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Identification of the role of spino-parabrachio-amygdaloid pathway in the pain-associated emotion

Research Project

Project/Area Number 25293136
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Pain science
Research InstitutionJikei University School of Medicine

Principal Investigator

Kato Fusao  東京慈恵会医科大学, 医学部, 教授 (20169519)

Co-Investigator(Renkei-kenkyūsha) Watabe M Ayako  東京慈恵会医科大学, 医学部, 教授 (00334277)
Takahashi Yukari  東京慈恵会医科大学, 医学部, 助教 (20613764)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Keywords扁桃体 / 腕傍核 / 慢性痛 / 恐怖・脅威学習 / 情動 / 光遺伝学 / 化学遺伝学 / 痛み / 恐怖学習 / アロディニア / チャネルロドプシン / 侵害受容性扁桃体 / 痛み情動 / 恐怖条件付け / CGRP / 有痛性糖尿病性神経障害 / シナプス伝達
Outline of Final Research Achievements

To clarify the mechanism underlying the link between pain and negative emotion (suffering), we focused on the spino-parabrachio-amygdaloid pathway: 1) Optogenetic activation of the parabrachial-central amygdala pathway alone functions as unconditioned stimulus in Pavlovian and operant conditional learning. 2) This evoked mono- and polysynaptic network-driven activities in the central amygdala neurons, which was potentiated in the persistent inflammatory pain model. And 3) chemogenetic inhibition of GABAergic neurons in the central amygdala in the inflammatory pain model mitigated hypersensitivity and chemogenetic activation of these gave rise to the hypersensitivity in normal rats. These results indicate that this pathway is the primary route for the aversive nociceptive information to activate the limbic system leading to not only the negative emotion but also the elevated sensitivity to potentially harmful events.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (105 results)

All 2017 2016 2015 2014 2013 Other

All Int'l Joint Research (8 results) Journal Article (15 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 13 results,  Open Access: 11 results,  Acknowledgement Compliant: 5 results) Presentation (77 results) (of which Int'l Joint Research: 12 results,  Invited: 17 results) Remarks (5 results)

  • [Int'l Joint Research] NeuroSpin, CEA(France)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] 4th Military Medical School(China)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] The Institute of Science and Technology(オーストリア)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] NIH/NCCIH(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] 第4軍医大学(中国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Tarbiat Modares University(イラン)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] University of Washington(米国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Institute of Science and Technology(オーストリア)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Facilitation of distinct inhibitory synaptic inputs by chemical anoxia in neurons in the oculomotor, facial and hypoglossal motor nuclei of the rat2017

    • Author(s)
      Takagi S, Kono Y, Nagase M, Mochio S, Kato F
    • Journal Title

      Exp Neurol

      Volume: 290 Pages: 95-105

    • DOI

      10.1016/j.expneurol.2017.01.007

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Overlapping memory trace indispensable for linking, but not recalling, individual memories.2017

    • Author(s)
      Yokose, J., Okubo-Suzuki, R., Nomoto, M., Ohkawa, N., Nishizono, H., Suzuki, A., Matsuo, M., Tsujimura, S., Takahashi, Y., Nagase, M.,Watabe, A.M., Sasahara, M., Kato, F., Inokuchi, K.
    • Journal Title

      Science

      Volume: 355 Issue: 6323 Pages: 398-403

    • DOI

      10.1126/science.aal2690

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Potentiation of NMDA receptor-mediated synaptic transmission at the parabrachial-central amygdala synapses by CGRP in mice2017

    • Author(s)
      Okutsu Y, Takahashi Y, Nagase M, Shinohara K, Ikeda R, Kato F
    • Journal Title

      Molecular Pain

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Synaptic and network consequences of monosynaptic nociceptive inputs of parabrachial nucleus origin in the central amygdala.2016

    • Author(s)
      Sugimura, YK., Takahashi, Y., Watabe, A.M., Kato, F.
    • Journal Title

