Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2017: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2014: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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Outline of Final Research Achievements |
Treatment with neutralizing antibody against varicella-zoster virus of infected cell induced antigenic modulation leading to latent state similar to the latency in neurons. Colocalization of the immediate early proteins and the transcription factor SP1 in untrated infected cells was altered by the antigenic modulation. Buthionine sulfoximine (BSO) treatment slowed the disappearance of their colocalization from the nucleus and prevented latent infection. Furthermore, Viral DNA become chromatin-associated status in latent infection, but BSO increased the amounts of chromainted free viral DNA.
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