| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Outline of Final Research Achievements |
Non Alcoholic Steato-hepatitis (NASH)is a emerging disease which arise from Non Alcoholic Fatty Liver(NAFLD). The number of NAFLD patient is estimated about 20 million in Japan. NASH is the highest number of patients among liver disease. In this study, we investigate the effect of free fatty acid, palmitate on mouse liver. Administration of free fatty acid induced the inflammatory cells infiltration and activate stellate cells and fibrosis formation in the liver. We showed the neutrophil infiltration is caused by the production of the chemokine by the free fatty acids whereas fibrosis directly induced by free fatty acids via TLR4.
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