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Associations between genetic alcohol sensitivity and mental disorders

Research Project

Project/Area Number 25293153
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Hygiene and public health
Research InstitutionWakayama Medical University

Principal Investigator

Yoshimasu Kouichi  和歌山県立医科大学, 医学部, 准教授 (40382337)

Co-Investigator(Kenkyū-buntansha) MIYASHITA Kazuhisa  和歌山県立医科大学, 医学部, 教授 (50124889)
TAKEMURA Shigeki  和歌山県立医科大学, 医学部, 助教 (70511559)
TSUNO Kanami  和歌山県立医科大学, 医学部, 助教 (30713309)
TAKESHITA Tatsuya  和歌山県立医科大学, 医学部, 教授 (20150310)
MURE Kanae  和歌山県立医科大学, 医学部, 准教授 (90268491)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Keywords遺伝子多型 / アルコール感受性 / 精神障害 / うつ病 / 人種間比較 / 関節リウマチ / 飲酒習慣 / 抑うつ症状 / 身体的要因 / 気分障害 / アルコール代謝酵素 / 地域住民 / 精神保健 / アルコール関連障害 / 成人保健
Outline of Final Research Achievements

Associations between genetic alcohol sensitivity regulated by ADH1B and ALDH2 pormorphism, and mental disorders were examined among Japanese employees and community dwellers. In addition, somatic factors associated with depression among Russian patients with reheumatoid arthritis (RA) were explored.
Genetic alcohol sensitivity was divided into five grade according to the combination of the two enzyme genotypes. Compared to subjects with high alcohol sensitivty, those with low alcohol sensitivity had greater risk of mental disorders among the employees. On the other hand, those with a middle grade of alcohol sensitivity had the highest risk of depression among community dwellers. Among Russian patients with RA, drinking habit was associated with a rather decreased risk of depression while not statistically significant.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (9 results)

All 2016 2015 Other

All Int'l Joint Research (1 results) Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 2 results,  Acknowledgement Compliant: 4 results) Presentation (3 results) (of which Int'l Joint Research: 2 results) Remarks (1 results)

  • [Int'l Joint Research] Ivanovo State Medical Academy(ロシア連邦)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] A pilot study of self-care program of mindful life approach for improvements of socially problematic behaviors of children with developmental disorders through caregivers2016

    • Author(s)
      Hidefumi Oga, Kouichi Yoshimasu
    • Journal Title

      Journal of Psychology and Psychotherapy

      Volume: 6 Issue: 02 Pages: 245-245

    • DOI

      10.4172/2161-0487.1000245

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Genetic Alcohol Sensitivity Regulated by ALDH2 and ADH1B Polymorphisms as Indicator of Mental Disorders in Japanese Employees2015

    • Author(s)
      Kouichi Yoshimasu, Kanae Mure, Marowa Hashimoto, Shigeki Takemura, Kanami Tsuno, Mariko Hayashida, Kenji Kinoshita, Tatsuya Takeshita, Kazuhisa Miyashita
    • Journal Title

      Alcohol and Alcoholism

      Volume: 50 Issue: 1 Pages: 39-45

    • DOI

      10.1093/alcalc/agu080

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Genetic alcohol sensitivity regulated by ALDH2 and ADH1B polymorphisms is strongly associated with depression and anxiety in Japanese employees2015

    • Author(s)
      Kouichi Yoshimasu, Kanae Mure, Marowa Hashimoto, Shigeki Takemura, Kanami Tsuno, Mariko Hayashida, Kenji Kinoshita, Tatsuya Takeshita, Kazuhisa Miyashita
    • Journal Title

      Drug and Alcohol Dependence

      Volume: 147 Pages: 130-136

    • DOI

      10.1016/j.drugalcdep.2014.11.034

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Influence of biomedical factors on the Five Viscera Score (FVS) on middle-aged and elderly: application of structural equation modeling2015

    • Author(s)
      Taro Tomura, Kouichi Yoshimasu, Shunji Sakaguchi, Kanami Tsuno, Shigeki Takemura, Nobuyuki Miyai, Kazuhisa Miyashita
    • Journal Title

      Evidence-Based Complementary and Alternative Medicine

      Volume: 未定

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Adults with persistent ADHD: gender and psychiatric comorbidities-a ppulation-based birth cohort-2016

    • Author(s)
      Kouichi Yoshimasu, William J. Barbaresi, Robert C. Colligan, Jill M. Killian, Robert G. Voigt, Amy L. Weaver, Slavica K. Katusic
    • Organizer
      第24回ヨーロッパ精神医学会
    • Place of Presentation
      スペイン・マドリッド
    • Year and Date
      2016-03-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Suicidality among adults with childhood identified ADHD: gender and psychiatric comorbidity-a population-based longitudinal study-2016

    • Author(s)
      Kouichi Yoshimasu, William J. Barbaresi, Robert C. Colligan, Jill M. Killian, Robert G. Voigt, Amy L. Weaver, Slavica K. Katusic
    • Organizer
      第24回ヨーロッパ精神医学会
    • Place of Presentation
      スペイン・マドリッド
    • Year and Date
      2016-03-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Genetic alcohol sensitivity as indicator of mental disorders

    • Author(s)
      Kouichi Yoshimasu, Kanae Mure, Shigeki Takemura, Kanami Tsuno, Tatsuya Takeshita, Kazuhisa Miyashita
    • Organizer
      22st Europearn Congress of Psychiatry
    • Place of Presentation
      ドイツ・ミュンヘン
    • Related Report
      2013 Annual Research Report
  • [Remarks] Ivanovo State Medical Academy

    • URL

      http://www.isma.ivanovo.ru/

    • Related Report
      2015 Annual Research Report

URL: 

Published: 2013-05-21   Modified: 2022-01-31  

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