Identification of the role of spino-parabrachio-amygdaloid pathway in the pain-associated emotion

• Project/Area Number: 25293136
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Pain science
• Research Institution: Jikei University School of Medicine
• Principal Investigator: Kato Fusao 東京慈恵会医科大学, 医学部, 教授 (20169519)
• Co-Investigator(Renkei-kenkyūsha): Watabe M Ayako 東京慈恵会医科大学, 医学部, 教授 (00334277) ; Takahashi Yukari 東京慈恵会医科大学, 医学部, 助教 (20613764)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000); Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2014: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2013: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
• Keywords: 扁桃体 / 腕傍核 / 慢性痛 / 恐怖・脅威学習 / 情動 / 光遺伝学 / 化学遺伝学 / 痛み / 恐怖学習 / アロディニア / チャネルロドプシン / 侵害受容性扁桃体 / 痛み情動 / 恐怖条件付け / CGRP / 有痛性糖尿病性神経障害 / シナプス伝達

Outline of Final Research Achievements

To clarify the mechanism underlying the link between pain and negative emotion (suffering), we focused on the spino-parabrachio-amygdaloid pathway: 1) Optogenetic activation of the parabrachial-central amygdala pathway alone functions as unconditioned stimulus in Pavlovian and operant conditional learning. 2) This evoked mono- and polysynaptic network-driven activities in the central amygdala neurons, which was potentiated in the persistent inflammatory pain model. And 3) chemogenetic inhibition of GABAergic neurons in the central amygdala in the inflammatory pain model mitigated hypersensitivity and chemogenetic activation of these gave rise to the hypersensitivity in normal rats. These results indicate that this pathway is the primary route for the aversive nociceptive information to activate the limbic system leading to not only the negative emotion but also the elevated sensitivity to potentially harmful events.

Research Products

• [Int'l Joint Research] NeuroSpin, CEA(France)
• [Int'l Joint Research] 4th Military Medical School(China)
• [Int'l Joint Research] The Institute of Science and Technology(オーストリア)
• [Int'l Joint Research] NIH/NCCIH(米国)
• [Int'l Joint Research] 第4軍医大学(中国)
• [Int'l Joint Research] Tarbiat Modares University(イラン)
• [Int'l Joint Research] University of Washington(米国)
• [Int'l Joint Research] Institute of Science and Technology(オーストリア)
• [Journal Article] Facilitation of distinct inhibitory synaptic inputs by chemical anoxia in neurons in the oculomotor, facial and hypoglossal motor nuclei of the rat (2017)
  • Author(s): Takagi S, Kono Y, Nagase M, Mochio S, Kato F
  • Journal Title: Exp Neurol Volume: 290 Pages: 95-105
  • DOI: 10.1016/j.expneurol.2017.01.007
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Overlapping memory trace indispensable for linking, but not recalling, individual memories. (2017)
  • Author(s): Yokose, J., Okubo-Suzuki, R., Nomoto, M., Ohkawa, N., Nishizono, H., Suzuki, A., Matsuo, M., Tsujimura, S., Takahashi, Y., Nagase, M.,Watabe, A.M., Sasahara, M., Kato, F., Inokuchi, K.
  • Journal Title: Science Volume: 355 Issue: 6323 Pages: 398-403
  • DOI: 10.1126/science.aal2690
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Potentiation of NMDA receptor-mediated synaptic transmission at the parabrachial-central amygdala synapses by CGRP in mice (2017)
  • Author(s): Okutsu Y, Takahashi Y, Nagase M, Shinohara K, Ikeda R, Kato F
  • Journal Title: Molecular Pain Volume: 印刷中
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Synaptic and network consequences of monosynaptic nociceptive inputs of parabrachial nucleus origin in the central amygdala. (2016)
  • Author(s): Sugimura, YK., Takahashi, Y., Watabe, A.M., Kato, F.
  • Journal Title: Journal of neurophysiology Volume: ｘｘ Issue: 6 Pages: 2721-2739
  • DOI: 10.1152/jn.00946.2015
  • Peer Reviewed / Open Access
• [Journal Article] Cellular tagging as a neural network mechanism for behavioral tagging. (2016)
  • Author(s): Nomoto, M., Ohkawa, N., Nishizono, H., Yokose, J., Suzuki, A., Matuo, M., Tsujimura, S., Takahashi, Y., Nagase, M., Watabe, A.M., Kato, F., Inokuchi, K.
