Basic study for the development of PET diagnosis specific for CD44 variant-positive gastric cancer stem like cells

• Project/Area Number: 25293178
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Keio University
• Principal Investigator: Suzuki Hidekazu 慶應義塾大学, 医学部, 教授 (70255454)
• Co-Investigator(Kenkyū-buntansha): INOUE HIROYOSHI 慶應義塾大学, 医学部, 教授 (10213175) ; MURAKAMI KOUJI 慶應義塾大学, 医学部, 教授 (50200267) ; SHIBATA SHINSUKE 慶應義塾大学, 医学部, 講師 (70407089)
• Co-Investigator(Renkei-kenkyūsha): SAYA HIDEYUKI 慶應義塾大学, 医学部, 教授 (80264282)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000); Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2014: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2013: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
• Keywords: CD44v9 / グルタチオン / 酸化ストレス / シスチントランスポーター / 胃癌幹細胞 / trastuzumab / シスチン / 胃がん / がん幹細胞 / 5-FU / PET / 生体内イメージング / ROS

Outline of Final Research Achievements

1)CD44v9-MKN28 cells were more resistant to 5-FU than CD44s-MKN28. With sulfasalazine, 5-FU enhanced ROS and reduced GSH even in CD44v9-MKN28, suggesting an importance of CD44v9 for 5-FU resistance. 2)Hp exposure significantly enhanced migration of CD44v9-MKN28, indicating that CagA accumulation by autophagy inhibition would accelerate tumor infiltration. 3)Trastuzumab significantly enhanced intramitochondrial MnSOD with the increase of GSH in CD44v9-NCI-N87 cells as compared to NCI-N87. 4)In xenografts, although 5-FU reduced tumor volume of CD44s-MKN28, no reduction of CD44v9-MKN28 was shown. With sulfasalazine, 5-FU significantly reduced tumor volume of CD44v9-MKN28, possibly by inhibiting CD44v9-xCT system, suggesting of xCT as a potential target of CD44v9 (+) cancer stem-like cells. (5)Hp infection expanded xenograft tumor of MNK28-CD44v9 compared to non-infected MNK28-CD44v9 or infected MKN28-CD44s, suggesting the high proliferative activity under CagA accumulation.

Research Products

• [Journal Article] A prospective study on symptom generation according to spicy food intake and TRPV1 genotypes in functional dyspepsia patients. (2016)
  • Author(s): Lee, S-Y., Masaoka, T., Han, H-S., Matsuzaki, J., Hong, M-J., Fukuhara, S., Choi, H-S, Suzuki, H.
  • Journal Title: Neurogastroenterol. Motil. Volume: -
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Influence of regular exercise on gastric emptying in healthy men: a pilot study. (2016)
  • Author(s): Matsuzaki, J., Suzuki, H.*, Masaoka, T., Tanaka, K., Mori, H., Kanai, T.
  • Journal Title: J. Clin. Biochem. Nutri. Volume: -
  • NAID: 130005262393
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Profile of acotiamide in the treatment of functional dyspepsia. (2016)
  • Author(s): Ueda, M., Iwasaki, E., Suzuki H.
  • Journal Title: Clin. Exp. Gastroenterol. Volume: 9 Pages: 83-88
  • DOI: 10.2147/ceg.s72172
  • Peer Reviewed / Open Access
• [Journal Article] Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). (2016)
  • Author(s): Klionsky, D.J., Abdelmohsen, K., Abe, A., Abedin, M.J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C.M., Suzuki, H. et al.
  • Journal Title: Autophagy Volume: 12 Pages: 1-222
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Family history is an independent risk factor for the progression of gastric atrophy among patients with Helicobacter pylori infection. (2016)
  • Author(s): Nishizawa, T., Suzuki, H., Sakitani, K., Yamashita, H., Yoshida, S., Hata, K., Kanazawa, T., Fujiwara, N., Kanai, T., Yahagi, N., Toyoshima, O.
  • Journal Title: United European Gastroenterology Journal Volume: - Issue: 1 Pages: 32-36
  • DOI: 10.1177/2050640616642341
  • Peer Reviewed / Open Access
• [Journal Article] Endoscopic slip knot clip suturing method: An ex vivo feasibility study (with video). (2016)
  • Author(s): Nishizawa, T., Uraoka, T., Sagara, S., Suzuki, H., Akimoto, T., Kanai, T., Yahagi, N.
  • Journal Title: Gastrointest. Endosc. Volume: 83 Pages: 447-450
  • Peer Reviewed / Open Access
• [Journal Article] Association of baseline plasma des-acyl ghrelin level with the response to rikkunshito in patients with functional dyspepsia. (2016)
  • Author(s): Togawa, K., Matsuzaki, J., Kobayakawa, M., Fukushima, Y., Suzaki, F., Kasugai, K., Nishizawa, T., Naito, Y., Hayakawa, T., Kamiya, T., Andoh, T., Yoshida, H., Tokura, Y., Nagata, H., Mori, M., Kato, K., Hosoda, H., Takebayashi, T., Miura, S., Uemura, N., Joh, T., Hibi, T., Suzuki, H.
  • Journal Title: J. Gastroenterol. Hepatol. Volume: 31 Issue: 2 Pages: 334-341
  • DOI: 10.1111/jgh.13074
  • Peer Reviewed / Open Access
• [Journal Article] Emerging treatments in neurogastroenterology: Acotiamade, a novel treatment option for functional dyspepsia (2016)
  • Author(s): Matsushita M., Masaoka T., Suzuki H.
  • Journal Title: Neurogastroenterol Motil. Volume: 28 Issue: 5 Pages: 631-8
  • DOI: 10.1111/nmo.12756
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effects of carbon dioxide insufflation in balloon-assisted enteroscopy: A systematic review and meta-analysis (2016)
  • Author(s): Nishizawa, T., Suzuki, H., Fujimoto, A., Ochiai, Y., Kanai, T., Yahagi, N.
  • Journal Title: United European Gastroenterology Journal Volume: 4 Issue: 1 Pages: 11-17
  • DOI: 10.1177/2050640615588024
  • Peer Reviewed / Open Access
• [Journal Article] Effects of preoperative proton pump inhibitor administration on bleeding after gastric endoscopic submucosal dissection: A systematic review and meta-analysis. (2016)
  • Author(s): Nishizawa, T., Suzuki, H.*, Akimoto, T., Maehata, T., Kanai, T., Morizane, T., Yahagi, N.
