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Elucidation of the mechanism of neoatherosclerosis

Research Project

Project/Area Number 25293182
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionKyoto University

Principal Investigator

KIMURA Takeshi  京都大学, 医学(系)研究科(研究院), 教授 (80359786)

Co-Investigator(Kenkyū-buntansha) ONO Koh  京都大学, 大学院医学研究科, 准教授 (00359275)
NISHI Eiichiro  京都大学, 大学院医学研究科, 准教授 (30362528)
SHIOI Tetsuo  京都大学, 大学院医学研究科, 講師 (50360095)
MAKIYAMA Takeru  京都大学, 大学院医学研究科, 助教 (30528302)
SAITO Naritatsu  京都大学, 大学院医学研究科, 助教 (20467484)
IMAI Masao  京都大学, 大学院医学研究科, 助教 (10625677)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Keywords動脈硬化 / ステント / 血栓 / 狭心症 / 心筋梗塞 / neoatherosclerosis
Outline of Final Research Achievements

Percutaneous coronary intervention using coronary stent is a standard therapy for ischemic heart disease. Restenosis after stent implantation is dramatically reduced by the development of drug eluting stent. However, very late stent thrombosis and late catch-up phenomenon, which is the restenosis several years after treatment, are still remained as serious problems. Recently, neoatherosclerosis is receiving research attention for the cause of such conditions. We performed clinical and basic research to contribute the elucidation of the mechanism of neoatherosclerosis.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (101 results)

All 2016 2015 2014 2013 Other

All Journal Article (57 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 56 results,  Open Access: 39 results,  Acknowledgement Compliant: 26 results) Presentation (38 results) (of which Int'l Joint Research: 8 results,  Invited: 3 results) Book (2 results) Remarks (3 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Enhanced engraftment, proliferation, and therapeutic potential in heart using optimized human iPSC-derived cardiomyocytes.2016

    • Author(s)
      Funakoshi S, Miki K, Takaki T, Okubo C, Hatani T, Chonabayashi K, Nishikawa M, Takei I, Oishi A, Narita M, Hoshijima M, Kimura T, Yamanaka S, Yoshida Y.
    • Journal Title

      Sci Rep.

      Volume: 6 Issue: 1 Pages: 19111-19111

    • DOI

      10.1038/srep19111

    • NAID

      120005756304

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Duration of Prehospital Resuscitation Efforts After Out-of-Hospital Cardiac Arrest.2016

    • Author(s)
      Nagao K, Nonogi H, Yonemoto N, Gaieski DF, Ito N, Takayama M, Shirai S, Furuya S, Tani S, Kimura T, Saku K; Japanese Circulation Society With Resuscitation Science Study (JCS-ReSS) Group*.
    • Journal Title

      Circulation

      Volume: 133 Issue: 14 Pages: 1386-96

    • DOI

      10.1161/circulationaha.115.018788

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 1-year outcomes with the Absorb bioresorbable scaffold in patients with coronary artery disease: a patient-level, pooled meta-analysis.2016

    • Author(s)
      Stone GW, Gao R, Kimura T, Kereiakes DJ, Ellis SG, Onuma Y, Cheong WF, Jones-McMeans J, Su X, Zhang Z, Serruys PW.
    • Journal Title

      Lancet

      Volume: 387 Issue: 10025 Pages: 1277-89

    • DOI

      10.1016/s0140-6736(15)01039-9

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The renin-angiotensin system promotes arrhythmogenic substrates andalethal arrhythmias in mice with non-ischemic cardiomyopathy2016

    • Author(s)
      Yamada C, Kuwahara K, Yamazaki M, Nakagawa Y, Nishikimi T, Kinoshita H, Kuwabara Y, Minami T, Yamada Y, Shibata J, Nakao K, , Arai Y, Honjo H, Kamiya K, Nakao K, Kimura T
    • Journal Title

      Cardiovascular Research

      Volume: 109 Issue: 1 Pages: 162-173

    • DOI

      10.1093/cvr/cvv248

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of Age and Sex on Clinical Outcomes after Percutaneous Coronary Intervention Relative to Coronary Artery Bypass Grafting in Patients with Triple Vessel Coronary Artery Disease.2016

    • Author(s)
      Yamaji K, Shiomi H, Morimoto T, Nakatsuma K, Toyota T, Ono K, Furukawa Y, Nakagawa Y, Kadota K, Ando K, Shirai S, Onodera T, Watanabe H, Natsuaki M, Sakata R, Hanyu M, Nishiwaki N, Komiya T, Kimura T.
    • Journal Title

      Circulation

      Volume: 115 Issue: 19 Pages: 020955-020955

    • DOI

      10.1161/circulationaha.115.020955

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Efficacy of Antiarrhythmic Drugs Short-Term Use After Catheter Ablation for Atrial Fibrillation (EAST-AF) trial.2016

    • Author(s)
      Kaitani K, Inoue k, Kobori A, Nakazawa Y, Ozawa T, et al.
    • Journal Title

      European Heart Journal.

      Volume: 7 Issue: 7 Pages: 610-618

    • DOI

      10.1093/eurheartj/ehv501

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A randomized trial evaluating everolimus-eluting Absorb bioresorbable scaffolds vs. everolimus-eluting metallic stents in patients with coronary artery disease: ABSORB Japan2015

    • Author(s)
      Kimura T, Kozuma K, Tanabe K, Nakamura S, Yamane M, Muramatsu T, Saito S, Yajima J, Hagiwara N, Mitsudo K, Popma JJ, Serruys PW, Onuma Y, Ying S, Cao S, Staehr P, Cheong WF, Kusano H, Stone GW; ABSORB Japan Investigators.
    • Journal Title

      Eur Heart J.

