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Search for mechanisms how Helicobacter pylori infection causes gastric cancer

Research Project

Project/Area Number 25293104
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Bacteriology (including mycology)
Research InstitutionOita University

Principal Investigator

YAMAOKA YOSHIO  大分大学, 医学部, 教授 (00544248)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2015: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Keywordsヘリコバクター・ピロリ / 病原因子 / 胃癌 / 胃がん / 動物モデル
Outline of Final Research Achievements

Helicobacter pylori (both strains TN2GF4 and SS1) could colonize gp130F759 mice, and mice infected with strain TN2GF4 showed severer inflammation than those with strain SS1. Strain TN2GF4 was East Asian-type and strain SS1 was Western-type, supporting the hypothesis that East Asian-type strains were more virulent than Western-type strains. Somewhat surprisingly, isogenic oipA mutants could not colonize the mice, suggesting that OipA plays important roles on colonization and the attachment of H. pylori to the epithelial cells. We also performed the analyses using outer membrane proteins of H. pylori, and showed that OipA formed virulent complex with other unknown virulence factors on the H. pylori surface.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (101 results)

All 2016 2015 2014 2013 Other

All Int'l Joint Research (6 results) Journal Article (58 results) (of which Int'l Joint Research: 15 results,  Peer Reviewed: 43 results,  Open Access: 21 results,  Acknowledgement Compliant: 24 results) Presentation (34 results) (of which Int'l Joint Research: 12 results,  Invited: 18 results) Book (1 results) Remarks (2 results)

  • [Int'l Joint Research] ベイラー医科大学(米国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] インドネシア大学/アイルランガ大学(インドネシア)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] モンゴル健康科学大学/ウランバートル第3病院(モンゴル)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] チュラロンコン大学/タマサート大学(タイ)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] チョーライ病院/108病院(ベトナム)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Extremely High Prevalence of Metronidazole-Resistant Helicobacter pylori Strains in Mountain People (Karen and Hmong) in Thailand.2016

    • Author(s)
      Vilaichone RK, Ratanachu-Ek T, Gamnarai P, Chaithongrat S, Uchida T, Yamaoka Y, Mahachai V.
    • Journal Title

      Am J Trop Med Hyg

      Volume: 94 Issue: 4 Pages: 717-720

    • DOI

      10.4269/ajtmh.15-0449

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Helicobacter pylori antibiotic susceptibility patterns in Bangladesh: Emerging levofloxacin resistance2016

    • Author(s)
      Aftab H, Miftahussurur M, Subsomwong P, Ahmed F, Khan AA, Yamaoka Y
    • Journal Title

      J Infect Dev Ctries

      Volume: 10 Issue: 03 Pages: 245-253

    • DOI

      10.3855/jidc.7713

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Rare Helicobacter pylori Virulence Genotypes in Bhutan2016

    • Author(s)
      Matsunari O, Miftahussurur M, Shiota S, Suzuki R, Vilaichone RK, Uchida T, Ratanachu-Ek T, Tshering L, Mahachai V, Yamaoka Y.
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 1-11

    • DOI

      10.1038/srep22584

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Characterisation of worldwide Helicobacter pylori strains reveals genetic conservation and essentiality of serine protease HtrA2016

    • Author(s)
      Tegtmeyer N, Moodley Y, Yamaoka Y, Pernitzsch SR, Schmidt V, Traverso FR, Schmidt TP, Rad R, Yeoh KG, Bow H, Torres J, Gerhard M, Schneider G, Wessler S, Backert S.
    • Journal Title

      Mol Microbiol

      Volume: 99 Issue: 5 Pages: 925-944

    • DOI

      10.1111/mmi.13276

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Antibiotic Resistant Pattern of Helicobacter Pylori Infection Based on Molecular Tests in Laos2016

    • Author(s)
      Vannarath S, Vilaichone RK, Rasachak B, Mairiang P, Yamaoka Y, Mahachai V
    • Journal Title

      Asian Pac J Cancer Prev

      Volume: 17 Pages: 285-287

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Diagnostic Methods of Helicobacter pylori Infection for Epidemiological Studies: Critical Importance of Indirect Test Validation2016