  • Journal Title: United European Gastroenterology Journal Volume: 4 Issue: 1 Pages: 5-10
  • DOI: 10.1177/2050640615588023
  • Peer Reviewed / Open Access
• [Journal Article] Safety and benefits of self-expandable metallic stents with chemotherapy for malignant gastric outlet obstruction. (2015)
  • Author(s): Miyabe K, Hayashi K, Nakazawa T, Sano H, Yamada T, Takada H, Naitoh I, Shimizu S, Kondo H, Nishi Y, Yoshida M, Umemura S, Hori Y, Kato A, Ohara H, Joh T.
  • Journal Title: Digestive Endoscopy Volume: 27 Issue: 1 Pages: 572-81
  • DOI: 10.1159/000440741
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Efficacy of 10-day and 14-day triple therapy as a third-line and fourth-line regimen for Helicobacter pylori eradication: a pilot study. (2015)
  • Author(s): Mori, H., Suzuki, H.*, Matsuzaki, J., Tsugawa, H., Fukuhara, S., Miyoshi, S., Hirata, K., Seino, T., Matsushita, M., Nishizawa, T., Masaoka, T., Kanai, T.
  • Journal Title: United European Gastroenterology Journal Volume: - Issue: 3 Pages: 380-387
  • DOI: 10.1177/2050640615618043
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Efficacy of 10-day Sitafloxacin-containing third-line rescue therapies for Helicobacter pylori strains containing the gyrA mutation (2015)
  • Author(s): Mori H., Suzuki H., Matsuzaki J., Tsugawa H., Fukuhara S., Miyoshi S., Hirata K., Seino T., Matsushita M., Masaoka T., Kanai T.
  • Journal Title: Helicobacter Volume: 27 Issue: 4 Pages: 286-94
  • DOI: 10.1111/hel.12286
  • Peer Reviewed / Open Access
• [Journal Article] First-line eradication for Helicobacter pylori-positive gastritis by esomeprazole-based triple therapy is influenced by CYP2C19 genotype. (2015)
  • Author(s): Saito Y, Serizawa H, Kato Y, Nakano M, Nakamura M, Saito H, Suzuki H, Kanai T.
  • Journal Title: World J. Gastroenterol. Volume: 21 Issue: 48 Pages: 13548-54
  • DOI: 10.3748/wjg.v21.i48.13548
  • Peer Reviewed / Open Access
• [Journal Article] BH3-only protein Bim is associated with the degree of Helicobacter pylori-induced gastritis and is localized to the mitochondria of inflammatory cells in the gastric mucosa (2015)
  • Author(s): Akazawa Y., Matsuda K., Isomoto H., Matsushima K., Kido Y., Urabe S., Yamaghchi N., Ohnita K., Takeshima F., Kondo H., Tsugawa H., Suzuki H., Moss J., Nakao K., Nakashima M.
  • Journal Title: Int. J. Med. Microbiol. Volume: 305 Issue: 6 Pages: 553-562
  • DOI: 10.1016/j.ijmm.2015.07.002
  • Peer Reviewed / Open Access
• [Journal Article] Association of Visceral Fat Area, Smoking, and Alcohol Consumption with Reflux Esophagitis and Barrett's Esophagus in Japan. (2015)
  • Author(s): Matsuzaki J, Suzuki H, Kobayakawa M, Inadomi JM, Takayama M, Makino K, Iwao Y, Sugino Y, Kanai T
  • Journal Title: PLoS One. Volume: 10 Issue: 7 Pages: 1-15
  • DOI: 10.1371/journal.pone.0133865
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] New Endoscopic Suturing Method:slip knot clip suturing. (2015)
  • Author(s): Nishizawa, T., Uraoka, T., Suzuki, H., Goto, O., Ochiai, Y., Fujimoto, A., Maehata, T., Kanai, T., Yahagi, N.
  • Journal Title: Gastrointest. Endosc. Volume: 82 Issue: 3 Pages: 570-571
  • DOI: 10.1016/j.gie.2015.04.012
  • Peer Reviewed / Open Access
• [Journal Article] Nordihydroguaiaretic acid disrupts the antioxidant ability of Helicobacter pylori through the repression of SodB activity in vitro. (2015)
  • Author(s): Tsugawa, H., Mori, H., Matsuzaki, J., Masaoka, T., Hirayama, T., Nagasawa, H., Sakakibara, Y., Suematsu, M., Suzuki, H.
  • Journal Title: Biomed. Res. Int. Volume: 2015 Pages: 734548-734548
  • DOI: 10.1155/2015/734548
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The “two-sword fencing” technique in endoscopic submucosal dissection. (2015)
  • Author(s): Nishizawa, T., Uraoka, T., Ochiai, Y., Suzuki, H., Goto, O., Fujimoto, A., Maehata, T., Kanai, T., Yahagi, N.
  • Journal Title: Clin. Endosc. Volume: 48 Issue: 1 Pages: 85-86
  • DOI: 10.5946/ce.2015.48.1.85
  • Peer Reviewed / Open Access
• [Journal Article] Survey of clinical practice for irritable bowel syndrome in East asian countries. (2015)
  • Author(s): Fukudo S, Hahm KB, Zhu Q, Sollano JD, Rani AA, Syam AF, Kachintorn U, Suzuki H, Kamiya T, Joh T, Uchiyama K, Naito Y, Takahashi S, Kinoshita Y, Ueno F, Yamagami H, Chan FK, Fock KM, Arakawa T; International Gastrointestinal Consensus Symposium Study Group.
  • Journal Title: Digestion Volume: 91 Issue: 1 Pages: 99-109
  • DOI: 10.1159/000369078
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Clarithromycin versus metronidazole as first-line Helicobacter pylori eradication: A multicenter, prospective, randomized controlled study in Japan. (2015)
  • Author(s): Nishizawa, T., Maekawa, T., Watanabe, N., Harada, N., Hosoda, Y., Yoshinaga, M., Yoshio, T., Ohta, H., Inoue, S., Toyokawa, T., Yamashita, H., Saito, H., Kuwai, T., Katayama, S., Masuda, E., Miyabayashi, H., Kimura, T., Nishizawa, Y., Takahashi, M., Suzuki, H.
  • Journal Title: J. Clin. Gastroenterol. Volume: 49 Issue: 6 Pages: 468-71
  • DOI: 10.1097/mcg.0000000000000165
  • Peer Reviewed / Open Access
• [Journal Article] Timing of oral refeeding in acute pancreatitis: A systematic review and meta-analysis. (2015)
  • Author(s): Horibe, M., Nishizawa, T., Suzuki, H., Minami, K., Yahagi, N., Iwasaki, E., Kanai, K.
  • Journal Title: United European Gastroenterology Journal Volume: - Issue: 6 Pages: 725-732
  • DOI: 10.1177/2050640615612368
  • Peer Reviewed / Open Access
• [Journal Article] Helicobacter pylori: Helicobacter pylori gastritis-a novel distinct disease entity. (2015)
  • Author(s): Suzuki, H.*, Mori, H.
