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Analysis of microenvironment-mediated treatment resistance of hepatocellular carcinoma in terms of integrated proteomics

Research Project

Project/Area Number 25293173
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionKumamoto University

Principal Investigator

Sasaki Yutaka  熊本大学, 大学院生命科学研究部, 教授 (70235282)

Co-Investigator(Kenkyū-buntansha) 渡邊 丈久  熊本大学, 生命科学研究部, 助教 (20634843)
直江 秀昭  熊本大学, 医学部附属病院, 助教 (30599246)
荒木 令江  熊本大学, 生命科学研究部, 准教授 (80253722)
藤元 治朗  兵庫医科大学, 医学部, 教授 (90199373)
Co-Investigator(Renkei-kenkyūsha) NAKAO MITSUYOSHI  熊本大学, 発生学研究所, 教授 (00217663)
Research Collaborator NAGAOKA KATSUYA  熊本大学, 医学部附属病院, 医員 (00759524)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2016: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2015: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Keywords肝癌 / 微小環境 / 治療抵抗性 / エピジェネテイクス / プロテオミクス / 翻訳後修飾 / 代謝リプログラミング / 細胞死抵抗性 / バイオインフォマテイクス / マルチオミクス / 癌 / 内科 / 燐酸化 / 遺伝子解析 / プロテオミクス
Outline of Final Research Achievements

Microenvironment surrounding cancer tissues might contribute much spatiotemporally so that cancer cells could obtain treatment resistance and exhibit biological characteristics. Comprehensive analysis of gene and protein expression in hepatoma cells, associated with analysis of post-translational modification, have described that phosphorylation status of thirty proteins has significantly changed under apoptotic stimulation. These proteins are including chaperon proteins, cytoskeleton-related molecules. In addition, nutritional environment would induce metabolic re-programming in terms of mediating the cross talk between the epigenome and lipid metabolism.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (90 results)

All 2017 2016 2015 2014 2013 Other

All Journal Article (51 results) (of which Peer Reviewed: 14 results,  Open Access: 8 results,  Acknowledgement Compliant: 1 results) Presentation (31 results) (of which Invited: 1 results) Book (8 results)

  • [Journal Article] Oral branched-chain amino acid granules improve structure and function of human serum albumin in liver cirrhotic patients2017

    • Author(s)
      Setoyama H, Tanaka M, Nagumo K, Naoe H, Watanabe T, Yoshimaru Y, Tateyama M, Sasaki M, Watanabe H, Otagiri M, Maruyama T and Sasaki Y
    • Journal Title

      J Gastroenterol

      Volume: - Issue: 6 Pages: 754-765

    • DOI

      10.1007/s00535-016-1281-2

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The glucocorticoid receptor regulates the ANGPTL4 gene in a CTCF-mediated chromatin context in human hepatic cells2017

    • Author(s)
      Nakamoto M, Ishihara K, Watanabe T, Hirosue A, Hino S, Shinohara M, Nakayama H, Nakao M
    • Journal Title

      PLoS One

      Volume: 12

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Outcomes of treatment with daclatasvir and asunaprevir for recurrent hepatitis C after liver transplantation2017

    • Author(s)
      Honda M, Sugawara Y, Watanabe T, Tateyama M, Tanaka M, Uchida K, Kawabata S, Yoshii D, Miura K, Isono K, Hayashida S, Ohya Y, Yamamoto H, Sasaki Y, Inomata Y
    • Journal Title

      Hepatology Research

      Volume: - Issue: 11 Pages: 1147-1154

    • DOI

      10.1111/hepr.12853

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ledipasvir and sofosbuvir for recurrent hepatitis C after liver transplantation2016

    • Author(s)
      Oya Y, Sugawara Y, Watanabe T, Yoshimaru Y, Honda M, Hashimoto S, Yoshii D, Isono K, Hayashida S, Yamamoto H, Tanaka M, Sasaki Y, Inomata Y
    • Journal Title

      Bioscience Trends

      Volume: 10 Pages: 496-499

    • NAID

      130005295919

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Expression of adipophilin in gastric epithelial neoplasia is associated with intestinal differentiation and discriminates between adenoma and adenocarcinoma.2016

    • Author(s)
      Gushima R, Yao T, Kurisaki-Arakawa A, Hara K, Hayashi T, Fukumura Y, Saito T, Arakawa A, Sasaki Y
    • Journal Title