    • Author(s)
      Miftahussurur M, Yamaoka Y
    • Journal Title

      Biomed Res Int

      Volume: 2016 Pages: 1-14

    • DOI

      10.1155/2016/4819423

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] RAD51 G135C genetic polymorphism and their potential role in gastric cancer induced by Helicobacter pylori infection in Bhutan2016

    • Author(s)
      Trang TT, Nagashima H, Uchida T, Mahachai V, Vilaichone RK, Tshering L, Binh TT, Yamaoka Y
    • Journal Title

      Epidemiol Infect

      Volume: 144 Issue: 2 Pages: 234-240

    • DOI

      10.1017/s0950268815001430

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Food Allergy and Helicobacter pylori Infection: A Systematic Review2016

    • Author(s)
      Ma ZF, Majid NA, Yamaoka Y, Lee YY
    • Journal Title

      Front Microbiol

      Volume: 7 Pages: 368-368

    • DOI

      10.3389/fmicb.2016.00368

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Prostate stem cell antigen gene TT genotype and development of intestinal metaplasia in Helicobacter pylori infection2016

    • Author(s)
      Uotani T, Sugimoto M, Ichikawa H, Tanaka S, Nagashima H, Uchida T, Graham DY, Yamaoka Y
    • Journal Title

      J Dig Dis

      Volume: 17 Issue: 1 Pages: 20-27

    • DOI

      10.1111/1751-2980.12309

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 第6回 インドネシアでの疫学調査 - その3 -2016

    • Author(s)
      山岡吉生
    • Journal Title

      Helicobacter Research

      Volume: 20 Pages: 5-17

    • Related Report
      2015 Annual Research Report
  • [Journal Article] XXVIIIth International Workshop on Helicobacter and Microbiota in Inflammation and Cancer (欧州ヘリコバクター学会)2016

    • Author(s)
      山岡吉生
    • Journal Title

      Helicobacter Research

      Volume: 20 Pages: 68-73

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Toll-like Receptor 10 in Helicobacter pylori Infection2015

    • Author(s)
      Nagashima H, Iwatani S, Cruz M, Jiménez Abreu JA, Uchida T, Mahachai V, Vilaichone RK, Graham DY, Yamaoka Y
    • Journal Title

      J Infect Dis

      Volume: 212 Issue: 10 Pages: 1666-1676

    • DOI

      10.1093/infdis/jiv270

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Geographical distribution of the incidence of gastric cancer in Bhutan2015

    • Author(s)
      Dendup T, Richter JM, Yamaoka Y, Wangchuk K, Malaty HM
    • Journal Title

      World J Gastroenterol

      Volume: 21 Issue: 38 Pages: 10883-10889

    • DOI

      10.3748/wjg.v21.i38.10883

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pathogenesis of Helicobacter pylori Infection2015

    • Author(s)
      Sgouras DN, Trang TT, Yamaoka Y
    • Journal Title

      Helicobacter

      Volume: Suppl1 Issue: S1 Pages: 8-16

    • DOI

      10.1111/hel.12251

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Gastric mucosa in Mongolian and Japanese patients with gastric cancer and Helicobacter pylori infection2015

    • Author(s)
      Matsuhisa T, Yamaoka Y, Uchida T, Duger D, Adiyasuren B, Khasag O, Tegshee T, Tsogt-Ochir B
    • Journal Title

      World J Gastroenterol

      Volume: 21 Issue: 27 Pages: 8408-8417

    • DOI

      10.3748/wjg.v21.i27.8408

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Helicobacter pylori dupA and smoking are associated with increased levels of interleukin-8 in gastric mucosa in Iraq-reply2015

    • Author(s)
      Nagashima H, Yamaoka Y
    • Journal Title

      Hum Pathol

      Volume: 46 Issue: 6 Pages: 931-931

    • DOI

      10.1016/j.humpath.2015.01.022

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Appropriate first-line regimens to combat Helicobacter pylori antibiotic resistance: an Asian perspective2015

    • Author(s)
      Miftahussurur M, Yamaoka Y
    • Journal Title

      Molecules

      Volume: 20 Issue: 4 Pages: 6068-6092

    • DOI

      10.3390/molecules20046068

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Influence of Prostate Stem Cell Antigen Gene Polymorphisms on Susceptibility to Helicobacter pylori-associated Diseases: A Case-control Study2015