  • Journal Title: Nature Rev. Gastroenterol. Hepatol. Volume: 12 Issue: 10 Pages: 556-557
  • DOI: 10.1038/nrgastro.2015.158
  • Peer Reviewed / Open Access
• [Journal Article] Role of microRNAs-221/222 in digestive systems. (2015)
  • Author(s): Matsuzaki, J., Suzuki, H.
  • Journal Title: J. Clin. Med. Volume: 4 Issue: 8 Pages: 1566-1577
  • DOI: 10.3390/jcm4081566
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Editorial: Helicobacter pylori and pathogenesis. (2015)
  • Author(s): Tomoda, A., Kamiya, S., Suzuki, H.
  • Journal Title: BioMed. Res. Int. Volume: 304768 Pages: 2-2
  • DOI: 10.1155/2015/304768
  • Peer Reviewed / Open Access
• [Journal Article] Letter: Prompt endoscopy in Asians with uninvestigated dyspepsia - authors' reply. (2015)
  • Author(s): Chen, S.L., Gwee, K.A., Lee, J.S., Miwa, H., Suzuki, H., Guo, P., Hao, Y.T., Chen, M.H.
  • Journal Title: Aliment. Pharm. Ther. Volume: 41 Issue: 8 Pages: 793-793
  • DOI: 10.1111/apt.13131
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Proton pump inhibitor alone vs proton pump inhibitor plus mucosal protective agents for endoscopic submucosal dissection-induced ulcer: a systematic review and meta-analysis (2015)
  • Author(s): Nishizawa, T., Suzuki, H.*, Kanai, T., Yahagi, N.
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 56 Issue: 2 Pages: 85-90
  • DOI: 10.3164/jcbn.14-101
  • NAID: 130004879373
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed / Open Access
• [Journal Article] Evidence-based clinical practice guidelines for functional dyspepsia. (2015)
  • Author(s): Miwa H, Kusano M, Arisawa T, Oshima T, Kato M, Joh T, Suzuki H, Tominaga K, Nakada K, Nagahara A, Futagami S, Manabe N, Inui A, Haruma K, Higuchi K, Yakabi K, Hongo M, Uemura N, Kinoshita Y, Sugano K, Shimosegawa T
  • Journal Title: J Gastroenterol Volume: 50 Issue: 2 Pages: 125-39
  • DOI: 10.1007/s00535-014-1022-3
  • Peer Reviewed / Open Access
• [Journal Article] Reply to letter: "Dexmedetomidine vs midazolam for gastrointestinal endoscopy". (2015)
  • Author(s): Nishizawa T, Suzuki H.
  • Journal Title: Digest. Endosc. Volume: 27 Issue: 4 Pages: 533-533
  • DOI: 10.1111/den.12459
  • Peer Reviewed / Open Access
• [Journal Article] Systematic review with meta-analysis: prompt endoscopy as the initial management strategy for uninvestigated dyspepsia in Asia. (2015)
  • Author(s): Chen, S.L., Gwee, K.A., Lee, J.S., Miwa, H., Suzuki, H., Guo, P., Hao, Y.T., Chen, M.H.
  • Journal Title: Aliment. Pharm. Ther. Volume: 41 Issue: 3 Pages: 239-252
  • DOI: 10.1111/apt.13028
  • Peer Reviewed / Open Access
• [Journal Article] Gastric carcinogenesis and underlying molecular mechanisms: Helicobacter pylori and novel targeted therapy. (2015)
  • Author(s): Nishizawa, T., Suzuki, H.
  • Journal Title: Biomed. Res. Int. Volume: 2015 Pages: 794378-794378
  • DOI: 10.1155/2015/794378
  • Peer Reviewed / Open Access
• [Journal Article] Second-look endoscopy after endoscopic submucosal dissection for gastric neoplasms: A systematic review. (2015)
  • Author(s): Nishizawa, T., Suzuki, H., Kinoshita, S., Goto, O., Kanai, T., Yahagi, N.
  • Journal Title: Digest. Endosc. Volume: 27 Issue: 3 Pages: 279-284
  • DOI: 10.1111/den.12410
  • Peer Reviewed / Open Access
• [Journal Article] Dexmedetomidine versus midazolam for gastrointestinal endoscopy: A meta-analysis. (2015)
  • Author(s): Nishizawa T, Suzuki, H., Sagara S, Kanai T, Yahagi N.
  • Journal Title: Digest. Endosc. Volume: 27 Issue: 1 Pages: 8-15
  • DOI: 10.1111/den.12399
  • NAID: 130005110111
  • Peer Reviewed / Open Access
• [Journal Article] Obscure Gastrointestinal Bleeding: Resection of a Pyogenic Granuloma of the Ileum via Double-balloon Enteroscopy. (2014)
  • Author(s): Hirata, K., Hosoe, N., Imaeda, H., Naganuma, M., Murata, H., Ueno, M., Suzuki, H., Ogata, H., Kanai, T.
  • Journal Title: Clin. J. Gastroenterol. Volume: 7 Pages: 397-401
  • Peer Reviewed / Open Access
• [Journal Article] Surveillance using trimodal imaging endoscopy after endoscopic submucosal dissection for superficial gastric neoplasia. (2014)
  • Author(s): Imaeda H, Hosoe N, Kashiwagi K, Ida Y, Nakamura R, Suzuki H, Saito Y, Yahagi N, Iwao Y, Kitagawa Y, Hibi T, Ogata H, Kanai T.
  • Journal Title: World Journal of Gastroenterology Volume: 20(43) Issue: 43 Pages: 16311-7
  • DOI: 10.3748/wjg.v20.i43.16311
  • Peer Reviewed / Open Access
• [Journal Article] Musosal expression of aquaporin-4 in the stomach of histamine type 2 receptor knockout mice and Helicobacter pylori-infected mice. (2014)
  • Author(s): Fukuhara, S., Matsuzaki, J., Tsugawa, H., Masaoka, T., Miyoshi, S., Mori, H., Fukushima, Y., Yasui, M., Kanai, T., Suzuki, H.
  • Journal Title: J. Gastroenterol. Hepatol. Volume: 29 Issue: S4 Pages: 53-59
  • DOI: 10.1111/jgh.12771
  • Peer Reviewed / Open Access
• [Journal Article] Alteration of angiogenesis in Helicobacter-heilmannii-induced MALT lymphoma: interaction with c-Met and HGF. (2014)
  • Author(s): Nakamura, M., Takahashi, T., Matsui, H., Baniwa, Y., Takahashi, S., Murayama, S.Y., Serizawa, H., Suzuki, H., Hibi, T.