      Virchow Arch

      Volume: 468 Issue: 2 Pages: 169-177

    • DOI

      10.1007/s00428-015-1870-0

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The retrovirus HTLV-1 inserts an ectopic CTCF-binding site into the human genome2016

    • Author(s)
      Satou Y, Miyazato P, Ishihara K, Yaguchi H, Melamed A, Miura M, Fukuda A, Nosaka K, Watanabe T, Rowan AG, Nakao M, Bangham CR
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 11 Pages: 3054-3059

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The longitudinal effect of the aldehyde dehydrogenase 2 *2 allele on the risk for non-alcoholic fatty liver disease2016

    • Author(s)
      Oniki K, Morita K, Watanabe T, Kajiwara A, Otake K, Nakagawa K, Sasaki Y, OgataY and Saruwatari J
    • Journal Title

      Nutrition & Diabetes

      Volume: 6

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 肝エネルギー代謝とエピゲノム解析のマルチオミクス解析2016

    • Author(s)
      長岡克弥、佐々木裕
    • Journal Title

      肝胆膵

      Volume: 73 Pages: 719-724

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 腹水とアルブミンの捉え方20162016

    • Author(s)
      瀬戸山博子、佐々木裕
    • Journal Title

      肝胆膵

      Volume: 72 Pages: 287-293

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 慢性肝不全に対する運動療法は有用である2016

    • Author(s)
      瀬戸山博子、佐々木裕
    • Journal Title

      救急集中治療 肝不全

      Volume: 28 Pages: 387-391

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Clinical impact of preoperative endoscopic ultrasound-guided fine needle aspiration for pancreatic ductal adenocarcinoma.2016

    • Author(s)
      Tsutsumi H, Hara K, Mizuno N, Hijioka S, Imaoka H, Tajika M, Tanaka T, Ishihara M, Yoshimura K, Shimizu Y, Niwa Y, Sasaki Y, Yamao K.
    • Journal Title

      Endoscopic Ultrasound

      Volume: in press Issue: 2 Pages: 94-94

    • DOI

      10.4103/2303-9027.180472

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Carbohydrate antigen 19-9 is a useful prognostic marker in esophagogastric junction adenocarcinoma.2015

    • Author(s)
      Tokunaga R, Imamura Y, Nakamura K, Uchihara T, Ishimoto T, Nakagawa S, Iwatsuki M, Baba Y, Sakamoto Y, Miyamoto Y, Yoshida N, Oyama S, Shono T, Naoe H, Saeki H, Oki E,Watanabe M, Sasaki Y, Maehara Y, Baba H
    • Journal Title

      Cancer Med

      Volume: 11 Issue: 11 Pages: 1659-66

    • DOI

      10.1002/cam4.514

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polythiol-containing, recombinant mannosylated-albumin is a superior CD68+/CD206+ Kupffer cell-targeted nano-antioxidant for the treatment of two acute hepatitis models.2015

    • Author(s)
      Maeda H, Hirata K, Watanabe H, Ishima Y, Chuang VT, Taguchi K, Inatsu A, Kinoshita M, Tanaka M, Sasaki Y, Otagiri M, Maruyama T.
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 352 Issue: 2 Pages: 244-257

    • DOI

      10.1124/jpet.114.219493

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lysine-specific demethylase 2 suppresses lipid influx and metabolism in hepatic cells2015

    • Author(s)
      Nagaoka K, Hino S, Sakamoto A, Anan K, Takase R, Umehara T, Yokoyama S, Sasaki Y and Nakao M.
    • Journal Title

      Molecular cellular Biology

      Volume: 35(7) Pages: 68-1080

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of sorafenib treatment and hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma: a comparative study using the propensity score matching method.2015

    • Author(s)
      Fukubayashi K, Tanaka M, Izumi K, Watanabe T, Fujie S, Kawasaki T, Yoshimaru Y, Tateyama M, Setoyama H, Naoe H, Kikuchi K and Sasaki Y
    • Journal Title

      Cancer Med.

