Roles of TGF-beta target genes TMEPAI and MafK on cancer development
| Project/Area Number |
25293092
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
WATANABE Yukihide 筑波大学, 医学医療系, 助教 (40618534)
OKITA Yukari 筑波大学, 医学医療系, 研究員 (30743710)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | がん / 足場非依存性増殖 / がん幹細胞 / トランスフォーミング増殖因子β / TGF-β / TMEPAI / MafK / GPNMB / 特殊環状ペプチド / MAFK / 上皮間葉転換 / 幹細胞 / Gpnmb |
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| Outline of Final Research Achievements |
Transforming Growth Factor-β (TGF-β) was discovered as a factor expressed by oncogenes and induces anchorage-independent soft agar colony formation together with TGF-α. In this study, we identified TMEPAI and MafK as target genes expressed by TGF-β and induces anchorage-independent growth and tumor formation. TMEPAI suppresses TGF-β/Smad signaling and activates AKT. MafK induces epithelial-mesenchymal transition and transmembrane glycoprotein GPNMB. These activities are essential for their tumorigenic activities. We further made antibodies for TMEPAI and MafK for further clinic-pathological studies.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] C18ORF1: A Novel Negative Regulator of TGF-β Signaling.2014
Author(s)
2. Nakano N, Maeyama K, Ikeno S, Itoh F, Togawa Y, Katsu Y, Thanh Thao, VN, Watanabe Y, Kato M & Itoh, S.
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Journal Title
J. Biol. Chem.,
Volume: 289
Issue: 18
Pages: 12680-12680
DOI
Related Report
Peer Reviewed
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[Journal Article] C18 ORF1: A Novel Negative Regulator of TGF-β Signaling.2014
Author(s)
Nakano N, Maeyama K, Sakata N, Itoh F, Akatsu R, Nakata M, Katsu Y, Ikeno S, Togawa Y, Thanh Thao Vo Nguyen TT, Watanabe Y, Kato M and Itoh S.
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Journal Title
Jounal of Biological Chemistry
Volume: 289
Related Report
Peer Reviewed
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