  • Journal Title: Nature Communications Volume: 7:12319 Issue: 1 Pages: 1-11
  • DOI: 10.1038/ncomms12319
  • Peer Reviewed / Open Access
• [Journal Article] Distinct effects of isoflurane on basal BOLD signals in tissue/vascular microstructures in rats (2016)
  • Author(s): Tsurugizawa T, Takahashi Y, Kato F
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 38977-38977
  • DOI: 10.1038/srep38977
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] SAD-B Kinase regulates presynaptic vesicular dynamics at hippocampal Schaffer collateral synapses and affects contextual fear memory. (2016)
  • Author(s): Watabe, A.M., Nagase, M., Hagiwara, A., Hida, Y., Tsuji, M., Ochiai, T., Kato, F., Ohtsuka, T.
  • Journal Title: Journal of Neurochemistry Volume: 136: Issue: 1 Pages: 36-47
  • DOI: 10.1111/jnc.13379
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Enhanced long-term potentiation in mature rats with a history of cryptogenic infantile spasms. (2016)
  • Author(s): Tsuji, M., Takahashi, Y., Watabe, A.M., Kato, F.
  • Journal Title: Epilepsia Volume: 57 Issue: 3 Pages: 495-505
  • DOI: 10.1111/epi.13315
  • Peer Reviewed / Open Access
• [Journal Article] Corticotropin-releasing factor enhances inhibitory synaptic transmission to type III neurons in the bed nucleus of the stria terminalis. (2015)
  • Author(s): Nagano Y, Kaneda K, Maruyama C, Ide S, Kato F, Minami M
  • Journal Title: Neurosci. Lett. Volume: 600 Pages: 56-61
  • DOI: 10.1016/j.neulet.2015.05.059
  • Peer Reviewed
• [Journal Article] Potentiation of acetylcholine-mediated facilitation of inhibitory synaptic transmission by an azaindolizione derivative, ZSET1446 (ST101), in the rat hippocampus (2015)
  • Author(s): Takeda K, Yamaguchi Y, Hino M, Kato F.
  • Journal Title: J Pharmacol Exp Ther. Volume: 356(2): Issue: 2 Pages: 445-55
  • DOI: 10.1124/jpet.115.229021
  • Peer Reviewed / Open Access
• [Journal Article] The lateral parabrachial nucleus is actively involved in the acquisition of fear memory in mice (2015)
  • Author(s): Sato M, Ito M, Nagase M, Sugimura YK, Takahashi Y, Watabe AM, Kato F
  • Journal Title: Molecular Brain Volume: 8 Issue: 1 Pages: 22-22
  • DOI: 10.1186/s13041-015-0108-z
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Artificial association of pre-stored information to generate a qualitatively new memory (2015)
  • Author(s): Ohkawa N, Saitoh Y, Suzuki A, Tsujimura S, Murayama E, Kosugi S, Nishizono H, Matsuo M, Takahashi Y, Nagase M, Sugimura YK, Watabe AM, Kato F, Inokuchi K
  • Journal Title: Cell Reports Volume: 11 Issue: 2 Pages: 1-9
  • DOI: 10.1016/j.celrep.2015.03.017
  • Peer Reviewed / Open Access
• [Journal Article] 脳はどのように痛みの慢性化を知るのか：慢性痛の生物学的理解を目指して (2014)
  • Author(s): 加藤総夫
  • Journal Title: 日本運動器疼痛学会誌 Volume: 6 Pages: 52-57
  • Open Access
• [Journal Article] Impaired noradrenaline homeostasis in rats with painful diabetic neuropathy as a target of duloxetine analgesia (2013)
  • Author(s): Kinoshita J, Takahashi Y, Watabe AM, Utsunomiya K and Kato F
  • Journal Title: Molecular pain Volume: 9 Pages: 59-59
  • DOI: 10.1186/1744-8069-9-59
  • Peer Reviewed
• [Journal Article] 【痛みと脳-慢性疼痛の解明に向けて-】 痛みと負情動 痛みの苦痛と優先的「割り込み」仮説 (2013)
  • Author(s): 加藤 総夫
  • Journal Title: ペインクリニック Volume: 34 Pages: 1059-1067
• [Presentation] 慢性痛関連症候を視る・測る・操作する (2017)
  • Author(s): 加藤総夫
  • Organizer: 第90回日本薬理学会年会
  • Place of Presentation: 長崎
• [Presentation] 下肢アロデニア成立における扁桃体中心核の役割 (2017)
  • Author(s): 杉本真理子, 高橋由香里, 加藤総夫.