    • Author(s)
      97.Ichikawa H, Sugimoto M, Uotani T, Sahara S, Yamade M, Iwaizumi M, Yamada T, Osawa S, Sugimoto K, Miyajima H, Yamaoka Y, Furuta T.
    • Journal Title

      Helicobacter

      Volume: 20 Issue: 2 Pages: 106-113

    • DOI

      10.1111/hel.12183

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 第1回 ブータンでの疫学調査2015

    • Author(s)
      山岡吉生
    • Journal Title

      Helicobacter Research

      Volume: 19 Pages: 197-204

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 第2回 ブータンでの疫学調査 - その2 -2015

    • Author(s)
      山岡吉生
    • Journal Title

      Helicobacter Research

      Volume: 19 Pages: 229-236

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 第3回 ミャンマーでの疫学調査2015

    • Author(s)
      山岡吉生
    • Journal Title

      Helicobacter Research

      Volume: 19 Pages: 324-332

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 第4回 インドネシアでの疫学調査 - その1 -2015

    • Author(s)
      山岡吉生
    • Journal Title

      Helicobacter Research

      Volume: 19 Pages: 424-435

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 第5回 インドネシアでの疫学調査 - その2 -2015

    • Author(s)
      山岡吉生
    • Journal Title

      Helicobacter Research

      Volume: 19 Pages: 528-536

    • Related Report
      2015 Annual Research Report
  • [Journal Article] CagAの差異で, 胃癌の発症率の地域差を説明することは本当にできるのか?2015

    • Author(s)
      山岡吉生, 松久威史, Subsomwong Phawinee, 鈴木留美子, 内田智久, Byambajav Tsogt-Ochir, Oyuntsetseg Khasag, Davaadorj Duger, Battulga Adiyasuren, Tserentogtoh Tegshee
    • Journal Title

      日本ヘリコバクター学会誌

      Volume: 16 Pages: 16-17

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Current Topics (現在のトピックス)2015

    • Author(s)
      山岡吉生
    • Journal Title

      日本ヘリコバクター学会誌

      Volume: 16 Pages: 63-63

    • Related Report
      2015 Annual Research Report
  • [Journal Article] H.pyloriの細菌学的性状, ゲノム構造2015

    • Author(s)
      山岡吉生
    • Journal Title

      臨床と微生物

      Volume: 42 Pages: 105-111

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Asia Pacific Digestive Week (APDW) 20142015

    • Author(s)
      山岡吉生
    • Journal Title

      Helicobacter Research

      Volume: 19 Pages: 185-188

    • Related Report
      2015 Annual Research Report
  • [Journal Article] わが国の地域によるHelicobacter pylori菌株の差異2015

    • Author(s)
      塩田星児, 鈴木留美子, 山岡吉生
    • Journal Title

      Helicobacter Research

      Volume: 19 Pages: 450-457

    • Related Report
      2015 Annual Research Report
  • [Journal Article] アジア地域 (人種) による菌株の差異2015

    • Author(s)
      鈴木留美子, 山岡吉生
    • Journal Title

      Helicobacter Research

      Volume: 19 Pages: 481-488

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Prevalence of Helicobacter pylori infection and atrophic gastritis in patients with dyspeptic symptoms in Myanmar2015

    • Author(s)
      Myint T, Shiota S, Vilaichone RK, Ni N, Aye TT, Matsuda M, Tran TT, Uchida T, Mahachai V, Yamaoka Y.
    • Journal Title

      World J Gastroenterol

      Volume: 21 Issue: 2 Pages: 629-636

    • DOI

      10.3748/wjg.v21.i2.629

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Differences in interleukin 8 expression in Helicobacter pylori-infected gastric mucosa tissues from patients in Bhutan and the Dominican Republic2015

    • Author(s)
      Nagashima H, Iwatani S, Cruz M, Jiménez Abreu JA, Tronilo L, Rodríguez E, Disla M, Terao H, Uchida T, Mahachai V, Vilaichone RK, Tshering L, Mitsui T, Shiota S, Graham DY, Yamaoka Y
    • Journal Title

      Hum Pathol

      Volume: 46 Issue: 1 Pages: 129-136

    • DOI

      10.1016/j.humpath.2014.10.006

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Search for novel candidate mutations for metronidazole resistance in Helicobacter pylori using next-generation sequencing2014

