Personalized medicine for patients with Helicobacter pylori infection
| Project/Area Number | 25293168 |
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Matsuda Koichi 東京大学, 新領域創成科学研究科, 教授 (90401257)
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| Co-Investigator(Renkei-kenkyūsha) |
TANIKAWA Chizu 東京大学, 医科学研究所, 助教 (30422421)
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| Research Collaborator |
TOYOSHIMA Osamu
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed(Fiscal Year 2015)
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| Budget Amount *help |
¥18,590,000 (Direct Cost : ¥14,300,000、Indirect Cost : ¥4,290,000)
Fiscal Year 2015 : ¥5,850,000 (Direct Cost : ¥4,500,000、Indirect Cost : ¥1,350,000)
Fiscal Year 2014 : ¥5,850,000 (Direct Cost : ¥4,500,000、Indirect Cost : ¥1,350,000)
Fiscal Year 2013 : ¥6,890,000 (Direct Cost : ¥5,300,000、Indirect Cost : ¥1,590,000)
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| Keywords | ヘリコバクター・ピロリ菌 / SNP / PSCA |
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| Outline of Final Research Achievements |
H. pylori is a gram-negative bacterium which is associated with gastric carcinoma, peptic ulcer, and MALT lymphoma. We have identified the association of prostate stem cell antigen (PSCA) polymorphism with H. pylori-related diseases including gastric cancer and peptic ulcer, however the role of this genetic variations on disease pathogenesis was largely remained to be elucidated. We have identified that PSCA variation is associated with risk of gastric ulcer, bladder cancer, and lung cancer. In addition, we found that PSCA protein is increased in the serum of several cancer patients. Moreover, T allele of SNP rs2294008 is associated with higher expression of PSCA mRNA. Interestingly, PSCA expression is decreased in gastric mucosa of H. pylori carrier and its expression was increased after eradication of H. pylori. Our finding suggests the possible role of PSCA in gastric cancer risk especially among subjects after H. pylori eradication.
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Report
(4results)
Research Products
(26results)
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[Journal Article] Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk2016
Author(s)
C. Zeng, K. Matsuda, W.H. Jia, J. Chang, S.S. Kweon, Y.B. Xiang, A. Shin, S.H. Jee, D.H. Kim, B. Zhang, Q. Cai, W. Zheng et al.
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Journal Title
Gastroenterology
Volume : In press
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Genome-wide association study identified SNP on 15q24 associated with bladder cancer risk in Japanese population.2015
Author(s)
Matsuda K, Takahashi A, Middlebrooks CD, Obara W, Nasu Y, Inoue K, Tamura K, Yamasaki I, Naya Y, Tanikawa C, Cui R, Figueroa JD, Silverman DT, Rothman N, Namiki M, Tomita Y, Nishiyama H, Kohri K, Deguchi T, Nakagawa M, Yokoyama M, Miki T, Kumon H, Fujioka T, Prokunina-Olsson L, Kubo M, Nakamura Y, Shuin T.
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Journal Title
Hum Mol Genet.
Volume : 24
Pages : 1177-1184
DOI
Related Report
Peer Reviewed
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[Journal Article] Impact of PSCA variation on gastric ulcer susceptibility.2013
Author(s)
C. Tanikawa, K. Matsuo, M. Kubo, A. Takahashi, H. Ito, H. Tanaka, Y. Yatabe, K. Yamao, N. Kamatani, K. Tajima, Y. Nakamura, K. Matsuda
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Identification of a functional variant in the MICA promoter which regulates MICA expression and increases HCV-related hepatocellular carcinoma risk.2013
Author(s)
P.H. Lo, Y. Urabe, V. Kumar, C. Tanikawa, K. Koike, N. Kato, D. Miki, K. Chayama, M. Kubo, Y. Nakamura, K. Matsuda
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Journal Title
Related Report
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