  • Organizer: 生理研研究会 『痛みの理解を目指した先端的アプローチ』
  • Place of Presentation: 岡崎
• [Presentation] 侵害受容と痛み情動-痛みの慢性化における扁桃体の役割 (2017)
  • Author(s): 高橋由香里, 杉本真理子, 宮沢祐太, 杉村弥恵, 篠原恵, 渡部文子, 加藤総夫.
  • Organizer: 第94回日本生理学会大会
  • Place of Presentation: 浜松
• [Presentation] ラット炎症性疼痛モデル異所性アロディニアへの扁桃体中心核の関与 (2017)
  • Author(s): 杉本真理子, 杉村弥恵, 宮沢祐太, 高橋由香里, 渡部文子, 加藤総夫
  • Organizer: 第94回日本生理学会大会
  • Place of Presentation: 浜松
• [Presentation] 痛みの慢性化に伴う脳内情動疼痛回路のアロスタシス的障害 (2016)
  • Author(s): 加藤総夫
  • Organizer: 第31回日本整形外科学会基礎学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2016-10-13
  • Invited
• [Presentation] Early chronification process in inflammatory pain; involvement of amygdala plasticity (2016)
  • Author(s): Kato F
  • Organizer: Pain Mechanisms and Therapeutics Conference
  • Place of Presentation: Sicily, Italie
  • Year and Date: 2016-06-05
  • Int'l Joint Research
• [Presentation] 疼痛と情動の脳内機構 (2016)
  • Author(s): 加藤総夫
  • Organizer: 第23回脳機能とリハビリテーション研究会学術集会
  • Place of Presentation: 千葉
  • Invited
• [Presentation] Amygdala CGRP receptors affect ectopic mechanical hypersensitivity of hindpaws in the orofacial inflammatory pain model (2016)
  • Author(s): Sugimoto M, Miyazawa Y, Takahashi Y, Kato F
  • Organizer: The 10th FENS Forum of Neuroscience
  • Place of Presentation: Copenhagen
  • Int'l Joint Research
• [Presentation] Neural circuits underlying flight-or-freeze behavior triggered by an environmental threat. (2016)
  • Author(s): Ito M, Nagase M, Sugimura YK, Takahashi Y, Watabe AM, Kato F
  • Organizer: The 39th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: 横浜
• [Presentation] Role of the amygdala in early phase of the central pain chronification (2016)
  • Author(s): Takahashi, Y., Miyazawa, Y., Sugimura, Y. K., Sugimoto, M. Shinohara, K., Ghasemi, Z., Watabe, A.M., Kato, F.
  • Organizer: The 39th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: 横浜
• [Presentation] Dendritic integration of excitatory inputs of distinct origins to distinct dendrite compartments in the central amygdala (2016)
  • Author(s): Nagase, M., Watabe, A. M., Kato, F.
  • Organizer: The 39th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: 横浜
• [Presentation] Visualization of spontaneous brain activity during pain chronification process with manganeseenhanced magnetic resonance imaging (MEMRI) (2016)
  • Author(s): Shinohara, Kei., Takahashi, Y., Tsurugizawa, T., Ikeda, R., Marumo, K., Kato, F.
