Identification of the role of spino-parabrachio-amygdaloid pathway in the pain-associated emotion
| Project/Area Number |
25293136
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
Kato Fusao 東京慈恵会医科大学, 医学部, 教授 (20169519)
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| Co-Investigator(Renkei-kenkyūsha) |
Watabe M Ayako 東京慈恵会医科大学, 医学部, 教授 (00334277)
Takahashi Yukari 東京慈恵会医科大学, 医学部, 助教 (20613764)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Keywords | 扁桃体 / 腕傍核 / 慢性痛 / 恐怖・脅威学習 / 情動 / 光遺伝学 / 化学遺伝学 / 痛み / 恐怖学習 / アロディニア / チャネルロドプシン / 侵害受容性扁桃体 / 痛み情動 / 恐怖条件付け / CGRP / 有痛性糖尿病性神経障害 / シナプス伝達 |
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| Outline of Final Research Achievements |
To clarify the mechanism underlying the link between pain and negative emotion (suffering), we focused on the spino-parabrachio-amygdaloid pathway: 1) Optogenetic activation of the parabrachial-central amygdala pathway alone functions as unconditioned stimulus in Pavlovian and operant conditional learning. 2) This evoked mono- and polysynaptic network-driven activities in the central amygdala neurons, which was potentiated in the persistent inflammatory pain model. And 3) chemogenetic inhibition of GABAergic neurons in the central amygdala in the inflammatory pain model mitigated hypersensitivity and chemogenetic activation of these gave rise to the hypersensitivity in normal rats. These results indicate that this pathway is the primary route for the aversive nociceptive information to activate the limbic system leading to not only the negative emotion but also the elevated sensitivity to potentially harmful events.
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Report
(5 results)
Research Products
(105 results)
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[Journal Article] Overlapping memory trace indispensable for linking, but not recalling, individual memories.2017
Author(s)
Yokose, J., Okubo-Suzuki, R., Nomoto, M., Ohkawa, N., Nishizono, H., Suzuki, A., Matsuo, M., Tsujimura, S., Takahashi, Y., Nagase, M.,Watabe, A.M., Sasahara, M., Kato, F., Inokuchi, K.
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Journal Title
Science
Volume: 355
Issue: 6323
Pages: 398-403
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Cellular tagging as a neural network mechanism for behavioral tagging.2016
Author(s)
Nomoto, M., Ohkawa, N., Nishizono, H., Yokose, J., Suzuki, A., Matuo, M., Tsujimura, S., Takahashi, Y., Nagase, M., Watabe, A.M., Kato, F., Inokuchi, K.
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Journal Title
Nature Communications
Volume: 7:12319
Issue: 1
Pages: 1-11
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] SAD-B Kinase regulates presynaptic vesicular dynamics at hippocampal Schaffer collateral synapses and affects contextual fear memory.2016
Author(s)
Watabe, A.M., Nagase, M., Hagiwara, A., Hida, Y., Tsuji, M., Ochiai, T., Kato, F., Ohtsuka, T.
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Journal Title
Journal of Neurochemistry
Volume: 136:
Issue: 1
Pages: 36-47
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Artificial association of pre-stored information to generate a qualitatively new memory2015
Author(s)
Ohkawa N, Saitoh Y, Suzuki A, Tsujimura S, Murayama E, Kosugi S, Nishizono H, Matsuo M, Takahashi Y, Nagase M, Sugimura YK, Watabe AM, Kato F, Inokuchi K
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Journal Title
Cell Reports
Volume: 11
Issue: 2
Pages: 1-9
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Role of the amygdala in early phase of the central pain chronification2016
Author(s)
Takahashi, Y., Miyazawa, Y., Sugimura, Y. K., Sugimoto, M. Shinohara, K., Ghasemi, Z., Watabe, A.M., Kato, F.
Organizer
The 39th Annual Meeting of the Japan Neuroscience Society
Place of Presentation
横浜
Related Report
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[Presentation] Visualization of spontaneous brain activity during pain chronification process with manganeseenhanced magnetic resonance imaging (MEMRI)2016
Author(s)
Shinohara, Kei., Takahashi, Y., Tsurugizawa, T., Ikeda, R., Marumo, K., Kato, F.
Organizer
The 39th Annual Meeting of the Japan Neuroscience Society
Place of Presentation
横浜
Related Report
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[Presentation] 痛みと扁桃体2015
Author(s)
加藤総夫
Organizer
日本ペインクリニック学会第49回大会
Place of Presentation
大阪
Year and Date
2015-07-25
Related Report
Invited
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