Genome epidemiologic study on lung cancer and estrogen-related genes.

• Project/Area Number: 25293143
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: Kyushu University
• Principal Investigator: Kiyohara Chikako 九州大学, 医学(系)研究科(研究院), 講師 (00169963)
• Co-Investigator(Kenkyū-buntansha): 中西 洋一 九州大学, 医学(系)研究科(研究院), 教授 (20172356) ; 高山 浩一 京都府立医科大学, 医学(系)研究科(研究院), 教授 (50274444) ; 堀内 孝彦 九州大学, 大学病院, 教授 (90219212)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000); Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2015: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2013: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
• Keywords: 肺がん / ゲノム疫学 / 遺伝子多型 / 国際共同研究 / 交互作用 / 喫煙 / エストロゲン / エストロゲン関連遺伝子 / ｹﾞﾉﾑ疫学

Outline of Final Research Achievements

Estrogen may be implicated in the development of lung cancer. The aims of this study were to evaluate the association between estrogen-related polymorphisms and lung cancer. We genotyped 19 polymorphisms in Japanese. The CYP1A1 rs464690 (adjusted odds ratio, 95% confidence interval: 1.72, 1.25 - 2.38), CYP1A1 rs1048943 (1.40, 1.02 - 1.92), GSTP1 rs1695 (1.48, 1.04 - 2.11), NQO1 rs1800566 (0.62, 0.45 - 0.86), COMT rs4680 (1.65, 1.18 - 2.30), CYP2A6 deletion (1.53, 1.05 - 2.25), CYP19A1 rs3764221 (1.46, 1.06 - 2.00) and GSTM1 deletion (1.38, 1.01 - 1.89) polymorphisms were significantly associated with lung cancer risk while other polymorphisms were not. The interactions between either the CYP1A1 rs1048943 (both multiplicative and additive interactions) or GSTM1 deletion (multiplicative interaction) polymorphism and smoking were significant. There were no significant interactions between smoking and either of the remaining polymorphisms.

Research Products

• [Journal Article] Effect modification by cigarette smoking on the association of genetic polymorphisms involved in inflammation and the risk of lung cancer: a case-control study in Japan. (2017)
  • Author(s): Yamamoto Y, Kiyohara C, Ogata S, Hamada N, NakanishiY
  • Journal Title: Oncol Lett Volume: 13 Pages: 3873-3881
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Association between genetic polymorphisms involved in the hypoxia-inducible factor pathway and lung cancer risk: a case-control study in Japan. (2017)
  • Author(s): Yamamoto Y, Kiyohara C, Ogata S, Hamada N, NakanishiY
  • Journal Title: Asia Pac J Clin Oncol Volume: in press Issue: 3 Pages: 234-242
  • DOI: 10.1111/ajco.12640
  • Peer Reviewed
• [Journal Article] CYP2E1 rs2031920, COMT rs4680 polymorphisms, cigarette smoking, alcohol use, and lung cancer risk in a Japanese population. (2016)
  • Author(s): Kakino K, Kiyohara C, Horiuchi T, Nakanishi Y
  • Journal Title: Asian Pac J Cancer Prev Volume: 17 Pages: 4063-4070
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Exposure to secondhand tobacco smoke and lung cancer by histological type: a pooled analysis of the International Lung Cancer Consortium (ILCCO). (2014)
  • Author(s): Kim CH, Kiyohara C, et al.
  • Journal Title: Int J Cancer Volume: 135 Issue: 8 Pages: 1918-1930
  • DOI: 10.1002/ijc.28835
  • Peer Reviewed / Open Access
• [Journal Article] Genetic polymorphisms involved in the inflammatory response and lung cancer risk: a case-control study in Japan (2014)
  • Author(s): Kiyohara C, Horiuchi T, Takayama K, Nakanishi Y
  • Journal Title: Cytokine Volume: 65 Issue: 1 Pages: 88-94
  • DOI: 10.1016/j.cyto.2013.09.015
  • Peer Reviewed / Open Access
• [Book] Encyclopedia of Cancer, 4th Edition (2015)
  • Author(s): Kiyohara C, Yoshimasu K.
  • Total Pages: 5083
  • Publisher: Springer-Verlag. NY