  • Organizer: The 39th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: 横浜
• [Presentation] ホルマリン炎症遷延性疼痛モデルを用いた脳内慢性化過程の解析 (2016)
  • Author(s): 加藤総夫
  • Organizer: 第36回鎮痛薬オピオイドペプチドシンポジウム
  • Place of Presentation: 札幌
  • Invited
• [Presentation] 炎症性疼痛モデルラットにおける扁桃体-中脳水道周囲灰白質シナプス伝達 (2016)
  • Author(s): 高橋由香里, Ghaseme Z, 杉村弥恵, 篠原 恵, 加藤総夫
  • Organizer: 第36回鎮痛薬オピオイドペプチドシンポジウム
  • Place of Presentation: 札幌
• [Presentation] 慢性腰痛と扁桃体可塑性 (2016)
  • Author(s): 加藤総夫
  • Organizer: 第24回日本腰痛学会
  • Place of Presentation: 甲府
  • Invited
• [Presentation] Plasticity in the parabrachial-amygdala circuit and its consequence in pain chronification (2016)
  • Author(s): Kato F
  • Organizer: Brain and New Pain Mechanisms, Satellite Symposium of 16th World Congress of Pain
  • Place of Presentation: 東京
  • Int'l Joint Research / Invited
• [Presentation] Non-amino acid neuromodulators regulate inflammation-induced generalized sessitization and voluntary choice of preferred environment (2016)
  • Author(s): Sugimoto, Y., Takahashi, Y., Miyazawa, Y., Watabe, A., Kato, F.
  • Organizer: The 16th World Congress on Pain
  • Place of Presentation: 横浜
  • Int'l Joint Research
• [Presentation] Fearing the pain: the parabrachio-amygdaloid pathway in aversive memory and pain chronification (2016)
  • Author(s): Kato F
  • Organizer: The 16th World Congress on Pain
  • Place of Presentation: 横浜
  • Int'l Joint Research
• [Presentation] Pathway-dependent differential effects of pregabalin on the excitatory inputs to the nociceptive amygdala in mice with inflammatory pain (2016)
  • Author(s): Yamamoto S, Takahashi Y, Watabe AM, Kato F
  • Organizer: The 16th World Congress on Pain
  • Place of Presentation: 横浜
  • Int'l Joint Research
• [Presentation] Optogenetic dissection of the amygdala-mediated control of the descending pain modulation (2016)
  • Author(s): Sugimura YK, Ghasemi Z, Takahashi Y, Yanagawa Y, Kaneko R, Watabe AM, Kato F
  • Organizer: Society for Neuroscience Annual Meeting 2016
  • Place of Presentation: San Diego
  • Int'l Joint Research
• [Presentation] 炎症性疼痛モデル持続性異所性痛覚過敏成立における扁桃体中心核の役割 (2016)
  • Author(s): 杉本真理子, 杉村弥恵, 宮沢祐太, 高橋由香里, 渡部文子, 加藤総夫
  • Organizer: 第9回日本運動器疼痛学会
  • Place of Presentation: 東京
• [Presentation] 痛みの慢性化と扁桃体神経可塑性. (2015)
  • Author(s): 加藤総夫.
  • Organizer: 平成27年度生理研究会 痛みの理解を目指した先端的アプローチ
  • Place of Presentation: 岡崎
  • Year and Date: 2015-12-17
  • Invited
• [Presentation] Role of parabrachial monosynaptic inputs in the central amygdala nucleus network. (2015)
  • Author(s): Sugimura YK, Takahashi Y, Watabe AM, Kato F.
  • Organizer: 8th Federation of Asian-Oceanian Physiological Societies (FAOPS) 2015 Congress
  • Place of Presentation: バンコク
  • Year and Date: 2015-11-22
  • Int'l Joint Research
• [Presentation] Visualization of spontaneous brain activity in chronic pain model with manganese-enhanced magnetic resonance imaging (MEMRI). (2015)
  • Author(s): Shinohara K, Takahashi Y, Tsurugizawa T, Ikeda R, Marumo K, Kato F.
  • Organizer: 8th Federation of Asian-Oceanian Physiological Societies (FAOPS) 2015 Congress
  • Place of Presentation: バンコク
  • Year and Date: 2015-11-22
  • Int'l Joint Research
• [Presentation] Painful diabetic neuropathy with streptozotocin involves plastic changes in ascending and descending pain pathways. (2015)
  • Author(s): Takahashi Y, Ochiai T, Kinoshita J, Watabe AM, Kamei J, Kato F
  • Organizer: the 8th Federation of Asian-Oceanian Physiological Societies (FAOPS) 2015 Congress
  • Place of Presentation: バンコク
  • Year and Date: 2015-11-22
  • Int'l Joint Research
• [Presentation] Roles of parabrachial-amygdala projection in inflammatory pain chronification. (2015)
  • Author(s): Kato F.
