| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
During our studies we obtained solid evidence that specific arms of the adaptive immune system play critical roles in controlling the structures of commensal bacteria in the gut. We found that Foxp3+T cells facilitate the diversification of bacteria responsible for immune homeostasis particularly species belonging to Firmicutes. We revealed that such control of indigenous bacteria by Foxp3+ T cells involved regulatory functions consisting of suppression of inflammation and regulation of IgA selection in Peyer's patches. We found that diversified and selected IgAs repertoires regulated by Foxp3+ T cells are moderately coating a large diversity of bacteria species thus contributing to their maintenance in the gut. In contrast, IgAs elicited in the absence of T cells abundantly coat bacterial species leading to their elimination rather than retention. Our results mark a paradigm shift in our understanding of immune-bacteria symbiosis in the gut (Kawamoto et al, Immunity 2014).
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