A prospective cohort study to examine the causal relationship between sleep disorder breathing and incidence of glucose abnormality
| Project/Area Number |
25293142
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | Juntendo University (2014-2015)
Ehime University (2013) |
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Principal Investigator |
Tanigawa Takeshi 順天堂大学, 医学(系)研究科(研究院), 教授 (80227214)
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Isao 愛媛大学, 大学院医学系研究科, 教授 (90253781)
KATO Tadahiro 愛媛大学, 教育学部, 准教授 (60325363)
YAMAUCHI Kanako 愛媛大学, 教育学部, 研究員 (20510283)
MARUYAMA Koutatsu 順天堂大学, 大学院医学研究科, 助教 (20627096)
FURUKAWA Shinya 愛媛大学, 大学院医学系研究科, 准教授 (60444733)
EGUCHI Eri 岡山大学, 大学院医歯薬学総合研究科, 助教 (60635118)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2015: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2014: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 睡眠呼吸障害 / 耐糖能異常 / コホート研究 / 糖尿病 / 肥満 / インスリン抵抗性 / 75gブドウ糖負荷試験 / 自律神経系機能 / 75g ブドウ糖負荷試験 |
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| Outline of Final Research Achievements |
We examined a causal relationship between sleep disorders breathing (SDB) and incidence of glucose abnormality in our prospective cohort study. The Toon Health Study, a prospective cohort study located in Toon city, Ehime prefecture, has started since 2009. The findings from cross-sectional study showed that severe SDB had higher prevalence of impaired glucose tolerance, and higher frequency of snoring had higher mean levels of systolic and diastolic blood pressures. Based on the findings of 5-year prospective followed-up study showed that SDB at baseline was not associated with incidence of glucose abnormality. However, persons with mild or severe SDB at both baseline and 5-year followed-up surveys had higher means of BMI at both surveys.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Impact of heart rate variability on C-reactive protein concentrations in Japanese adult nonsmokers: The Toon Health Study.2016
Author(s)
Saito I., Hitsumoto S., Maruyama K., Eguchi E., Kato T., Okamoto A., Kawamura R., Takata Y., Nishida W., Nishimiya T., Onuma H., Osawa H., Tanigawa T.
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Journal Title
Atherosclerosis
Volume: 244
Pages: 79-85
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Heart Rate Variability, Insulin Resistance, and Insulin Sensitivity in Japanese Adults: The Toon Health Study2015
Author(s)
Saito I., Hitsumoto S., Maruyama K., Nishida W., Eguchi E., Kato T., Kawamura R., Takata Y., Onuma H., Osawa H., Tanigawa T.
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Journal Title
Journal of Epidemiology
Volume: 25
Issue: 9
Pages: 583-591
DOI
NAID
ISSN
0917-5040, 1349-9092
Related Report
Peer Reviewed / Acknowledgement Compliant
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