  • Journal Title: J. Gastroenterol. Hepatol. Volume: 29 Issue: S4 Pages: 70-76
  • DOI: 10.1111/jgh.12776
  • Peer Reviewed / Open Access
• [Journal Article] Clarithromycin versus metronidazole as first-line Helicobacter pylori eradication: A multicenter, prospective, randomized controlled study in Japan. (2014)
  • Author(s): Nishizawa, T., Maekawa, T., Watanabe, N., Harada, N., Hosoda, Y., Yoshinaga, M., Yoshio, T., Ohta, H., Inoue, S., Toyokawa, T., Yamashita, H., Saito, H., Kuwai, T., Katayama, S., Masuda, E., Miyabayashi, H., Kimura, T., Nishizawa, Y., Takahashi, M., Suzuki, H.
  • Journal Title: J. Clin. Gastroenterol. Volume: Epub
  • Peer Reviewed / Open Access
• [Journal Article] Randomised clinical trial : rikkunshito in the treatment of functional dyspepsia–a multi-centre, double-blind, randomised, placebo-controlled study (2014)
  • Author(s): Suzuki, H., Matsuzaki, J., Fukushima, Y., Suzaki, F., Kasugai, K., Nishizawa, T., Naito, Y., Hayakawa, T., Kamiya, T., Andoh, T., Yoshida, H., Tokura, Y., Nagata, H., Kobayakawa, M., Mori, M., Kato, K., Hosoda, H., Takabayashi, T., Miura, S., Uemura, N., Joh, T., Hibi, T., Tack, J.
  • Journal Title: Neurogastr oenterol. Motil. Volume: (Epub) Issue: 7 Pages: 950-961
  • DOI: 10.1111/nmo.12348
  • Peer Reviewed / Open Access
• [Journal Article] Control of tip deflection by right pinkie shaft grip: right pinkie maneuver. (2014)
  • Author(s): Nishizawa, T., Uraoka, T., Suzuki, H., Ochiai, Y., Goto, O., Fujimoto, A., Maehata, T., Kanai, T., Yahagi, N.
  • Journal Title: Gastrointest. Endosc. Volume: 80 Issue: 6 Pages: 1208-1208
  • DOI: 10.1016/j.gie.2014.08.016
  • Peer Reviewed / Open Access
• [Journal Article] Control of the treatment device for endoscope by left hand: two fingers method. (2014)
  • Author(s): Nishizawa, T., Uraoka, T., Suzuki, H., Kinoshita, S., Ochiai, Y., Goto, O., Fujimoto, A., Kanai, T., Yahagi, N.
  • Journal Title: Gastrointest. Endosc. Volume: 80 Issue: 6 Pages: 1206-1207
  • DOI: 10.1016/j.gie.2014.07.063
  • Peer Reviewed / Open Access
• [Journal Article] Greater loss of productivity among Japanese workers with gastroesophageal reflux disease (GERD) symptoms that persist vs resolve on medical therapy. (2014)
  • Author(s): Suzuki, H., Matsuzaki, J., Masaoka, T., Inadomi, J.M.
  • Journal Title: Neurogastroenterol. Motil. Volume: - Issue: 6 Pages: 764-771
  • DOI: 10.1111/nmo.12319
  • Peer Reviewed / Open Access
• [Journal Article] Ameliorative effect of mepenzolate bromide against pulmonary fibrosis. (2014)
  • Author(s): Kurotsu, S., Tanaka, K., Niino, T., Asano, T., Sugizaki, T., Azuma, A., Suzuki, H., Mizushima, T.
  • Journal Title: J. Pharmacol. Exp. Ther. Volume: 350 Issue: 1 Pages: 79-88
  • DOI: 10.1124/jpet.114.213009
  • Peer Reviewed / Open Access
• [Journal Article] Superiority of pulmonary administration of mepenzolate bromide over of her routes as treatment for chronic obstructive pulmonary disease (2014)
  • Author(s): Tanaka K., et al.
  • Journal Title: Sci Rep. Volume: 4 Issue: 1 Pages: 1-11
  • DOI: 10.1038/srep04510
  • Peer Reviewed / Open Access
• [Journal Article] A questionnaire-based survey on the diagnosis and management of inflammatory bowel disease in East Asian countries in 2012. (2014)
  • Author(s): Hida, N., Nakamura, S., Hahm, K-B., Sollano, J.D., Zhu, Q., Rani, A.A., Syam, A.F., Kachintorn, U., Ueno, F., Joh, T., Naito, Y., Suzuki, H., Takahashi, S., Fukudo, S., Fujiwara, Y., Kinoshita, Y., Uchiyama, K., Yamaguchi, Y., Yoshida, A., Arakawa, T., Matsumoto, T., The IGICS Study Group.
  • Journal Title: Digestion Volume: 89(1) Issue: 1 Pages: 88-103
  • DOI: 10.1159/000356706
  • Peer Reviewed / Open Access
• [Journal Article] New pharmaceutical treatment of gastric MALT lymphoma: anti-angiogenesis treatment using VEGF receptor antibodies and celecoxib. (2014)
  • Author(s): Nakamura, M., Takahashi, T., Matsui, H., Takahashi, S., Murayama, SY., Suzuki, H., Tsuchimoto, K.
  • Journal Title: Curr. Pharm. Des. Volume: 20 Pages: 1097-1103
  • Peer Reviewed / Open Access
• [Journal Article] Effect of supplementation with rebamipide for Helicobacter pylori eradication therapy: a systematic review and meta-analysis. (2014)
  • Author(s): Nishizawa, T., Nishizawa, Y., Yahagi, N., Kanai, T., Takahashi, M., Suzuki, H.
  • Journal Title: J. Gastroenterol. Hepatol. Volume: 29 Issue: S4 Pages: 20-24
  • DOI: 10.1111/jgh.12769
  • Peer Reviewed / Open Access
• [Journal Article] Mechanisms of Helicobacter pylori antibiotic resistance and molecular testing. (2014)
  • Author(s): Nishizawa, T., Suzuki, H.
  • Journal Title: Front. Mol. Biosci. Volume: 1 Pages: 19-19
  • DOI: 10.3389/fmolb.2014.00019
  • Peer Reviewed / Open Access
• [Journal Article] Propofol vs traditional sedative agents for endoscopic submucosal dissection: A systematic review. (2014)
  • Author(s): Nishizawa, T., Suzuki, H., Matsuzaki, J., Kanai, T., Yahagi, N.
  • Journal Title: Digest. Endosc. Volume: 26 Issue: 6 Pages: 701-706
  • DOI: 10.1111/den.12342
  • Peer Reviewed / Open Access
• [Journal Article] Does the AIMS65, a new risk score for upper gastrointestinal bleeding, work in Japan? (2014)
  • Author(s): Masaoka, T., Suzuki, H.
