Risk prediction of cardiovascular diseases based on novel retinal vascular imaging biomarkers

• Project/Area Number: 25293138
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: Yamagata University
• Principal Investigator: Kawasaki Ryo 山形大学, 医学(系)研究科(研究院), 准教授 (70301067)
• Co-Investigator(Kenkyū-buntansha): OIZUMI Toshihide 山形大学, 大学院医学系研究科, 講師 (00344797) ; DAIMON Makoto 弘前大学, 大学院医学系研究科, 教授 (20241698) ; KONTA Tsuneo 山形大学, 医学部, 准教授 (60333952) ; SHIBATA Yoko 山形大学, 医学部, 講師 (60333978)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000); Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2013: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
• Keywords: 予防医学 / 疫学 / 循環器 / 網膜 / 循環器高血圧 / 糖尿病 / 呼吸器疾患

Outline of Final Research Achievements

Background: Retinal vasculature is unique “window” where vessels can be observed in vivo. Retinal vascular signs have been utilized as a marker to indicate risk of hypertension and arteriolosclerosis. However, there was an issue that inter-rater agreement is not good; thus, quantitative markers have been warranted. Aim: We studies whether newer markers of retinal vasculature by quantifying retinal morphological features. Results: We found that the presence of retinal vascular diseases was associated with higher risk of stroke. Retinal vascular calibre was associated with smoking sensitivity related to deterioration in male smokers, risk of micro-albuminuria, and insulin resistance all associated with the further risk of cardiovascular diseases.

