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A cohort study on exposure levels of non-persistent insecticides during the fetal period and their effects on the children's development

Research Project

Project/Area Number 25293151
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Hygiene and public health
Research InstitutionNagoya City University

Principal Investigator

KAMIJIMA Michihiro  名古屋市立大学, 医学(系)研究科(研究院), 教授 (80281070)

Co-Investigator(Kenkyū-buntansha) ITO Yuki  名古屋市立大学, 大学院医学研究科, 講師 (80452192)
UEYAMA Jun  名古屋大学, 大学院医学系研究科, 准教授 (00397465)
NAKAI Kunihiko  東北大学, 大学院医学系研究科, 教授 (00291336)
Co-Investigator(Renkei-kenkyūsha) EBARA Takeshi  名古屋市立大学, 大学院医学研究科, 講師 (50405156)
Research Collaborator KATO Sayaka  名古屋市立大学, 大学院医学研究科, 特任助教 (40723002)
OGURI Tomoko  名古屋市立大学, 大学院医学研究科, 特任助教 (30737341)
HIROTAKA Sato  名古屋市立大学, 大学院医学研究科, 助教 (70775965)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2015: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Keywords環境対応 / 人間生活環境 / 有害化学物質 / 社会医学
Outline of Final Research Achievements

In recent years, health risks due to exposure to low-level chemicals have drawn global attention. This project, focusing on insecticides, aimed to build a birth cohort in which their urinary exposure biomarkers could be measured and to estimate their levels during pregnancy. In addition, cross-sectional surveys were conducted in different populations to clarify the biomarker levels in 3-year-old children and if the individual difference in their metabolism could affect their urinary concentrations.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (24 results)

All 2016 2015 2014 Other

All Int'l Joint Research (1 results) Journal Article (8 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 5 results,  Acknowledgement Compliant: 2 results,  Open Access: 2 results) Presentation (14 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results) Remarks (1 results)

  • [Int'l Joint Research] 上海交通大学(中国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Exposure characterization of three major insecticide lines in urine of young children in Japan―neonicotinoids, organophosphates, and pyrethroid2016

    • Author(s)
      Aya Osaka, Jun Ueyama, Takaaki Kondo, Hiroshi Nomura, Yuka Sugiura, Isao Saito, Kunihiko Nakane, Ayuko Takaishi, Hiroko Ogi, Shinya Wakusawa, Yuki Ito, Michihiro Kamijima
    • Journal Title

      Environmental Research

      Volume: 147 Pages: 89-96

    • DOI

      10.1016/j.envres.2016.01.028

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Effects of Paraoxonase 1 gene polymorphisms on organophosphate insecticide metabolism in Japanese pest control workers2016

    • Author(s)
      Hirotaka Sato, Yuki Ito, Jun Ueyama, Yuya Kano, Tomoya Arakawa, Masahiro Gotoh, Takaaki Kondo, Yuka Sugiura, Isao Saito, Eiji Shibata, Michihiro Kamijima
    • Journal Title

      Journal of Occupational Health

      Volume: 58 Issue: 1 Pages: 56-65

    • DOI

      10.1539/joh.15-0175-OA

    • NAID

      130005127681

    • ISSN
      1341-9145, 1348-9585
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 環境省エコチル調査~子どもの健康と環境に関する全国調査~2016

    • Author(s)
      上島通浩、小栗朋子、加藤沙耶香、榎原毅
    • Journal Title

      保健師ジャーナル

      Volume: 72 Pages: 291-295

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 子どもの健康と環境に関する世界の取り組みの現状と環境省エコチル調査2016

    • Author(s)
      上島通浩
    • Journal Title

      愛知県小児科医会会報

      Volume: 印刷中

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Comparison of Different Urine Pretreatments for Biological Monitoring of Pyrethroid Insecticides.2015

    • Author(s)
      Toshima H, Yoshinaga J, Shiraishi H, Ito Y, Kamijima M, Ueyama J.
    • Journal Title