      Volume: 8 Issue: 8 Pages: 1214-23

    • DOI

      10.1002/cam4.476

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 急性ウイルス肝炎の近年の動向と感染源2015

    • Author(s)
      徳永尭之,田中基彦,佐々木裕
    • Journal Title

      Medicina

      Volume: 52 Pages: 226-229

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Grand Rounds 進行肝細胞癌2015

    • Author(s)
      田中基彦,佐々木裕
    • Journal Title

      消化器の臨床

      Volume: 18 Pages: 5-14

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 特集肝疾患診療の新展開 肝細胞がんの診療ガイドライン2015

    • Author(s)
      田中基彦,佐々木裕
    • Journal Title

      日医雑誌

      Volume: 144 Pages: 1439-1444

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 学会だより 第51回日本肝臓学会総会2015

    • Author(s)
      田中基彦
    • Journal Title

      臨床消化器内科

      Volume: 30 Pages: 1316-1316

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Lysine-specific demethylase LSD2 suppresses lipid influx and metabolism in hepatic cells.2015

    • Author(s)
      Nagaoka K, Hino S, Sakamoto A, Anan K, Takase R, Umehara T, Yokoyama S, Sasaki Y and Nakao M.
    • Journal Title

      Molecular Cellular Biology

      Volume: in press

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Cys34-cysteinylated human serum albumin is a sensitive plasma marker in oxidative stress-related chronic disease.2014

    • Author(s)
      Nagumo K, Tanaka M, Chuang V, Setoyama H, Watanabe H, Yamada N, Kubota K, Tanaka M, Matsushita K, Yoshida A, Jinnouchi H, Anraku M, Kadowaki D, Ishima Y, Sasaki Y, Otagiri M, Maruyama T.
    • Journal Title

      PLOS ONE

      Volume: 9(1)

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Development and validation of a symptom scale specific for ascites accompanied with cirrhosis: the ASI-72014

    • Author(s)
      Onishi Y, Wakita T, Fukuhara S, Noguchi Y, Okada M, Sakaida I, Sasaki Y and Kobayashi K.
    • Journal Title

      Clinical and Translational Gastroenterology

      Volume: 5

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Clinicopathological differences of laterally spreading tumors arising in the colon and rectum.2014

    • Author(s)
      Miyamoto H, Ikematsu H, Fujii S, Osera S, Odagaki T, Oono Y, Yano T, Ochiai A, Sasaki Y, Kaneko K.
    • Journal Title

      Int J Colorectal Dis.

      Volume: 29(9) Pages: 1069-1075

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 脳死肝移植登録中にB型急性肝炎を発症した原発性胆汁性肝硬変の1例.2014

    • Author(s)
      平江麻衣、渡邊丈久、吉丸洋子、川崎剛、泉和寛、溝部典生、福林光太郎、立山雅邦、田中基彦、猪山賢一、佐々木裕.
    • Journal Title

      肝臓

      Volume: 55 Pages: 176-781

    • NAID

      130003393972

    • Related Report
      2014 Annual Research Report
  • [Journal Article] NF-κBシグナル研究のこれまでの変遷. 特集/肝胆膵領域におけるNF-κB研究の最前線.2014

    • Author(s)
      渡邊丈久、佐々木裕.
    • Journal Title

      肝胆膵

      Volume: 68 Pages: 495-503

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 肝炎ウイルス2014

    • Author(s)
      田中基彦,佐々木裕.
    • Journal Title

      診断と治療

      Volume: 102 Pages: 827-832

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 高度進行肝細胞癌に対する治療法選択-ソラフェニブと肝動注化学療法の比較.2014

    • Author(s)
      田中基彦,福林光太郎,泉和寛,立山雅邦,佐々木 裕.
    • Journal Title

      消化器内科

      Volume: 59 Pages: 68-76

    • Related Report
      2014 Annual Research Report
  • [Journal Article] C型肝炎深慮における肝臓専門医の役割2014

    • Author(s)
      立山雅邦、渡邊丈久、福林光太郎、田中基彦、佐々木裕.
    • Journal Title

      臨床消化器内科

      Volume: 6月増刊号 29 Pages: 88-91

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Translationally Controlled Tumor Protein is a Novel Biological Target for Neurofibromatosis Type 1 (NF1)-associated Tumors.2014

    • Author(s)
      Kobayashi, D., Hirayama M., Komohara, Y., Mizuguchi, S, Wilson Morifuji, M. Patrakitkomjorn, S, Ihn, H., Takeya, M, Kuramochi, A., and Araki, N*.
    • Journal Title

      J. Biol. Chem.

      Volume: 289(38) Issue: 38 Pages: 26314-26

    • DOI

      10.1074/jbc.m114.568253

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of a fully automated two-dimensional electrophoresis device, Auto-2D, and its application for the integrated proteomics2014