    • Author(s)
      Binh TT, Suzuki R, Trang TT, Kwon DH, Yamaoka Y
    • Journal Title

      Antimicrob Agents Chemother

      Volume: 59 Issue: 4 Pages: 2343-2348

    • DOI

      10.1128/aac.04852-14

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification of Helicobacter pylori infection in symptomatic patients in Surabaya, Indonesia, using five diagnostic tests2014

    • Author(s)
      Miftahussurur M, Shiota S, Suzuki R, Matsuda M, Uchida T, Kido Y, Kawamoto F, Maimunah U, Adi P, Rezkitha Y, Nasronudin, Nusi I, Yamaoka Y
    • Journal Title

      Epidemiol Infect.

      Volume: 143 Issue: 5 Pages: 986-996

    • DOI

      10.1017/s095026881400154x

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Biomarkers for Helicobacter pylori infection and gastroduodenal diseases.2014

    • Author(s)
      Shiota S, Yamaoka Y
    • Journal Title

      Biomark Med

      Volume: 8 Issue: 9 Pages: 1127-1137

    • DOI

      10.2217/bmm.14.72

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Extremely low Helicobacter pylori prevalence in North Sulawesi, Indonesia and identification of a Maori-tribe type strain: a cross sectional study2014

    • Author(s)
      Miftahussurur M, Tuda J, Suzuki R, Kido Y, Kawamoto F, Matsuda M, Tantular IS, Pusarawati S, Nasronudin, Harijanto PN, Yamaoka Y
    • Journal Title

      Gut Pathog

      Volume: 6 Issue: 1

    • DOI

      10.1186/s13099-014-0042-0

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Genetic battle between Helicobacter pylori and humans. The mechanism underlying homologous recombination in bacteria, which can infect human cells.2014

    • Author(s)
      Hanada K, Yamaoka Y
    • Journal Title

      Microbes Infect

      Volume: 16 Issue: 10 Pages: 833-839

    • DOI

      10.1016/j.micinf.2014.08.001

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Helicobacter pylori from gastric cancer and duodenal ulcer show same phylogeographic origin in the Andean region in Colombia.2014

    • Author(s)
      Shiota S, Suzuki R, Matsuo Y, Miftahussurur M, Tran TT, Binh TT, Yamaoka Y
    • Journal Title

      PLoS One

      Volume: 9 Issue: 8 Pages: e105392-e105392

    • DOI

      10.1371/journal.pone.0105392

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification of the genes that contribute to lactate utilization in Helicobacter pylori.2014

    • Author(s)
      Iwatani S, Nagashima H, Reddy R, Shiota S, Graham DY, Yamaoka Y
    • Journal Title

      PLoS One

      Volume: 9 Issue: 7 Pages: 103506-103506

    • DOI

      10.1371/journal.pone.0103506

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Helicobacter pylori infection introduces DNA double-strand breaks in host cells2014

    • Author(s)
      Hanada K, Uchida T, Tsukamoto Y, Watada M, Yamaguchi N, Yamamoto K, Shiota S, Moriyama M, Graham DY, Yamaoka Y
    • Journal Title

      Infect Immun.

      Volume: 82 Issue: 10 Pages: 4182-4189

    • DOI

      10.1128/iai.02368-14

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Helicobacter pylori virulence and cancer pathogenesis.2014

    • Author(s)
      Yamaoka Y, Graham DY
    • Journal Title

      Future Oncol.

      Volume: 10 Issue: 8 Pages: 1487-1500

    • DOI

      10.2217/fon.14.29

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Virulence genes of Helicobacter pylori in the Dominican Republic2014

    • Author(s)
      Shiota S, Cruz M, Abreu JA, Mitsui T, Terao H, Disla M, Iwatani S, Nagashima H, Matsuda M, Uchida T, Tronilo L, Rodríguez E, Yamaoka Y
    • Journal Title

      J Med Microbiol

      Volume: 63 Issue: 9 Pages: 1189-1196

    • DOI

      10.1099/jmm.0.075275-0

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Complete Genome Sequences of Eight Helicobacter pylori Strains with Different Virulence Factor Genotypes and Methylation Profiles, Isolated from Patients with Diverse Gastrointestinal Diseases on Okinawa Island, Japan, Determined Using PacBio Single-Molecule Real-Time Technology2014