      Volume: 36 Issue: 47 Pages: 3332

    • DOI

      10.1093/eurheartj/ehv435

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Everolimus-eluting bioresorbable vascular scaffolds versus everolimus-eluting metallic stents: a meta-analysis of randomised controlled trials.2015

    • Author(s)
      Cassese S, Byrne RA, Ndrepepa G, Kufner S, Wiebe J, Repp J, Schunkert H, Fusaro M, Kimura T, Kastrati A.
    • Journal Title

      Lancet

      Volume: 387 Issue: 10018 Pages: 537-544

    • DOI

      10.1016/s0140-6736(15)00979-4

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] High-density lipoprotein cholesterol levels and cardiovascular outcomes in Japanese patients after percutaneous coronary intervention: a report from the CREDO-Kyoto registry cohort-2.2015

    • Author(s)
      Izuhara M, Ono K, Shiomi H, Morimoto T, Furukawa Y, Nakagawa Y, Shizuta S, Tada T, Tazaki J, Horie T, Kuwabara Y, Baba O, Nishino T, Kita T, Kimura T; CREDO-Kyoto PCI/CABG Registry Cohort-2 Investigators.
    • Journal Title

      Atherosclerosis.

      Volume: 242(2) Issue: 2 Pages: 632-8

    • DOI

      10.1016/j.atherosclerosis.2015.05.010

    • NAID

      120005678183

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Adenosine triphosphate-guided pulmonary vein isolation for atrial fibrillation: the UNmasking Dormant Electrical Reconduction by Adenosine TriPhosphate (UNDER-ATP) trial.2015

    • Author(s)
      Kobori A, Shizuta S, Inoue K, Kaitani K, Morimoto T, Nakazawa Y, Ozawa T, et al.
    • Journal Title

      European Heart Journal.

      Volume: 7 Pages: 3276-3287

    • DOI

      10.1093/eurheartj/ehv457

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Expression Patterns of miRNA-423-5p in the Serum and Pericardial Fluid in Patients Undergoing Cardiac Surgery.2015

    • Author(s)
      Miyamoto S, Usami S, Kuwabara Y, Horie T, Baba O, Hakuno D, Nakashima Y, Nishiga M, Izuhara M, Nakao T, Nishino T, Ide Y, Nakazeki F, Wang J, Ueyama K, Kimura T, Ono K.
    • Journal Title

      PLoS One.

      Volume: 10(11) Issue: 11 Pages: e0142904-e0142904

    • DOI

      10.1371/journal.pone.0142904

    • NAID

      120005749912

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] MicroRNA-33a/b in Lipid Metabolism2015

    • Author(s)
      Ono K, Horie T, Nishino T, Baba O, Kuwabara Y, Yokode M, Kita T, Kimura T.
    • Journal Title

      Circulation Journal

      Volume: 79 Issue: 2 Pages: 278-284

    • DOI

      10.1253/circj.CJ-14-1252

    • NAID

      130004927073

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of Five-Year Outcome of Percutaneous Coronary Intervention With Coronary Artery Bypass Grafting in Triple-Vessel Coronary Artery Disease (from the Coronary Revascularization DemonstratingOutcome Study in Kyoto PCI/CABG Registry Cohort-2).2015

    • Author(s)
      Shiomi H, Morimoto T, Furukawa Y, Nakagawa Y, Tazaki J, Sakata R, Okabayashi H, Hanyu M, Shimamoto M, Nishiwaki N, Komiya T,Kimura T; CREDO-Kyoto PCI/CABG Registry Cohort-2 Investigators.
    • Journal Title

      Am J Cardiol.

      Volume: 116 Issue: 1 Pages: 59-65

    • DOI

      10.1016/j.amjcard.2015.03.040

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Initial Surgical Versus Conservative Strategies in Patients With Asymptomatic Severe Aortic Stenosis.2015

    • Author(s)
      Taniguchi T, Morimoto T, Shiomi H et al.
    • Journal Title

      J Am Coll Cardiol.

      Volume: 66 Issue: 25 Pages: 2827-38

    • DOI

      10.1016/j.jacc.2015.10.001

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Meta-analysis of long-term clinical outcomes of everolimus-eluting stents.2015

    • Author(s)
      Toyota T, Shiomi H, Morimoto T, Kimura T.
    • Journal Title

      Am J Cardiol.

      Volume: 116 Issue: 2 Pages: 187-94

    • DOI

      10.1016/j.amjcard.2015.03.059

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Antiplatelet therapy discontinuation and the risk of serious cardiovascular events after coronary stenting: observations from the CREDO-Kyoto Registry Cohort-2.2015

    • Author(s)
      Watanabe H, Morimoto T, Natsuaki M, Furukawa Y, Nakagawa Y, Kadota K, Yamaji K, Ando K, Shizuta S, Shiomi H, Tada T, Tazaki J, Kato Y, Hayano M, Abe M, Tamura T, Shirotani M, Miki S, Matsuda M, Takahashi M, Ishii K, Tanaka M, Aoyama T, Doi O, Horie M, et ai.
    • Journal Title

      PLoS One

      Volume: 10(4) Issue: 4 Pages: e0124314-e0124314

    • DOI

      10.1371/journal.pone.0124314

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Clinical efficacy of thrombus aspiration on 5-year clinical outcomes in patients with ST-segment elevation acute myocardial infarction undergoing percutaneous coronary intervention.2015

    • Author(s)
      Watanabe H, Shiomi H, Nakatsuma K et al.
    • Journal Title

      J Am Heart Assoc.