    • Author(s)
      Araki N*, Nambu, NA., Midorikawa U, Nishimura M, Kobayashi D.
    • Journal Title

      J. Electrophoresis

      Volume: 58(2) Pages: 39-42

    • NAID

      130004704682

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multivariate logistic regression analysis for prediction of clinically relevant pancreatic fistula in the early phase after2014

    • Author(s)
      Kosaka H, Kuroda N, Suzumura K, Asano Y, Okada T, Fujimoto J.
    • Journal Title

      J Hepatobiliary Pancreat Sci

      Volume: 21 Pages: 128-33

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Interferonγ and plasminogen activator inhibitor 1 regulate adhesion formation after partial2014

    • Author(s)
      Ohashi K, Yoshimoto T, Kosaka H, Hirano T, Iimuro Y, Nakanishi K, Fujimoto J.
    • Journal Title

      Brit J Surg

      Volume: 101 Pages: 398-407

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Cys34-cysteinylated human serum albumin is a sensitive plasma marker in oxidative stress-related chronic disease.2014

    • Author(s)
      Nagumo K, Tanaka M, Chuang V, Setoyama H, Watanabe H, Yamada N, Kubota K, Tanaka M, Matsushita K, Yoshida A, Jinnouchi H, Anraku M, Kadowaki D, Ishima Y, Sasaki Y, Otagiri M, Maruyama T.
    • Journal Title

      PLOS ONE 9(1) e85216

      Volume: in press

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Development and validation of a symptom scale specific for ascites accompanied with cirrhosis: the ASI-72014

    • Author(s)
      Onishi Y, Wakita T, Fukuhara S, Noguchi Y, Okada M, Sakaida I, Sasaki Y and Kobayashi K.
    • Journal Title

      Clinical and Translational Gastroenterology (2014)5,e48

      Volume: in press Issue: 2 Pages: e48-e48

    • DOI

      10.1038/ctg.2013.20

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Endoscopic diagnosis and treatment of superficial colorectal neoplasm2014

    • Author(s)
      Shono T, Nonaka K, Ochiai Y, Nakao M, Togawa O, Nishimura M, Ishikawa K, Arai S, Sakurai K, Sasaki Y and Kita H.
    • Journal Title

      Current Research in Cancer

      Volume: in press

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Multivariate logistic regression analysis for prediction of clinically relevant pancreatic fistula in the early phase after pancreaticoduodenectomy.2014

    • Author(s)
      Kosaka H, Kuroda N, Suzumura K, Asano Y, Okada T, Fujimoto J
    • Journal Title

      J Hepatobiliary Pancreat Sci

      Volume: in press

    • Related Report
      2013 Annual Research Report
  • [Journal Article] New malignant grading system for hepatocellular carcinoma using Sonazoid contrast agent for ultrasonography.2014

    • Author(s)
      Tanaka H, Iijima H, Ishi A, takashima T, Sakai Y, Aizawa K, Ikeda N, Iwata N, Enomoto H, Saito M, Imanishi H, Hirota S, Fujimoto J, NIshiguchi S
    • Journal Title

      J Gastroenterol

      Volume: in press

    • Related Report
      2013 Annual Research Report
  • [Journal Article] A nationwide survey in Japan regarding splenectomy/partial splenic embolization for interferon treatment targeting hepatitis C virus-related chronic liver disease in patients with a low platelet count.2014

    • Author(s)
      Ikeda N, Imanishi H, Aizawa N, Tanaka H, Iwata Y, Enomoto H, Saito M, Iijima H, Iimuro Y, Fujimoto J, Yamamoto S, Hirota S, Kudo M, Arii S, Nishiguchi S
    • Journal Title

      Hepatol Res

      Volume: in press

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Safety of hepatic resection for hepatocellular carcinoma in obese patients with cirrhosis.2014

    • Author(s)
      Tanaka S, Iimuro Y, Hirano T, Hai S,Suzumura K, Nakamura I, Kondo Y, Fujimoto J
    • Journal Title

      Surg Today

      Volume: in press

    • Related Report
      2013 Annual Research Report
  • [Journal Article] IFN-g and plasminogen activator inhibitor-1 regulate adhesion formation after partial hepatectomy.2014