      Journal of neurophysiology

      Volume: xx Issue: 6 Pages: 2721-2739

    • DOI

      10.1152/jn.00946.2015

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cellular tagging as a neural network mechanism for behavioral tagging.2016

    • Author(s)
      Nomoto, M., Ohkawa, N., Nishizono, H., Yokose, J., Suzuki, A., Matuo, M., Tsujimura, S., Takahashi, Y., Nagase, M., Watabe, A.M., Kato, F., Inokuchi, K.
    • Journal Title

      Nature Communications

      Volume: 7:12319 Issue: 1 Pages: 1-11

    • DOI

      10.1038/ncomms12319

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Distinct effects of isoflurane on basal BOLD signals in tissue/vascular microstructures in rats2016

    • Author(s)
      Tsurugizawa T, Takahashi Y, Kato F
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 38977-38977

    • DOI

      10.1038/srep38977

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] SAD-B Kinase regulates presynaptic vesicular dynamics at hippocampal Schaffer collateral synapses and affects contextual fear memory.2016

    • Author(s)
      Watabe, A.M., Nagase, M., Hagiwara, A., Hida, Y., Tsuji, M., Ochiai, T., Kato, F., Ohtsuka, T.
    • Journal Title

      Journal of Neurochemistry

      Volume: 136: Issue: 1 Pages: 36-47

    • DOI

      10.1111/jnc.13379

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Enhanced long-term potentiation in mature rats with a history of cryptogenic infantile spasms.2016

    • Author(s)
      Tsuji, M., Takahashi, Y., Watabe, A.M., Kato, F.
    • Journal Title

      Epilepsia

      Volume: 57 Issue: 3 Pages: 495-505

    • DOI

      10.1111/epi.13315

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Corticotropin-releasing factor enhances inhibitory synaptic transmission to type III neurons in the bed nucleus of the stria terminalis.2015

    • Author(s)
      Nagano Y, Kaneda K, Maruyama C, Ide S, Kato F, Minami M
    • Journal Title

      Neurosci. Lett.

      Volume: 600 Pages: 56-61

    • DOI

      10.1016/j.neulet.2015.05.059

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Potentiation of acetylcholine-mediated facilitation of inhibitory synaptic transmission by an azaindolizione derivative, ZSET1446 (ST101), in the rat hippocampus2015

    • Author(s)
      Takeda K, Yamaguchi Y, Hino M, Kato F.
    • Journal Title

      J Pharmacol Exp Ther.

      Volume: 356(2): Issue: 2 Pages: 445-55

    • DOI

      10.1124/jpet.115.229021

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The lateral parabrachial nucleus is actively involved in the acquisition of fear memory in mice2015

    • Author(s)
      Sato M, Ito M, Nagase M, Sugimura YK, Takahashi Y, Watabe AM, Kato F
    • Journal Title

      Molecular Brain

      Volume: 8 Issue: 1 Pages: 22-22

    • DOI

      10.1186/s13041-015-0108-z

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Artificial association of pre-stored information to generate a qualitatively new memory2015

    • Author(s)
      Ohkawa N, Saitoh Y, Suzuki A, Tsujimura S, Murayama E, Kosugi S, Nishizono H, Matsuo M, Takahashi Y, Nagase M, Sugimura YK, Watabe AM, Kato F, Inokuchi K
    • Journal Title

      Cell Reports

      Volume: 11 Issue: 2 Pages: 1-9

    • DOI

      10.1016/j.celrep.2015.03.017

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 脳はどのように痛みの慢性化を知るのか:慢性痛の生物学的理解を目指して2014

    • Author(s)
      加藤総夫
    • Journal Title

      日本運動器疼痛学会誌

      Volume: 6 Pages: 52-57

    • Related Report
      2014 Annual Research Report
    • Open Access
  • [Journal Article] Impaired noradrenaline homeostasis in rats with painful diabetic neuropathy as a target of duloxetine analgesia2013

    • Author(s)
      Kinoshita J, Takahashi Y, Watabe AM, Utsunomiya K and Kato F
    • Journal Title

