Pathophysiological study of the mice with thymicolymphaticus-like phenotypes

Research Project

Project/Area Number	25293164
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Partial Multi-year Fund
Section	一般
Research Field	Legal medicine
Research Institution	Hyogo Medical University
Principal Investigator	Nishio Hajime 兵庫医科大学, 医学部, 教授 (90253260)
Co-Investigator(Kenkyū-buntansha)	Okudaira Noriyuki 兵庫医科大学, 医学部, 助教 (10635585)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000) Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000) Fiscal Year 2014: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000) Fiscal Year 2013: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Keywords	胸腺 / 突然死 / 不整脈 / RyR2 / カルシウム動態 / 遺伝性不整脈原因遺伝子
Outline of Final Research Achievements	We studied the relationship between cardiac ryanodine receptor gene mutation and hypertrophy of the thymus, which is sometimes observed in sudden death cases of the young at autopsy. No case was found in the juvenile death cases with mutations of the ryanodine receptor gene during the examined years. We also examined the possibility that the cardiac ryanodine receptor gene mutations could lead to the hypertrophy of the thymus by producing model animals with ryanodine receptor antibodies. There were no model animals with elevation of the antibody titers against synthetic ryanodine peptide and thymic hypertrophy. Further study is necessary for understanding the possible involvement of the pathway through cardiac ryanodine receptor and thymic hypertrophy.