    • Author(s)
      Ohashi K, Yoshimoto T, Kosaka H, Hirano T, Iimuro Y, Nakanishi K, Fujimoto J:
    • Journal Title

      Brit J Surg

      Volume: in press

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Blochage of CXCR2 suppresses tumor growth of intrahepatic cholangiocellular carcinoma.2014

    • Author(s)
      Sueoka H, Hirano T, Uda H, Iimuro Y, Yamanaka J, Fujimoto J.
    • Journal Title

      Surgery

      Volume: in press

    • Related Report
      2013 Annual Research Report
  • [Journal Article] The APC/C activator Cdh1 regulates the G2/M transition during differentiation of placental trophoblast stem cells.2013

    • Author(s)
      Naoe H, Chiyoda T, Ishizawa J, Masuda K, Saya H, Kuninaka S.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 430 Pages: 757-762

    • Related Report
      2013 Annual Research Report
  • [Journal Article] A synthetic nanofibrillar matrix promotes in vitro hepatic differentiation of embryonic stem cells and induced pluripotent stem cells.2013

    • Author(s)
      Yamazoe T, Shiraki N, Toyoda M, Kiyokawa N, Okita H, Miyagawa Y, Akutsu H, Umezawa A, Sasaki Y, Kume K, Kume S.
    • Journal Title

      J Cell Sci 1

      Volume: 126 Pages: 5391-5399

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Angiogenesis is crucial for liver regeneration after partial hepatectomy.2013

    • Author(s)
      Uda Y, Hirano T, Son G, Iimuro Y, Uyama N, Yamanaka J, Mori A, Arii S, Fujimoto J
    • Journal Title

      Surgery

      Volume: 153 Pages: 70-7

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Interferon-gamma-mediated tossue factor expression contributes to t-cell-mediated hepatitis through induction of hypercoagulation in mice.2013

    • Author(s)
      Kato J, Okamoto T, Motoyama H, Uchiyama R, Kirchhofer D, Rooilen NV, Enomoto H, Nishiguchi S, Kawada N, Fujimoto J, Tsutsui H
    • Journal Title

      Hepatology

      Volume: 57 Pages: 363-372

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Regional hepatic regeneration after liver resection correlates well with preceeding changes in the regional portal circulation in humans.2013

    • Author(s)
      Iimuro Y, Kondo Y, Suzumura K, Uyama N, Asano Y, Hirano T, Yamanaka J, Iijima H, NIshiguchi S, Fujimoto J
    • Journal Title

      Dig Dis Sci

      Volume: 58 Pages: 3001-9

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Primary adenocarcinoma arising in an interposed colon.2013

    • Author(s)
      Suzumura K, Oh K, Kuroda N, Iimuro Y, Uyama N, Torii I, Fujimoto J
    • Journal Title

      Esophagus

      Volume: 10 Pages: 99-102

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Solitary mediastinal metastasis of hepatocellular carcinoma treated by video-assisted thoracic surgery2013

    • Author(s)
      Suzumura K, Hirano H, Kuroda K, Iimuro Y, Okada T, Hashimoto M, Hasegawa S, Fujimoto J
    • Journal Title

      report of a case. Gen Thorac Cardiovasc Surg

      Volume: 61 Pages: 651-654

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Rare form of extraovarian peritoneal papillary serous carcinoma with solitary cystic lesion mimicking a liver tumor,2013

    • Author(s)
      Iimuro Y, Ohashi K, Suzumura K, Hai s, Nakamura I, Kondo Y, Asano Y, Okada T, Hirano T, Kuroda N, Hirota S, Fujimoto J
    • Journal Title

      report of a case. Clin J Gastroenterol

      Volume: 6 Pages: 145-9

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Integrated proteomics identified a novel activation signaling of dynein IC2-GR-COX-1 in NF1 disease model cells.2013

    • Author(s)
      Hirayama M, Kobayashi D, Mizuguchi S, Morikawa T, Nagayama M, Wilson MM, Nambu NA, Yoshizawa A, Kawano S, and Araki N*
    • Journal Title

      Mol. Cell. Proteomics

      Volume: 12(5) Pages: 1377-94

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Epiplakin modifies the motility of the HeLa cells and accumulates at the outer surfaces of three-dimensional cell clusters.2013

    • Author(s)
      Shimada H, Nambu-Niibori A, Wilson-Morifuji M, Mizuguchi S, Araki N*, Mezaki Y, Senoo H, Ishikawa K, Okamoto O, Fujiwara S*.
    • Journal Title

