Pathophysiological Interplay between Liver Fibrosis, Regeneration and Hepatocarcinogenesis from the Viewpoint of Stem/progenitor Cell Differentiation

• Project/Area Number: 25293179
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Tokai University
• Principal Investigator: INAGAKI Yutaka 東海大学, 医学部, 教授 (80193548)
• Co-Investigator(Kenkyū-buntansha): 紙谷 聡英 東海大学, 医学部, 准教授 (30321904) ; 住吉 秀明 東海大学, 医学部, 講師 (60343357)
• Co-Investigator(Renkei-kenkyūsha): HOZUMI Katsuto 東海大学, 医学部, 准教授 (30246079)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000); Fiscal Year 2016: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2015: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
• Keywords: 肝前駆細胞 / 線維化 / 再生 / 発癌 / 肝線維化 / 内科 / 再生医学 / 発がん

Outline of Final Research Achievements

Liver regeneration is severely impaired and hepatocellular carcinoma (HCC) develops frequently in advanced liver fibrosis. The present study was conducted to explore the effects of Jagged1/Notch signal on the induction of hepatic progenitor cells accelerating fibrotic liver regeneration as well as the occurrence of HCC in the fibrotic liver.
Experiments using Jagged1 knockout mice indicated that Jagged1 expressed by activated hepatic stellate cells stimulates Notch2 signal in adjacent hepatocytes, resulting in their dedifferentiation into hepatic progenitor cells. These cells contribute to regeneration of the fibrotic liver. It was also revealed that the Jagged1/Notch signal suppressed the occurrence of diethylnitrosamine-induced HCC.

Research Products

• [Journal Article] Identification of a novel alpha-fetoprotein- expressing cell population induced by Jagged1/Notch2 signal in murine fibrotic liver. (2017)
  • Author(s): Yasuhiro Nakano, Sachie Nakao, Hideaki Sumiyoshi, Kenichiro Mikami, Yuri Tanno, Minako Sueoka, Daigo Kasahara, Hiroshi Kimura, Tadashi Moro, Akihide Kamiya, Katsuto Hozumi, Yutaka Inagaki
  • Journal Title: Hepatol Commun Volume: 印刷中 Issue: 3 Pages: 1-15
  • DOI: 10.1002/hep4.1026
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Adhesive and robust multi-layered poly(lactic acid) nanosheets for hemostatic dressing in liver injury model. (2017)
  • Author(s): Takuya Komachi, Hideaki Sumiyoshi, Yutaka Inagaki, Shinji Takeoka, Yu Nagase, Yosuke Okamura
  • Journal Title: J Biomed Mater Res Part B Volume: 印刷中 Issue: 7 Pages: 1-11
  • DOI: 10.1002/jbm.b.33714
  • Peer Reviewed / Open Access
• [Journal Article] 肝線維化研究は、どこに向かうのか． (2017)
  • Author(s): 稲垣 豊
  • Journal Title: 肝胆膵 Volume: 74 Pages: 7-9
• [Journal Article] Deficiency of X-linked protein kinase Nrk during pregnancy triggers breast tumor in mice (2016)
  • Author(s): Yanagawa T, Denda K, Inatani T, Fukushima T, Tanaka T, Kumaki N, Inagaki Y, Komada M
  • Journal Title: Am. J. Pathol. Volume: 186 Issue: 10 Pages: 2751-2760
  • DOI: 10.1016/j.ajpath.2016.06.005
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Foetal hepatic progenitor cells assume a cholangiocytic cell phenotype during two-dimensional pre-culture. (2016)
  • Author(s): Kazuya Anzai, Hiromi Chikada, Kota Tsuruya, Kinuyo Ida, Tatehiro Kagawa, Yutaka Inagaki, Tesuya Mine, Akihide Kamiya
  • Journal Title: Sci Rep Volume: 6 Issue: 1 Pages: 28283-28283
  • DOI: 10.1038/srep28283
  • Peer Reviewed / Open Access
• [Journal Article] Intestinal Fibrosis and Liver Fibrosis: Consequences of Chronic Inflammation or Independent Pathophysiology? (2016)
  • Author(s): Rieder F, Bettenworth D, Imai J, Inagaki Y.
