| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2015: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
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| Outline of Final Research Achievements |
Activation and subsequent induction into cardiomyocytes differentiation of endogenous cardiac stem or progenitor cells is a new strategy for cardiac regeneration. We examined the mechanisms of endogenous cardiac regeneration after epicardial engraftment of cardiac progenitor cell (CPC) scaffold. Transplantation of CPC scaffold reduced the DNA damage of cardiac side population cells. CPC scaffold secreted the several factors that promote angiogenesis, inhibit apoptotic cell death, or reduce emigration of neutrophils. Transplantation of CPC scaffold preserved the expression of aldehyde dehydrogenase 2 in the injured heart. We established a multi colored mouse heart model for lineage tracing. By using this model we quantified the dynamics of cardiomyocyte division after myocardial injury.
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