research: 4 results,  Invited: 2 results) Book (2 results) Remarks (3 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] Increased soluble CD155 in the serum of cancer patients2016

    • Author(s)
      Iguchi-Manaka A, Okumura G, Kojima H, Cho Y, Hirochika R, Bando H, Sato T, Yoshikawa H, Hara H, Shibuya A, Shibuya K.
    • Journal Title

      PLoS One

      Volume: 11(4) Issue: 4 Pages: 1-12

    • DOI

      10.1371/journal.pone.0152982

    • NAID

      120007135543

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Apoptotic epithelial cells control the abundance of Treg cells at barrier surfaces2016

    • Author(s)
      Nakahashi-Oda C, Udayanga KGS, Nakamura Y, Nakazawa Y, Miki H, Iino S, Tahara-Hanaoka S, Shibuya K, Shibuya A.
    • Journal Title

      Nature Immunol, 17(4):441-453, 2016

      Volume: 17 Issue: 4 Pages: 441-453

    • DOI

      10.1038/ni.3345

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Expression of DNAM-1 (CD226) on inflammatory monocytes2015

    • Author(s)
      Vo AV, Takenaka E, Shibuya A, Shibuya K.
    • Journal Title

      Mol Immunol

      Volume: 69 Pages: 70-76

    • DOI

      10.1016/j.molimm.2015.11.009

    • NAID

      120007129692

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] IgM-Dependent Phagocytosis in Microglia Is Mediated by Complement Receptor 3, Not Fcα/μ Receptor2015

    • Author(s)
      Weinstein JR, Quan Y, Hanson JF, Colonna L, Iorga M, Honda S, Shibuya K, Shibuya A, Elkon KB, Möller T.
    • Journal Title

      J Immunol

      Volume: 195(11) Issue: 11 Pages: 5309-5317

    • DOI

      10.4049/jimmunol.1401195

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] CD155 (PVR/Necl5) Mediates a Costimulatory Signal in CD4+ T Cells and Regulates Allergic Inflammation2015

    • Author(s)
      4.Yamashita--Kanemaru Y, Takahashi Y, Wang Y, Tahara-Hanaoka S, Honda S, Bernhardt G, Shibuya A, Shibuya K.
    • Journal Title

      J Immunol, 194(12):5644-5653, 2015

      Volume: 194 Issue: 12 Pages: 5644-5653

    • DOI

      10.4049/jimmunol.1401942

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] CD155 (PVR/Necl5) mediates a costimulatory signal in CD4+ T cells and regulates allergic inflammations.2015

    • Author(s)
      Yamashita Y, Takahashi Y, Wang Y, Tahara-Hanaoka S, Honda S, Bernhardt G, Shibuya A, Shibuya K.
    • Journal Title

      J Immunol

      Volume: in press

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased CD11b+ Gr-1+ cell population in the placenta after infection with Toxoplasma gondii.2015

    • Author(s)
      Takeshima K, Sato K, Nabekura T, Nagamune K, Hamada H, Yoshikawa H, Shibuya A, Shibuya K.
    • Journal Title

      Microbiol. immunol

      Volume: 59 Issue: 2 Pages: 95-98

    • DOI

      10.1111/1348-0421.12225

    • NAID

      120007130301

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Increased CD112 expression in methylcholanthrene-induced tumors in CD155-deficient mice.2014

    • Author(s)
      Nagumo Y, Iguchi-Manaka A, Shibuya A, Shibuya K.
    • Journal Title

      PLoS ONE

      Volume: 9(11) Issue: 11 Pages: e112415-e112415

    • DOI

      10.1371/journal.pone.0112415

    • NAID

      120007136536

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Toll-like receptor 4 and MAIR-II/CLM-4/LMIR2 immunoreceptor regulate VLA-4-mediated infammatory monocyte migration2014

    • Author(s)
      Naoya T otsuka, Yun-Gi Kim, Kazumasa Kanemaru, Kouta Niizuma, Eiji Umemoto, Kei Nagai, Satoko T ahara-Hanaoka, Chigusa Nakahasi-Oda, Shin-ichiro Honda, Masayuki Miyasaka, Kazuko Shibuya & Akira Shibuya
    • Journal Title

      Nature Communications

      Volume: 5:4710 Issue: 1 Pages: 4710-4710

    • DOI

      10.1038/ncomms5710

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Serum under-O-glycosylated IgA1 level is not correlated with glomerular IgA deposition based upon heterogeneity in the composition of immune complexes in IgA nephropathy.2014