  • Journal Title: Inflamm Intest Dis Volume: 印刷中 Issue: 1 Pages: 41-49
  • DOI: 10.1159/000445135
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] ミトコンドリア酸化ストレスと肝線維化． (2016)
  • Author(s): 茂呂 忠、石井恭正、稲垣 豊
  • Journal Title: 細胞 Volume: 48 Pages: 530-533
• [Journal Article] マクロファージによる肝線維症の病態形成． (2016)
  • Author(s): 柳川享世、稲垣 豊
  • Journal Title: 医学のあゆみ Volume: 259 Pages: 524-528
• [Journal Article] A combination of mitochondrial oxidative stress and excess fat/calorie intake accelerates steatohepatitis by enhancing hepatic CC chemokine production in mice. (2016)
  • Author(s): Moro T, Nakao S, Sumiyoshi H, Ishii T, Miyazawa M, Ishii N, Sato T, Iida Y, Okada Y, Tanaka M, Hayashi H, Ueha S, Matsushima K, Inagaki Y
  • Journal Title: PLoS ONE Volume: 11 Issue: 1 Pages: e0146592-e0146592
  • DOI: 10.1371/journal.pone.0146592
  • Peer Reviewed / Open Access
• [Journal Article] Local fibroblast proliferation but not influx is responsible for synovial hyperplasia in a murine model of rheumatoid arthritis. (2016)
  • Author(s): Yusuke Matsuo, Fumitaka Mizoguchi, Tetsuya Saito, Kimito Kawahata, Satoshi Ueha, Kouji Matsushima, Yutaka Inagaki, Nobuyuki Miyasaka, and Hitoshi Kohsaka
  • Journal Title: Biochem Biophys Res Commun Volume: 470 Issue: 3 Pages: 504-509
  • DOI: 10.1016/j.bbrc.2016.01.121
  • Peer Reviewed / Open Access
• [Journal Article] Heat Shock Protein 27 Plays a Pivotal Role in Myofibroblast Differentiation and in the Development of Bleomycin-Induced Pulmonary Fibrosis (2016)
  • Author(s): Park AM, Kanai K, Itoh T, Sato T, Tsukui T, Inagaki Y, Selman M, Matsushima K, Yoshie O.
  • Journal Title: Plos One Volume: 11 Issue: 2 Pages: e0148998-e0148998
  • DOI: 10.1371/journal.pone.0148998
  • Peer Reviewed / Open Access
• [Journal Article] Spatiotemporal expression of matrix metalloproteinase-1 in progression of nonalcoholic steatohepatitis. (2016)
  • Author(s): Hiroaki Yokomori, Yutaka Inagaki, Wataru Ando, Mitsuko Hara, Takako Komiyama, Soichi Kojima, Masaya Oda, Hajime Kuroda, Yutaka Suzuki, Isao Okazaki:
  • Journal Title: J Mod Human Pathol Volume: 1 Issue: 2 Pages: 11-20
  • DOI: 10.14312/2397-6845.2016-3
  • Peer Reviewed / Open Access
• [Journal Article] A paracrine mechanism accelerating expansion of human induced pluripotent stem cell-derived hepatic progenitor-like cells (2015)
  • Author(s): Kota Tsuruya, Hiromi Chikada, Kinuyo Ida, Kazuya Anzai, Tatehiro Kagawa, Yutaka Inagaki, Tetsuya Mine, and Akihide Kamiya
  • Journal Title: Stem cells and Developments Volume: null Issue: 14 Pages: 1691-1702
  • DOI: 10.1089/scd.2014.0479
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Mice overexpressing integrin αv in fibroblasts exhibit dermal thinning of the skin. (2015)
  • Author(s): Wang Z, Jinnin M, Kobayashi Y, Kudo H, Inoue K, Nakayama W, Honda N, Makino K, Kajihara I, Makino T, Fukushima S, Inagaki Y, Ihn H.
  • Journal Title: J Dermatol Sci. Volume: 79 Issue: 3 Pages: 268-278
  • DOI: 10.1016/j.jdermsci.2015.06.008
  • Peer Reviewed / Open Access
• [Journal Article] Reduced supply of monocyte-derived macrophages leads to a transition from nodular to diffuse lesions and tissue cell activation in silica-induced pulmonary fibrosis in mice. (2015)
  • Author(s): Shigeyuki Shichino, Jun Abe, Satoshi Ueha, Mikiya Otsuji, Tatsuya Tsukui, Mizuha Kosugi-Kanaya, Francis HW Shand, Shin-ichi Hashimoto, Hiroshi I. Suzuki, Teppei Morikawa, Yutaka Inagaki, and Kouji Matsushima:
  • Journal Title: Am J Pathol Volume: 185 Issue: 11 Pages: 2923-2938
  • DOI: 10.1016/j.ajpath.2015.07.013
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Intratracheal cell transfer demonstrates the profibrotic potential of resident fibroblasts in pulmonary fibrosis. (2015)
  • Author(s): TatsuyaTsukui, Satoshi Ueha, Shigeyuki Shichino, Yutaka Inagaki, and Kouji Matsushima:
  • Journal Title: Am J Pathol Volume: 185 Issue: 11 Pages: 2939-2948
  • DOI: 10.1016/j.ajpath.2015.07.022
  • Peer Reviewed
• [Journal Article] Anti-fibrotic effects of a novel small compound on the regulation of cytokine production in a mouse model of colorectal fibrosis. (2015)
  • Author(s): Imai J, Hozumi K, Sumiyoshi H, Yazawa M, Hirano K, Abe J, Higashi K, Inagaki Y, Mine T
  • Journal Title: Biochem Biophys Res Commun Volume: 468 Issue: 4 Pages: 554-560
  • DOI: 10.1016/j.bbrc.2015.10.123
  • Peer Reviewed
• [Journal Article] Stem and progenitor cell systems in liver development and regeneration. (2015)
  • Author(s): Akihide Kamiya, Yutaka Inagaki:
  • Journal Title: Hepatol Res Volume: 45 Issue: 1 Pages: 29-37
  • DOI: 10.1111/hepr.12349
  • Peer Reviewed
• [Journal Article] A novel small compound accelerates dermal wound healing by modifying infiltration, proliferation and migration of distinct cellular components in mice (2014)
  • Author(s): Yamaoka H, Sumiyoshi H, Higashi K, Nakao S, Minakawa K, Sumida K, Saito K, Ikoma N, Mabuchi T, Ozawa A, and Inagaki Y.