      J. Dermatol,

      Volume: 40(4) Pages: 249-58

    • Related Report
      2013 Annual Research Report
  • [Presentation] Integrative role of histone Iysine demethylase LSD 1/2 in liver cancer metabolism2016

    • Author(s)
      Katsuya Nagaoka , Shinjiro Hino , Akihisa Sakamoto , Jack R Wands , Mitsuyoshi Nakao , Yutaka Sasaki
    • Organizer
      AASLD The Liver Meeting
    • Place of Presentation
      Boston
    • Year and Date
      2016-11-11
    • Related Report
      2016 Annual Research Report
  • [Presentation] A novel serum biomarker , clusterin , could be an early predictor of response to sorafenib2016

    • Author(s)
      Takehisa Watanabe , Satoshi Narahara , Motohiko Tanaka , Yutaka Sasaki
    • Organizer
      AASLD The Liver Meeting
    • Place of Presentation
      Boston
    • Year and Date
      2016-11-11
    • Related Report
      2016 Annual Research Report
  • [Presentation] Clinical outcomes of hepatocellular carcinoma patients who obtained HCV eradication after interferon therapy2016

    • Author(s)
      Motohiko Tanaka, Yoko Yoshimaru, Takayoshi Sonoda, Takayuki Tokunaga, Takeshi Kawasaki, Satomi Fujie, Takehisa Watanabe, Hiroko Setoyama, Masakuni Tateyama, Yutaka Sasaki
    • Organizer
      HCV2016
    • Place of Presentation
      Kyoto
    • Year and Date
      2016-10-11
    • Related Report
      2016 Annual Research Report
  • [Presentation] Combination therapy with Daclatasvir and Asunaprevir for the patients infected with HCV genotype 12016

    • Author(s)
      Masakuni Tateyama , Motohiko Tanaka, Takayuki Tokunaga, Takeshi Kawasaki, Satomi Fujie, Yoko Yoshimaru, Takehisa Watanabe, Hiroko Setoyama, Takeyasu Kounoe, Yoshinari Sakai, Masato Sasaki, Kazuhiro Sugi, Shiho Miyase, Shigetoshi Fujiyama, Yutaka Sasaki
    • Organizer
      HCV2016
    • Place of Presentation
      Kyoto
    • Year and Date
      2016-10-11
    • Related Report
      2016 Annual Research Report
  • [Presentation] 当科におけるSVR後肝癌の実態2016

    • Author(s)
      吉丸洋子、田中基彦、佐々木裕
    • Organizer
      第52回日本肝臓学会総会
    • Place of Presentation
      千葉
    • Year and Date
      2016-05-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] 肝癌の治療抵抗性を担う責任分子の同定と機能解析2016

    • Author(s)
      直江秀昭、田中基彦、佐々木裕
    • Organizer
      第52回日本肝臓学会総会
    • Place of Presentation
      千葉
    • Year and Date
      2016-05-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] エピジェネティクス因子による肝脂質代謝調節~ヒストン修飾酵素LSD2に焦点を当てたNASH・NAFLDの病態解明に向けて~2016

    • Author(s)
      長岡克弥、渡邊丈久、佐々木裕
    • Organizer
      第52回日本肝臓学会総会
    • Place of Presentation
      千葉
    • Year and Date
      2016-05-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] 血清還元型アルブミン量を用いた代償性肝硬変の早期診断2016

    • Author(s)
      瀬戸山博子、田中基彦、佐々木裕
    • Organizer
      第102回日本消化器病学会総会
    • Place of Presentation
      東京
    • Year and Date
      2016-04-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] Integrated proteomics analyses identified a phosphoprotein relevant to apoptosis resistance in human hepatocellular carcinoma2015

    • Author(s)
      Naoe H, Hoshida Y, Yokote S, Fujie S, Watanabe T, Nagaoka K, Yamazoe T , Setoyama H, Tanaka M, Fujimoto J, Araki N, Sasaki Y
    • Organizer
      The 65th annual meeting of the American association for the study of liver disease (AASLD2015)
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2015-11-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] Human mercapto-albumin level is a useful biomarker of progression and  functional property of human serum albumin in chronic liver disease2015

