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Epidemiological study comparing an asbestos mine and an asbestos textile plan

Research Project

Project/Area Number 25293154
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Hygiene and public health
Research InstitutionTeikyo University

Principal Investigator

Yano Eiji  帝京大学, 大学院公衆衛生学研究科, 教授 (50114690)

Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2013: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Keywords石綿 / クリソタイル / アンフィボール / トレモライト / 肺がん / 疫学 / 石綿鉱山 / 繊維濃度 / 悪性中皮腫 / コホート / 中国 / 繊維サイズ / 電子顕微鏡
Outline of Final Research Achievements

Three major issues in relation with asbestos carcinogenicity were discussed. Finding many lung cancer cases in a chrysotile dominant plant, Amphibole Hypothesis does not seem to stand at least for lung cancer. The pardoxical difference for the chrysotile/tremolite ratio between work environment and lung tissue may be related to different aerodynamic property, clearance mechanism of lung, and labile nature of chrysotile both in the formalin bath and in the lung tissue. Textile Mystery or difference of cancer incidence between the asbestos mine and asbestos textile plant at the same level of exposure may be explained by the inappropriate conversion of mass particle concentration to fiber concentration.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (11 results)

All 2016 2014 2013 Other

All Int'l Joint Research (4 results) Journal Article (6 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 6 results,  Open Access: 5 results) Remarks (1 results)

  • [Int'l Joint Research] 香港中文大学(香港)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] ハーバード大学(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Chinese University of Hong Kong(香港)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Harvard University(米国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Exposure-response estimate for lung cancer and asbestosis in a predominantly chrysotile-exposed Chinese factory cohort2016

    • Author(s)
      Courtice MN, Wang X, Lin S, Yu IT, Berman DW, Yano E
    • Journal Title

      Am J Ind Med

      Volume: 59 Issue: 5 Pages: 369-78

    • DOI

      10.1002/ajim.22579

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Size- and type-specific exposure assessment of an asbestos products factory in China2016

    • Author(s)
      Courtice MN, Berman DW, Yano E, Kohyama N, Wang X
    • Journal Title

      J Expo Sci Environ Epidemiol.

      Volume: 26 Issue: 1 Pages: 63-9

    • DOI

      10.1038/jes.2015.46

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Exposure-specific lung cancer risks in Chinese chrysotile textile workers and mining workers.2014

    • Author(s)
      Wang X, Lin S, Yano E, Yu IT, Courtice M, Lan Y, Christiani DC
    • Journal Title

      Lung Cancer

      Volume: 85 Issue: 2 Pages: 119-124

    • DOI

      10.1016/j.lungcan.2014.04.011

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Exposure to chrysotile mining dust and digestive cancer mortality in a Chinese miner/miller cohort.2014

    • Author(s)
      Lin S, Wang X, Yano E, Yu I, Lan Y, Courtice MN, Christiani DC.
    • Journal Title

      Occup Environ Med.

      Volume: 71 Issue: 5 Pages: 323-8

    • DOI

      10.1136/oemed-2013-101360

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Difference in concentration trends of airborne particulate matter during rush hour on weekdays and Sundays in Tokyo, Japan.2014

    • Author(s)
      Hara K, Homma J, Tamura K, Inoue M, Karita K, Kondo Y, Yano E
    • Journal Title

      J Air Waste Manag Assoc

      Volume: 64 Pages: 1045-1053

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cancer mortality in Chinese chrysotile asbestos miners: exposure-response relationships.2013

    • Author(s)
      Wang X, Yano E, Lin S, Yu IT, Lan Y, Tse LA, Qiu H, Christiani DC
    • Journal Title

      PLoS One

      Volume: 8 Issue: 8 Pages: 1-8

    • DOI

      10.1371/journal.pone.0071899

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Remarks] 帝京大学大学院公衆衛生学研究科

    • URL

      http://www.med.teikyo-u.ac.jp/~tsph/publication.html

    • Related Report
      2014 Annual Research Report

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Published: 2013-05-21   Modified: 2022-02-16  

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