      Journal of Analytical Toxicology

      Volume: 39(2) Issue: 2 Pages: 113-119

    • DOI

      10.1093/jat/bku142

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biological Monitoring Method for Urinary Neonicotinoid Insecticides Using LC-MS/MS and Its Application to Japanese Adults2014

    • Author(s)
      Ueyama J, Nomura H, Kondo T, Saito I, Ito Y, Osaka A, Kamijima M.
    • Journal Title

      Journal of Occupational Health

      Volume: 56 Issue: 6 Pages: 461-468

    • DOI

      10.1539/joh.14-0077-OA

    • NAID

      130004704507

    • ISSN
      1341-9145, 1348-9585
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A revised method for determination of dialkylphosphate levels in human urine by solid-phase extraction and liquid chromatography with tandem mass spectrometry: application to human urine samples from Japanese children.2014

    • Author(s)
      Ueyama J, Saito I, Takaishi A, Nomura H, Inoue M, Osaka A, Sugiura Y, Hayashi Y, Wakusawa S, Ogi H, Inuzuka K, Kamijima M, Kondo T.
    • Journal Title

      Environ Health Prev Med

      Volume: 19 Issue: 6 Pages: 405-413

    • DOI

      10.1007/s12199-014-0407-5

    • NAID

      50009331968

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 子どもの健康と環境に関する全国調査(エコチル調査):概要並びに東海地区における実施状況と今後の展望2014

    • Author(s)
      上島通浩、榎原毅、宮田麻衣子、加藤沙耶香、若林千鶴子、伊藤由起、齋藤伸治、杉浦真弓.
    • Journal Title

      東海産科婦人科学会雑誌

      Volume: 51 Pages: 9-15

    • Related Report
      2014 Annual Research Report
    • Acknowledgement Compliant
  • [Presentation] バイオロジカルモニタリングによる農薬の個人暴露評価2015

    • Author(s)
      上島通浩
    • Organizer
      第23回農薬レギュラトリーサイエンス研究会
    • Place of Presentation
      文部科学省研究交流センター(茨城県・つくば市)
    • Year and Date
      2015-11-30
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 有機リン系殺虫剤分解酵素活性と尿中代謝物の関連2015

    • Author(s)
      佐藤博貴、伊藤由紀、上山純、加納裕也、荒川朋弥、五藤雅博、近藤高明
    • Organizer
      平成27年度 日本産業衛生学会東海地方会学会
    • Place of Presentation
      名古屋大学(名古屋市)
    • Year and Date
      2015-11-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] 殺虫剤の個人曝露量測定と健康リスク評価2015

    • Author(s)
      上島通浩、伊藤由起、上山 純
    • Organizer
      第42回日本毒性学会学術年会
    • Place of Presentation
      金沢県立音楽堂(金沢市)
    • Year and Date
      2015-06-29
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Paraoxonase 1 (PON1) polymorphisms, serum enzyme activity and urinary metabolite concentrations of organophosphorus insecticides in pest control workers in Japan.2015

    • Author(s)
      Sato H, Ito Y, Ueyama J, Kano Y, Arakawa T, Gotoh M, Kondo T, Sugiura T, Shibata E, Kamijima M.
    • Organizer
      31st International Congress on Occupational Health.
    • Place of Presentation
      COEX Convention Center(Korea)
    • Year and Date
      2015-06-02
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Paraoxonase 1 (PON1) polymorphisms, serum enzyme activity and urinary metabolite concentrations of organophosphorus insecticides in pest control workers in Japan.2015

    • Author(s)
      H.Sato, Y.Ito, J.Ueyama, Y.Kano, T.Arakawa, M.Gotoh, T.Kondo, Y.Sugiura, E.Shibata, M.Kamijima
    • Organizer
      31st International Congress on Occupational Health
    • Place of Presentation
      COEX(Seoul )
    • Year and Date
      2015-05-31 – 2015-06-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] 有機リン系殺虫剤散布作業者における、パラオキソナーゼ1酵素活性と尿中代謝物濃度の関連2015

