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Personalized medicine for patients with Helicobacter pylori infection

Research Project

Project/Area Number 25293168
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionThe University of Tokyo

Principal Investigator

Matsuda Koichi  東京大学, 新領域創成科学研究科, 教授 (90401257)

Co-Investigator(Renkei-kenkyūsha) TANIKAWA Chizu  東京大学, 医科学研究所, 助教 (30422421)
Research Collaborator TOYOSHIMA Osamu  
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2015: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Keywordsヘリコバクター・ピロリ菌 / SNP / PSCA
Outline of Final Research Achievements

H. pylori is a gram-negative bacterium which is associated with gastric carcinoma, peptic ulcer, and MALT lymphoma. We have identified the association of prostate stem cell antigen (PSCA) polymorphism with H. pylori-related diseases including gastric cancer and peptic ulcer, however the role of this genetic variations on disease pathogenesis was largely remained to be elucidated. We have identified that PSCA variation is associated with risk of gastric ulcer, bladder cancer, and lung cancer. In addition, we found that PSCA protein is increased in the serum of several cancer patients. Moreover, T allele of SNP rs2294008 is associated with higher expression of PSCA mRNA. Interestingly, PSCA expression is decreased in gastric mucosa of H. pylori carrier and its expression was increased after eradication of H. pylori. Our finding suggests the possible role of PSCA in gastric cancer risk especially among subjects after H. pylori eradication.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report

Research Products

(26 results)

All 2016 2015 2014 2013 Other

All Int'l Joint Research Journal Article Presentation Remarks

  • [Int'l Joint Research] NCI(USA)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Regulation of iron homeostasis by the p53-ISCU pathway.2016

    • Author(s)
      Yuki Funauchi, Chizu Tanikawa, Paulisally Hau Yi Lo, Jinichi Mori, Yataro Daigo, Atsushi Takano, Yohei Miyagi, Atsushi Okawa, Yusuke Nakamura, Koichi Matsuda
    • Journal Title

      Sci Rep

      Volume: 5 Pages: 16497-16497

    • DOI
      10.1038/srep16497
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Regulation of myo-inositol biosynthesis by p53-ISYNA1 pathway.2016

    • Author(s)
      Tomoyuki Koguchi, Chizu Tanikawa, Jinichi Mori, Yoshiyuki Kojima, Koichi Matsuda
    • Journal Title

      Int J Oncol.

      Volume: 印刷中 Pages: 2415-24

    • DOI
      10.3892/ijo.2016.3456
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Cystatin C as a p53-inducible apoptotic mediator which regulates Cathepsin L activity2016

    • Author(s)
      Jinichi Mori, Chizu Tanikawa, Yuki Funauchi, Paulisally Hau Yi Lo, Yusuke Nakamura, Koichi Matsuda
    • Journal Title

      Cancer Science

      Volume: 107 Pages: 298-306

    • DOI
      10.1111/cas.12881
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk2016

    • Author(s)
      C. Zeng, K. Matsuda, W.H. Jia, J. Chang, S.S. Kweon, Y.B. Xiang, A. Shin, S.H. Jee, D.H. Kim, B. Zhang, Q. Cai, W. Zheng et al.
    • Journal Title

      Gastroenterology

      Volume: In press

    • DOI
      10.1053/j.gastro.2016.02.076
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Construction of a population-specific HLA imputation reference panel and its application to Graves' disease risk in Japanese2015

    • Author(s)
      Okada Y, Momozawa Y, Ashikawa K, Kanai M, Matsuda K et al.
    • Journal Title

      Nature Genetics

      Volume: 42 Pages: 798-802

    • DOI
      10.1038/ng.3310
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Directional dominance on stature and cognition in diverse human populations,2015

    • Author(s)
      Joshi PK, Esko T, Mattsson H, Eklund N, Gandin I, ... Okada Y et al.
    • Journal Title

      Nature

      Volume: 523 Pages: 459-462

    • DOI
      10.1038/nature14618
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genome-wide association study identified SNP on 15q24 associated with bladder cancer risk in Japanese population2015

    • Author(s)
      Matsuda K, Takahashi A, Middlebrooks CD, Obara W, Nasu Y, Inoue K, Tamura K, Yamasaki I, Naya Y, Tanikawa C, Cui R, Figueroa JD, Silverman DT, Rothman N, Namiki M, Tomita Y, Nishiyama H, Kohri K, Deguchi T, Nakagawa M, Yokoyama M, Miki T, Kumon H, Fujioka T, Prokunina-Olsson L, Kubo M, Nakamura Y, Shuin T.
    • Journal Title

      Hum Mol Genet

      Volume: 24 Pages: 1177-1184

    • DOI
      10.1093/hmg/ddu512
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of novel epigenetically inactivated gene PAMR1 in breast carcinoma.2015

    • Author(s)
      Lo PH, Tanikawa C, Katagiri T, Nakamura Y, Matsuda K.
    • Journal Title

      Oncol Rep.