  • Journal Title: Digest. Endosc. Volume: 26 Issue: 3 Pages: 331-332
  • DOI: 10.1111/den.12224
  • Peer Reviewed / Open Access
• [Journal Article] Does bile reflux influence the progression of Barrett's esophagus to adenocarcinoma? (2014)
  • Author(s): Masaoka, T., Suzuki, H.
  • Journal Title: J. Neurogastroenterol. Motil. Volume: 20(1) Issue: 1 Pages: 124-126
  • DOI: 10.5056/jnm.2014.20.1.124
  • Peer Reviewed / Open Access
• [Journal Article] MicroRNAs in Barrett’s esophagus: Future prospects. (2014)
  • Author(s): Matsuzaki, J., Suzuki, H.
  • Journal Title: Front. Genet. Volume: 5 Pages: 69-69
  • DOI: 10.3389/fgene.2014.00069
  • Peer Reviewed / Open Access
• [Journal Article] New pharmaceutical treatment of gastric MALT lymphoma: anti-angiogenesis treatment using VEGF receptor antibodies and celecoxib. (2014)
  • Author(s): Nakamura, M., Takahashi, T., Matsui, H., Takahashi, S., Murayama, SY.,Suzuki, H., Tsuchimoto, K.
  • Journal Title: Curr. Pharm. Des. Volume: 20(7) Pages: 1097-103
  • Peer Reviewed
• [Journal Article] World’s first telepathology experiments employing ultra-high-speed internet satellite, nickenemaed “KIZUNA”. (2013)
  • Author(s): Sawai T, Uzuki M, Miura Y, Kamataki A, Matsumura T, Saito K, Kurose A, Osamura YR, Yoshimi N, Kanno H, Moriya T, Ishida Y, Satoh Y, Nakao M, Ogawa E, Matsuo S, Kasai H, Kumagai K, Motoda T, Hopson N
  • Journal Title: J Pathol Inform Volume: 4 Issue: 1 Pages: 24-24
  • DOI: 10.4103/2153-3539.119002
  • Peer Reviewed / Open Access
• [Journal Article] Effect of ursodeoxycholic acid and endoscopic sphincterotomy in long-term stenting for common bile duct stones. (2013)
  • Author(s): Toshihiro Nishizawa
  • Journal Title: J. Gastroenterol. Hepatol. Volume: 28 Issue: 1 Pages: 63-7
  • DOI: 10.1111/jgh.12012
  • Peer Reviewed
• [Journal Article] Helicobacter pyloriinfection in functional dyspepsia. (2013)
  • Author(s): Suzuki, H., Moayyedi, P.
  • Journal Title: Nat. Rev. Gastroenterol. Hepatol. Volume: 10(3) Issue: 3 Pages: 168-74
  • DOI: 10.1038/nrgastro.2013.9
  • Peer Reviewed
• [Journal Article] Improvement of reflux symptom related quality of life after <i>Helicobacter pylori</i> eradication therapy (2013)
  • Author(s): Kenro Hirata
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 52 Issue: 2 Pages: 172-178
  • DOI: 10.3164/jcbn.12-107
  • NAID: 130004466704
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed
• [Journal Article] Musashi-1 post-transcriptionally enhances phosphotyrosine-binding domain- containing m-Numb protein expression in regenerating gastric mucosa. (2013)
  • Author(s): Tetsufumi Takahashi
  • Journal Title: PLoS One Volume: 8 Issue: 1 Pages: 1-13
  • DOI: 10.1371/journal.pone.0053540
  • Peer Reviewed
• [Journal Article] Impaired heme oxygenase-1 induction in the gastric antrum induces disruption of the interstitial cells of Cajal network in a rat model of streptozotocin-induced diabetes. (2013)
  • Author(s): Sachiko Mogami
  • Journal Title: Neurogastroenterol. Motil. Volume: in press Issue: 7 Pages: 609-609
  • DOI: 10.1111/nmo.12122
  • Peer Reviewed
• [Journal Article] Validation of the GerdQ questionnaire for the management of gastro-oesophageal reflux disease in Japan (2013)
  • Author(s): Suzuki H, Matsuzaki J, Okada S, et al.
  • Journal Title: United European Gastroenterology Journal Volume: (印刷中) Issue: 3 Pages: 175-183
  • DOI: 10.1177/2050640613485238
  • Peer Reviewed
• [Journal Article] Progressive liver failure induced by everolimus for renal cell carcinoma in a 58-year-old male hepatitis B virus carrier. (2013)
  • Author(s): Mizuno, S., Yamagishi, Y., Ebinuma, H., Nakamoto, N., Katahira, M., Sasaki, A., Sakamoto, M., Suzuki, H., Kanai, T., Hibi, T.
  • Journal Title: Clin. J. Gastroenterol. Volume: 6(2) Pages: 188-192
  • Peer Reviewed
• [Journal Article] The role of microRNAin gastric malignancy. (2013)
  • Author(s): Nishizawa, T., Suzuki, H
  • Journal Title: Int. J. Mol. Sci. Volume: 14(5) Issue: 5 Pages: 9487-9496
  • DOI: 10.3390/ijms14059487
  • Peer Reviewed
• [Journal Article] Delay of second-line eradication therapy for H. pylori can increase eradication failure. (2013)
  • Author(s): Nishizawa, T., Suzuki, H., Takahashi, M., Suzuki, M., Hibi, T.
  • Journal Title: J. Gastroenterol. Hepatol. Volume: 28(10) Issue: 10 Pages: 1608-1610
  • DOI: 10.1111/jgh.12281
  • Peer Reviewed
• [Journal Article] Trends of second-line eradication therapy for Helicobacter pylori in Japan: A Multicenter Study in the Tokyo Metropolitan Area. (2013)
  • Author(s): Asaoka, D., Nagahara, A., Matsuhisa, T., Takahashi, S., Tokunaga, K., Kawai, T., Suzuki, H., Suzuki, M., Nishizawa, T., Kurihara, N., Ito, M., Sasaki, H., Omata, F., Mizuno, S., Torii, A., Ohkusa, T., Mine, T., Sakaki, N.
  • Journal Title: Helicobacter Volume: 18(6) Issue: 6 Pages: 468-472
  • DOI: 10.1111/hel.12063
  • Peer Reviewed
• [Journal Article] CD44 variant 9 expression in primary early gastric cancer as a predictive marker for recurrence. (2013)
  • Author(s): Hirata K, Suzuki H, Imaeda H, Matsuzaki J, Tsugawa H, Nagano O, Asakura K, Saya H, Hibi T
  • Journal Title: Br J Cancer Volume: 109 Issue: 2 Pages: 379-386
  • DOI: 10.1038/bjc.2013.314
  • Peer Reviewed
• [Journal Article] Do we need to eradicate H. pylori in patients with GORD? (2013)
  • Author(s): Masaoka, T., Suzuki, H.
