Search for mechanisms how Helicobacter pylori infection causes gastric cancer
| Project/Area Number |
25293104
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bacteriology (including mycology)
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| Research Institution | Oita University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2015: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Keywords | ヘリコバクター・ピロリ / 病原因子 / 胃癌 / 胃がん / 動物モデル |
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| Outline of Final Research Achievements |
Helicobacter pylori (both strains TN2GF4 and SS1) could colonize gp130F759 mice, and mice infected with strain TN2GF4 showed severer inflammation than those with strain SS1. Strain TN2GF4 was East Asian-type and strain SS1 was Western-type, supporting the hypothesis that East Asian-type strains were more virulent than Western-type strains. Somewhat surprisingly, isogenic oipA mutants could not colonize the mice, suggesting that OipA plays important roles on colonization and the attachment of H. pylori to the epithelial cells. We also performed the analyses using outer membrane proteins of H. pylori, and showed that OipA formed virulent complex with other unknown virulence factors on the H. pylori surface.
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Report
(4 results)
Research Products
(101 results)
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[Journal Article] Characterisation of worldwide Helicobacter pylori strains reveals genetic conservation and essentiality of serine protease HtrA2016
Author(s)
Tegtmeyer N, Moodley Y, Yamaoka Y, Pernitzsch SR, Schmidt V, Traverso FR, Schmidt TP, Rad R, Yeoh KG, Bow H, Torres J, Gerhard M, Schneider G, Wessler S, Backert S.
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Journal Title
Mol Microbiol
Volume: 99
Issue: 5
Pages: 925-944
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Influence of Prostate Stem Cell Antigen Gene Polymorphisms on Susceptibility to Helicobacter pylori-associated Diseases: A Case-control Study2015
Author(s)
97.Ichikawa H, Sugimoto M, Uotani T, Sahara S, Yamade M, Iwaizumi M, Yamada T, Osawa S, Sugimoto K, Miyajima H, Yamaoka Y, Furuta T.
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Journal Title
Helicobacter
Volume: 20
Issue: 2
Pages: 106-113
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] CagAの差異で, 胃癌の発症率の地域差を説明することは本当にできるのか?2015
Author(s)
山岡吉生, 松久威史, Subsomwong Phawinee, 鈴木留美子, 内田智久, Byambajav Tsogt-Ochir, Oyuntsetseg Khasag, Davaadorj Duger, Battulga Adiyasuren, Tserentogtoh Tegshee
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Journal Title
日本ヘリコバクター学会誌
Volume: 16
Pages: 16-17
Related Report
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[Journal Article] Differences in interleukin 8 expression in Helicobacter pylori-infected gastric mucosa tissues from patients in Bhutan and the Dominican Republic2015
Author(s)
Nagashima H, Iwatani S, Cruz M, Jiménez Abreu JA, Tronilo L, Rodríguez E, Disla M, Terao H, Uchida T, Mahachai V, Vilaichone RK, Tshering L, Mitsui T, Shiota S, Graham DY, Yamaoka Y
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Journal Title
Hum Pathol
Volume: 46
Issue: 1
Pages: 129-136
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Identification of Helicobacter pylori infection in symptomatic patients in Surabaya, Indonesia, using five diagnostic tests2014
Author(s)
Miftahussurur M, Shiota S, Suzuki R, Matsuda M, Uchida T, Kido Y, Kawamoto F, Maimunah U, Adi P, Rezkitha Y, Nasronudin, Nusi I, Yamaoka Y
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Journal Title
Epidemiol Infect.
Volume: 143
Issue: 5
Pages: 986-996
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Extremely low Helicobacter pylori prevalence in North Sulawesi, Indonesia and identification of a Maori-tribe type strain: a cross sectional study2014
Author(s)
Miftahussurur M, Tuda J, Suzuki R, Kido Y, Kawamoto F, Matsuda M, Tantular IS, Pusarawati S, Nasronudin, Harijanto PN, Yamaoka Y
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Journal Title
Gut Pathog
Volume: 6
Issue: 1
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Virulence genes of Helicobacter pylori in the Dominican Republic2014
Author(s)
Shiota S, Cruz M, Abreu JA, Mitsui T, Terao H, Disla M, Iwatani S, Nagashima H, Matsuda M, Uchida T, Tronilo L, Rodríguez E, Yamaoka Y
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Journal Title
J Med Microbiol
Volume: 63
Issue: 9
Pages: 1189-1196
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Complete Genome Sequences of Eight Helicobacter pylori Strains with Different Virulence Factor Genotypes and Methylation Profiles, Isolated from Patients with Diverse Gastrointestinal Diseases on Okinawa Island, Japan, Determined Using PacBio Single-Molecule Real-Time Technology2014
Author(s)
Satou K, Shiroma A, Teruya K, Shimoji M, Nakano K, Juan A, Tamotsu H, Terabayashi Y, Aoyama M, Teruya M, Suzuki R, Matsuda M, Sekine A, Kinjo N, Kinjo F, Yamaoka Y, Hirano T
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Journal Title
Genome Announc
Volume: 2
Issue: 2
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Hiroyuki Nagashima, Iwatani S, Tanaka S, Uotani T, Cruz M, Jimenez JA, Uchida T, Mahachai V, Vilaichone R, Graham DY,, Yamaoka Y.2015
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