Elucidating the role of IgA in host-bacterial symbiosis in the gut
| Project/Area Number |
25293118
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Fagarasan Sidonia 国立研究開発法人理化学研究所, 統合生命医科学研究センター, チームリーダー (00391970)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | IgA / 腸内細菌叢 / 免疫学 / 免疫 |
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| Outline of Final Research Achievements |
During our studies we obtained solid evidence that specific arms of the adaptive immune system play critical roles in controlling the structures of commensal bacteria in the gut. We found that Foxp3+T cells facilitate the diversification of bacteria responsible for immune homeostasis particularly species belonging to Firmicutes. We revealed that such control of indigenous bacteria by Foxp3+ T cells involved regulatory functions consisting of suppression of inflammation and regulation of IgA selection in Peyer's patches. We found that diversified and selected IgAs repertoires regulated by Foxp3+ T cells are moderately coating a large diversity of bacteria species thus contributing to their maintenance in the gut. In contrast, IgAs elicited in the absence of T cells abundantly coat bacterial species leading to their elimination rather than retention. Our results mark a paradigm shift in our understanding of immune-bacteria symbiosis in the gut (Kawamoto et al, Immunity 2014).
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis2014
Author(s)
Shimpei Kawamoto, Mikako Maruya, Lucia M. Kato, Wataru Suda, Koji Atarashi, Yasuko Doi, Yumi Tsutsui, Hongyan Qin, Kenya Honda, Takaharu Okada, Masahira Hattori, and Sidonia Fagarasan
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Journal Title
Immunity
Volume: 41
Issue: 1
Pages: 152-165
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Innate lymphoid cells integrate stromal and immunological signals to enhance antibody production by splenic marginal zone B cells2014
Author(s)
Giuliana Magri, Michio Miyajima, Sabrina Bascones, Arthur Mortha, Irene Puga, Linda Cassis, Carolina M Barra, Laura Comerma, Aleksey Chudnovskiy, Maurizio Gentile, David Llige, Montserrat Cols, Sergi Serrano, Juan Ignacio Aróstegui, Manel Juan, Jordi Yagüe, Miriam Merad, Sidonia Fagarasan & Andrea Cerutti
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Journal Title
Nature Immunology
Volume: 15
Issue: 4
Pages: 354-364
DOI
Related Report
Peer Reviewed
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