  • Journal Title: ueg journal Volume: 1(4) Issue: 4 Pages: 223-225
  • DOI: 10.1177/2050640613497713
  • Peer Reviewed
• [Journal Article] Bile Acids Increase Levels of microRNAs 221 and 222, Leading to Degradation of CDX2 During Esophageal Carcinogenesis (2013)
  • Author(s): J. Matsuzaki, H. Suzuki, H. Tsugawa, M. Watanabe, S. Hossain, T. Akaike, T. Hibi, et. al.
  • Journal Title: Gastroenterology Volume: (In Press) Issue: 6 Pages: 1300-1311
  • DOI: 10.1053/j.gastro.2013.08.008
  • Peer Reviewed
• [Journal Article] Mepenzolate bromide displays beneficial effects in a mouse model of chronic obstructive pulmonary disease. (2013)
  • Author(s): Tanaka K., et al.
  • Journal Title: Nat Commun. Volume: 4 Issue: 1 Pages: 1-13
  • DOI: 10.1038/ncomms3686
  • Peer Reviewed
• [Journal Article] Effect of lansoprazole on the epigastric symptoms of functional dyspepsia (ELF study) : a multicenter, prospective, randomized, double-blind, placebo-controlled clinical trial (2013)
  • Author(s): Suzuki, H., Kusunoki, H., Kamiya, T., Futagami, S., Yamaguchi, Y., Nishizawa, T., Iwasaki, E., Matsuzaki, J., Takahashi, S., Sakamoto, C., Haruma, K., Joh, T., Asakura, K., Hibi, T.
  • Journal Title: ueg journal Volume: 1(6) Issue: 6 Pages: 445-452
  • DOI: 10.1177/2050640613510904
  • Peer Reviewed
• [Journal Article] Endoscopic microvascular patterns of gastrointestinal cancer. (2013)
  • Author(s): Nishizawa, T., Suzuki, H.
  • Journal Title: Microvasc. Rev. Commun. Volume: 6(1) Pages: 9-12
  • NAID: 130004467816
  • Peer Reviewed
• [Journal Article] Biliary Findings Assist in Predicting Enlargement of Intraductal Papillary Mucinous Neoplasms of the Pancreas (2012)
  • Author(s): Matsuzaki J, Suzuki H, Okuda S, et al.
  • Journal Title: Clininal Gastroenterology and Hepatology Volume: (印刷中) Issue: 5 Pages: 548-554
  • DOI: 10.1016/j.cgh.2012.11.027
  • Peer Reviewed
• [Presentation] 胃発がんに関わるピロリ菌感染宿主細胞のオートファジー発現調節機構 (2016)
  • Author(s): 津川仁、森英毅、三好佐和子、柏崎有紀、松崎潤太郎、佐藤聡、井本正哉、末松誠、鈴木秀和
  • Organizer: 第88回日本胃癌学会総会
  • Place of Presentation: 別府国際コンベンションセンター（大分県別府市）
  • Year and Date: 2016-03-19
• [Presentation] Repression of autophagy in gastric epithelial cells infected with H. pylori induces CD44 expression through the accumulation of CagA oncoprotein. (2015)
  • Author(s): Tsugawa H., Kashiwazaki Y., Mori H., Matsuzaki J., Masaoka T., Suematsu M., Suzuki H.
  • Organizer: 10th World Congress for Microcirculation
  • Place of Presentation: 国立京都国際会館（京都府京都市）
  • Year and Date: 2015-09-25
  • Int'l Joint Research
• [Presentation] CD44発現に繋がるピロリ菌感染宿主細胞キャラクター (2015)
  • Author(s): 津川仁、柏崎有紀、森英毅、松崎潤太郎、佐藤聡、金井弥栄、井本正哉、末松誠、鈴木秀和
  • Organizer: 第21回日本ヘリコバクター学会
  • Place of Presentation: 神戸ポートピアホテル（兵庫県神戸市）
  • Year and Date: 2015-06-26
• [Presentation] CagA蓄積性オートファジー不全胃癌細胞にH. pylori感染が与える影響 (2015)
  • Author(s): 森英毅、津川仁、松崎潤太郎、岩崎栄典、西澤俊宏、正岡建洋、金井隆典、鈴木秀和
  • Organizer: 第43回日本潰瘍学会
  • Place of Presentation: 沖縄科学技術大学院大学（沖縄県恩納村）
  • Year and Date: 2015-06-19
• [Presentation] Overexpression of CD44v9 in gastric cancer cells confers resistance to trastuzumab by inducing antioxidant enzymes that inhibit tumor cell death induced by oxidative stress (2015)
  • Author(s): Hideki Mori, Hidekazu Suzuki, Juntaro Matsuzaki, Hitoshi Tsugawa, Sawako Miyoshi, Tatsuhiro Masaoka, Takanori Kanai
  • Organizer: Digestive Disease Week 2015
  • Place of Presentation: ワシントンDC(米国）
  • Year and Date: 2015-05-17
  • Int'l Joint Research
• [Presentation] 酸化ストレス抵抗性胃がん幹胞におけるTrastuzumab耐性メカニズムの解明 (2015)
  • Author(s): 森英毅、津川仁、鈴木秀和
  • Organizer: 第101回日本消化器病学会総会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2015-04-23
• [Presentation] オートファジー不全胃癌細胞株に対してH. pylori感染が与える影響の検討 (2015)
  • Author(s): 森英毅、津川仁、鈴木秀和
  • Organizer: 第101回日本消化器病学会総会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2015-04-23
• [Presentation] Major publications in FGID and Neurogastroenterology from the West. (2015)
  • Author(s): Suzuki, H.
  • Organizer: The 4th Biennial Congress of the Asian Neurogastroenterology and Motility Association (ANMA)
  • Place of Presentation: Gurgaon, Delhi, India
  • Year and Date: 2015-02-08
  • Invited
• [Presentation] HER2陽性胃癌における酸化ストレス抵抗性がん幹細胞によるTrastuzumab耐性の獲得機構 (2014)
  • Author(s): 森英毅、津川仁、鈴木秀和
  • Organizer: JDDW 2014 （日本消化器関連学会週間 2014）
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
  • Year and Date: 2014-10-23
• [Presentation] Enhanced migration and proliferation in CD44v9-expressing cancer stem-like cells with H. pylori infection. (2014)
  • Author(s): Mori, H., Miyoshi, S., Tsugawa, H., Matsuzaki, J., Fukuhara, S., Masaoka, T., Kanai, T., Suzuki, H.