      Molecular pain

      Volume: 9 Pages: 59-59

    • DOI

      10.1186/1744-8069-9-59

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 【痛みと脳-慢性疼痛の解明に向けて-】 痛みと負情動 痛みの苦痛と優先的「割り込み」仮説2013

    • Author(s)
      加藤 総夫
    • Journal Title

      ペインクリニック

      Volume: 34 Pages: 1059-1067

    • Related Report
      2013 Annual Research Report
  • [Presentation] 慢性痛関連症候を視る・測る・操作する2017

    • Author(s)
      加藤総夫
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎
    • Related Report
      2016 Annual Research Report
  • [Presentation] 下肢アロデニア成立における扁桃体中心核の役割2017

    • Author(s)
      杉本真理子, 高橋由香里, 加藤総夫.
    • Organizer
      生理研研究会 『痛みの理解を目指した先端的アプローチ』
    • Place of Presentation
      岡崎
    • Related Report
      2016 Annual Research Report
  • [Presentation] 侵害受容と痛み情動-痛みの慢性化における扁桃体の役割2017

    • Author(s)
      高橋由香里, 杉本真理子, 宮沢祐太, 杉村弥恵, 篠原恵, 渡部文子, 加藤総夫.
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      浜松
    • Related Report
      2016 Annual Research Report
  • [Presentation] ラット炎症性疼痛モデル異所性アロディニアへの扁桃体中心核の関与2017

    • Author(s)
      杉本真理子, 杉村弥恵, 宮沢祐太, 高橋由香里, 渡部文子, 加藤総夫
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      浜松
    • Related Report
      2016 Annual Research Report
  • [Presentation] 痛みの慢性化に伴う脳内情動疼痛回路のアロスタシス的障害2016

    • Author(s)
      加藤総夫
    • Organizer
      第31回日本整形外科学会基礎学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2016-10-13
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Early chronification process in inflammatory pain; involvement of amygdala plasticity2016

    • Author(s)
      Kato F
    • Organizer
      Pain Mechanisms and Therapeutics Conference
    • Place of Presentation
      Sicily, Italie
    • Year and Date
      2016-06-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 疼痛と情動の脳内機構2016

    • Author(s)
      加藤総夫
    • Organizer
      第23回脳機能とリハビリテーション研究会学術集会
    • Place of Presentation
      千葉
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Amygdala CGRP receptors affect ectopic mechanical hypersensitivity of hindpaws in the orofacial inflammatory pain model2016

    • Author(s)
      Sugimoto M, Miyazawa Y, Takahashi Y, Kato F
    • Organizer
      The 10th FENS Forum of Neuroscience
    • Place of Presentation
      Copenhagen
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Neural circuits underlying flight-or-freeze behavior triggered by an environmental threat.2016

    • Author(s)
      Ito M, Nagase M, Sugimura YK, Takahashi Y, Watabe AM, Kato F
    • Organizer
      The 39th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      横浜
    • Related Report
      2016 Annual Research Report
  • [Presentation] Role of the amygdala in early phase of the central pain chronification2016

    • Author(s)
      Takahashi, Y., Miyazawa, Y., Sugimura, Y. K., Sugimoto, M. Shinohara, K., Ghasemi, Z., Watabe, A.M., Kato, F.
    • Organizer
      The 39th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      横浜
    • Related Report
      2016 Annual Research Report
  • [Presentation] Dendritic integration of excitatory inputs of distinct origins to distinct dendrite compartments in the central amygdala2016

    • Author(s)
      Nagase, M., Watabe, A. M., Kato, F.
    • Organizer
      The 39th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      横浜
    • Related Report
      2016 Annual Research Report
  • [Presentation] Visualization of spontaneous brain activity during pain chronification process with manganeseenhanced magnetic resonance imaging (MEMRI)2016