    • Author(s)
      Setoyama H, Tanaka M, Naoe H, Tateyama M, Watanabe T, Yoshimaru Y, Fujie S, Oniki K, Saruwatari J, Watanabe H, Maruyama T, Sasaki Y
    • Organizer
      Human mercapto-albumin level is a useful biomarker of progression and  functional property of human serum albumin in chronic liver disease
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2015-11-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] Lymphotoxin-β regulated by NF-κB is a useful biomarker related to poor prognosis in hepatocellular carcinoma.2015

    • Author(s)
      Watanabe T, Fujie S, Tokunaga T, Izumi K, Kawasaki T, Yoshimaru Y, Setoyama H, Fukubayashi K, Tateyama M, Tanaka M, and Sasaki Y
    • Organizer
      3.Takehisa Watanabe, Satomi Fujie, Takayuki Tokunaga, Kazuhiro Izumi, Takeshi Kawasaki, Youko yoshimaru, Hiroko Setoyama, Kotaro Fukubayashi, Masakuni Tateyama, Motohiko Tanaka, and Yutaka Sasaki
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2015-11-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] 肝細胞癌の治療抵抗性を担う分子の抽出と解析2015

    • Author(s)
      直江秀昭、田中基彦、佐々木裕
    • Organizer
      第51回日本肝臓学会総会
    • Place of Presentation
      熊本
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 核酸アナログ治療例と自然経過例から考えるB型慢性肝炎診療2015

    • Author(s)
      田中基彦、立山雅邦、佐々木裕
    • Organizer
      第51回日本肝臓学会総会
    • Place of Presentation
      熊本
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] アルブミンの構造的・機能的改善を目指した肝硬変における分岐鎖アミノ酸治療2015

    • Author(s)
      瀬戸山博子、田中基彦、丸山徹
    • Organizer
      第51回日本肝臓学会総会
    • Place of Presentation
      熊本
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] ソラフェニブと肝動注化学療法の治療成績から考える予後予測と治療選択2015

    • Author(s)
      福林光太郎、田中基彦、佐々木裕
    • Organizer
      第51回日本肝臓学会総会
    • Place of Presentation
      熊本
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 肝臓の脂質バランス維持におけるヒストンH3K4脱メチル化酵素LSD2の役割:非アルコール性脂肪肝炎の病態解明に向けて2015

    • Author(s)
      長岡克弥、中尾光善、佐々木裕
    • Organizer
      第51回日本肝臓学会総会
    • Place of Presentation
      熊本
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 肝炎・肝細胞癌誘導因子であるLTβの発現様式を用いた肝細胞がんの個別化医療の可能性2015

    • Author(s)
      渡邊丈久、田中基彦、佐々木裕
    • Organizer
      第51回日本肝臓学会総会
    • Place of Presentation
      熊本
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 薬剤スクリーニングによるヒト誘導多能性幹細胞の肝成熟化メカニズムの解明2015

    • Author(s)
      山添太士、佐々木裕
    • Organizer
      第51回日本肝臓学会総会
    • Place of Presentation
      熊本
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 当科における非B非C型肝硬変の実態2015

    • Author(s)
      吉丸洋子、田中基彦、佐々木裕
    • Organizer
      第51回日本肝臓学会総会
    • Place of Presentation
      熊本
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 肝疾患診療レベルの向上と均てん化を目指した本県における取組みと問題点2015

    • Author(s)
      田中基彦、福林光太郎、佐々木裕
    • Organizer
      第51回日本肝臓学会総会
    • Place of Presentation
      熊本
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 当科および当科関連施設で治療した肝嚢胞40例の検討2015

    • Author(s)
      德永尭之、今村治男、佐々木裕
    • Organizer
      第51回日本肝臓学会総会
    • Place of Presentation
      熊本
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 当科におけるBCLC advanced stage 肝細胞癌の治療成績 ソラフェニブと肝動注化学療法のマッチング比較を含めて2015

    • Author(s)
      福林光太郎、田中基彦、佐々木裕
    • Organizer
      第101回日本消化器病学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2015-04-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] 慢性肝疾患における血清アルブミンの酸化ストレス制御への関与2015

    • Author(s)
      瀬戸山博子
    • Organizer
      第101回日本消化器病学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2015-04-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] 全自動全自動2次元電気泳動装置の開発と融合プロテオミクスへの応用2014