    • Author(s)
      Satake K, Shimizu Y, Sasaki Y, Yanagawa H, Suzuki H, Suzuki Y, Horikoshi S, Honda S, Shibuya K, Shibuya A, Tomino Y.
    • Journal Title

      BMC Nephrology

      Volume: 15:89 Issue: 1 Pages: 89-89

    • DOI

      10.1186/1471-2369-15-89

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Establishment and Characterization of a Novel Anti-DNAM-1 Monoclonal Antibody2013

    • Author(s)
      Yamashita Y, Abe F, Hirochika R, Tahara-Hanaoka S, Shibuya A, Shibuya K.
    • Journal Title

      Monoclonal Antibodies in Immunodiagnosis and Immunotherapy

      Volume: 32(1) Issue: 1 Pages: 60-64

    • DOI

      10.1089/mab.2012.0083

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD226 interaction with CD155 impacts on retention and negative selection of CD8 positive thymocytes as well as T cell differentiation to follicular helper cells in Peyer's Patches.2013

    • Author(s)
      Danisch S et. al.
    • Journal Title

      Immunobiology

      Volume: 218 Issue: 2 Pages: 152-158

    • DOI

      10.1016/j.imbio.2012.02.010

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Expression of DNAM-1 (CD226) on inflammatory monocytes The 55th Midwinter Conference of Immunologists2016

    • Author(s)
      Vo AV, Takenaka E, Shibuya A, Shibuya K
    • Organizer
      The 55th Midwinter Conference of Immunologists
    • Place of Presentation
      Asilomar Conference Grounds, Pacific Grove California, (USA)
    • Year and Date
      2016-01-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Increased soluble CD155 in patients with various cancers2015

    • Author(s)
      Iguchi-Manaka A, Shibuya A, Shibuya K
    • Organizer
      第44回日本免疫学会総会・学術集会
    • Place of Presentation
      札幌コンベンションセンター(札幌)
    • Year and Date
      2015-11-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Involvement of DNAM-1 (CD226) expressed on small peritoneal macrophages in antigen presentation2015

    • Author(s)
      Takenaka E, Vo AV, Shibuya A, Shibuya K
    • Organizer
      第44回日本免疫学会総会・学術集会
    • Place of Presentation
      札幌コンベンションセンター(札幌)
    • Year and Date
      2015-11-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] evelopment of a novel method for isolation of follicular dendritic cells2015

    • Author(s)
      Sato K, Honda S, Shibuya K, Shibuya A.
    • Organizer
      第44回日本免疫学会総会・学術集会
    • Place of Presentation
      札幌コンベンションセンター(札幌)
    • Year and Date
      2015-11-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] The role of DNAM-1 and CD155 in tumor immunity and escape2015

    • Author(s)
      Shibuya K, Iguchi-Manaka A, Kojima H, Cho Y, Hirochika R, Shibuya A.
    • Organizer
      International Symposium on Immune Regulation
    • Place of Presentation
      Oarai Park Hotel, Oarai (Japan)
    • Year and Date
      2015-10-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Apoptotic epithelial cells control regulatory T cell expansion2015

    • Author(s)
      Nakahashi-Oda C, Udayanga K G S, Nakamura Y, Nakazawa Y, Totsuka N, Miki H, Iino S, Tahara-Hanaoka S, Honda S, Shibuya K, Shibuya A.
    • Organizer
      International Symposium on Immune Regulation
    • Place of Presentation
      Oarai Park Hotel, Oarai (Japan)
    • Year and Date
      2015-10-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Marginal zone B cells exacerbate endotoxic shock via interleukin-6 secretion induced by Fcα/μR-coupled TLR4 signaling International Symposium on Immune Regulation2015

    • Author(s)
      Honda S, Sato K, Totsuka N, Fujiyama S, Fujimoto M, Miyake K, Nakahashi-Oda C, Tahara-Hanaoka S, Honda S, Shibuya K, Shibuya A.
    • Organizer
      International Symposium on Immune Regulation
    • Place of Presentation
      Oarai Park Hotel, Oarai (Japan)
    • Year and Date
      2015-10-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Increased soluble CD155 in the serum of cancer patients2015

    • Author(s)
      Iguchi-Manaka A, Hiroshi Kojima, Cho Y, Shibuya A, Shibuya K
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] 癌患者血清における可溶型CD155の上昇2015