  • Organizer: the 6th Asian Pain Symposium (APS 2015)
  • Place of Presentation: 蘇州
  • Year and Date: 2015-11-08
  • Int'l Joint Research
• [Presentation] マンガン造影MRI法を用いた炎症性疼痛モデルの脳機能画像解析. (2015)
  • Author(s): 篠原恵, 奥津裕也, 池田亮, 高橋由香里, 加藤総夫, 丸毛啓史.
  • Organizer: 第30回日本整形外科学会基礎学術集会
  • Place of Presentation: 富山
  • Year and Date: 2015-10-22
• [Presentation] Right side specific potentiation of parabrachial-central amygdala transmission by trigeminal nerve-mediated inflammatory pain. (2015)
  • Author(s): Miyazawa Y, Sugimoto M, Takahashi Y, Watabe AM, Kato F.
  • Organizer: Society for Neuroscience 2015
  • Place of Presentation: シカゴ
  • Year and Date: 2015-10-17
  • Int'l Joint Research
• [Presentation] 可塑性病としての慢性痛とその新たな治療標的. (2015)
  • Author(s): 加藤総夫.
  • Organizer: 第133回日本薬理学会関東部会
  • Place of Presentation: 千葉
  • Year and Date: 2015-10-10
  • Invited
• [Presentation] マンガン造影小動物MRIによる炎症性疼痛発症過程の脳機能画像化. (2015)
  • Author(s): 篠原恵, 高橋由香里, 奥津裕也, 池田亮, 丸毛啓史, 加藤総夫.
  • Organizer: 第132回成医会総会
  • Place of Presentation: 東京
  • Year and Date: 2015-10-08
• [Presentation] 痛みのネットワークを探る-光遺伝学から超高磁場MRI画像解析まで-. (2015)
  • Author(s): 加藤総夫.
  • Organizer: 第246回生理学東京談話会
  • Place of Presentation: 東京
  • Year and Date: 2015-09-26
  • Invited
• [Presentation] Spontaneous pain in awake animals - an application of manganese-enhanced magnetic resonance imaging (MEMRI) to understand the brain process of the chronic pain. (2015)
  • Author(s): Shinohara K, Takahashi Y, Tsurugizawa T, Ikeda R, Marumo K, Kato F.
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-07-28
• [Presentation] 痛みと扁桃体 (2015)
  • Author(s): 加藤総夫
  • Organizer: 日本ペインクリニック学会第49回大会
  • Place of Presentation: 大阪
  • Year and Date: 2015-07-25
  • Invited
• [Presentation] 痛み情動と扁桃体. (2015)
  • Author(s): 加藤総夫.
  • Organizer: 第37回日本疼痛学会
  • Place of Presentation: 熊本
  • Year and Date: 2015-07-03
  • Invited
• [Presentation] オプトジェネティクスを用いた侵害受容-情動回路の解析. (2015)
  • Author(s): 杉村弥恵，高橋由香里，渡部文子，加藤総夫.
  • Organizer: 第37回日本疼痛学会
  • Place of Presentation: 熊本
  • Year and Date: 2015-07-03
• [Presentation] 痛みを生み出す脳機構. (2015)
  • Author(s): 加藤総夫.