  • Journal Title: J Dermatol Sci 2014 Volume: (in press) Issue: 3 Pages: 204-213
  • DOI: 10.1016/j.jdermsci.2014.03.002
  • Peer Reviewed
• [Journal Article] Mechanisms of action of acetaldehyde in the up regulation of the human 2(I) collagen gene in hepatic stellate cells-key roles of Ski, SMAD3, SMAD4 and SMAD7 (2014)
  • Author(s): Karina Reyes-Gordillo, Ruchi Shah, Jaime Arellanes-Robledo, Zamira Hernández-Nazara, Ana Rosa Rincón-Sánchez, Yutaka Inagaki, Marcos Rojkind, M. Raj Lakshman
  • Journal Title: Am J Pathol Volume: in press Issue: 5 Pages: 1458-1467
  • DOI: 10.1016/j.ajpath.2014.01.020
  • Peer Reviewed
• [Journal Article] Lymph Node Stromal Cells Negatively Regulate Antigen-Specific CD4+ T Cell Responses. (2014)
  • Author(s): Abe J, Shichino S, Ueha S, Hashimoto S, Tomura M, Inagaki Y, Stein JV, Matsushima K.
  • Journal Title: J Immunol. Volume: 193 Issue: 4 Pages: 1636-1644
  • DOI: 10.4049/jimmunol.1302946
  • Peer Reviewed
• [Journal Article] Macrophage-inducible C-type lectin underlies obesity-induced adipose tissue fibrosis. (2014)
  • Author(s): Tanaka M, Ikeda K, Suganami T, et al.
  • Journal Title: Nat Commun Volume: 5 Issue: 1 Pages: 4982-4982
  • DOI: 10.1038/ncomms5982
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Fibrogenesis and carcinogenesis in nonalcoholic steatohepatitis (NASH): Involvement of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinase (TIMPs). (2014)
  • Author(s): Isao Okazaki, Takufumi Noro, Eigoro Yamanouchi, Hajime Kuroda, Masayuki Nakano, Hiroaki Yokomori, Yutaka Inagaki
  • Journal Title: Cancers Volume: 6 Issue: 3 Pages: 1220-1255
  • DOI: 10.3390/cancers6031220
  • Peer Reviewed
• [Journal Article] 肝線維化改善の分子・細胞基盤 (2014)
  • Author(s): 稲垣 豊、茂呂 忠、住吉秀明
  • Journal Title: 肝胆膵 Volume: 68 Pages: 709-715
• [Journal Article] 肝臓の線維化とその治療 (2014)
  • Author(s): 稲垣 豊、住吉秀明
  • Journal Title: 日本内科学会雑誌 Volume: 103 Pages: 2171-2175
• [Journal Article] Fibrogenesis and Carcinogenesis in NASH: Role of MMPs and TIMPs (2014)
  • Author(s): Isao Okazaki, Takufumi Noro, Eigoro Yamanouchi, Hajime Kuroda, Masayuki Nakano, Hiroaki Yokomori, Yutaka Inagaki
  • Journal Title: Cancers Volume: in press
• [Journal Article] Qualitative Rather than Quantitative Changes Are Hallmarks of Fibroblasts in Bleomycin-Induced Pulmonary Fibrosis (2013)
  • Author(s): Tatsuya Tsukui, Satoshi Ueha, Jun Abe, Shin-ichi Hashimoto, Shigeyuki Shichino, Takeshi Shimaoka, Francis H. W. Shand, Yasuka Arakawa, Kenshiro Oshima, Masahira Hattori, Yutaka
  • Journal Title: The American Journal of Pathology Volume: 3 Issue: 3 Pages: 758-773
  • DOI: 10.1016/j.ajpath.2013.06.005
  • Peer Reviewed
• [Journal Article] ERK-dependent downregulation of Skp2 reduces Myc activity with HGF, leading to inhibition of cell proliferation through a decrease in Id1 expression (2013)
  • Author(s): Li, X., Bian, Y., Takizawa, Y., Hashimoto, T., Ikoma, T., Tanaka, J., Kitamura, N., Inagaki, Y., Komada, M., and Tanaka, T.