      Volume: 33 Pages: 267-273

    • DOI
      10.3892/or.2014.3581
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Late Cornified Envelope Group I, a novel target of p53, regulates PRMT5 activity2014

    • Author(s)
      Deng Z, Matsuda K, Tanikawa C, Lin J, Furukawa Y, Hamamoto R, Nakamura Y.
    • Journal Title

      Neoplasia.

      Volume: 16 Pages: 656-664

    • DOI
      10.1016/j.neo.2014.07.008
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk2014

    • Author(s)
      Zhang B, Jia WH, Matsuda K, Zheng W. et al.
    • Journal Title

      Nat Genet

      Volume: 46 Pages: 533-542

    • DOI
      10.1038/ng.2985
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of PSCA variation on gastric ulcer susceptibility.2013

    • Author(s)
      C. Tanikawa, K. Matsuo, M. Kubo, A. Takahashi, H. Ito, H. Tanaka, Y. Yatabe, K. Yamao, N. Kamatani, K. Tajima, Y. Nakamura, K. Matsuda
    • Journal Title

      Plos one

      Volume: 8

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome wide association study of age at menarche in the Japanese population.2013

    • Author(s)
      C. Tanikawa, Y. Okada, A. Takahashi, K. Oda, N. Kamatani, M. Kubo, Y. Nakamura, K. Matsuda
    • Journal Title

      Plos one

      Volume: 8

    • DOI
      10.1371/annotation/1238450b-9ba4-4afb-aee3-a3c11b4f5ea1
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a functional variant in the MICA promoter which regulates MICA expression and increases HCV-related hepatocellular carcinoma risk.2013

    • Author(s)
      P.H. Lo, Y. Urabe, V. Kumar, C. Tanikawa, K. Koike, N. Kato, D. Miki, K. Chayama, M. Kubo, Y. Nakamura, K. Matsuda
    • Journal Title

      Plos one

      Volume: 8

    • Related Report
      2013 Annual Research Report
  • [Presentation] Impact of genetic variations on chronic viral infection and prognosis2016

    • Author(s)
      Koichi Matsuda
    • Organizer
      APASL 2016
    • Place of Presentation
      高輪プリンスホテル(東京都港区)
    • Year and Date
      2016-02-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] がんGWAS研究の最前線と社会実装へ向けた取り組み2015

    • Author(s)
      松田 浩一
    • Organizer
      日本人類遺伝学会 第60回大会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Multi-Omics analysis of p53 signaling pathway2015

    • Author(s)
      Koichi Matsuda
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] ゲノム成果の臨床応用に向けて2015

    • Author(s)
      松田浩一
    • Organizer
      第38回 日本がん疫学・分子疫学研究会総会
    • Place of Presentation
      ラフレさいたま(さいたま市)
    • Year and Date
      2015-06-05
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] PSCA as a potential therapeutic and prognostic biomarker for common cancers2015

    • Author(s)
      Koichi Matsuda, Chizu Tanikawa, Yusuke Nakamura.
    • Organizer
      AACR annual meeting
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2015-04-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The Biobank Japan Project for Personalized medicine2015

    • Author(s)
      Koichi Matsuda
    • Organizer
      2015 SNUCRI Cancer Symposium
    • Place of Presentation
      Hwasun-gun, Jeollanam-do, Korea
    • Year and Date
      2015-04-01
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] BioBank Japan Project for personalize medicine2014

    • Author(s)
      Koichi Matsuda
    • Organizer
      The 73rd Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] バイオバンクジャパンについて2014

    • Author(s)
      松田浩一
    • Organizer
      第103回 日本病理学会
    • Place of Presentation
      広島
    • Year and Date
      2014-04-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] PSCA as a potential therapeutic and prognostic biomarker for common cancer2014

    • Author(s)
      Koichi Matsuda
    • Organizer
      AACR annual meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2014-04-05 – 2014-04-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] The roles of gene-environmental interaction in human carcinogenesis2013

    • Author(s)
      Koichi Matsuda Michiaki Kubo Chizu Tanikawa, Yusuke Nakamura
    • Organizer
      日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] GWAS of diseases related withHelicobacter pylori infection2013

    • Author(s)
      Koichi Matsuda1, Chizu Tanikawa1, Michiaki Kubo2, Yusuke Nakamura
    • Organizer
      AACR-JCA joint symposium
    • Place of Presentation
      幕張
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Remarks] 松田研究室ホームページ

    • URL
      http://square.umin.ac.jp/matsudalab/index.html
    • Related Report
      2015 Annual Research Report

URL: 

Published: 2013-05-21   Modified: 2019-07-29  

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