  • Organizer: 第50回日本理学療法学術大会
  • Place of Presentation: 東京
  • Year and Date: 2015-06-05
  • Invited
• [Presentation] What is the biological significance of emotion in pain and its regulation? (2015)
  • Author(s): Kato F
  • Organizer: 第92回日本生理学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-03-21 – 2015-03-23
• [Presentation] Optogenetic demonstration of direct input from the lateral parabrachial nucleus to the nociceptive amygdala (2015)
  • Author(s): Sugimura YK, Takahashi Y, Watabe AM, Kato F
  • Organizer: 第92回日本生理学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-03-21 – 2015-03-23
• [Presentation] Syanptic potentiation in the central amygdala in trigeminal inflammatory pain model of rats (2015)
  • Author(s): Miyazawa Y, Takahashi Y, Watabe AM, Kato F
  • Organizer: 第92回日本生理学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-03-21 – 2015-03-23
• [Presentation] Effects of neurotoxic destruction of noradrenergic fibers of the central nucleus of amygdala on rat inflammatory orofacial pain (2015)
  • Author(s): Sugimoto M, Takahashi Y, Watabe AM, Kato F
  • Organizer: 第92回日本生理学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-03-21 – 2015-03-23
• [Presentation] Pain chronification and amygdala plasticity (2015)
  • Author(s): Kato F
  • Organizer: AND (Association of the Study for Neurons and Diseases) Winter Mini-Conference
  • Place of Presentation: 熱海
  • Year and Date: 2015-01-21
  • Invited
• [Presentation] Parabrachial-amygdala projection in the inflammatory pain chronification (2014)
  • Author(s): Kato F
  • Organizer: The First CiNet Conference - New Directions in Pain Neuroscience
  • Place of Presentation: 大阪
  • Year and Date: 2014-12-02 – 2014-12-05
  • Invited
• [Presentation] 内臓情報を伝えるシナプス機構の分子生理学的解析 (2014)
  • Author(s): 加藤総夫
  • Organizer: 第67回日本自律神経学会総会
  • Place of Presentation: 大宮
  • Year and Date: 2014-10-30 – 2014-10-31
• [Presentation] 痛みの慢性化におけるCGRPの役割 遺伝子欠損マウスを用いた扁桃体興奮性シナプス伝達の解析 (2014)
  • Author(s): 篠原 恵, 奥津 裕也, 池田 亮, 高橋 由香里, 栗原 裕基, 加藤 総夫, 丸毛 啓史
  • Organizer: 第29回日本整形外科学会基礎学術集会
  • Place of Presentation: 鹿児島
  • Year and Date: 2014-10-08 – 2014-10-09
• [Presentation] 痛みの慢性化と扁桃体神経可塑性 (2014)
  • Author(s): 加藤総夫
  • Organizer: 第29回整形外科学会基礎学術集会
  • Place of Presentation: 鹿児島
  • Year and Date: 2014-10-08 – 2014-10-09
  • Invited
• [Presentation] Amygdala plasticity in the chronification process of inflammatory pain (2014)
  • Author(s): Kato F
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-11 – 2014-09-14
• [Presentation] Role of CGRP in inflammatory pain-induced potentiation in the central amygdala (2014)
  • Author(s): Shinohara K, Ikeda R, Takahashi Y, Kurihara H, Marumo K, Kato F
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-11 – 2014-09-14
• [Presentation] Two ｄistinct ｔypes of adrenoceptors modurate network activity in the central nucleus of amygdala (2014)
  • Author(s): Yamamoto S, Takahashi Y, Watabe AM, Kato F
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-11 – 2014-09-14
• [Presentation] Synaptic potentiation in the nociceptive amygdala (2014)
  • Author(s): Kato F
  • Organizer: 8th IGAKUKEN International Symposium on“Pain Modulation and Opioid Functions”