  • Journal Title: Mol. Cancer Res. Volume: 11 Issue: 11 Pages: 1437-1447
  • DOI: 10.1158/1541-7786.mcr-12-0718
  • Peer Reviewed
• [Journal Article] マウス皮膚創傷治癒モデルにおける筋膜由来線維芽細胞と希少コラーゲンのはたらき (2013)
  • Author(s): 住吉秀明、稲垣 豊
  • Journal Title: 食品加工技術 Volume: 33 Pages: 124-130
  • NAID: 40019805327
• [Presentation] Jagged1/Notchシグナルを介した線維肝再生における前駆細胞動員機構の解明． (2017)
  • Author(s): 中野泰博、中尾祥絵、住吉秀明、三上健一郎、丹野友里、末岡 美那子 、笠原大瑚、木村 啓志、茂呂 忠、紙谷聡英、穂積勝人、稲垣 豊
  • Organizer: 第16回日本再生医療学会総会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2017-03-09
• [Presentation] 肝臓における薬物代謝の性差を制御する分子メカニズム． (2017)
  • Author(s): 近田裕美、井田絹代、稲垣 豊、紙谷聡英
  • Organizer: 第16回日本再生医療学会総会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2017-03-09
• [Presentation] Jagged1/Notchシグナルは線維肝再生における肝前駆細胞の動員に機能する． (2016)
  • Author(s): 中野泰博、中尾祥絵、住吉秀明、三上健一郎、丹野友里、末岡 美那子 、笠原大瑚、木村啓志、茂呂 忠、紙谷聡英、穂積勝人、稲垣 豊
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-12-01
• [Presentation] 酸素濃度勾配制御による肝小葉モデルの構築． (2016)
  • Author(s): 笠原大瑚、住吉秀明、柳川享世、中野泰博、紙谷聡英、木村啓志、稲垣 豊
  • Organizer: 第30回肝類洞壁細胞研究会学術大会
  • Place of Presentation: 富山国際会議場（富山県富山市）
  • Year and Date: 2016-11-25
• [Presentation] ミトコンドリア酸化ストレスと高脂肪・高カロリー食摂取による脂肪性肝疾患の進展機構． (2016)
  • Author(s): 茂呂 忠、中尾祥絵、住吉秀明、石井恭正、石井直明、稲垣 豊
  • Organizer: 第30回肝類洞壁細胞研究会学術大会
  • Place of Presentation: 富山国際会議場（富山県富山市）
  • Year and Date: 2016-11-25
• [Presentation] An angiotensin receptor-like 1 receptor, APJ, plays an important role in promoting fibrosis and angiogenesis in an early stage of non-alcoholic steatohepatitis. (2016)
  • Author(s): Wataru Ando, Hiroaki Yokomori, Yutaka Inagaki, Rie Kubota, Katsuya Otori, Isao Okazaki
  • Organizer: 67th Annual Meeting of the American Association for the Study of Liver Diseases
  • Place of Presentation: Hynes Convention Center (Boston, MA, U.S.A.)
  • Year and Date: 2016-11-14
  • Int'l Joint Research
• [Presentation] Functional analysis of a novel regeneration factor, opioid growth factor receptor-like 1, that regulates both hepatic development and regeneration of injured/fibrotic liver. (2016)
  • Author(s): Takayo Yanagawa, Hideaki Sumiyoshi, Yousuke Chiba, Yuhei Suzuki, Sachie Nakao, Hiromi Chikada, Akihide Kamiya, Yutaka Inagaki
  • Organizer: 67th Annual Meeting of the American Association for the Study of Liver Diseases
  • Place of Presentation: Hynes Convention Center (Boston, MA, U.S.A.)
  • Year and Date: 2016-11-14
  • Int'l Joint Research
• [Presentation] Expression of MMP-1 in hepatic progenitor cells is a significant biomarker of human early nonalcoholic steatohepatitis. (2016)
  • Author(s): Hiroaki Yokomori, Yutaka Inagaki, Wataru Ando, Masaya Oda, Isao Okazaki
  • Organizer: 67th Annual Meeting of the American Association for the Study of Liver Diseases
  • Place of Presentation: Hynes Convention Center (Boston, MA, U.S.A.)