    • Author(s)
      佐藤博貴、伊藤由起、上山純、加納裕也、荒川朋弥、五藤雅博、近藤高明、杉浦友香、斎藤勲、柴田英治、上島通浩
    • Organizer
      第88回産業衛生学会
    • Place of Presentation
      グランフロント大阪(大阪)
    • Year and Date
      2015-05-13 – 2015-05-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] 有機リン系殺虫剤散布作業者における、パラオキソナーゼ1酵素活性と尿中代謝物濃度の関連.2015

    • Author(s)
      佐藤博貴、伊藤由起、上山純、加納裕也、荒川朋弥、五藤雅博、近藤高明、杉浦友香、斎藤勲、柴田英治、上島通浩.
    • Organizer
      第88回日本産業衛生学会
    • Place of Presentation
      グランフロント大阪ナレッジキャピタル(大阪市)
    • Year and Date
      2015-05-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] 3歳児における尿中殺虫剤曝露指標の相関関係2015

    • Author(s)
      上山純、大坂彩、野村洸司、斎藤勲、近藤高明、黄木弘子、高石亜有子、伊藤由起、上島通浩
    • Organizer
      第85回日本衛生学会
    • Place of Presentation
      和歌山県民文化会館(和歌山)
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 使い捨てオムツを用いた原中低分子代謝物類の網羅的分析2015

    • Author(s)
      杉浦友香、上山純、上田裕子、涌澤伸哉、上島通浩
    • Organizer
      第85回日本衛生学会
    • Place of Presentation
      和歌山県民文化会館(和歌山)
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 3歳児を対象とした有機リン系・ピレスロイド系・ネオニコチノイド系殺虫剤の尿中曝露指標一斉分析2014

    • Author(s)
      大坂彩、上山純、野村洸司、斎藤勲、近藤高明、黄木弘子、高石亜有子、伊藤由起、上島通浩
    • Organizer
      第42回 産業中毒・生物学的モニタリング研究会
    • Place of Presentation
      松本市中央公民館(長野)
    • Year and Date
      2014-10-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] 有機リン系殺虫剤曝露と尿中代謝物濃度および代謝酵素活性の関連について2014

    • Author(s)
      佐藤博貴、伊藤由起、上山純、加納裕也、荒川朋弥、五藤雅博、近藤高明、杉浦友香、斎藤勲、柴田英治、上島通浩
    • Organizer
      第42回 産業中毒・生物学的モニタリング研究会
    • Place of Presentation
      松本市中央公民館(長野)
    • Year and Date
      2014-10-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] 害虫防除作業者における殺虫剤解毒作用へのパラオキソナーゼ1遺伝子多型の影響2014

    • Author(s)
      佐藤博貴,伊藤由起,荒川朋弥,加納裕也,上山純,五藤雅博,柴田英治,近藤高明,上島通浩
    • Organizer
      第87回日本産業衛生学会
    • Place of Presentation
      岡山コンベンションセンター(岡山)
    • Year and Date
      2014-05-25 – 2014-05-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 日本人小児を対象とした尿中ピレスロイド系殺虫剤代謝物の高感度分析2014

    • Author(s)
      大坂彩,上山純,近藤高明,野村洸司,斎藤勲,犬塚君雄,黄木弘子,高石亜有子,上島通浩.
    • Organizer
      第84日本衛生学会
    • Place of Presentation
      岡山コンベンションセンター(岡山)
    • Year and Date
      2014-05-25 – 2014-05-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] LC-MS/MSによる尿中ネオニコチノイド系殺虫剤類の同時定量分析法2014

    • Author(s)
      上山純,野村洸司,斎藤勲,近藤高明,伊藤由紀,上島通浩.
    • Organizer
      第84日本衛生学会
    • Place of Presentation
      岡山コンベンションセンター(岡山)
    • Year and Date
      2014-05-25 – 2014-05-27
    • Related Report
      2014 Annual Research Report
  • [Remarks] 名古屋市立大学大学院医学研究科環境労働衛生学分野ホームページ「研究内容」

    • URL

      http://www.med.nagoya-cu.ac.jp/hygiene.dir/study.html

    • Related Report
      2015 Annual Research Report

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Published: 2013-05-21   Modified: 2022-01-31  

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