      Volume: 4 Issue: 11

    • DOI

      10.1161/jaha.115.001945

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Influence of Sex on Long-Term Outcomes Afte Implantation of Bare-Metal Stent: A Multicenter Report From the Coronary Revascularization Demonstrating Outcome Study-Kyoto (CREDO-Kyoto) Registry Cohort-1.2015

    • Author(s)
      Yamaji K, Shiomi H, Morimoto T, Toyota T, Ono K, Furukawa Y, Nakagawa Y, Kadota K, Ando K, Shirai S, Kato M, Takatsu Y, Doi O, Kambara H, Suwa S, Onodera T, Watanabe H, Natsuaki M, Kimura T
    • Journal Title

      Circulation.

      Volume: 132 Issue: 24 Pages: 2323-33

    • DOI

      10.1161/circulationaha.115.017168

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] In vitro assessment of physiological impact of recipient artery intervention on the contralateral donor artery.2015

    • Author(s)
      Watanabe H, Saito N, Matsuo H, Kawase Y, Watanabe S, Bao B, Yamamoto E, Higami H, Nakatsuma K, Kimura T.
    • Journal Title

      Cardiovasc Revasc Med.

      Volume: 16 Pages: 90-100

    • Related Report
      2014 Annual Research Report
    • Open Access / Acknowledgement Compliant
  • [Journal Article] Relationships between nutritional status and markers of congestion in patients with pulmonary arterial hypertension.2015

    • Author(s)
      Kawamoto A, Kato T, Minamino-Muta E, Okano Y, Shioi T, Kimura T.
    • Journal Title

      Int J Cardiol.

      Volume: 187 Pages: 27-28

    • DOI

      10.1016/j.ijcard.2015.03.354

    • NAID

      120006305980

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Clinical Impact of Left Ventricular Outflow Tract Obstruction in Takotsubo Cardiomyopathy2015

    • Author(s)
      Kawaji T, Shiomi H, Morimoto T, Tazaki J, Imai M, Saito N, Makiyama T, Shizuta S, Ono K, Kimura T.
    • Journal Title

      Circulation Journal

      Volume: 79 Issue: 4 Pages: 839-846

    • DOI

      10.1253/circj.CJ-14-1148

    • NAID

      130005130261

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Five-Year Outcomes of Percutaneous Versus Surgical Coronary Revascularization in PatientsWith Diabetes Mellitus (from the CREDO-Kyoto PCI/CABG Registry Cohort-2).2015

    • Author(s)
      Marui A, Kimura T, Nishiwaki N, Mitsudo K, Komiya T, Hanyu M, Shiomi H, Tanaka S, Sakata R; CREDO-Kyoto PCI/CABG Registry Cohort-2 Investigators.
    • Journal Title

      Am J Cardiol.

      Volume: 115 Issue: 8 Pages: 1063-72

    • DOI

      10.1016/j.amjcard.2015.01.544

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Intravascular ultrasound observation of an obstruction of the left main coronary artery caused by displaced leaflet calcification and hematoma after transcatheter aortic valve implantation.2015

    • Author(s)
      Taniguchi T, Saito N, Minakata K, Imai M, Watanabe H, Toyota T, Watanabe S, Tazaki J, Koizumi S, Hirao S, Yamazaki K, Daijo H, Sakata R, Kimura T
    • Journal Title

      Circulation

      Volume: 131 Issue: 7

    • DOI

      10.1161/circulationaha.114.014690

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The organ-protective effect of N-type Ca(2+) channelblockade.2015

    • Author(s)
      Kuwahara K, Kimura T.
    • Journal Title

      Pharmacol Ther.

      Volume: 15 Pages: 00045-5

    • DOI

      10.1016/j.pharmthera.2015.02.001

    • NAID

      120005663276

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Measurement of technetium-99m sestamibi signals in rats administered a mitochondrial uncoupler and in a rat model of heart failure2015

    • Author(s)
      Kawamoto A, Kato T, Shioi T, Okuda J, Kawashima T. Tamaki Y, Niizuma S, Tanada Y, Takemura G, Narazaki M, Matsuda T, Kimura T
    • Journal Title

      PLoS One.

      Volume: 10 Issue: 1 Pages: e0117091-e0117091

    • DOI

      10.1371/journal.pone.0117091

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effect of radiofrequency catheter ablation of persistent atrial fibrillation on the left atrial function: assessment by 320-row multislice computed tomography.2015

    • Author(s)
      Hanazawa K, Kaitani K, Hayama Y, Onishi N, Tamaki Y, Miyake M, Kondo H,Tamura T, Izumi C, Shizuta S, Kimura T, Nakagawa Y.
    • Journal Title

      Int J Cardiol.

