| Project/Area Number |
25293145
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | National Defense Medical College |
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Principal Investigator |
Matsuo Hirotaka 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, その他部局等, 講師 (00528292)
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| Co-Investigator(Kenkyū-buntansha) |
四ノ宮 成祥 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, その他部局等, 教授 (40505260)
山本 健 久留米大学, 医学部, 教授 (60274528)
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| Co-Investigator(Renkei-kenkyūsha) |
HAMAJIMA NOBUYUKI 名古屋大学, 大学院・医学系研究科, 教授 (30172969)
ICHIDA KIMIYOSHI 東京薬科大学, 病態生理学, 教授 (80183169)
TAKADA TAPPEI 東京大学, 薬学部, 講師 (90376468)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
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| Keywords | 分子遺伝疫学 / 予防医学 / 個人差医療 / 尿酸 / 遺伝統計学 / 個人差医療に基づく予防医学 / テーラーメイド医療 / ゲノムワイド関連解析 / 痛風関連遺伝子 / 遺伝子 / トランスポーター / トランスレーショナルリサーチ / 生活習慣病 / 分子疫学 / ゲノム |
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| Outline of Final Research Achievements |
In this study, we collected a large number of genome samples and clinical information from gout/hyperuricemia cases and controls, and conducted genome-wide association analyses for all and subtype-divided participants. Also, we performed molecular functional analyses on those encoded by the identified gout/urate-associated genes, and investigated their genetic association with gout/hyperuricemia. From these studies, we identified ten loci which included subtype specific ones. Furthermore, we revealed that the dysfunctional variants of urate exporter ABCG2 gene have a large effect on gout progression not only for each individual, but also for Japanese population. In other words, we elucidated possibilities of screening a high-risk population by genotyping, and also clarified potentialities of personalized medicine based on their variants.
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