Regulatory mechanism of inflammation and inflammation-related cancer by regulating Ras-Raf-ERK/MAPK
| Project/Area Number |
25293095
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ITO Toshihiro 岡山大学, 大学院医歯薬学総合研究科, 講師 (00595712)
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| Research Collaborator |
TAKAHASHI Sakuma
FUSHIMI Soichiro
TAIRA Asako
ITAKURA Junya
WATANABE Haruyuki
SATO Miwa
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Keywords | 炎症 / シグナル伝達・抑制 / 炎症とがん / 炎症・自然免疫 / シグナル伝達 / 発がん / 急性肺傷害 / 炎症性腸疾患 / ウイルス感染 |
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| Outline of Final Research Achievements |
In this project, we have analyzed the role of Ras-Raf-ERK/MAPK and its endogenous inhibitor, Spred-2 in various animal models, using Spred-2 knock-out (KO) mice. We have demonstrated that Spred-2 plays a central role in the regulation of inflammation in various types of inflammation. Our results suggest that Spred-2 can be a new target for controlling inflammation. We also demonstrated that Spred-2 expressed in clinical cancer tissue may be involved carcinogenesis and cancer progression. Furthermore, our results indicate that Spred-2 may be essential regulator of cancer metastasis by modulating epithelial mesenchymal transition (EMT).
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Redox-active protein thioredoxin-1 administration ameliorates influenza A virus (H1N1)-induced acute lung injury in mice.2013
Author(s)
Yashiro M, Tsukahara H, Matsukawa A, Yamada M, Fujii Y, Nagaoka Y, Tsuge M, Yamashita N, Ito T, Yamada M, Masutani H, Yodoi J, Morishima T
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Journal Title
Crit Care Med.
Volume: 41
Pages: 171-181
NAID
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Peer Reviewed
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[Presentation] The impact of Spred-2 on colonic repair in mice with DSS-undued colitis2013
Author(s)
Takahashi S, Fushimi S, Ito T, Inokuchi T, Nakarai A, Akita M, Harada K, Hiraoka S, Okada H, Yamamoto K, Matsukawa A
Organizer
UEG Week 2013
Place of Presentation
Berlin
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[Book] 病理と臨床2014
Author(s)
板倉淳哉, 伏見聡一郎, 荻野哲也, 伊藤利洋, 小田晋輔, 河原明奈, 萩谷英大, 桑原宏子, 松川昭博
Publisher
文光堂
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