| Project/Area Number |
25293152
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hygiene and public health
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| Research Institution | Osaka City University |
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Principal Investigator |
OHFUJI Satoko 大阪市立大学, 大学院医学研究科, 准教授 (70433290)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUSHIMA Wakaba 大阪市立大学, 大学院医学研究科, 教授 (70420734)
KONDO Kyoko 大阪市立大学, 医学部・附属病院運営本部, 技術職員 (80420727)
MAEDA Akiko 大阪市立大学, 大学院医学研究科, 研究員 (40250279)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 感染症 / インフルエンザ / 乳児 / 疫学 / ワクチン有効性 |
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| Outline of Final Research Achievements |
To examine the effectiveness of maternal influenza vaccination on preventing influenza in infants under 6 months of age, we conducted a cohort study among 4,068 infants born before 2013/14 influenza season in Osaka. During 2013/14 season, a total of 85 infants (2%) were diagnosed with influenza and 19 infants (0.5%) were hospitalized with influenza. Maternal influenza vaccination (especially prenatal vaccination) revealed to have a decreasing effect on infants' influenza. Vaccine effectiveness of prenatal vaccination was 60% (95% confidence interval: 13%-82%), whereas that of postpartum vaccination was 48% (-41-81%). Although maternal influenza vaccination was also associated with decreasing infants' influenza-related hospitalization, vaccine effectiveness (70%) could not reach to the statistically significance due to limited number of hospitalized cases.
Present findings indicated that pregnant women should receive influenza vaccination in order to protect their infants.
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