    • Author(s)
      Shinohara, Kei., Takahashi, Y., Tsurugizawa, T., Ikeda, R., Marumo, K., Kato, F.
    • Organizer
      The 39th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      横浜
    • Related Report
      2016 Annual Research Report
  • [Presentation] ホルマリン炎症遷延性疼痛モデルを用いた脳内慢性化過程の解析2016

    • Author(s)
      加藤総夫
    • Organizer
      第36回鎮痛薬オピオイドペプチドシンポジウム
    • Place of Presentation
      札幌
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 炎症性疼痛モデルラットにおける扁桃体-中脳水道周囲灰白質シナプス伝達2016

    • Author(s)
      高橋由香里, Ghaseme Z, 杉村弥恵, 篠原 恵, 加藤総夫
    • Organizer
      第36回鎮痛薬オピオイドペプチドシンポジウム
    • Place of Presentation
      札幌
    • Related Report
      2016 Annual Research Report
  • [Presentation] 慢性腰痛と扁桃体可塑性2016

    • Author(s)
      加藤総夫
    • Organizer
      第24回日本腰痛学会
    • Place of Presentation
      甲府
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Plasticity in the parabrachial-amygdala circuit and its consequence in pain chronification2016

    • Author(s)
      Kato F
    • Organizer
      Brain and New Pain Mechanisms, Satellite Symposium of 16th World Congress of Pain
    • Place of Presentation
      東京
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Non-amino acid neuromodulators regulate inflammation-induced generalized sessitization and voluntary choice of preferred environment2016

    • Author(s)
      Sugimoto, Y., Takahashi, Y., Miyazawa, Y., Watabe, A., Kato, F.
    • Organizer
      The 16th World Congress on Pain
    • Place of Presentation
      横浜
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Fearing the pain: the parabrachio-amygdaloid pathway in aversive memory and pain chronification2016

    • Author(s)
      Kato F
    • Organizer
      The 16th World Congress on Pain
    • Place of Presentation
      横浜
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Pathway-dependent differential effects of pregabalin on the excitatory inputs to the nociceptive amygdala in mice with inflammatory pain2016

    • Author(s)
      Yamamoto S, Takahashi Y, Watabe AM, Kato F
    • Organizer
      The 16th World Congress on Pain
    • Place of Presentation
      横浜
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Optogenetic dissection of the amygdala-mediated control of the descending pain modulation2016

    • Author(s)
      Sugimura YK, Ghasemi Z, Takahashi Y, Yanagawa Y, Kaneko R, Watabe AM, Kato F
    • Organizer
      Society for Neuroscience Annual Meeting 2016
    • Place of Presentation
      San Diego
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 炎症性疼痛モデル持続性異所性痛覚過敏成立における扁桃体中心核の役割2016

    • Author(s)
      杉本真理子, 杉村弥恵, 宮沢祐太, 高橋由香里, 渡部文子, 加藤総夫
    • Organizer
      第9回日本運動器疼痛学会
    • Place of Presentation
      東京
    • Related Report
      2016 Annual Research Report
  • [Presentation] 痛みの慢性化と扁桃体神経可塑性.2015

    • Author(s)
      加藤総夫.
    • Organizer
      平成27年度生理研究会 痛みの理解を目指した先端的アプローチ
    • Place of Presentation
      岡崎
    • Year and Date
      2015-12-17
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Role of parabrachial monosynaptic inputs in the central amygdala nucleus network.2015

    • Author(s)
      Sugimura YK, Takahashi Y, Watabe AM, Kato F.
    • Organizer
      8th Federation of Asian-Oceanian Physiological Societies (FAOPS) 2015 Congress
    • Place of Presentation
      バンコク
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Visualization of spontaneous brain activity in chronic pain model with manganese-enhanced magnetic resonance imaging (MEMRI).2015

    • Author(s)
      Shinohara K, Takahashi Y, Tsurugizawa T, Ikeda R, Marumo K, Kato F.
    • Organizer
      8th Federation of Asian-Oceanian Physiological Societies (FAOPS) 2015 Congress
    • Place of Presentation
      バンコク
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Painful diabetic neuropathy with streptozotocin involves plastic changes in ascending and descending pain pathways.2015