  • Year and Date: 2016-11-13
  • Int'l Joint Research
• [Presentation] Contribution of Jagged1/Notch signaling to murine fibrotic liver regeneration through possible dedifferentiation of mature hepatocytes. (2016)
  • Author(s): Yasuhiro Nakano, Sachie Nakao, Hideaki Sumiyoshi, Kenichiro Mikami, Yuri Tanno, Daigo Kasahara, Hiroshi Kimura, Tadashi Moro, Akihide Kamiya, Katsuto Hozumi, Yutaka Inagaki
  • Organizer: 67th Annual Meeting of the American Association for the Study of Liver Diseases
  • Place of Presentation: Hynes Convention Center (Boston, MA, U.S.A.)
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Pathophysiological interplay between fibrosis and regeneration of the liver. (2016)
  • Author(s): Yutaka Inagaki
  • Organizer: Asian Pacific Digestive Week 2016
  • Place of Presentation: 神戸ポートアイランド（兵庫県神戸市）
  • Year and Date: 2016-11-04
  • Int'l Joint Research / Invited
• [Presentation] Contribution of Jagged1/Notch signaling to murine fibrotic liver regeneration through possible dedifferentiation of mature hepatocytes. (2016)
  • Author(s): Yasuhiro Nakano, Sachie Nakao, Hideaki Sumiyoshi, Kenichiro Mikami, Yuri Tanno, Minako Sueoka, Daigo Kasahara, Hiroshi Kimura, Tadashi Moro, Akihide Kamiya, Katsuto Hozumi, Yutaka Inagaki
  • Organizer: 9th Notch Meeting
  • Place of Presentation: 国立遺伝学研究所（静岡県三島市）
  • Year and Date: 2016-10-05
• [Presentation] ミトコンドリア酸化ストレスと高脂肪・高カロリー食摂取による肝線維化の進展機構． (2016)
  • Author(s): 稲垣 豊
  • Organizer: 第3回肝臓と糖尿病・代謝研究会
  • Place of Presentation: 石川県立音楽堂（石川県金沢市）
  • Year and Date: 2016-07-16
  • Invited
• [Presentation] 肝発生および線維肝再生過程における肝前駆細胞は、間葉系細胞のJagged-1をリガンドとするNotchシグナルによって制御される． (2016)
  • Author(s): 中野泰博、中尾祥絵、住吉秀明、三上健一郎、丹野友里、茂呂 忠、紙谷聡英、穂積勝人、稲垣 豊
  • Organizer: 第23回肝細胞研究会
  • Place of Presentation: 大阪大学中之島センター （大阪府大阪市）
  • Year and Date: 2016-07-07
• [Presentation] 肝臓における薬物代謝の性差を制御する分子メカニズム． (2016)
  • Author(s): 近田裕美、井田絹代、稲垣 豊、紙谷聡英
  • Organizer: 第23回肝細胞研究会
  • Place of Presentation: 大阪大学中之島センター （大阪府大阪市）
  • Year and Date: 2016-07-07
• [Presentation] 臓器線維症の病態解明に立脚した新たな診断・治療法の開発に向けた拠点形成． (2016)
  • Author(s): 稲垣 豊、住吉秀明
  • Organizer: 第48回日本結合組織学会学術大会
  • Place of Presentation: 長崎大学医学部（長崎県長崎市）
  • Year and Date: 2016-06-25
  • Invited
• [Presentation] 肝発生と傷害・線維肝の再生過程を制御する共通分子としてのOGFRL1の機能解析． (2016)
  • Author(s): 柳川享世、住吉秀明、千葉陽介、鈴木悠平、中尾祥絵、近田裕美、紙谷聡英、稲垣 豊
  • Organizer: 第48回日本結合組織学会学術大会
  • Place of Presentation: 長崎大学医学部（長崎県長崎市）
  • Year and Date: 2016-06-25
• [Presentation] 髄と肝臓の連関からみた炎症・線維化と再生の病態連繋． (2016)
  • Author(s): 稲垣 豊
  • Organizer: 第37回日本炎症・再生医学会
  • Place of Presentation: みやこめっせ（京都府京都市）
  • Year and Date: 2016-06-16
  • Invited
• [Presentation] Notch/Jagged-1シグナルを介した線維肝における肝前駆細胞動員機構の解明． (2016)
  • Author(s): 中野泰博、住吉秀明、稲垣 豊
  • Organizer: 第52回日本肝臓学会総会
  • Place of Presentation: ホテルニューオータニ幕張（千葉県千葉市）
  • Year and Date: 2016-05-19
• [Presentation] 線維肝に対する新規の再生促進因子 Opioid Growth Factor Receptor-like 1の発現動態と機能解析． (2016)
  • Author(s): 柳川享世、住吉秀明、千葉陽介、鈴木悠平、中尾祥絵、近田裕美、紙谷聡英、稲垣 豊
  • Organizer: 第52回日本肝臓学会総会
  • Place of Presentation: ホテルニューオータニ幕張（千葉県千葉市）