    • Author(s)
      Satou K, Shiroma A, Teruya K, Shimoji M, Nakano K, Juan A, Tamotsu H, Terabayashi Y, Aoyama M, Teruya M, Suzuki R, Matsuda M, Sekine A, Kinjo N, Kinjo F, Yamaoka Y, Hirano T
    • Journal Title

      Genome Announc

      Volume: 2 Issue: 2

    • DOI

      10.1128/genomea.00286-14

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Discovery of novel mutations for clarithromycin resistance in Helicobacter pylori by using next-generation sequencing2014

    • Author(s)
      Binh TT, Shiota S, Suzuki R, Matsuda M, Trang TT, Kwon DH, Iwatani S, Yamaoka Y
    • Journal Title

      J Antimicrob Chemother

      Volume: 69 Issue: 7 Pages: 1796-1803

    • DOI

      10.1093/jac/dku050

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Strategy for the treatment of Helicobacter pylori infection2014

    • Author(s)
      Shiota S, Yamaoka Y
    • Journal Title

      Curr Pharm Des

      Volume: 20 Pages: 4489-4500

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] ヘリコバクター・ピロリとは何もの ー病原性の歴史も含めてー2014

    • Author(s)
      山岡 吉生
    • Journal Title

      化学療法の領域

      Volume: 30 Pages: 30-38

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ヘリコバクター・ピロリの病原因子と分子疫学に関する研究2014

    • Author(s)
      山岡 吉生
    • Journal Title

      化学療法の領域

      Volume: 30 Pages: 100-107

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Helicobacter pylori 感染症の疫学と感染経路2014

    • Author(s)
      永島裕之、手島理絵、山岡 吉生
    • Journal Title

      Helicobacter Research

      Volume: 18 Pages: 28-31

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Discovery of novel mutations for clarithromycin resistance in Helicobacter pylori by using next-generation sequencing.2014

    • Author(s)
      Binh TT, Shiota S, Suzuki R, Matsuda M, Trang TT, Kwon DH, Iwatani S, Yamaoka Y
    • Journal Title

      J Antimicrob Chemother

      Volume: 未定

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum Helicobacter pylori CagA antibody titer as a useful marker for advanced inflammation in the stomach in Japan2014

    • Author(s)
      Shiota S, Murakami K, Okimoto T, Kodama M, Yamaoka Y
    • Journal Title

      J Gastroenterol Hepatol

      Volume: 29 Issue: 1 Pages: 67-73

    • DOI

      10.1111/jgh.12359

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Complete Genome Sequences of Helicobacter pylori Clarithromycin-Resistant Strains2014

    • Author(s)
      Binh TT, Suzuki R, Shiota S, Kwon DH, Yamaoka Y
    • Journal Title

      Genome Announc.

      Volume: 1 Issue: 6

    • DOI

      10.1128/genomea.00912-13

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Strategy for the Treatment of Helicobacter pylori Infection.2014

    • Author(s)
      Shiota S, Yamaoka Y
    • Journal Title

      Curr Pharm Des

      Volume: 未定

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CagA-dependent downregulation of B7-H2 expression on gastric mucosa and inhibition of Th17 responses during Helicobacter pylori infection2013

    • Author(s)
      Lina TT, Pinchuk IV, House J, Yamaoka Y, Graham DY, Beswick EJ, Reyes VE
    • Journal Title

      J Immunol

      Volume: 191 Issue: 7 Pages: 3838-3846

    • DOI

      10.4049/jimmunol.1300524

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Seroprevalence of Helicobacter pylori infection and gastric mucosal atrophy in Bhutan, a country with a high prevalence of gastric cancer2013

    • Author(s)
      Shiota S, Mahachai V, Vilaichone RK, Ratanachu-ek T, Tshering L, Uchida T, Matsunari O, Yamaoka Y
    • Journal Title

      J Med Microbiol

      Volume: 62 Issue: 10 Pages: 1571-1578

    • DOI

      10.1099/jmm.0.060905-0

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antibiotics resistance rate of Helicobacter pylori in Bhutan2013

    • Author(s)
      Vilaichone RK, Yamaoka Y, Shiota S, Ratanachu-ek T, Tshering L, Uchida T, Fujioka T, Mahachai V
    • Journal Title

