| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
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| Outline of Final Research Achievements |
The aims of this study was to clarify the molecular mechanisms of cardiac dysfunction, especially of mitochondria dysfunction, on acute myocardial infarction or a designer drug MDMA poisoning, and new findings were as follow;
1. Mitochondria of both rat and human cardiomyocytes have a calcium-dependent protease caplain. Acute myocardial infarction-activated mitochondrial calpain cleaves mitochondrial functional proteins, resulting in cardiac dysfunction.
2. In rat heart, MDMA causes lysosome destabilization following activation of the autophagy-lysosomal pathway, through which released lysosomal proteases damage myofibrils and induce cardiac dysfunction.
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