      Volume: 179 Pages: 449-54

    • DOI

      10.1016/j.ijcard.2014.11.103

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] MicroRNA-451 exacerbates lipotoxicity in cardiac myocytes and high-fat diet-induced cardiac hypertrophy in mice through suppression of the LKB1/AMPK pathway.2015

    • Author(s)
      Kuwabara Y, Horie T, Baba O, Watanabe S, Nishiga M, Usami S, Izuhara M, Nakao T, Nishino T, Otsu K, Kita T, Kimura T, Ono K.
    • Journal Title

      Circulation Research

      Volume: 116 Issue: 2 Pages: 279-288

    • DOI

      10.1161/circresaha.116.304707

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Outcomes of everolimus-eluting stent incomplete stent apposition: a serial optical coherence tomography analysis2015

    • Author(s)
      Shimamura, K
    • Journal Title

      Eur Heart J Cardiovasc Imaging

      Volume: 16 Issue: 1 Pages: 23

    • DOI

      10.1093/ehjci/jeu174

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cost analysis of non-invasive fractional flow reserve derived from coronary computed tomographic angiography in Japan.2015

    • Author(s)
      Kimura T, Shiomi H, Kuribayashi S, Isshiki T, Kanazawa S, Ito H, Ikeda S, Forrest B, Zarins CK, Hlatky MA, Norgaard BL.
    • Journal Title

      Cardiovasc Interv Ther.

      Volume: 30 Issue: 1 Pages: 38-44

    • DOI

      10.1007/s12928-014-0285-1

    • NAID

      40020374211

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Effect of Statin Therapy on Cardiovascular Outcomes after Coronary Revascularization in Patients over 80 Years of Age2014

    • Author(s)
      Natsuaki M, Morimoto T, Furukawa Y, Shiomi H, Ono K, Kimura T
    • Journal Title

      Atherosclerosis

      Volume: 237 Issue: 2 Pages: 821-828

    • DOI

      10.1016/j.atherosclerosis.2014.10.108

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of localized hypersensitivity and in-stent neoatherosclerosis with the very late drug-eluting stent thrombosis.2014

    • Author(s)
      Yamaji K, Kubo S, Inoue K, Kadota K, Kuramitsu S, Shirai S, Ando K, Nobuyoshi M, Mitsudo K, Kimura T.
    • Journal Title

      PLoS One.

      Volume: 25 Issue: 11 Pages: e113870-e113870

    • DOI

      10.1371/journal.pone.0113870

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Serofendic acid protects against myocardial ischemia-reperfusion injury in rats.2014

    • Author(s)
      Ioroi T, Akao M, Iguchi M, Kato M, Kimura T, Izumi Y, Akaike A, Kume T.
    • Journal Title

      J Pharmacol Sci.

      Volume: 126 Pages: 274-80

    • NAID

      130004704280

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Cardiac-Specific Inhibition of Kinase Activity in Calcium/Calmodulin-Dependent Protein Kinase Kinase-β Leads to Accelerated Left Ventricular Remodeling and Heart Failure after Transverse Aortic Constriction in Mice2014

    • Author(s)
      Shin Watanabe, Takahiro Horie, Kazuya Nagao, Yasuhide Kuwabara, Osamu Baba, Hitoo Nishi, Naoya Sowa, Michiko Narazaki, Tetsuya Matsuda, Genzou Takemura, Hiromichi Wada, Koji Hasegawa, Takeshi Kimura, Koh Ono
    • Journal Title

      PLoS ONE

      Volume: 9 Issue: 9 Pages: e108201-e108201

    • DOI

      10.1371/journal.pone.0108201

    • NAID

      120005496630

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of Pre-infarction Angina Pectoris on Long-term Survival in Patients with ST-segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention2014

    • Author(s)
      Taniguchi T, Shiomi H, Toyota T, Morimoto T, Akao M, Nakatsuma K, Ono K, Makiyama T, Shizuta S, Furukawa Y, Nakagawa Y, Ando K, Kadota K, Horie M, Kimura T.
    • Journal Title

      Am J Cardiol

      Volume: 114 Issue: 8 Pages: 1179-1186

    • DOI

      10.1016/j.amjcard.2014.07.038

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of five-year outcomes of coronary artery bypass grafting versus percutaneous coronary intervention in patients with left ventricular ejection fractions≤50% versus >50% (from the CREDO-Kyoto PCI/CABG Registry Cohort-2).2014

    • Author(s)
      Marui A, Kimura T, Nishiwaki N, Mitsudo K, Komiya T, Hanyu M, Shiomi H, Tanaka S, Sakata R; CREDO-Kyoto PCI/CABG Registry Cohort-2 Investigators.
    • Journal Title

      Am J Cardiol.

      Volume: 114 Issue: 7 Pages: 988-96

    • DOI

      10.1016/j.amjcard.2014.07.007

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Inhibition of N-type Ca2+ channels ameliorates an imbalance in cardiac autonomic nerve activity and prevents lethal arrhythmias in mice with heart failure.2014

    • Author(s)
      Yamada Y, Kinoshita H, Kuwahara K, Nakagawa Y, Kuwabara Y, Minami T, Yamada C, Shibata J, Nakao K, Cho K, Arai Y, Yasuno S, Nishikimi T, Ueshima K, Kamakura S, Nishida M, Kiyonaka S, Mori Y, Kimura T, Kangawa K, Nakao K.
    • Journal Title

      Cardiovasc Research

      Volume: 104 Issue: 1 Pages: 183-193

    • DOI

      10.1093/cvr/cvu185

    • NAID

      120005619790

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Incidence and Outcome of Surgical Procedures After Coronary Artery Bypass Grafting Compared With Those After Percutaneous Coronary Intervention2014

    • Author(s)
      Tokushige A, Shiomi H, Morimoto T, Ono K, Furukawa Y, Nakagawa Y, Kadota K, Ando K, Shizuta S, Tada T, Tazaki J, Kato Y, Hayano M, Abe M, Hamasaki S, Ohishi M, Nakashima H et al.
    • Journal Title

      Circ Cardiovasc Interv.