      World J Gastroenterol

      Volume: 19 Issue: 33 Pages: 5508-5512

    • DOI

      10.3748/wjg.v19.i33.5508

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of prehistoric human migration by Helicobacter pylori2013

    • Author(s)
      Suzuki R, Yamaoka Y
    • Journal Title

      Nihon Rinsho

      Volume: 71 Pages: 1368-1373

    • NAID

      40019751379

    • Related Report
      2013 Annual Research Report
  • [Journal Article] The significance of virulence factors in Helicobacter pylori.2013

    • Author(s)
      Shiota S, Suzuki R, Yamaoka Y
    • Journal Title

      J Dig Dis

      Volume: Mar 1 Issue: 7 Pages: 341-349

    • DOI

      10.1111/1751-2980.12054

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extremely high prevalence of Helicobacter pylori infection in Bhutan2013

    • Author(s)
      Vilaichone RK, Mahachai V, Shiota S, Uchida T, Ratanachu-ek T, Tshering L, Tung NL, Fujioka T, Moriyama M, Yamaoka Y
    • Journal Title

      World J Gastroenterol

      Volume: 19 Issue: 18 Pages: 2806-2810

    • DOI

      10.3748/wjg.v19.i18.2806

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Helicobacter pyloriと胃癌2013

    • Author(s)
      山岡吉生
    • Journal Title

      臨床検査

      Volume: 57 Pages: 760-766

    • Related Report
      2013 Annual Research Report
  • [Presentation] Commensal bacteriaとしてのH. pylori感染症におけるToll-like receptor 10の役割2015

    • Author(s)
      永島裕之, 山岡吉生
    • Organizer
      日本消化器病学会
    • Place of Presentation
      グランドプリンスホテル(東京都港区)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] The difference of cagA genotype of Helicobacter pylori alone cannot explain the geographic differences in gastric cancer incidence in Mongolia2015

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      XXVIIIth International Workshop on Helicobacter and Microbiota in Inflammation and Cancer
    • Place of Presentation
      ニコシア(キプロス共和国)
    • Year and Date
      2015-09-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Molecular epidemiology of Helicobacter pylori in ASEAN countries: Focused in Indonesia2015

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      KONKERPAS PPHI-PGI-PEGI2015
    • Place of Presentation
      マラン(インドネシア)
    • Year and Date
      2015-08-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ヘリコバクター・ピロリゲノムの地理的多様性と人類の移動2015

    • Author(s)
      鈴木留美子、山岡吉生
    • Organizer
      第21回日本ヘリコバクター学会
    • Place of Presentation
      神戸ポートピアホテル(兵庫県神戸市)
    • Year and Date
      2015-06-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] Molecular epidemiology of Helicobacter pylori: association between H. pylori and disease outcomes2015

    • Author(s)
      Yoshio Yamaoka, Jimenez A Joze, Modesto Cruz
    • Organizer
      XII Congreso Centroamericano y del Caribe de parasitologia y Medicina Tropical
    • Place of Presentation
      プンタカナ(ドミニカ共和国)
    • Year and Date
      2015-06-13
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Self-organizing mini-guts from a single intestinal stem cell: the organoids2015

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      XI Congreso INternacional de Investigacion cientifica
    • Place of Presentation
      サントドミンゴ(ドミニカ共和国)
    • Year and Date
      2015-06-10
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Molecular epidemiology of Helicobacter pylori infection in Nepal: the mountains people could be a high-risk population2015

    • Author(s)
      Muhammad Miftahussurur, Sharma RP, Shrestha PK, Suzuki R, Shiota S, Uchida T, Yamaoka Y
    • Organizer
      Digestive Disease Week 2015
    • Place of Presentation
      ワシントンDC(アメリカ合衆国)
    • Year and Date
      2015-05-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prevalence and virulence factors characteristics of Helicobacter pylori infection in five largest islands in Indonesia2015

    • Author(s)
      Muhammad Miftahussurur, Shym AF, Makmun D, Nusi A, Uchida T, Suzuki R, Yamaoka Y
    • Organizer
      Digestive Disease Week 2015
    • Place of Presentation
      ワシントンDC(アメリカ合衆国)
    • Year and Date
      2015-05-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Hiroyuki Nagashima, Iwatani S, Tanaka S, Uotani T, Cruz M, Jimenez JA, Uchida T, Mahachai V, Vilaichone R, Graham DY,, Yamaoka Y.2015