    • Author(s)
      井口研子、渋谷彰、渋谷和子
    • Organizer
      第7回血液疾患免疫療法研究会学術集会
    • Place of Presentation
      東京大学 伊藤国際学術研究センター(東京)
    • Year and Date
      2015-09-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] 免疫監視と免疫逃避におけるポリオウイルスレセプターの役割2015

    • Author(s)
      渋谷 和子
    • Organizer
      東北大学加齢医学研究所セミナー
    • Place of Presentation
      東北大学加齢医学研究所(仙台)
    • Year and Date
      2015-03-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Critical role of DNAM-1 in acute and chronic allograft rejection.2015

    • Author(s)
      阿部 史枝、渋谷 和子、渋谷 彰
    • Organizer
      第3回筑波大学・東京理科大学生命医科学研究所合同リトリート
    • Place of Presentation
      東京理科大学セミナーハウス(野田)
    • Year and Date
      2015-03-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] Soluble CD155 is involved in the escape from tumor immunity.2015

    • Author(s)
      井口 研子、渋谷 彰、渋谷 和子
    • Organizer
      第3回筑波大学・東京理科大学生命医科学研究所合同リトリート
    • Place of Presentation
      東京理科大学セミナーハウス(野田)
    • Year and Date
      2015-03-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] Soluble CD155 is involved in the escape from tumor immunity.2015

    • Author(s)
      Iguchi-Manaka A, Shibuya A, Shibuya K.
    • Organizer
      第5回新学術発がんスパイラル国際シンポジウム
    • Place of Presentation
      神戸ポートピアホテル(神戸)
    • Year and Date
      2015-02-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] DNAM-1 (CD226) plays an important role in antigen presentation by small peritoneal macrophages.2015

    • Author(s)
      Takenaka E, Shibuya A, Shibuya K.
    • Organizer
      第5回新学術発がんスパイラル国際シンポジウム
    • Place of Presentation
      神戸ポートピアホテル(神戸)
    • Year and Date
      2015-02-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] DNAM-1 (CD226) plays an important role in antigen presentation by small peritoneal macrophages.2014

    • Author(s)
      Takenaka E, Shibuya A, Shibuya K.
    • Organizer
      第43 回日本免疫学会総会・学術集会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2014-12-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Soluble CD155 is involved in the escape from tumor immunity.2014

    • Author(s)
      Iguchi-Manaka A, Shibuya A, Shibuya K.
    • Organizer
      第43 回日本免疫学会総会・学術集会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2014-12-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] Toll-like receptor 4 and MAIR-II/CLM-4/LMIR2 immunoreceptor regulate VLA-4-mediated inflammatory monocyte migration.2014

    • Author(s)
      Totsuka N, Kim YG, Kanemaru K, Niizuma K, Umemoto E, Nagai K, Tahara-Hanaoka S, Nakahashi-Oda C, Honda S, Miyasaka M, Shibuya K, Shibuya A.
    • Organizer
      第43 回日本免疫学会総会・学術集会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2014-12-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] CD155 regulates regulatory T cell population and attenuates acute graft-versus-host disease.2014

    • Author(s)
      Kanaya M, Shibuya K, Abe F, Teshima T, Shibuya A.
    • Organizer
      第76回日本血液学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2014-10-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] 免疫システムの人為的制御と疾患の克服2014

    • Author(s)
      渋谷 和子
    • Organizer
      第46回日本医学教育学会大会
    • Place of Presentation
      和歌山県立医科大学(和歌山)
    • Year and Date
      2014-07-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 可溶型ポリオウイルスレセプター(CD155)によるがん免疫逃避2014

    • Author(s)
      渋谷 和子
    • Organizer
      第26回千葉基礎・臨床免疫セミナー
    • Place of Presentation
      千葉大亥鼻イノベーションプラザ(千葉)
    • Year and Date
      2014-05-22
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 腫瘍免役逃避機構における可溶型CD155の役割2014

    • Author(s)
      井口 研子、清松 裕子、池田 達彦、坂東 裕子、渋谷 彰、渋谷 和子、原 尚人
    • Organizer
      第114回日本外科学会定期学術集会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2014-04-03 – 2014-04-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Involvement of soluble CD155 in cancer immune escape.2013

    • Author(s)
      Iguchi A, Shibuya A, Shibuya K
    • Organizer
      第42回日本免疫学会総会・学術集会
    • Place of Presentation
      幕張メッセ(千葉)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Fca/mR (CD351) regulates inflammatory responses of marginal zone B cells against experimental septic shock.2013