  • Year and Date: 2016-05-19
• [Presentation] 肝前駆細胞の動員・増殖を促す新規分子を用いた線維肝に対する再生治療戦略． (2016)
  • Author(s): 住吉秀明、柳川享世、稲垣 豊
  • Organizer: 第102回日本消化器病学会総会
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2016-04-22
  • Invited
• [Presentation] ：コラーゲン成形の改良による優れた人工真皮の検討． (2016)
  • Author(s): 住吉秀明、千葉陽介、中尾祥絵、稲垣 豊
  • Organizer: 第15回日本再生医療学会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2016-03-19
• [Presentation] Mechanism of Liver Fibrosis. (2016)
  • Author(s): Yutaka Inagaki
  • Organizer: 25th Conference of the Asian Pacific Association for the Study of the Liver
  • Place of Presentation: グランドプリンスホテル新高輪（東京都港区）
  • Year and Date: 2016-02-23
  • Int'l Joint Research / Invited
• [Presentation] Deletion of sphingosine 1-phospahte (S1P) receptor-2 (S1P2) inhibits lung fibrosis through altering alveolar macrophage polarization and senescence in mice. (2015)
  • Author(s): Juan Juan Zhao, Yasuo Okamoto, Kazuaki Yoshioka, Sho Aki, Noriko Takuwa, Yutaka Inagaki, Chiaki Takahashi, and Yoh Takuwa
  • Organizer: Biochemistry and Molecular Biology 2015
  • Place of Presentation: 神戸ポートアイランド（兵庫県神戸市）
  • Year and Date: 2015-12-04
  • Int'l Joint Research
• [Presentation] Opioid growth factor receptor-like 1; a novel bone marrow cells-derived factor that accelerates regeneration of murine fibrotic liver. (2015)
  • Author(s): Takayo Yanagawa, Hideaki Sumiyoshi, Sachie Nakao, Masato Otsuka, Minoru Kimura, Yosuke Chiba, Shintaro Satake, Tadashi Moro, Hiromi Chikada, Akihide Kamiya, Yutaka Inagaki
  • Organizer: 66th Annual Meeting of the American Association for the Study of Liver Diseases
  • Place of Presentation: Moscone West Convention Center (アメリカ合衆国カリフォルニア州）
  • Year and Date: 2015-11-16
  • Int'l Joint Research
• [Presentation] Identification of a novel bone marrow cells-derived factor that accelerates regeneration of fibrotic liver. (2015)
  • Author(s): Yutaka Inagaki
  • Organizer: 18th International Symposium on Cells of Hepatic Sinusoid
  • Place of Presentation: Asilomar Conference Grounds (アメリカ合衆国カリフォルニア州）
  • Year and Date: 2015-11-12
  • Int'l Joint Research / Invited
• [Presentation] 微小環境制御による肝小葉構造の構築 (2015)
  • Author(s): 笠原大瑚、住吉秀明、柳川享世、中尾祥絵、茂呂 忠、木村啓志、稲垣 豊
  • Organizer: 第29回肝類洞壁細胞研究会学術集会
  • Place of Presentation: 秋田市にぎわい交流館AU（秋田県秋田市）
  • Year and Date: 2015-10-31
• [Presentation] 骨髄細胞に由来する線維肝再生促進因子OGFRL1の機能解析． (2015)
  • Author(s): 柳川享世、住吉秀明、大塚正人、木村 穣、千葉陽介、佐竹晋太郎、福光 博、中尾祥絵、近田裕美、紙谷聡英、稲垣 豊
  • Organizer: 第22回肝細胞研究会
  • Place of Presentation: 米子コンベンションセンター（鳥取県米子市）
  • Year and Date: 2015-06-05
• [Presentation] 肝線維化と再生の病態連繋 (2015)
  • Author(s): 稲垣 豊、住吉秀明
  • Organizer: 第22回肝細胞研究会
  • Place of Presentation: 米子コンベンションセンター（鳥取県米子市）
  • Year and Date: 2015-06-04
  • Invited
• [Presentation] Notch/Jagged-1シグナルを介した肝線維化と再生・発癌の病態連繋． (2015)
  • Author(s): 稲垣 豊、住吉秀明、三上健一郎
  • Organizer: 第51回日本肝臓学会総会
  • Place of Presentation: ホテル日航熊本（熊本県熊本市）
  • Year and Date: 2015-05-22
• [Presentation] ゲノム編集技術 CRSPR/Cas9を用いた新規肝再生促進因子 OGFRL1の機能解析．、 (2015)
  • Author(s): 柳川享世、住吉秀明、大塚正人、木村 穣、福光 寛、中尾祥絵、千葉陽介、佐竹晋太郎、近田裕美、紙谷聡英、 茂呂 忠、稲垣 豊