    • Author(s)
      Toll-like receptor10 in Helicobacter pylori infection
    • Organizer
      Digestive Disease Week 2015
    • Place of Presentation
      ワシントンDC(アメリカ合衆国)
    • Year and Date
      2015-05-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of autophagy related genes in patients with Helicobacter pylori infection2015

    • Author(s)
      Shingo Tanaka, Nagashima H, Uotani T, Cruz M, Graham DY,, Yamaoka Y.
    • Organizer
      Digestive Disease Week 2015
    • Place of Presentation
      ワシントンDC(アメリカ合衆国)
    • Year and Date
      2015-05-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prostate stem cell antigen gene polymorphisms as a predictive factor for Helicobacter pylori infection associated intestinal metaplasia2015

    • Author(s)
      Takahiko Uotani, Sugumoto M, Ichikawa H, Tanaka S, Nagashima H, Uchida T, Furuta T, Graham DY,, Yamaoka Y
    • Organizer
      Digestive Disease Week 2015
    • Place of Presentation
      ワシントンDC(アメリカ合衆国)
    • Year and Date
      2015-05-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] RAD51 G135C genetic polymorphism and potential role in gastric cancer induced Helicobacter pylori2015

    • Author(s)
      Tran Huyen Trang, Yoshio Yamaoka
    • Organizer
      The 3rd JSGE International Topic Conference
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2015-04-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prevalence of H.pylori infection in different ethnic groups in Maesot, Thailand2015

    • Author(s)
      Phawinee Subsomwong, Muhammad Miftahussurur, Tomohisa Uchida, Varocha Mahachai, Ratha-korn Vilaichone, Yoshio Yamaoka
    • Organizer
      The 3rd JSGE International Topic Conference
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2015-04-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Helicobacter pylori infection and gastric mucosal atrophy in two ethnics group in Nepal2015

    • Author(s)
      Muhammad Miftahussurur, Rabi Prakash Sharma, Seiji Shiota, Rumiko Suzuki, Tomohisa Uchida, Miyuki Matsuda, Yoshio Yamaoka
    • Organizer
      The 3rd JSGE International Topic Conference
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2015-04-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The diversity of Helicobacter pylori: correlation to laboratory diagnosis2014

    • Author(s)
      Yamaoka Y
    • Organizer
      9th National Symposium & Workshop of Indonesia Antimicrobiol Resistance Watch and Annual Scientific Meeting of Indonesian Society for Clinical Microbiologist
    • Place of Presentation
      ジャカルタ(インドネシア)
    • Year and Date
      2014-11-29 – 2014-11-30
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Genomic diversity of Helicobacter pylori in Asia2014

    • Author(s)
      Yamaoka Y
    • Organizer
      Asian Pacific Digestive Week
    • Place of Presentation
      バリ島(インドネシア)
    • Year and Date
      2014-11-22 – 2014-11-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] CagAの差異で、胃癌の発症率の地域差を説明することは本当にできるのか?2014

    • Author(s)
      山岡吉生
    • Organizer
      日本ヘリコバクター学会
    • Place of Presentation
      ステーションカンファレンス東京(東京都千代田区)
    • Year and Date
      2014-06-28 – 2014-06-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Does the difference of CagA phenotype explain the geographic differences in gastric cancer incidence?2014

    • Author(s)
      Yamaoka Y
    • Organizer
      4th Mongolian Digestive Disease Week 2014
    • Place of Presentation
      ウランバートル(モンゴル)
    • Year and Date
      2014-06-18 – 2014-06-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Self-organizing mini-guts from a single intestinal stem cell: the organoids2014

    • Author(s)
      Yamaoka Y
    • Organizer
      4th Mongolian Digestive Disease Week 2014
    • Place of Presentation
      ウランバートル(モンゴル)
    • Year and Date
      2014-06-18 – 2014-06-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] The relations of bacterial and host factors in Helicobacter pylori infected gastric mucosa2014

    • Author(s)
      Yamaoka Y, Cruz M, Disla M, Graham DY, Iwatani S, Jimenez JA, Nagashima H
    • Organizer
      X Congreso International de Investigacion Cientifica
    • Place of Presentation
      サントドミンゴ(ドミニカ共和国)
    • Year and Date
      2014-06-12 – 2014-06-14
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Molecular epidemiology and outcome of Helicobacter pylori in Laos2014