  • Place of Presentation: 東京
  • Year and Date: 2014-09-05
  • Invited
• [Presentation] Independent roles of distinct types of adrenoceptors in synaptic modulation of network activity in the central nucleus of amygdala (2014)
  • Author(s): Yamamoto S, Takahashi Y, Watabe AM, Kato F
  • Organizer: 9th FENS Forum of Neuroscience
  • Place of Presentation: Milan
  • Year and Date: 2014-07-05 – 2014-07-09
• [Presentation] Optogenetic stimulation of parabrachio-amygdaloid pathway modulates excitability of the nociceptive amygdala (2014)
  • Author(s): Sugimura Y, Takahashi Y, Watabe AM, Kato F
  • Organizer: 9th FENS Forum of Neuroscience
  • Place of Presentation: Milan
  • Year and Date: 2014-07-05 – 2014-07-09
• [Presentation] Insulin attenuates synaptic potentiation in the nociceptive amygdala in a rodent model of painful diabetic neuropathy (2014)
  • Author(s): Takahashi Y, Ochiai T, Asato M, Watabe AM, Ohsawa M, Kamei J, Kato F
  • Organizer: 9th FENS Forum of Neuroscience
  • Place of Presentation: Milan
  • Year and Date: 2014-07-05 – 2014-07-09
• [Presentation] 生物進化から考える慢性痛の新たな治療戦略-マトリクスを超えて (2014)
  • Author(s): 加藤総夫
  • Organizer: 第36回日本疼痛学会
  • Place of Presentation: 大阪
  • Year and Date: 2014-06-20 – 2014-06-21
  • Invited
• [Presentation] 温度嗜好性自由行動試験を用いた自発性疼痛の評価 (2014)
  • Author(s): 杉本 真理子, 宮沢 祐太, 高橋 由香里, 加藤 総夫
  • Organizer: 第91回日本生理学会大会
  • Place of Presentation: 鹿児島
• [Presentation] ラット顔面炎症性ホルマリン疼痛モデルにおける侵害受容扁桃体シナプス増強 (2014)
  • Author(s): 宮沢 祐太, 高橋 由香里, 渡部 文子, 加藤 総夫
  • Organizer: 第91回日本生理学会大会
  • Place of Presentation: 鹿児島
• [Presentation] 侵害受容扁桃体における腕傍核‐扁桃体路の光活性化 (2014)
  • Author(s): 杉村 弥恵, 高橋 由香里, 渡部 文子, 加藤 総夫
  • Organizer: 第91回日本生理学会大会
  • Place of Presentation: 鹿児島
• [Presentation] 侵害受容情報と痛み情動記憶を結ぶ腕傍核 (2014)
  • Author(s): 加藤 総夫
  • Organizer: 第91回日本生理学会大会
  • Place of Presentation: 鹿児島
• [Presentation] 恐怖記憶形成における扁桃体神経回路制御 (2014)
  • Author(s): 渡部 文子, 佐藤 優, 加藤 総夫
  • Organizer: 第91回日本生理学会大会
  • Place of Presentation: 鹿児島
• [Presentation] 痛みの苦痛の生物学的意義- 侵害受容扁桃体と慢性痛におけるその可塑性 (2013)
  • Author(s): 加藤 総夫
  • Organizer: 第43回日本ペインクリニック学会関西支部学術集会
  • Place of Presentation: 大阪
  • Invited
• [Presentation] ノルアドレナリン下行性疼痛制御系の有痛性糖尿病神経障害形成における役割 (2013)
  • Author(s): 木下 淳, 高橋 由香里, 部 文子, 的場 圭一郎, 石澤 将, 金澤 康, 川浪 大治, 横田 太持, 加藤 総夫, 宇都宮 一典
  • Organizer: 第56回日本糖尿病学会年次学術集会
  • Place of Presentation: 熊本
• [Presentation] 侵害受容性扁桃体の薬理学的抑制による疼痛関連情動行動の変容 (2013)
  • Author(s): 杉本 真理子, 高橋 由香里, 加藤 総夫
  • Organizer: 日本麻酔科学会第60回学術集会
  • Place of Presentation: 札幌
• [Presentation] ノルアドレナリンはβ受容体を介して扁桃体中心核内側亜核への抑制性入力を増強する (2013)
  • Author(s): 山本 純偉, 高橋 由香里, 田中 誠, 加藤 総夫
  • Organizer: 日本麻酔科学会第60回学術集会
  • Place of Presentation: 札幌
• [Presentation] ホルマリン誘発炎症痛モデルにおける疼痛行動と侵害受容扁桃体シナプス増強の時間的乖離 (2013)
  • Author(s): 宮沢 祐太, 杉本 真理子, 高橋 由香里, 加藤 総夫
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 京都
• [Presentation] 恐怖記憶形成により誘導される扁桃体中心核シナプス増強 (2013)
  • Author(s): 渡部 文子, 加藤 総夫
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 京都
• [Presentation] 有痛性神経障害糖尿病ラットにおけるノルアドレナリン下行性疼痛制御系の機能不全 (2013)
  • Author(s): 木下 淳, 高橋 由香里, 渡部 文子, 宇都宮 一典, 加藤 総夫
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 京都