  • Organizer: 第47回日本結合組織学会学術大会
  • Place of Presentation: コクヨホール（東京都港区）
  • Year and Date: 2015-05-16
• [Presentation] ミトコンドリア由来酸化ストレスによる脂肪性肝炎の線維化促進機序の解明． (2015)
  • Author(s): 茂呂 忠、中尾祥絵、住吉秀明、石井恭正、宮沢正樹、石井直明、稲垣 豊：、2015年5月16日、東京
  • Organizer: 第47回日本結合組織学会学術大会
  • Place of Presentation: コクヨホール（東京都港区）
  • Year and Date: 2015-05-16
• [Presentation] 低分子化合物HSc025はPirin誘導による線維芽細胞の遊走促進を介して創傷治癒を促す． (2015)
  • Author(s): 住吉秀明、山岡華児、東 清史、中尾祥絵、柳川享世、茂呂 忠、斎藤幸一、馬渕 智生、小澤 明、稲垣 豊
  • Organizer: 第47回日本結合組織学会学術大会
  • Place of Presentation: コクヨホール（東京都港区）
  • Year and Date: 2015-05-16
• [Presentation] ゲノム編集技術を用いた線維肝再生促進因子OGREL1の機能解析 (2015)
  • Author(s): 住吉秀明、大塚正人、木村 穣、福光 寛、中尾祥絵、近田裕美、紙谷聡英、稲垣 豊
  • Organizer: 第14回日本再生医療学会
  • Place of Presentation: 横浜
  • Year and Date: 2015-03-20
• [Presentation] ゲノム編集技術を用いた線維肝再生促進因子OGREL1の機能解析 (2014)
  • Author(s): 住吉秀明、大塚正人、木村 穣、福光 寛、中尾祥絵、近田裕美、紙谷聡英、稲垣 豊
  • Organizer: 第28回肝類洞壁細胞研究会学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2014-12-13
• [Presentation] Localizations and functional roles of MMP-1 in the early and advanced stages of human non-alcoholic steatohepatitis. (2014)
  • Author(s): Hiroaki Yokomori, Isao Okazaki, Masaya Oda, Wataru Ando, Yutaka Suzuki, Tsutsui Nobuhiko, Eigoro Yamanouchi, Hajime Kuroda, Soichi Kojima, Mitsuko Hara, Yutaka Inagaki
  • Organizer: 45th Annual Meeting of the American Association for the Study of Liver Diseases
  • Place of Presentation: Boston
  • Year and Date: 2014-11-11
• [Presentation] The serum levels of SDF-1α correlated with the fibrosis and suggested the appearance of hepatic progenitor cells in the advanced stage of NASH. (2014)
  • Author(s): Wataru Ando, Hiroaki Yokomori, Yutaka Inagaki, Isao Okazaki, Yutaka Suzuki, Tsutsui Nobuhiro, Eigoro Tamanouchi, Hiroki Tanabe, Hajime Kuroda, Soichi Kojima, Mitsuko Hara, Masaya Oda, Takako Komiyama
  • Organizer: 45th Annual Meeting of the American Association for the Study of Liver Diseases
  • Place of Presentation: Boston
  • Year and Date: 2014-11-11
• [Presentation] A Novel therapy for liver fibrosis using ex vivo modified mesenchymal stem cells. (2014)
  • Author(s): Hideaki Sumiyoshi, Akihide Kamiya, Yutaka Inagaki
  • Organizer: 第18回日本肝臓学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2014-10-23
• [Presentation] Direct contribution of mitochondrial oxidative stress to hepatic fibrogenesis. (2014)
  • Author(s): Tadashi Moro, Hideaki Sumiyoshi, Yutaka Inagaki
  • Organizer: 第18回日本肝臓学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2014-10-23
• [Presentation] ミトコンドリア酸化ストレスによる肝線維化の病態形成 (2014)
  • Author(s): 稲垣 豊、石井恭正、茂呂 忠
  • Organizer: 第21回肝細胞研究会
  • Place of Presentation: 東京
  • Year and Date: 2014-06-27
  • Invited
• [Presentation] 骨髄細胞に由来する新たな肝繊維化改善・再生促進因子の同定 (2014)
  • Author(s): 住吉秀明、東 清史、中尾祥絵、皆川香織、紙谷聡英、茂呂 忠、斎藤幸一、稲垣 豊
  • Organizer: 第４６回日本結合組織学会学術大会・第６１回マトリックス研究会大会合同学術大会
  • Place of Presentation: 名古屋
  • Year and Date: 2014-06-07
• [Presentation] ミトコンドリア由来活性酸素惹起モデルマウスを用いた酸化ストレスによる肝繊維化促進機序の解明 (2014)
  • Author(s): 茂呂 忠、住吉秀明、稲垣 豊
  • Organizer: 第50回日本肝臓学会総会