    • Author(s)
      Vannarath S, Vilaichone RK, Rasachak B, Mahachai V, Mairlang P, Yamaoka Y.
    • Organizer
      アメリカ消化器病学会
    • Place of Presentation
      シカゴ(米国)
    • Year and Date
      2014-05-03 – 2014-05-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] The relations of bacterial and host factors of IL-8 expression in Helicobacter pylori infected gastric mucosa2014

    • Author(s)
      Nagashima H, Iwatani S, Cruz M, Jimenez JA, Mahachai V, Vilaichone RK, Uchida T, Shiota S, Graham DY, Yamaoka Y
    • Organizer
      アメリカ消化器病学会
    • Place of Presentation
      シカゴ(米国)
    • Year and Date
      2014-05-03 – 2014-05-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] Helicobacter pyloriのOuter membrane protein A (OipA)による病原性発現機構の分子基盤2014

    • Author(s)
      城戸康年、松尾祐一、山岡吉生
    • Organizer
      日本消化器病学会総会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2014-04-23 – 2014-04-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Carcinogenesis of Helicobacter pylori infection2014

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      The 3rd Dong-A International Medical Symposium
    • Place of Presentation
      Dong-A大学(韓国釜山市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Helicobacter pyloriのOuter inflammatory protein A (OipA)による病原性発現機構の分子基盤2014

    • Author(s)
      城戸康年、松尾祐一、山岡吉生
    • Organizer
      第100回日本消化器病学会総会
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Helicobacter pyloriと生体防御2013

    • Author(s)
      山岡吉生
    • Organizer
      第24回日本生体防除学会
    • Place of Presentation
      くまもと森都心プラザ(熊本県熊本市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Helicobacter pylori Current status in Dominican Republic 1st phase2013

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      XXII Congreso Nacional de Gastroenterologia
    • Place of Presentation
      ハードロックホテル(ドミニカ共和国プンタカナ市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Genetic characteristics of Helicobacter pylori and its relation to gastric cancer2013

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      XXII Congreso Nacional de Gastroenterologia
    • Place of Presentation
      ハードロックホテル(ドミニカ共和国プンタカナ市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] The Mongolian gerbil model2013

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      XXVIth International Workshop on Helicobacter pylori and related bacteria in chronic digestive inflammation and gastric cancer
    • Place of Presentation
      Facultad de Medicina de la Univeridad Autonoma(スペイン マドリッド市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Helicobacter pylori genotypes in Asian countries2013

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      XXVIth International Workshop on Helicobacter pylori and related bacteria in chronic digestive inflammation and gastric cancer
    • Place of Presentation
      Facultad de Medicina de la Univeridad Autonoma(スペイン マドリッド市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ピロリ菌研究の面白さ;沖縄特有のピロリ菌の発見も含めて

    • Author(s)
      山岡吉生
    • Organizer
      第9回沖縄上部消化管の炎症を考える会
    • Place of Presentation
      ザ・ナハテラス(沖縄県那覇市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ピロリ菌感染症の臨床と研究

    • Author(s)
      山岡吉生
    • Organizer
      第303回日本内科学会地方会 生涯教育講演会
    • Place of Presentation
      ロワジールホテル(沖縄県那覇市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Genotypes of Helicobacter pylori in Asian countries

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      Mongolia-Japan joint symposium for Helicobacter pylori
    • Place of Presentation
      モンゴル健康科学大学(モンゴル共和国ウランバートル市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Helicobacter pylori and gastric cancer in Asia: from epidemiological view

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      Seoul National University Gastroenterology Meeting
    • Place of Presentation
      ソウル国立大学(韓国ソウル市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] 胃がんリスク検診(ABC検診)マニュアル:改正2版2015

    • Author(s)
      山岡 吉生
    • Total Pages
      3
    • Publisher
      南山堂
    • Related Report
      2014 Annual Research Report
  • [Remarks] http://www.med.oita-u.ac.jp/phealth2/index.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] http://www.med.oita-u.ac.jp/phealth2/index.html

    • Related Report
      2013 Annual Research Report

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Published: 2013-05-21   Modified: 2022-01-27  

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