      Volume: 7 Issue: 4 Pages: 482-491

    • DOI

      10.1161/circinterventions.113.001056

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Predictive Performance of SYNTAX Score II in Patients With Left Main and Multivessel Coronary Artery Disease-analysis of CREDO-Kyoto registry.2014

    • Author(s)
      Campos CM, van Klaveren D, Iqbal J, Onuma Y, Zhang YJ, Garcia-Garcia HM, Morel MA, Farooq V, Shiomi H, Furukawa Y, Nakagawa Y, Kadota K, Lemos PA, Kimura T, Steyerberg EW, Serruys PW.
    • Journal Title

      Circ J.

      Volume: 78 Pages: 1942-9

    • NAID

      130004926990

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Comparison of Long-term Mortality After Acute Myocardial Infarction Treated by Percutaneous Coronary Intervention in Patients Living Alone versus Not Living Alone at the Time of Hospitalization2014

    • Author(s)
      Nakatsuma K, Shiomi H, Watanabe H, Morimoto T, Taniguchi T, Toyota T, Furukawa Y, Nakagawa Y, Horie M, Kimura T
    • Journal Title

      Am J Cardiol.

      Volume: 114 Issue: 4 Pages: 522-527

    • DOI

      10.1016/j.amjcard.2014.05.029

    • NAID

      120005469579

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Percutaneous coronary intervention versus coronary artery bypass grafting in patients with end-stage renal disease requiring dialysis (5-year outcomes of the CREDO-Kyoto PCI/CABG Registry Cohort-2).2014

    • Author(s)
      Marui A, Kimura T, Nishiwaki N, Mitsudo K, Komiya T, Hanyu M, Shiomi H, Tanaka S, Sakata R; CREDO-Kyoto PCI/CABG Registry Cohort-2 Investigators.
    • Journal Title

      Am J Cardiol.

      Volume: 114 Issue: 4 Pages: 555-61

    • DOI

      10.1016/j.amjcard.2014.05.034

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo.2014

    • Author(s)
      Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Nakazeki F, Ide Y, Koyama S, Sowa N, Yahagi N, Shimano H, Nakamura T, Hasegawa K, Kume N, Yokode M, Kita T, Kimura T, Ono K.
    • Journal Title

      Scientific Reports

      Volume: 4 Issue: 1 Pages: 5312-5312

    • DOI

      10.1038/srep05312

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relation of Contrast-Induced Nephropathy to Long-Term Mortality after Percutaneous Coronary Intervention2014

    • Author(s)
      Abe M, Morimoto T, Akao M, Furukawa Y, Nakagawa Y, Shizuta S, Ehara N, Taniguchi R, Doi T, Nishiyama K, Ozasa N, Saito N, Hoshino K, Mitsuoka H, Toma M, Tamura T, Haruna Y, Kita T, Kimura T.
    • Journal Title

      Am J Cardiol.

      Volume: 114 Issue: 3 Pages: 362-368

    • DOI

      10.1016/j.amjcard.2014.05.009

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anticoagulant and Antiplatelet Therapy in Patients with Atrial Fibrillation Undergoing Percutaneous Coronary Intervention2014

    • Author(s)
      Goto K, Nakai K, Shizuta S, Morimoto T, Shiomi H, Natsuaki M, Tahata M, Ota C, Ono K, Makiyama T, Nakagawa Y, Furukawa Y, et al.
    • Journal Title

      Am J Cardiol

      Volume: 114 Issue: 1 Pages: 70-78

    • DOI

      10.1016/j.amjcard.2014.03.060

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] AMAP1 as a negative-feedback regulator of nuclear factor-κB under inflammatory conditions.2014

    • Author(s)
      Tien, D.N., Kishihata, M., Yoshikawa, A., Hashimoto, A., Sabe, H., Nishi, E., Kamei, K., Arai, H., Kita, T., Kimura, T., Yokode, M. and Ashida, N.
    • Journal Title

      Sci Rep.

      Volume: 4 Issue: 1 Pages: 5094-5094

    • DOI

      10.1038/srep05094

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Long-term efficacy and safety outcomes after unrestricted use of drug-eluting stents in patients with acute coronary syndrome: mortality and major bleeding in a single-center registry.2014

    • Author(s)
      Kawaji T, Shiomi H, Morimoto T, Tamura T, Nishikawa R, Yano M, Tazaki J, Imai M, Saito N, Makiyama T, Shizuta S, Ono K, Kimura T.
    • Journal Title

      Circ J.

      Volume: 78 Pages: 1628-35

    • NAID

      130004926956

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Long-term clinical outcomes after everolimus- and sirolimus-eluting coronary stent implantation: Final 3-year follow-up of the randomized evaluation of sirolimus-eluting versus everolimus-eluting stent trial2014

    • Author(s)
      Shiomi H, Kozuma K, Morimoto T, Igarashi K, Kadota K, Tanabe K, Morino Y, Akasaka T, Abe M, Suwa S, Muramatsu T, Kobayashi M, Dai K, Nakao K, Uematsu M, Tarutani Y, Fujii K, Simonton CA, Kimura T; RESET Investigators.
    • Journal Title

      Circ Cardiovasc Interv.

      Volume: 7 Issue: 3 Pages: 343

    • DOI

      10.1161/circinterventions.113.001322

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Late adverse events after implantation of sirolimus-eluting stent and bare-metal stent: long-term (5-7 years) follow-up of the coronary revascularization demonstrating outcome study-kyoto registry cohort-2.2014

    • Author(s)
      Natsuaki M, Morimoto T, Furukawa Y, Nakagawa Y, Kadota K, Yamaji K, Ando K, Shizuta S, Shiomi H, Tada T, Tazaki J, Kato Y, Hayano M, Abe M, Tamura T, Shirotani M, Miki S, Matsuda M, Takahashi M, Ishii K, Tanaka M, Aoyama T, Doi O, Hattori R, Kato M, Suwa S, Takizawa A, Takatsu Y, Kita T, Kimura T
    • Journal Title

      Circ Cardiovasc Interv.