  • Place of Presentation: 東京
  • Year and Date: 2014-05-29
• [Presentation] 肝臓の線維化とその治療 (2014)
  • Author(s): 稲垣 豊
  • Organizer: 第111回内科学会総会・講演会
  • Place of Presentation: 東京
  • Year and Date: 2014-04-13
  • Invited
• [Presentation] 細胞系譜特異的Notch/Jagged-1シグナルによる肝線維化と前駆細胞動員の制御機構
  • Author(s): 住吉秀明、三上健一郎、茂呂 忠、紙谷聡英、稲垣 豊
  • Organizer: 第49回日本肝臓学会総会
  • Place of Presentation: 東京
• [Presentation] 新規低分子化合物HSc025は細胞増殖と遊走を活性化して創傷治癒を促す
  • Author(s): 住吉秀明、山岡華児、中尾祥絵、生駒憲広、馬渕智生、小澤 明、東 清史、斎藤幸一、稲垣 豊
  • Organizer: 第45回日本結合組織学会学術大会・第60回マトリックス研究会大会合同学術大会
  • Place of Presentation: 和歌山
• [Presentation] 胆汁うっ滞型肝線維症におけるコラーゲン産生細胞の起源と初期動態
  • Author(s): 中尾祥絵、茂呂 忠、住吉秀明、稲垣 豊
  • Organizer: 第45回日本結合組織学会学術大会・第60回マトリックス研究会大会合同学術大会
  • Place of Presentation: 和歌山
• [Presentation] ミトコンドリア由来活性酸素惹起モデルマウスを用いた酸化ストレスによる肝線維化促進機序の解明
  • Author(s): 茂呂 忠、中尾祥絵、住吉秀明、宮沢正樹、石井恭正、石井直明、稲垣 豊
  • Organizer: 第45回日本結合組織学会学術大会・第60回マトリックス研究会大会合同学術大会
  • Place of Presentation: 和歌山
• [Presentation] Mitochondrial oxidative stress exacerbates inflammation and subsequent fibrogenesis in high fat diet-induced murine hepatic steatosis
  • Author(s): Tadashi Moro, Sachie Nakao, Hideaki Sumiyoshi, Takamasa Ishii, Masaki Miyazawa, Naoaki Ishii, Yutaka Inagaki
  • Organizer: 17th International Symposium on Cells of the Hepatic Sinusoid
  • Place of Presentation: 大阪
• [Presentation] Identification of a novel bone marrow cell-derived factor that suppresses fibrogenesis and accelerates regeneration of murine fibrotic liver
  • Author(s): Hideaki Sumiyoshi, Hiroshi Fukumitsu, Reiichi Higashiyama, Sachie Nakao, Kaori Minakawa, Minako Sueoka, Hiromi Chikada, Akihide Kamiya, Kiyoshi Higashi, Koichi Saito, Yutaka Inagaki
  • Organizer: The 20th Annual Meeting of the Japanese Society for the Research of Hepatic Cells
  • Place of Presentation: 大阪
• [Presentation] Direct contribution of mitochondrial oxidative stress to hepatic fibrogenesis
  • Author(s): Tadashi Moro, Sachie Nakao, Hideaki Sumiyoshi, Takamasa Ishii, Masaki Miyazawa, Naoaki Ishii, Yutaka Inagaki
  • Organizer: 64th Annual Meeting of the American Association for the Study of Liver Diseases
  • Place of Presentation: ワシントンDC
• [Presentation] Pirin誘導低分子化合物Hsc025は細胞増殖と遊走を活性化して創傷治癒を促す
  • Author(s): 住吉秀明、山岡華児、中尾祥絵、生駒憲広、馬渕智生、小澤 明、東 清史、斎藤幸一、稲垣 豊
  • Organizer: 第13回日本再生医療学会総会
  • Place of Presentation: 京都
• [Book] 日本肝臓学会創立50周年記念誌 (2014)
  • Author(s): 肝線維化研究の進歩と治療の展望
  • Publisher: 日本肝臓学会
• [Remarks] 東海大学大学院マトリックス医学生物学センター
  • URL: http://matrix.med.u-tokai.ac.jp/index.html
• [Remarks] 東海大学大学院医学研究科
  • URL: http://www.med.u-tokai.ac.jp/daigakuin/web/matrix.html
• [Remarks] 東海大学大学院マトリックス医学生物学センター
  • URL: http://matrix.med.u-tokai.ac.jp/
• [Remarks] 東海大学医学部 再生医療科学
  • URL: http://matrix.med.u-tokai.ac.jp/index.html
• [Remarks] 東海大学大学院医学研究科 マトリックス医学生物学センター
  • URL: http://www.med.u-tokai.ac.jp/daigakuin/web/matrix.html
• [Remarks] 東海大学大学院医学研究科
  • URL: http://www.med.u-tokai.ac.jp/daigakuin/pdf/inagaki_yutaka_2014_04_01.pdf
• [Remarks] 東海大学大学院医学研究科マトリックス医学生物学センター
  • URL: http://www.med.u-tokai.ac.jp/daigakuin/web/matrix.html