    • Author(s)
      Takahashi Y, Ochiai T, Kinoshita J, Watabe AM, Kamei J, Kato F
    • Organizer
      the 8th Federation of Asian-Oceanian Physiological Societies (FAOPS) 2015 Congress
    • Place of Presentation
      バンコク
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Roles of parabrachial-amygdala projection in inflammatory pain chronification.2015

    • Author(s)
      Kato F.
    • Organizer
      the 6th Asian Pain Symposium (APS 2015)
    • Place of Presentation
      蘇州
    • Year and Date
      2015-11-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] マンガン造影MRI法を用いた炎症性疼痛モデルの脳機能画像解析.2015

    • Author(s)
      篠原恵, 奥津裕也, 池田亮, 高橋由香里, 加藤総夫, 丸毛啓史.
    • Organizer
      第30回日本整形外科学会基礎学術集会
    • Place of Presentation
      富山
    • Year and Date
      2015-10-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Right side specific potentiation of parabrachial-central amygdala transmission by trigeminal nerve-mediated inflammatory pain.2015

    • Author(s)
      Miyazawa Y, Sugimoto M, Takahashi Y, Watabe AM, Kato F.
    • Organizer
      Society for Neuroscience 2015
    • Place of Presentation
      シカゴ
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 可塑性病としての慢性痛とその新たな治療標的.2015

    • Author(s)
      加藤総夫.
    • Organizer
      第133回日本薬理学会関東部会
    • Place of Presentation
      千葉
    • Year and Date
      2015-10-10
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] マンガン造影小動物MRIによる炎症性疼痛発症過程の脳機能画像化.2015

    • Author(s)
      篠原恵, 高橋由香里, 奥津裕也, 池田亮, 丸毛啓史, 加藤総夫.
    • Organizer
      第132回成医会総会
    • Place of Presentation
      東京
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] 痛みのネットワークを探る-光遺伝学から超高磁場MRI画像解析まで-.2015

    • Author(s)
      加藤総夫.
    • Organizer
      第246回生理学東京談話会
    • Place of Presentation
      東京
    • Year and Date
      2015-09-26
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Spontaneous pain in awake animals - an application of manganese-enhanced magnetic resonance imaging (MEMRI) to understand the brain process of the chronic pain.2015

    • Author(s)
      Shinohara K, Takahashi Y, Tsurugizawa T, Ikeda R, Marumo K, Kato F.
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 痛みと扁桃体2015

    • Author(s)
      加藤総夫
    • Organizer
      日本ペインクリニック学会第49回大会
    • Place of Presentation
      大阪
    • Year and Date
      2015-07-25
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 痛み情動と扁桃体.2015

    • Author(s)
      加藤総夫.
    • Organizer
      第37回日本疼痛学会
    • Place of Presentation
      熊本
    • Year and Date
      2015-07-03
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] オプトジェネティクスを用いた侵害受容-情動回路の解析.2015

    • Author(s)
      杉村弥恵,高橋由香里,渡部文子,加藤総夫.
    • Organizer
      第37回日本疼痛学会
    • Place of Presentation
      熊本
    • Year and Date
      2015-07-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] 痛みを生み出す脳機構.2015

    • Author(s)
      加藤総夫.
    • Organizer
      第50回日本理学療法学術大会
    • Place of Presentation
      東京
    • Year and Date
      2015-06-05
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] What is the biological significance of emotion in pain and its regulation?2015

    • Author(s)
      Kato F
    • Organizer
      第92回日本生理学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Optogenetic demonstration of direct input from the lateral parabrachial nucleus to the nociceptive amygdala2015

    • Author(s)
      Sugimura YK, Takahashi Y, Watabe AM, Kato F
    • Organizer
      第92回日本生理学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Syanptic potentiation in the central amygdala in trigeminal inflammatory pain model of rats2015