      Volume: 7 Issue: 2 Pages: 168-79

    • DOI

      10.1161/circinterventions.113.000987

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Critical roles of nardilysin in the maintenance of body temperature homeostasis2014

    • Author(s)
      Hiraoka Y, Matsuoka T, Ohno M, Nakamura K, Saijo S, Matsumura S, Nishi K, Sakamoto J, Chen Po-Min, Inoue K, Fushiki T, Kita T, Kimura T and Nishi E
    • Journal Title

      Nat. Commun

      Volume: 5 Issue: 1 Pages: 3224-3224

    • DOI

      10.1038/ncomms4224

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nardilysin prevents amyloid plaque formation by enhancing a-secretase activity in an Alzheimer's disease mouse model2014

    • Author(s)
      Ohno M, Hiraoka Y, Lichtenthaler S, Nishi K, Saijo S, Matsuoka T, Tomimoto H, Araki W, Takahashi R, Kita T, Kimura T and Nishi E
    • Journal Title

      Neurobiol Aging

      Volume: 35 Issue: 1 Pages: 213-22

    • DOI

      10.1016/j.neurobiolaging.2013.07.014

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] MicroRNAs and Lipoprotein Metabolism.2014

    • Author(s)
      Horie T, Baba O, Kuwabara Y, Yokode M, Kita T, Kimura T, Ono K.
    • Journal Title

      J Atheroscler Thromb.

      Volume: 21 Pages: 17-22

    • NAID

      130004845461

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Myocardial expression level of neural cell adhesion molecule correlates with reduced left ventricular function in human cardiomyopathy2014

    • Author(s)
      Nagao K, Sowa N, Inoue K, Tokunaga M, Fukuchi K, Uchiyama K, Ito H, Hayashi F, Makita T, Inada T, Tanaka M, Kimura T, and Ono K
    • Journal Title

      Circulation; Heart Failur

      Volume: 7 Issue: 2 Pages: 351-8

    • DOI

      10.1161/circheartfailure.113.000939

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two-year outcome of a randomized trial comparing second-generation drug-eluting stents using biodegradable or durable polymer2013

    • Author(s)
      Natsuaki M, Kozuma K, Morimoto T, Kadota K, Muramatsu T, Nakagawa Y, Akasaka T, Igarashi K, Tanabe K, Morino Y, Ishikawa T, Nishikawa H, Awata M, Abe M, Okada H, Takatsu Y, Ogata N, Kimura K, Urasawa K, Tarutani Y, Shiode N, Kimura T; NEXT Investigators.
    • Journal Title

      J Am Coll Cardiol.

      Volume: 311 Issue: 20 Pages: 2125

    • DOI

      10.1001/jama.2014.3584

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice.2013

    • Author(s)
      Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Sowa N, Yahagi N, Shimano H, Matsumura S, Inoue K, Marusawa H, Nakamura T, Hasegawa K, Kume N, Yokode M, Kita T, Kimura T, Ono K
    • Journal Title

      Nat Commun.

      Volume: 4:2883 Issue: 1 Pages: 2883-2883

    • DOI

      10.1038/ncomms3883

    • NAID

      120005349007

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Persistent overexpression of phosphoglycerate mutase, a glycolytic enzyme, modifies energy metabolism and reduces stress resistance of heart in mice2013

    • Author(s)
      Okuda, J., Niizuma, S., Shioi, T., Kato, T., Inuzuka, Y., Kawashima, T., Tamaki, Y., Kawamoto, A., Tanada, Y., Iwanaga, Y., Narazaki, M., Matsuda, T., Adachi, S., Soga, T., Takemura, G., Kondoh, H., Kita, T., Kimura, T.
    • Journal Title

      PLoS ONE

      Volume: 8 Issue: 8 Pages: e72173-e72173

    • DOI

      10.1371/journal.pone.0072173

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ultrastructural maturation of human-induced pluripotent stem cell-derived cardiomyocytes in a long-term culture.2013

    • Author(s)
      Kamakura T, Makiyama T, Sasaki K, Yoshida Y, Wuriyanghai Y, Chen J, Hattori T, Ohno S, Kita T, Horie M, Yamanaka S, Kimura T.
    • Journal Title

      Circ J.

      Volume: 77 Pages: 1307-14

    • NAID

      10031151395

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long Term Follow-up of a Pediatric Cohort with Short QT Syndrome.2013

    • Author(s)
      Villafane J, Atallah J,Horie M, et al.
    • Journal Title

      J Am Coll Cardiol.

      Volume: 61(11) Issue: 11 Pages: 1183-91

    • DOI

      10.1016/j.jacc.2012.12.025

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Three-year outcome after percutaneous coronary intervention and coronary artery bypass grafting in patients with triple-vessel coronary artery disease: observations from the CREDO-Kyoto PCI/CABG registry cohort-2.2013

    • Author(s)
      Tazaki J, Shiomi H, Morimoto T, Imai M, Yamaji K, Sakata R, Okabayashi H, Hanyu M, Shimamoto M, Nishiwaki N, Komiya T, Kimura T; CREDO-Kyoto PCI/CABG registry cohort-2 investigators.
    • Journal Title

      EuroIntervention.