  • Organizer: European Helicobacter Study Group：XXVIIth International Workshop on Helicobacter & Microbiota in Inflammation & Cancer
  • Place of Presentation: Rome, Italy
  • Year and Date: 2014-09-13
• [Presentation] 胃食道逆流症(GERD)－病態・症状、診断、労働生産性から. (2014)
  • Author(s): 鈴木秀和
  • Organizer: 第56回日本平滑筋学会総会
  • Place of Presentation: 新横浜プリンスホテル（神奈川県横浜市）
  • Year and Date: 2014-08-07
  • Invited
• [Presentation] 生まれ変わる慢性胃炎の診療法～ガイドラインに基づく診療法について～ (2014)
  • Author(s): 鈴木秀和
  • Organizer: 第87回日本消化器内視鏡学会総会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）
  • Year and Date: 2014-05-16
  • Invited
• [Presentation] Efficacy and safety of rikkunshito, a Japanese herbal medicine, on the treatment of functional dyspepsia: a multi-center, double-blind, randomized, placebo-controlled study. (2014)
  • Author(s): Suzuki, H., Matsuzaki, J., Fukushima, Y., Suzaki, F., Kasugai, K., Nishizawa, T., Naito, Y., Hayakawa, T., Kamiya, T., Ando, T., Yoshida, H., Tokura, Y., Nagata, H., Kobayakawa, M., Mori, M., Kato, K., Hosoda, H., Takebayashi, T., Miura, S., Uemura, N., Joh, T., Hibi, T., Tack, J.
  • Organizer: Digestive Disease Week 2014
  • Place of Presentation: Chicago, U.S.A.
  • Year and Date: 2014-05-03
• [Presentation] CD44v9 results in resistance to trastuzumab via induction of ROS resistance (2014)
  • Author(s): Mori, H., Suzuki, H., Matsuzaki, J., Tsugawa, H., Fukuhara, S., Miyoshi, S., Masaoka, T., Kanai, T., Saya, H.
  • Organizer: Digestive Disease Week 2014
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-05-03
• [Presentation] 機能性ディスペプシア（FD）に対する六君子湯の有効性（多施設共同二重盲検無作為化プラセボ対照比較試験) (2014)
  • Author(s): 鈴木秀和、松崎潤太郎、福嶋康之
  • Organizer: 第100回日本消化器病学会総会
  • Place of Presentation: 東京国際フォーラム（東京都千代田区）
  • Year and Date: 2014-04-23
• [Presentation] Bile Acids Enhance Oncogenic miR-221/222 in the Transformation From Barrett’s Esphagus to Adenocarcinoma. (2013)
  • Author(s): Matsuzaki, J., Suzuki, H., Tsugawa, H., Saito, Y., Hossain, S., Arai, E., Sekine, S., Kanai, Y., Watanabe, M., Akaike, T., Mukaisho, K., Auwerx, J., Hibi, Y.
  • Organizer: Digestive Disease Week 2013
  • Place of Presentation: Orlando
• [Presentation] Expression of CD44 Variant 9 Contributes to 5-Fluorouracil Resistance in Gastric Cancer Trough Anti-Oxidative Stress Mechanism.
  • Author(s): Okada, S., Suzuki, H., Masaoka, T., Tsugawa, H., Matsuzaki, J., Fukuhara, S., Hirata, K., Mori, H., Saya, H., Hibi, T.
  • Organizer: Digestive Disease Week 2013
  • Place of Presentation: Orlando
• [Presentation] The Loss of Work Productivity Associated with Gastroesophageal Reflux Disease (GERD) in a Japanese Working Population
  • Author(s): Suzuki, H., Matsuzaki, J., Masaoka, T., Okada, S., Inadomi, J., Hibi, T.
  • Organizer: Digestive Disease Week 2013
  • Place of Presentation: Orlando
• [Presentation] Application of 13C-acetic acid breath test for animals with impaired gastric motility
  • Author(s): Fukuhara, S., Suzuki, H., Masaoka, T., Suemasu, S., Matsuzaki, J., Tsugawa, H., Okada, S., Hirata, K., Mori, H., Saito, Y., Mizushima, T., Hibi, T.
  • Organizer: Digestive Disease Week 2013
  • Place of Presentation: Orlamdo
• [Presentation] Role of microRNA and cancer stem cells in gastric carcinogenesis
  • Author(s): Hidekazu Suzuki
  • Organizer: The XXVIth International Workshop on Helicobacter and related bacteria in chronic digestive inflammation and gastric cancer
  • Place of Presentation: Madrid
  • Invited
• [Presentation] Analysis of CagA serotypes with Helicobacter pylori multiplex serology
  • Author(s): Michel, A., Wang, S., Zhang, W., Kist, M., Figueroa, G., Dondog, B., Suzuki, H., Pawlita, M.
  • Organizer: The XXVIth International Workshop on Helicobacter and related bacteria in chronic digestive inflammation and gastric cancer
  • Place of Presentation: Madrid
• [Presentation] Trends of second-line eradication therapy for Helicobacter pylori in Japan: A Multicenter Study in the Tokyo Metropolitan Area
  • Author(s): Asaoka, D., Nagahara, A., Matsuhisa, T., Takahashi, S., Tokunaga, K., Kawai, T., Kawakami, K., Suzuki, H., Suzuki, M., Nishizawa, T., Kurihara, N., Ito, M., Sasaki, H., Omata, F., Mizuno, S., Torii, A., Ohkusa, T., Mine, T., Sakaki, N.
  • Organizer: The XXVIth International Workshop on Helicobacter and related bacteria in chronic digestive inflammation and gastric cancer
  • Place of Presentation: Madrid
• [Presentation] Influence of Helicobacter pylori on gastric carcinogenesis and functional disturbance
  • Author(s): Hidekazu Suzuki
  • Organizer: The International Joint Meeting of IBS Conference and Rome Committee in Tokyo
  • Place of Presentation: Tokyo
  • Invited
• [Presentation] Autophagy causing CagA degradation is triggered by cytoplasmic accumulation of low-density lipoprotein receptor-related protein-1 (LRP1) in gastric epithelial cells infected with H. pylori.
  • Author(s): Tsugawa, H., Matsuzaki, J., Okada, S., Fukuhara, S., Mori, H., Masaoka, T., Sato, A., Saya, H., Hatakayama, M., Hirayama, T., Suzuki, H.
