| Project/Area Number |
25293101
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Parasitology (including sanitary zoology)
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| Research Institution | Nagasaki University |
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Principal Investigator |
YUI Katsuyuki 長崎大学, 医歯薬学総合研究科(医学系), 教授 (90274638)
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| Co-Investigator(Kenkyū-buntansha) |
KIMURA Daisuke 長崎大学, 医歯薬学総合研究科(医学系), 助教 (50423637)
SHITASHIGE Miki 長崎大学, 医歯薬学総合研究科(医学系), 准教授 (00392340)
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHIDA Hiroki 佐賀大学, 医学部, 教授 (40260715)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | T細胞 / マラリア / サイトカイン / 赤血球 / 免疫抑制 / 制御 / マウス / Ｔ細胞 / 免疫制御 / 感染 |
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| Outline of Final Research Achievements |
We reported unique regulatory CD4+ T cells that produce IL-27, dimeric regulatory cytokine of IL-12 family, in response to T cell receptor stimulation during malaria infection, inhibiting IL-2 production and clonal expansion of other T cells in an IL-27-dependent manner. IL-27-producing CD4+ T cells were malaria antigen-specific CD4+ T cells, and were distinct from Foxp3+ regulatory T cells, interferon (IFN)-γ producing Th1, or IL-10 producing Tr1 cells. In mice lacking IL-27 in T cells, IL-2 production was restored and clonal expansion and IFN-γ production by specific CD4+ T cells were improved, culminating in reduced parasite burden. This study highlights a unique population of IL-27 producing regulatory CD4+ T cells and their critical role in the regulation of the protective immune response against malaria parasites.
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