Research Products

• [Int'l Joint Research] Centre for Eye Research Australia/Baker IDI Heart and Diabetes Institute/Centre for Vision Research(Australia)
• [Int'l Joint Research] Singapore Eye Research Institute/Singapore National Eye Centre(Singapore)
• [Int'l Joint Research] Gadjah Mada University(Indonesia)
• [Int'l Joint Research]
• [Journal Article] Gene-environment interactions in obesity: implication for future applications in preventive medicine. (2016)
  • Author(s): Nakamura S, Narimatsu H, Sato H, Sho R, Otani K, Kawasaki R, Karasawa S, Daimon M, Yamashita H, Kubota I, Ueno Y, Kato T, Yoshioka T, Fukao A, Kayama T.
  • Journal Title: J Hum Genet. Volume: 61 Issue: 4 Pages: 317-322
  • DOI: 10.1038/jhg.2015.148
  • NAID: 40020802847
  • Peer Reviewed
• [Journal Article] Trends in the incidences of acute myocardial infarction in coastal and inland areas in Japan: The Yamagata AMI Registry. (2015)
  • Author(s): Wanezaki M, Watanabe T, Nishiyama S, Hirayama A, Arimoto T, Takahashi H, Shishido T, Miyamoto T, Kawasaki R, Fukao A, Kubota I.
  • Journal Title: J Cardiol. Volume: - Issue: 2 Pages: 274-279
  • DOI: 10.1016/j.jjcc.2015.08.015
  • Peer Reviewed / Open Access
• [Journal Article] Retinal arteriolar narrowing is associated with 4-year risk of incident metabolic syndrome. (2015)
  • Author(s): Saito K, Kawasaki Y, Nagao Y, Kawasaki R
  • Journal Title: Nutr Diabetes Volume: 5 Issue: 6 Pages: e165-e165
  • DOI: 10.1038/nutd.2015.15
  • Peer Reviewed / Open Access
• [Journal Article] Slight increase in urinary albumin excretion within the normal range predicts incident hypertension in a community-based Japanese population: the Takahata study (2015)
  • Author(s): Hirayama A, Konta T, Hozawa A, Kawasaki R, Watanabe T, Shibata Y, Kayama T, Fukao A, Kubota I
  • Journal Title: Hypertension Research Volume: 38 Issue: 1 Pages: 56-60
  • DOI: 10.1038/hr.2014.117
  • Peer Reviewed / Open Access
• [Journal Article] Applying data envelopment analysis to preventive medicine: a novel method for constructing a personalized risk model of obesity. (2015)
  • Author(s): Narimatsu H, Nakata Y, Nakamura S, Sato H, Sho R, Otani K, Kawasaki R, Kubota I, Ueno Y, Kato T, Yamashita H, Fukao A, Kayama T.
  • Journal Title: PLoS One. Volume: 10 Issue: 5 Pages: e0126443-e0126443
  • DOI: 10.1371/journal.pone.0126443
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Health management in cancer survivors: Findings from a population-based prospective cohort study-the Yamagata Study (Takahata). (2015)
  • Author(s): Nakamura S, Narimatsu H, Ito Sasahara Y, Sho R, Kawasaki R, Yamashita H, Kubota I, Ueno Y, Kato T, Yoshioka T, Fukao A, Kayama T.
  • Journal Title: Cancer Sci Volume: 106 Issue: 11 Pages: 1607-1615
  • DOI: 10.1111/cas.12811
  • Peer Reviewed
• [Journal Article] Retinal vessel tortuosity and its relation to traditional and novel vascular risk markers in persons with diabetes. (2015)
  • Author(s): Sasongko MB, Wong TY, Nguyen TT, Cheung CY, Shaw J, Kawasaki R, Lamoureux EL, Wang JJ.
  • Journal Title: Current Eye Research Volume: - Pages: 1-7
  • DOI: 10.3109/02713683.2015.1034371
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Ocular higher-order wavefront aberrations in the Japanese adult population: the Yamagata Study (Funagata). (2014)
  • Author(s): Namba H, Kawasaki R, Narumi M, Sugano A, Homma K, Nishi K, Murakami T, Kato T, Kayama T, Yamashita H.
  • Journal Title: Invest Ophthal Vis Sci Volume: 56 Issue: 1 Pages: 90-97
  • DOI: 10.1167/iovs.14-15261
  • Peer Reviewed
• [Presentation] Epidemiological studies in Ophthalmology (2016)
  • Author(s): Ryo Kawasaki
  • Organizer: 第１２０回日本眼科学会総会
  • Place of Presentation: 宮城県仙台市仙台国際センター
  • Year and Date: 2016-04-07
  • Invited
• [Presentation] PCV and AMD (2016)
  • Author(s): Ryo Kawasaki
  • Organizer: The 31st Asian Pacific Academy of Ophthalmology Congress
  • Place of Presentation: Taipei International Convention Center, Taipei, Taiwan
  • Year and Date: 2016-03-24
  • Int'l Joint Research
• [Presentation] 主成分分析を用いた食パターンと生活習慣病関連指標の関連. (2016)
  • Author(s): 早坂美希, 平山敦士, 邵力, 川崎良, 深尾彰
  • Organizer: 第42回山形県公衆衛生学会
  • Place of Presentation: 山形県山形市県立医療大学講堂
  • Year and Date: 2016-03-07