    • Author(s)
      荒木令江
    • Organizer
      日本電気泳動学会シンポジウム
    • Place of Presentation
      横浜
    • Year and Date
      2014-10-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] Integrated Proteomics for Cancer Stem Cells,2014

    • Author(s)
      9.Araki N, Nambu AN, Midorikawa U, Mizuguchi S, Kobayashi D, Hirayama M, Wilson MM, Kawano S, Nakamura H, Kuratsu J.
    • Organizer
      HUPO 12th Annual World Congress
    • Place of Presentation
      Madrid Spain
    • Year and Date
      2014-10-06 – 2014-10-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] 当科におけるASH/NASH肝癌の臨床的特徴

    • Author(s)
      吉丸洋子、田中基彦、佐々木裕
    • Organizer
      第17回日本肝臓学会大会 (JDDW 2013)
    • Place of Presentation
      グランドプリンスホテル高輪(東京都港区)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ソラフェニブと動注化学療法の治療成績から考える進行肝細胞癌に対する治療選択

    • Author(s)
      福林光太郎、田中基彦、佐々木裕
    • Organizer
      第49回日本肝臓学会総会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 当院において大腸ESDを施行しえた表在型大腸腫瘍105例に関する検討

    • Author(s)
      庄野孝、櫻井宏一、佐々木裕
    • Organizer
      第95回日本消化器内視鏡学会九州支部例会
    • Place of Presentation
      北九州国際会議場(北九州市小倉北区)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 進行肝細胞癌に対する化学療法の検討

    • Author(s)
      田中基彦、福林光太郎、佐々木裕
    • Organizer
      第40回日本肝臓学会西部会
    • Place of Presentation
      岐阜都ホテル(岐阜市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 融合プロテオミクスによるがん細胞およびがん幹細胞の悪性化ネットワーク抽出と治療ターゲットの検索.

    • Author(s)
      荒木令江
    • Organizer
      第40回BMS (Biological Mass Spectrometry)コンファレンス
    • Place of Presentation
      シーガイアコンベンションセンター(宮崎市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 融合プロテオミクスを基盤とした病態システムズバイオロジーによる癌の治療標的検出への挑戦.

    • Author(s)
      荒木令江
    • Organizer
      バイオシグナル教育特別講演
    • Place of Presentation
      神戸大学(神戸市中央区)
    • Related Report
      2013 Annual Research Report
  • [Book] 肝硬変の成因別実態2014 泉並木監修2015

    • Author(s)
      吉丸洋子,田中基彦,佐々木裕
    • Publisher
      医学図書出版株式会社
    • Related Report
      2015 Annual Research Report
  • [Book] 診断フローチャート.HEPATOLOGY PRACTICE第5巻 肝がんの診療を極める2014

    • Author(s)
      田中基彦,佐々木裕.
    • Publisher
      文光堂
    • Related Report
      2014 Annual Research Report
  • [Book] 融合プロテオミクスによるは発がんメカニズムの解析 医学のあゆみ、「臨床プロテオミクス」2014

    • Author(s)
      荒木令江* 小林大樹
    • Publisher
      医歯薬出版
    • Related Report
      2014 Annual Research Report
  • [Book] 専門医のための消化器病学 第2版(肝細胞癌と癌幹細胞)2013

    • Author(s)
      渡邊丈久、佐々木裕
    • Total Pages
      686
    • Publisher
      医学書院
    • Related Report
      2013 Annual Research Report
  • [Book] 最新医学別冊 改訂第2版(新しい診断と治療ABC, 44 肝硬変)2013

    • Author(s)
      渡邊丈久、田中基彦、佐々木裕
    • Publisher
      最新医学社
    • Related Report
      2013 Annual Research Report
  • [Book] Hepatology practice 第2巻(アルコール性肝障害と肝炎ウイルス)2013

    • Author(s)
      渡邊丈久、佐々木 裕
    • Total Pages
      399
    • Publisher
      文光堂
    • Related Report
      2013 Annual Research Report
  • [Book] 肝臓専門医テキスト 日本肝臓学会編(第IX章 23.転移性肝癌)2013

    • Author(s)
      直江秀昭
    • Total Pages
      497
    • Publisher
      南江堂
    • Related Report
      2013 Annual Research Report
  • [Book] 「プロテオミクス辞典」 日本プロテオーム学会編2013

    • Author(s)
      荒木令江
    • Total Pages
      127
    • Publisher
      講談社
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-21   Modified: 2019-07-29  

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