    • Author(s)
      Honda S, Yoshizawa Y, Sato K, Fujimoto M, Nakahashi-Oda C, Tahara-Hanaoka S, Shibuya K, Shibuya A.
    • Organizer
      第42回日本免疫学会総会・学術集会
    • Place of Presentation
      幕張メッセ(千葉)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Involvement of CD300a in the pathogenesis of DSS-induced colitis.2013

    • Author(s)
      Totsuka N, Kim YG, Tahara-Hanaoka S, Nakahashi-Oda C, Honda S, Shibuya K, Shibuya A.
    • Organizer
      第42回日本免疫学会総会・学術集会
    • Place of Presentation
      幕張メッセ(千葉)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Critical role of DNAM-1 in acute and chronic allograft rejection.2013

    • Author(s)
      Abe F, Shibuya K, Shibuya A.
    • Organizer
      第42回日本免疫学会総会・学術集会
    • Place of Presentation
      幕張メッセ(千葉)
    • Related Report
      2013 Annual Research Report
  • [Presentation] A co-stimulatory molecule CD155 on CD4+ T Cells regulates allergic reactions by induction of interferon-γ-dependent th1 development.2013

    • Author(s)
      Yamashita Y, Takahashi Y, Wang Y, Shibuya A, Shibuya K.
    • Organizer
      第42回日本免疫学会総会・学術集会
    • Place of Presentation
      幕張メッセ(千葉)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Soluble DNAX accessory molecule-1 (sDNAM-1) is a novel predictive biomarker for acute graft-versus-host disease.2013

    • Author(s)
      Kanaya M, Shibuya K, Shibuya A.
    • Organizer
      第42回日本免疫学会総会・学術集会
    • Place of Presentation
      幕張メッセ(千葉)
    • Related Report
      2013 Annual Research Report
  • [Presentation] CD155 is a co-stimulatory molecule involved in Th1 development. International Symposium Immune Regulation by Immunoreceptors.

    • Author(s)
      Yamashita Y, Takahashi Y, Abe F, Shibuya A, Shibuya K.
    • Organizer
      International Symposium Immune Regulation by Immunoreceptors.
    • Place of Presentation
      University of Tsukuba.(つくば)
    • Related Report
      2013 Annual Research Report
  • [Presentation] The role of an activating receptor, DNAM-1 (CD226), on small peritoneal macrophages (SPMs).

    • Author(s)
      Takenaka E, Shibuya A, Shibuya K.
    • Organizer
      International Symposium Immune Regulation by Immunoreceptors.
    • Place of Presentation
      University of Tsukuba.(つくば)
    • Related Report
      2013 Annual Research Report
  • [Book] 実験医学別冊 最強のステップUPシリーズ 直伝!フローサイトメトリー 面白いほど使いこなせる!2014

    • Author(s)
      金丸 由美、渋谷 和子
    • Publisher
      羊土社
    • Related Report
      2013 Annual Research Report
  • [Book] 公益財団法人金原一郎記念医学医療振興財団「生体の科学」2013

    • Author(s)
      竹中 江里、渋谷 和子、渋谷 彰
    • Publisher
      医学書院
    • Related Report
      2013 Annual Research Report
  • [Remarks] 免疫学研究室ホームページ

    • URL

      http://immuno-tsukuba.com/index.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] つくばリポジトリ

    • URL

      https://tsukuba.repo.nii.ac.jp/index.php?action=pages_view_main&active_action=repository_view_main_item_snippet&index_id=987&pn=1&count=20&order=7&lang=japanese&page_id=13&block_id=83

    • Related Report
      2014 Annual Research Report
  • [Remarks] TRIOS

    • URL

      http://trios.tsukuba.ac.jp/researcher/0000001639

    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] 可溶型CD155タンパク質を用いた癌の検出方法2015

    • Inventor(s)
      渋谷彰、渋谷和子、井口研子
    • Industrial Property Rights Holder
      渋谷彰、渋谷和子、井口研子
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-01-26
    • Acquisition Date
      2015-07-27
    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] 可溶型CD155タンパク質を用いた癌の検出方法2015

    • Inventor(s)
      渋谷 彰、渋谷 和子、井口 研子
    • Industrial Property Rights Holder
      渋谷 彰、渋谷 和子、井口 研子
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-01-26
    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] 免疫疾患に対する医薬組成物2014

    • Inventor(s)
      渋谷 和子、渋谷 彰、山下 由美
    • Industrial Property Rights Holder
      渋谷 和子、渋谷 彰、山下 由美
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-03-13
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-21   Modified: 2019-07-29  

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