• [Presentation] Non-invasive measurements of the retinal vascular tree. “Personalized treatment based on retinal vascular markers – advancing from bench to bedside” (2016)
  • Author(s): Ryo Kawasaki
  • Organizer: Professor Jakob Grauslund Inaugural Seminar
  • Place of Presentation: University of South Denmark, Odense, Denmark
  • Year and Date: 2016-02-25
  • Invited
• [Presentation] 6年間でのbody mass index (BMI) 変化量に関連する因子の探索：山形コホート研究 (高畠) (2016)
  • Author(s): 早坂 美希、平山 敦士、川崎 良、深尾 彰
  • Organizer: 第２６回日本疫学会
  • Place of Presentation: 鳥取県米子市米子コンベンションセンター
  • Year and Date: 2016-01-21
• [Presentation] 糖尿病網膜症の診断と疫学 (2015)
  • Author(s): 川崎良
  • Organizer: 第21回日本糖尿病眼学会総会
  • Place of Presentation: 愛知県名古屋市ウィンク愛知
  • Year and Date: 2015-11-27
• [Presentation] Updated Epidemiology of Diabetic Retinopathy and How Can We Fill in the "Knowing-Doing" Gap? (2015)
  • Author(s): Ryo Kawasaki
  • Organizer: World Health Summit 2015
  • Place of Presentation: Federal Foreign Office, Berlin, Germany
  • Year and Date: 2015-10-11
  • Int'l Joint Research / Invited
• [Presentation] Five-year incidence of branch retinal vein occlusion and its systemic and retinal risk associations: the Funagata Study. (2014)
  • Author(s): Kawasaki R, Sugano A, Kawasaki Y, Oizumi T, Daimon M, Kato T, Yamashita H, Kayama T, for the Yamagata Cohort Study.
  • Organizer: European Association for Vision and Eye Research 2014 Congress
  • Place of Presentation: フランス・ニース・アクロポリスコンベンションセンター
  • Year and Date: 2014-10-03
• [Presentation] Narrowing of retinal arterioles might reflect smoking sensitivity, a risk of chronic obstructive pulmonary disease. (2014)
  • Author(s): Hirayama A, Kawasaki R, Shibata Y, Konta T, Narimatsu H, Kayama T, Yamashita H, Kubota I, Fukao A.
  • Organizer: 2014 ARVO
  • Place of Presentation: 米国・オーランド・オレンジカウンティコンベンションセンター
  • Year and Date: 2014-05-03 – 2014-05-08
• [Presentation] Evidence-based screening of diabetic retinopathy. Symposium: Evidence-based approach to the Diagnosis and Management of DR and DME. (2014)
  • Author(s): Kawasaki R
  • Organizer: World Ophthalmology Congress 2014 Tokyo
  • Place of Presentation: 東京・東京国際フォーラム
  • Year and Date: 2014-04-02 – 2014-04-06
  • Invited
• [Presentation] Epidemiological studies and genetic studies. Symposium: Population-based cohort studies: Knowledge gained, Lessons learned, and Gaps remained. (2014)
  • Author(s): Kawasaki R
  • Organizer: World Ophthalmology Congress 2014 Tokyo
  • Place of Presentation: 東京・東京国際フォーラム
  • Year and Date: 2014-04-02 – 2014-04-06
  • Invited
• [Presentation] Narrowing of the retinal arterioles is associated with increased risk of 7-year incident albuminuria: the Takahata Study. (2014)
  • Author(s): Hirayama A, Kawasaki R, Konta T, Hozawa A, Fukao A, Yamashita H, Kayama T, Kubota I.
  • Organizer: American Heart Association EPI/NPAM 2014
  • Place of Presentation: 米国サンフランシスコHilton San Francisco
• [Presentation] Retinal vascular signs and systemic/ocular disease associations - New insights into old classics - (2014)
  • Author(s): Kawasaki R.
  • Organizer: Ophthalmic Epidemiology in Taiwan– Shihpai study and beyond
  • Place of Presentation: 台湾Taipei Veterans General Hospital
  • Invited
• [Presentation] Axial length and its associations in an adult Japanese population: the Funagata study. (2013)
  • Author(s): Sugano A, Tanabe Y, Saito K, Homma K, Kawasaki R, Kato T, Kayama T, Yamashita H.
  • Organizer: ARVO Annual Meeting
  • Place of Presentation: 米国シアトルWashington State Convention Center
• [Presentation] Investigation of the correlation among diameter of retinal vessel and arteriosclerosis risk factors including hypoadiponectinemia. (2013)
  • Author(s): Homma K, Kawasaki R, Tanabe Y, Saito K, Sugano A, Hozawa A, Kato T, Kubota I, Kayama T, Yamashita H.
  • Organizer: ARVO Annual Meeting
  • Place of Presentation: 米国シアトルWashington State Convention Center
• [Presentation] Retinal Vascular Signs and Cardiovascular Diseases, and Beyond…-New Insights into Old Classics- (2013)
  • Author(s): Kawasaki R.
  • Organizer: Invited lecture at School of Computing, University of Dundee
  • Place of Presentation: 英国スコットランドUniversity of Dundee
  • Invited
• [Presentation] 糖尿病患者における網膜血管径とインスリン抵抗性の関連 (2013)
  • Author(s): 川崎良、平山敦士、本間慶、今田恒夫、久保田功、加藤丈夫、嘉山孝正、山下英俊、深尾彰
  • Organizer: 日本糖尿病眼学会
  • Place of Presentation: 神戸国際会議場