Identifying several novel biomarkers of malignant tumors
| Project/Area Number |
25293130
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2013: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Keywords | biomarker / 悪性腫瘍 / RB1CC1 / p62/SQSTM1 / がん幹細胞 / 分子標的 / RAB39A / RXRB / バイオマーカー / 癌 / 臨床検査 / 放射線治療 |
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| Outline of Final Research Achievements |
In order to renovate the clinical laboratory examination for malignant tumors, we clinically verified the originally developed biomarkers such as RB1CC1 and p62/SQSTM1, etc. In parallel, we also conducted the trial identification of unknown biomarkers for tumors using the model mice with genetic mutations caused by ENU.
From a different side, gene expression in cancer and the stem cells (CSCs) was investigated by comparisons with normal cells through global transcriptomics and principal component analyses. We found that novel molecules are selectively expressed in cancer cells of different histotypes, and we made an application for Japanese patents about these molecular candidatesas promising therapeutic targets for cancer.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Intratumoral acidosis fosters cancer-induced bone pain through the activation of the mesenchymal tumor-associated stroma in bone metastasis from breast carcinoma.2017
Author(s)
Di Pompo G, Lemma S, Canti L, Rucci N, Ponzetti M, Errani C, Donati DM, Russell S, Gillies R, Chano T, Baldini N, Avnet S.
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Journal Title
Oncotarget.
Volume: Apr 13
Issue: 33
Pages: 1-19
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Altered pH gradient at the plasma membrane of osteosarcoma cells is a key mechanism of drug resistance.2016
Author(s)
Avnet S, Lemma S, Cortini M, Pellegrini P, Perut F, Zini N, Kusuzaki K, Chano T, Grisendi G, Dominici M, De Milito A, Baldini N.
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Journal Title
Oncotarget.
Volume: 7(39)
Issue: 39
Pages: 63408-63423
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Mammalian autophagy is essential for hepatic and renal ketogenesis during starvation.2016
Author(s)
Takagi A, Kume S, Kondo M, Nakazawa J, Chin-Kanasaki M, Araki H, Araki S, Koya D, Haneda M, Chano T, Matsusaka T, Nagao K, Adachi Y, Chan L, Maegawa H, Uzu T.
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Journal Title
Sci Rep
Volume: 6
Issue: 1
Pages: 18944-18944
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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