  • Organizer: UEGW2013
  • Place of Presentation: Berlin
• [Presentation] H. pylori eradication for cancer prevention in clinical practice
  • Author(s): Hidekazu Suzuki
  • Organizer: UEGW2013
  • Place of Presentation: Berlin
  • Invited
• [Presentation] Involvement of stemness factors in the intestinal transdifferentiation of gastric epithelial cells
  • Author(s): Fujii, Y., Suzuki, H., Aburatani, H., Hatakayama, M.
  • Organizer: The 4th JCA-AACR Special Joint Conference
  • Place of Presentation: Urayasu
• [Presentation] CD44v9 play a role to anti-tumor effect against human gastric cancer by trastuzumab.
  • Author(s): Mori, H., Suzuki, H., Matsuzaki, J., Tsugawa, H., Fukuhara, S., Miyoshi, S., Masaoka, T., Kanai, T., Saya, H.
  • Organizer: The 4th JCA-AACR Special Joint Conference
  • Place of Presentation: Urayasu
• [Presentation] Escaped autophagy of H. pylori-derived oncoprotein CagA in gastric cancer stem-like cells
  • Author(s): Hidekazu Suzuki
  • Organizer: The 4th JCA-AACR Special Joint Conference
  • Place of Presentation: Urayasu
  • Invited
• [Presentation] High-level resistance to metronidazole for Helicobacter pylori is more prevalent in patients with postprandial distress syndrome.
  • Author(s): Matsuzaki, J., Suzuki, H., Mori, H., Tsugawa, H., Masaoka, T., Miyoshi, S., Fukuhara, S., Kanai, T.
  • Organizer: The 4th Asian Pacific Single Topic Conference
  • Place of Presentation: Tagaytay
  • Invited
• [Presentation] Impairment of apolipoprotein E evokes delayed gastric emptying through nitrergic dysfunction.
  • Author(s): Fukuhara, S., Suzuki, H., Masaoka, T., Tsugawa, H., Okada, S., Mori, H., Hirata, K., Matsuzaki, J., Iwasaki, E., Mizushima, T., Suzuki, M.
  • Organizer: The 7th International Gastrointestinal Consensus Symposium (IGICS)
  • Place of Presentation: Fukushima
• [Presentation] Expression of CD44 variant 9 contributes to 5-fluorouracil resistance in gastric cancer through anti-oxidative stress mechanism
  • Author(s): Miyoshi, S., Suzuki, H., Tsugawa, H., Masaoka, T., Matsuzaki, J., Fukuhara, S., Hirata, K., Mori, H., Kanani, T., Saya, H.
  • Organizer: 17th Biennial Meeting of Society for Free Radical Research International (SFRRI2014)
  • Place of Presentation: Kyoto
• [Presentation] The role of reactive oxygen species (ROS) in gastric carcinogenesis evoked by H. pylori infection
  • Author(s): Tsugawa, H., Suzuki, H.
  • Organizer: 17th Biennial Meeting of Society for Free Radical Research International (SFRRI2014)
  • Place of Presentation: Kyoto
• [Presentation] Helicobacter pylori感染症 -酸化ストレス関連性病態機序-
  • Author(s): 鈴木秀和
  • Organizer: 第66回日本酸化ストレス学会学術集会
  • Place of Presentation: 名古屋
  • Invited
• [Presentation] H. pyloriがん蛋白質CagAのCD44v9発現がん幹細胞特異的蓄積メカニズムの発見
  • Author(s): 津川仁、鈴木秀和、佐谷秀行、松崎潤太郎、平田賢郎、福原誠一郎、岡田佐和子、正岡建洋、畠山昌則、平山壽哉、日比紀文
  • Organizer: 第19回日本ヘリコバクター学会学術集会
  • Place of Presentation: 長崎
• [Presentation] 国民総除菌で胃がんを撲滅する。
  • Author(s): 鈴木秀和
  • Organizer: 第19回日本ヘリコバクター学会学術集会
  • Place of Presentation: 長崎
  • Invited
• [Presentation] ピロリ菌感染時の胃発がんリスクを規定するオートファジーの発現制御システム
  • Author(s): 津川仁、鈴木秀和
  • Organizer: 第72回日本癌学会学術集会
  • Place of Presentation: 横浜
• [Presentation] 食道腺がんにおけるmiR-221/222の発現動態と抗マイクロRNA治療標的としての有用性
  • Author(s): 松崎潤太郎、鈴木秀和、日比紀文
  • Organizer: 第21回日本消化器病関連学会週間(JDDW2013)
  • Place of Presentation: 東京
• [Presentation] H. pylori感染症とFD
  • Author(s): 鈴木秀和
  • Organizer: 第15回日本神経消化器病学会
  • Place of Presentation: 出雲
  • Invited
• [Presentation] ピロリ菌がん蛋白質CagAを排除する宿主応答
  • Author(s): 津川仁、鈴木秀和
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 神戸
• [Presentation] ピロリ菌感染症の診療を巡る最新知識
  • Author(s): 鈴木秀和
  • Organizer: 第42回日本総合健診医学会大会
  • Place of Presentation: 東京
  • Invited
• [Presentation] がん蛋白質CagAの細胞内安定性を規定するautophagyの発現制御システム
  • Author(s): 津川仁、鈴木秀和、森英毅、福原誠一郎、岡田佐和子、正岡建洋、佐藤聡、井本正哉、金井隆典
  • Organizer: 第10回日本消化管学会総会学術総会
  • Place of Presentation: 福島
• [Book] Helicobacter pylori (2016)
  • Author(s): Hidekazu Suzuki, Robin Warren, Barry Marshall eds.
  • Total Pages: 267
  • Publisher: Springer Japan
• [Book] 消化器疾患の最新の治療 2015-2016 (2015)
  • Author(s): 福原誠一郎, 鈴木秀和
  • Publisher: 南江堂
• [Book] eBook: OXIDATIVE STRESS AND DIETARY ANTIOXIDANTS (2014)
  • Author(s): Suzuki, H., Nishizawa, T.
  • Publisher: Academic Press
• [Book] eBook: Helicobacter pylori - A Worldwide Perspective 2014 (2014)
  • Author(s): Suzuki, H., Nishizawa, T., Hibi, T.
  • Publisher: Bentham Science Publishers
• [Book] CANCER: OXIDATIVE STRESS AND DIETARY ANTIOXIDANTS (2014)
  • Author(s): Suzuki, H., Nishizawa, T.
  • Publisher: Academic Press
• [Patent(Industrial Property Rights)] 宿主異物排除応答依存的除菌剤 (2014)
  • Inventor(s): 鈴木秀和、津川仁、榊原康文
  • Industrial Property Rights Holder: 鈴木秀和、津川仁、榊原康文
  • Industrial Property Rights Type: 特許
  • Filing Date: 2014-05-22