      Volume: 9 Issue: 4 Pages: 437-45

    • DOI

      10.4244/eijv9i4a72

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] High-density Lipoprotein Cholesterol Levels and Cardiovascular Outcomes in Japanese Patients after Percutaneous Coronary Intervention from the CREDO-Kyoto Registry Cohort-2.2016

    • Author(s)
      Izuhara M.
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      仙台国際センター外(仙台市)
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] MicroRNA-451 Exacerbates Lipotoxicity in Cardiomyocytes and High-Fat Diet-Induced Cardiac Hypertrophy in Mice through Suppression of the LKB1/AMPK Pathway.2016

    • Author(s)
      Ono K.
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      仙台国際センター外(仙台市)
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] CREDO-Kyoto PCI/CABG Registry Cohort-2Investigators. High-density lipoprotein cholesterol levels and cardiovascular outcomes in Japanese patients after percutaneous coronary intervention: A report from the CREDO-Kyoto registry cohort-2.2015

    • Author(s)
      Izuhara M, Ono K, Shiomi H, Morimoto T, Furukawa Y, Nakagawa Y, Shizuta S, Tada T, Tazaki J, Horie T, Kuwabara Y, Baba O, Nishino T, Kita T, Kimura T.
    • Organizer
      American Heart Association Annual Scientific Sessions 2015
    • Place of Presentation
      Orlando, Florida(USA)
    • Year and Date
      2015-11-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Reappraisal of antithrombotic-regimen in patients with atrial fibrillation after drug-eluting stent implantation. When to skip aspirin? Look back on the case-experience.2015

    • Author(s)
      Toyota T.
    • Organizer
      American Heart Association Annual Scientific Sessions 2015
    • Place of Presentation
      Orlando, Florida(USA)
    • Year and Date
      2015-11-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Session IV. DES Thrombosis and Restenosis.2015

    • Author(s)
      Kimura T.
    • Organizer
      TCT 2015
    • Place of Presentation
      Orlando, Florida(USA)
    • Year and Date
      2015-10-11
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Plenary Session VII. First Report Investigations.2015

    • Author(s)
      Kimura T.
    • Organizer
      TCT 2015
    • Place of Presentation
      Orlando, Florida(USA)
    • Year and Date
      2015-10-11
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Successful Percutaneous Closure of Large and Maialigment Atrial Septal Defects with Plumonary Hypertension.2015

    • Author(s)
      Imai M, Watanabe S, Toyoda T, Kimura T.
    • Organizer
      CSI 2015
    • Place of Presentation
      Frankfrut(Germany)
    • Year and Date
      2015-08-30
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ABSORB Japan. 12-month clinical and 13-month angiographic outcomes from a randomized trial evaluating the Absorb Bioresorbable Vascular Scaffold vs_ metallic DES in de novo native coronary artery lesions.2015

    • Author(s)
      Kimura T.
    • Organizer
      ESC CONGRESS 2015
    • Place of Presentation
      London(UK)
    • Year and Date
      2015-08-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clinical impact of chronic total occlusion in non-infarct-related artery on long-term clinical outcomes in patients with multi-vessel disease undergoing primary PCI for ST-elevation acute myocardial infarction (from the CREDO-Kyoto AMIregistry).2015

    • Author(s)
      Watanabe H, Shiomi H, Kimura T.
    • Organizer
      ESC CONGRESS 2015
    • Place of Presentation
      London(UK)
    • Year and Date
      2015-08-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Short versus prolonged dual antiplatelet therapy (DAPT) duration after coronary stent implantation: a comparison between the DAPT trial and 9 other trials evaluating DAPT duration.2015

    • Author(s)
      Toyota T, Shiomi H, Morimoto T, Natsuaki M, Kimura T.
    • Organizer
      ESC CONGRESS 2015
    • Place of Presentation
      London(UK)
    • Year and Date
      2015-08-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] DES 留置後の至適 DAPT 施行期間についての考察2015

    • Author(s)
      木村 剛
    • Organizer
      第79回 日本循環器学会学術集会
    • Place of Presentation
      大阪国際会議場外(大阪市)
    • Year and Date
      2015-04-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] 大規模レジストリ―の将来展望 CREDO-Kyoto Registry2015

    • Author(s)
      木村 剛
    • Organizer
      第79回 日本循環器学会学術集会
    • Place of Presentation
      大阪国際会議場外(大阪市)
    • Year and Date
      2015-04-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] miR-33a/bによる細胞・臓器レベルの脂質代謝制御機構2015

    • Author(s)
      尾野 亘
    • Organizer
      第44回日本心脈管作動物質学会
    • Place of Presentation
      高松
    • Year and Date
      2015-02-07
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Microrna-33, Located Within Srebf2 Intron, Regulate Fatty Acid Synthesis via Targeting SREBP-1 in vivo2014

    • Author(s)
      1)Nishino T, Horie T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Ide Y, Nakazeki F, Koyama S, Yokode M, Kita T, Kimura T, Ono K.
    • Organizer
      American Heart Association Annual Scientific Sessions 2014
    • Place of Presentation
      Chicago
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] MicroRNA-33b Knock-in Mice for an Intron of Sterol Regulatory Element-Binding Factor 1 (Srebf1) Exhibit Reduced HDL-C in vivo2014

    • Author(s)
      2)Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Ide Y, Nakazeki F, Koyama S, Yokode M, Kita T, Kimura T, Ono K.
    • Organizer
      American Heart Association Annual Scientific Sessions 2014
    • Place of Presentation
      Chicago
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Serum HDL-C decreases in microRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1).2014