    • Author(s)
      Miyazawa Y, Takahashi Y, Watabe AM, Kato F
    • Organizer
      第92回日本生理学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Effects of neurotoxic destruction of noradrenergic fibers of the central nucleus of amygdala on rat inflammatory orofacial pain2015

    • Author(s)
      Sugimoto M, Takahashi Y, Watabe AM, Kato F
    • Organizer
      第92回日本生理学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Pain chronification and amygdala plasticity2015

    • Author(s)
      Kato F
    • Organizer
      AND (Association of the Study for Neurons and Diseases) Winter Mini-Conference
    • Place of Presentation
      熱海
    • Year and Date
      2015-01-21
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Parabrachial-amygdala projection in the inflammatory pain chronification2014

    • Author(s)
      Kato F
    • Organizer
      The First CiNet Conference - New Directions in Pain Neuroscience
    • Place of Presentation
      大阪
    • Year and Date
      2014-12-02 – 2014-12-05
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 内臓情報を伝えるシナプス機構の分子生理学的解析2014

    • Author(s)
      加藤総夫
    • Organizer
      第67回日本自律神経学会総会
    • Place of Presentation
      大宮
    • Year and Date
      2014-10-30 – 2014-10-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] 痛みの慢性化におけるCGRPの役割 遺伝子欠損マウスを用いた扁桃体興奮性シナプス伝達の解析2014

    • Author(s)
      篠原 恵, 奥津 裕也, 池田 亮, 高橋 由香里, 栗原 裕基, 加藤 総夫, 丸毛 啓史
    • Organizer
      第29回日本整形外科学会基礎学術集会
    • Place of Presentation
      鹿児島
    • Year and Date
      2014-10-08 – 2014-10-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] 痛みの慢性化と扁桃体神経可塑性2014

    • Author(s)
      加藤総夫
    • Organizer
      第29回整形外科学会基礎学術集会
    • Place of Presentation
      鹿児島
    • Year and Date
      2014-10-08 – 2014-10-09
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Amygdala plasticity in the chronification process of inflammatory pain2014

    • Author(s)
      Kato F
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-11 – 2014-09-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] Role of CGRP in inflammatory pain-induced potentiation in the central amygdala2014

    • Author(s)
      Shinohara K, Ikeda R, Takahashi Y, Kurihara H, Marumo K, Kato F
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-11 – 2014-09-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] Two distinct types of adrenoceptors modurate network activity in the central nucleus of amygdala2014

    • Author(s)
      Yamamoto S, Takahashi Y, Watabe AM, Kato F
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-11 – 2014-09-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] Synaptic potentiation in the nociceptive amygdala2014

    • Author(s)
      Kato F
    • Organizer
      8th IGAKUKEN International Symposium on“Pain Modulation and Opioid Functions”
    • Place of Presentation
      東京
    • Year and Date
      2014-09-05
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Independent roles of distinct types of adrenoceptors in synaptic modulation of network activity in the central nucleus of amygdala2014

    • Author(s)
      Yamamoto S, Takahashi Y, Watabe AM, Kato F
    • Organizer
      9th FENS Forum of Neuroscience
    • Place of Presentation
      Milan
    • Year and Date
      2014-07-05 – 2014-07-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] Optogenetic stimulation of parabrachio-amygdaloid pathway modulates excitability of the nociceptive amygdala2014

    • Author(s)
      Sugimura Y, Takahashi Y, Watabe AM, Kato F
    • Organizer
      9th FENS Forum of Neuroscience
    • Place of Presentation
      Milan
    • Year and Date
      2014-07-05 – 2014-07-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] Insulin attenuates synaptic potentiation in the nociceptive amygdala in a rodent model of painful diabetic neuropathy2014

    • Author(s)
      Takahashi Y, Ochiai T, Asato M, Watabe AM, Ohsawa M, Kamei J, Kato F
    • Organizer
      9th FENS Forum of Neuroscience
    • Place of Presentation
      Milan
    • Year and Date
      2014-07-05 – 2014-07-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] 生物進化から考える慢性痛の新たな治療戦略-マトリクスを超えて2014

