Analysis of the role of DCIR2 in the function of CD4+conventional dendritic cells
Project/Area Number |
25293117
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Immunology
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Research Institution | University of Miyazaki |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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Keywords | 樹状細胞 / 自然免疫 / 適応免疫 / T細胞 / 機能抑制分子 |
Outline of Final Research Achievements |
Here, we show that DCIR2 is a regulatory receptor for the activation of CD4+cDCs that impairs inflammation and T-cell immunity. Dcir2-/-CD4+cDCs show enhanced cytokine production and T-cell priming following TLR-mediated activation. Furthermore, Dcir2-/- mice exhibit TLR-mediated hyperinflammation. Upon antigenic immunization,Dcir2-/- mice show not only augmented T-cell responses but also progressive autoimmune pathogenesis. Thus, our findings highlight roles of Clec4A4 in regulation of the function of CD4+cDCs for control of the magnitude and quality of immune response.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Critical roles of a dendritic cell subset expressing a chemokine receptor, XCR12013
Author(s)
C. Yamazaki, M. Sugiyama, T. Ohta, H. Hemmi, E. Hamada, I. Sasaki, Y. Fukuda, T. Yano, M. Nobuoka, T. Hirashima, A. Iizuka, K. Sato, T. Tanaka, K. Hoshino, T. Kaisho
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Journal Title
J. Immunol
Volume: 190
Issue: 12
Pages: 6071-6082
DOI
Related Report
Peer Reviewed
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