• [Presentation] ノルアドレナリンはβ受容体を介して扁桃体中心核内側亜核への抑制性入力を増強させる (2013)
  • Author(s): 山本 純偉, 高橋 由香里, 渡部 文子, 田中 誠, 加藤 総夫
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 京都
• [Presentation] The central amygdala - where pain meets fear (2013)
  • Author(s): Kato F
  • Organizer: The 8th International Conference for Neurons and Brain Diseases
  • Place of Presentation: Singapore
• [Presentation] 侵害受容性扁桃体シナプス増強の疼痛モデル依存性 (2013)
  • Author(s): 加藤 総夫, 落合 敏平, 安井 豊, 池田 亮, 宮沢 祐太, 杉本 真理子, 杉村 弥恵, 渡部 文子, 高橋 由香里
  • Organizer: 第35回日本疼痛学会
  • Place of Presentation: 大宮
• [Presentation] Synaptic potentiation in the central amygdala of painful diabetic neuropathy model (2013)
  • Author(s): Kato F
  • Organizer: Amygdala in Health & Disease
  • Place of Presentation: Easton
• [Presentation] 情動行動発現における脊髄後角―腕傍核―扁桃体路の意義 (2013)
  • Author(s): 加藤 総夫
  • Organizer: 平成25年度生理学研究所研究会 感覚刺激・薬物による快・不快情動生成機構とその破綻
  • Place of Presentation: 岡崎
• [Presentation] Synaptic plasticity in the central amygdala of streptozotocin-induced diabetic neuropathic pain model (2013)
  • Author(s): Takahashi Y, Ochiai T, Watabe AM and Kato F
  • Organizer: Neural Circuits underlying Nociception and Pain and their Plasticity
  • Place of Presentation: Heidelberg
• [Presentation] Optogenetic activation of parabrachio-amygdaloid pathway (2013)
  • Author(s): Sugimura YK, Takahashi Y, Watabe AM and Kato F
  • Organizer: Neural Circuits underlying Nociception and Pain and their Plasticity
  • Place of Presentation: Heidelberg
• [Presentation] Noradrenaline dramatically increases GABAergic inputs through beta adrenoceptor in central nucleus of amygdala (2013)
  • Author(s): Yamamoto S, Takahashi Y, Watabe AM, Tanaka M and Kato F
  • Organizer: The ANESTHESIOLOGY 2013 annual meeting
  • Place of Presentation: San Francisco
• [Presentation] Noradrenaline dramatically increases GABAergic inputs through beta adrenoceptor activation in medial division of the central nucleus of amygdala (2013)
  • Author(s): Yamamoto S, Takahashi Y, Watabe AM, Tanaka M and Kato F
  • Organizer: The 43rd annual meeting of the Society for Neuroscience
  • Place of Presentation: San Diego
• [Presentation] Lateral parabrachial nucleus is involved in the acquisition of fear memory in mice (2013)
  • Author(s): Sato M, Watabe AM and Kato F
  • Organizer: The 43rd annual meeting of the Society for Neuroscience
  • Place of Presentation: San Diego
• [Presentation] 脳はどのように痛みの慢性化を知るのか？ (2013)
  • Author(s): 加藤 総夫, 池田 亮, 篠原 恵, 奥津 裕也, 高橋 由香里, 丸毛 啓史
  • Organizer: 第6回日本運動器疼痛学会
  • Place of Presentation: 神戸
• [Presentation] Nociceptive amygdala in various chronic pain models (2013)
  • Author(s): Kato F
  • Organizer: 5th Asian Pain Symposium
  • Place of Presentation: 岡崎
• [Remarks] 痛み情報がどのように情動回路を活性化するか解明！
  • URL: http://www.jikei-neuroscience.com/website/2017/05/post-fb43.html
• [Remarks] 身体に及ぶ危険・脅威を学習させる信号経路を解明！
  • URL: http://www.jikei-neuroscience.com/website/2017/05/post-9537.html
• [Remarks] 最新の研究成果
  • URL: http://www.jikei-neuroscience.com/website/what_we_have_found_recently/index.html
• [Remarks] 最新の研究成果
• [Remarks] 痛みと情動、特に慢性痛による扁桃体ネットワークのシナプス可塑性に関する研究
  • URL: http://lablog.neurophysiology-jikei.jp/pain_amygdala.html