| Project/Area Number |
25293105
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bacteriology (including mycology)
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
Matsuzaki Goro 琉球大学, 熱帯生物圏研究センター, 教授 (30229455)
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| Co-Investigator(Kenkyū-buntansha) |
Umemura Masayuki 琉球大学, 熱帯生物圏研究センター, 准教授 (90359985)
Ohara Naoya 岡山大学, 医歯学総合研究科, 教授 (70223930)
Arakawa Takeshi 琉球大学, 熱帯生物圏研究センター, 教授 (50305190)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2015: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2014: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
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| Keywords | 結核菌 / 肺感染 / ケモカイン / ケモカインレセプター / Ｔ細胞 / インターロイキン-17 / ワクチン / BCG / T細胞 / インターロイキン１７ / 細菌 / 結核 / 感染 / 免疫 / 生体防御 |
|---|
| Outline of Final Research Achievements |
Analysis of chemokine receptors on CD4+ T cells migrated in the Mycobacterium tuberculosis-infected lung showed expression of CXCR3, but anti-CXCR3 mAb-treated mice suggested dispensable role of CXCR3 in the T cell migration. On the other hand, involvement of chemokines are suggested by enhancement of vaccine efficacy of BCG after inoculation of IL-17-inducing vaccine in the lung. Fluorescent protein-expressing M. tuberculosis was also developed to visualize interaction of T cell migration to infected microfoci by using fluorescent microscope incubator system introduced in P3 laboratory.
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