    • Author(s)
      加藤総夫
    • Organizer
      第36回日本疼痛学会
    • Place of Presentation
      大阪
    • Year and Date
      2014-06-20 – 2014-06-21
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 温度嗜好性自由行動試験を用いた自発性疼痛の評価2014

    • Author(s)
      杉本 真理子, 宮沢 祐太, 高橋 由香里, 加藤 総夫
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Annual Research Report
  • [Presentation] ラット顔面炎症性ホルマリン疼痛モデルにおける侵害受容扁桃体シナプス増強2014

    • Author(s)
      宮沢 祐太, 高橋 由香里, 渡部 文子, 加藤 総夫
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Annual Research Report
  • [Presentation] 侵害受容扁桃体における腕傍核‐扁桃体路の光活性化2014

    • Author(s)
      杉村 弥恵, 高橋 由香里, 渡部 文子, 加藤 総夫
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Annual Research Report
  • [Presentation] 侵害受容情報と痛み情動記憶を結ぶ腕傍核2014

    • Author(s)
      加藤 総夫
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Annual Research Report
  • [Presentation] 恐怖記憶形成における扁桃体神経回路制御2014

    • Author(s)
      渡部 文子, 佐藤 優, 加藤 総夫
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Annual Research Report
  • [Presentation] 痛みの苦痛の生物学的意義- 侵害受容扁桃体と慢性痛におけるその可塑性2013

    • Author(s)
      加藤 総夫
    • Organizer
      第43回日本ペインクリニック学会関西支部学術集会
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ノルアドレナリン下行性疼痛制御系の有痛性糖尿病神経障害形成における役割2013

    • Author(s)
      木下 淳, 高橋 由香里, 部 文子, 的場 圭一郎, 石澤 将, 金澤 康, 川浪 大治, 横田 太持, 加藤 総夫, 宇都宮 一典
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      熊本
    • Related Report
      2013 Annual Research Report
  • [Presentation] 侵害受容性扁桃体の薬理学的抑制による疼痛関連情動行動の変容2013

    • Author(s)
      杉本 真理子, 高橋 由香里, 加藤 総夫
    • Organizer
      日本麻酔科学会第60回学術集会
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] ノルアドレナリンはβ受容体を介して扁桃体中心核内側亜核への抑制性入力を増強する2013

    • Author(s)
      山本 純偉, 高橋 由香里, 田中 誠, 加藤 総夫
    • Organizer
      日本麻酔科学会第60回学術集会
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] ホルマリン誘発炎症痛モデルにおける疼痛行動と侵害受容扁桃体シナプス増強の時間的乖離2013

    • Author(s)
      宮沢 祐太, 杉本 真理子, 高橋 由香里, 加藤 総夫
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 恐怖記憶形成により誘導される扁桃体中心核シナプス増強2013

    • Author(s)
      渡部 文子, 加藤 総夫
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 有痛性神経障害糖尿病ラットにおけるノルアドレナリン下行性疼痛制御系の機能不全2013

    • Author(s)
      木下 淳, 高橋 由香里, 渡部 文子, 宇都宮 一典, 加藤 総夫
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] ノルアドレナリンはβ受容体を介して扁桃体中心核内側亜核への抑制性入力を増強させる2013

    • Author(s)
      山本 純偉, 高橋 由香里, 渡部 文子, 田中 誠, 加藤 総夫
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] The central amygdala - where pain meets fear2013

    • Author(s)
      Kato F
    • Organizer
      The 8th International Conference for Neurons and Brain Diseases
    • Place of Presentation
      Singapore
    • Related Report
      2013 Annual Research Report
  • [Presentation] 侵害受容性扁桃体シナプス増強の疼痛モデル依存性2013

    • Author(s)
      加藤 総夫, 落合 敏平, 安井 豊, 池田 亮, 宮沢 祐太, 杉本 真理子, 杉村 弥恵, 渡部 文子, 高橋 由香里
    • Organizer
      第35回日本疼痛学会
    • Place of Presentation
      大宮
    • Related Report
      2013 Annual Research Report
  • [Presentation] Synaptic potentiation in the central amygdala of painful diabetic neuropathy model2013

    • Author(s)
      Kato F
    • Organizer
      Amygdala in Health & Disease
    • Place of Presentation
      Easton
    • Related Report
      2013 Annual Research Report
  • [Presentation] 情動行動発現における脊髄後角―腕傍核―扁桃体路の意義2013

    • Author(s)
      加藤 総夫
    • Organizer
      平成25年度生理学研究所研究会 感覚刺激・薬物による快・不快情動生成機構とその破綻
    • Place of Presentation
      岡崎
    • Related Report
      2013 Annual Research Report
  • [Presentation] Synaptic plasticity in the central amygdala of streptozotocin-induced diabetic neuropathic pain model2013

    • Author(s)
      Takahashi Y, Ochiai T, Watabe AM and Kato F
    • Organizer
      Neural Circuits underlying Nociception and Pain and their Plasticity
    • Place of Presentation
      Heidelberg
    • Related Report
      2013 Annual Research Report
  • [Presentation] Optogenetic activation of parabrachio-amygdaloid pathway2013

    • Author(s)
      Sugimura YK, Takahashi Y, Watabe AM and Kato F
    • Organizer
      Neural Circuits underlying Nociception and Pain and their Plasticity
    • Place of Presentation
      Heidelberg
    • Related Report
      2013 Annual Research Report
  • [Presentation] Noradrenaline dramatically increases GABAergic inputs through beta adrenoceptor in central nucleus of amygdala2013

    • Author(s)
      Yamamoto S, Takahashi Y, Watabe AM, Tanaka M and Kato F
    • Organizer
      The ANESTHESIOLOGY 2013 annual meeting
    • Place of Presentation
      San Francisco
    • Related Report
      2013 Annual Research Report
  • [Presentation] Noradrenaline dramatically increases GABAergic inputs through beta adrenoceptor activation in medial division of the central nucleus of amygdala2013

    • Author(s)
      Yamamoto S, Takahashi Y, Watabe AM, Tanaka M and Kato F
    • Organizer
      The 43rd annual meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego
    • Related Report
      2013 Annual Research Report
  • [Presentation] Lateral parabrachial nucleus is involved in the acquisition of fear memory in mice2013

    • Author(s)
      Sato M, Watabe AM and Kato F
    • Organizer
      The 43rd annual meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego
    • Related Report
      2013 Annual Research Report
  • [Presentation] 脳はどのように痛みの慢性化を知るのか?2013

    • Author(s)
      加藤 総夫, 池田 亮, 篠原 恵, 奥津 裕也, 高橋 由香里, 丸毛 啓史
    • Organizer
      第6回日本運動器疼痛学会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] Nociceptive amygdala in various chronic pain models2013

    • Author(s)
      Kato F
    • Organizer
      5th Asian Pain Symposium
    • Place of Presentation
      岡崎
    • Related Report
      2013 Annual Research Report
  • [Remarks] 痛み情報がどのように情動回路を活性化するか解明!

    • URL

      http://www.jikei-neuroscience.com/website/2017/05/post-fb43.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 身体に及ぶ危険・脅威を学習させる信号経路を解明!

    • URL

      http://www.jikei-neuroscience.com/website/2017/05/post-9537.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 最新の研究成果

    • URL

      http://www.jikei-neuroscience.com/website/what_we_have_found_recently/index.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 最新の研究成果

    • Related Report
      2014 Annual Research Report
  • [Remarks] 痛みと情動、特に慢性痛による扁桃体ネットワークのシナプス可塑性に関する研究

    • URL

      http://lablog.neurophysiology-jikei.jp/pain_amygdala.html

    • Related Report
      2013 Annual Research Report

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Published: 2013-05-21   Modified: 2022-02-16  

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