    • Author(s)
      Horie T, Nishino T, Baba O, Kuwabara Y, Nakano T, Nishiga M, Usami S, Izuhara M, Kimura T, Ono K.
    • Organizer
      9th Metabolic Syndrome, Type 2 Diabetes and Atherosclerosis Congress
    • Place of Presentation
      Kyoto
    • Year and Date
      2014-09-12 – 2014-09-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] MicroRNA-33 deficiency reduces atherosclerotic plaque progression in apoE knockout mice.2014

    • Author(s)
      Baba O, Horie T, Ono K, Kuwabara Y, Sowa N, Hasegawa K, Kume N, Yokode M, Kita T, Kimura T.
    • Organizer
      9th Metabolic Syndrome, Type 2 Diabetes and Atherosclerosis Congress
    • Place of Presentation
      Kyoto
    • Year and Date
      2014-09-12 – 2014-09-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] MicroRNA-451 is involved in diabetic cardiomyopathy through suppression of the LKB1/AMPK pathway.2014

    • Author(s)
      Kuwabara Y, Horie T, Baba O, Nishiga M, Usami S, Izuhara M, Nakao T, Nishino T, Kita T, Kimura T, Ono K.
    • Organizer
      9th Metabolic Syndrome, Type 2 Diabetes and Atherosclerosis Congress
    • Place of Presentation
      Kyoto
    • Year and Date
      2014-09-12 – 2014-09-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] MicroRNA-33, embedded in Srebf2 intron, regulate fatty acid synthesis through targeting SREBP-1 in vivo.2014

    • Author(s)
      Nishino T, Horie T, Baba O, Kuwabara Y, YOkode M, Kita T, Kimura T, Ono K.
    • Organizer
      9th Metabolic Syndrome, Type 2 Diabetes and Atherosclerosis Congress
    • Place of Presentation
      Kyoto
    • Year and Date
      2014-09-12 – 2014-09-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] microRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo.2014

    • Author(s)
      尾野 亘、堀江貴裕、西野共達、北 徹、木村 剛
    • Organizer
      第5回 Molecular Cardiovascular Conference Ⅱ
    • Place of Presentation
      神戸
    • Year and Date
      2014-09-05 – 2014-09-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 2)飽和脂肪酸により誘導されるmicroRNA-451は、糖尿病性心筋症の増悪因子である。2014

    • Author(s)
      桑原康秀、堀江貴裕、馬場 理、出原正康、宇佐美俊輔、中尾哲史、西賀雅隆、西野共達、井手裕也、中関典子、小山智史、木村 剛、尾野 亘
    • Organizer
      第5回 Molecular Cardiovascular Conference Ⅱ
    • Place of Presentation
      神戸
    • Year and Date
      2014-09-05 – 2014-09-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] MicroRNA-33 deficiency leads to high fat diet- induced obesity and insulin resistance in vivo.2014

    • Author(s)
      Horie T, Nishino T, Baba O, Kuwabara Y, Nakano T, Nishiga M, Usami S, Izuhara M, Kimura T, Ono K.
    • Organizer
      European Society of Cardiology Congress 2014
    • Place of Presentation
      Barcerona
    • Year and Date
      2014-08-30 – 2014-09-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] MicroRNA-33, embedded in Srebf2 intron, regulate fatty acid synthesis through targeting SREBP-1 in vivo.2014

    • Author(s)
      Nishino T, Horie T, Baba O, Kuwabara Y, YOkode M, Kita T, Kimura T, Ono K.
    • Organizer
      European Society of Cardiology Congress 2014
    • Place of Presentation
      Balcerona
    • Year and Date
      2014-08-30 – 2014-09-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] microRNA-33の動脈硬化・脂質制御における役割2014

    • Author(s)
      尾野 亘
    • Organizer
      第46回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      2014-07-10
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] High impact of microRNA-33 on atherosclerosis and lipid metabolism2014

    • Author(s)
      尾野 亘
    • Organizer
      第46回日本動脈硬化学会総会・学術集会 第9回五島雄一郎賞受賞講演
    • Place of Presentation
      東京
    • Year and Date
      2014-07-10
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein-2 (Srebp2) regulates Srebp1 in vivo2014

    • Author(s)
      Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Sowa N, Yahagi N, Shimano H, Hasegawa K, Kume N Yokode M, Kita T, Kimura T, Ono K.
    • Organizer
      The 18th International Vascular Biology Meeting
    • Place of Presentation
      Kyoto
    • Year and Date
      2014-04-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] MicroRNA-33 deficiency reduces atherosclerotic plaque progression in apoE knockout mice2014

    • Author(s)
      Baba O, Horie T, Kuwabara Y, Chujo Y, Watanabe S, Kinoshita M, Horiguchi M, Nakamura T, Chonabayashi K, Hishizawa M, Hasegawa K, Kume N Yokode M, Kita T, Kimura T, Ono K.
    • Organizer
      The 18th International Vascular Biology Meeting
    • Place of Presentation
      Kyoto
    • Year and Date
      2014-04-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] SREBP-2のイントロンに存在するマイクロRNA-33はSREBP-1の発現を制御する2014

    • Author(s)
      堀江貴裕
    • Organizer
      第51回日本臨床分子医学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2014-04-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] microRNA-451はLKB1-AMPK経路を抑制することで、ラット心筋細胞において細胞障害を、生体においては高脂肪食誘導性心肥大を誘導する2014

    • Author(s)
      桑原康秀
    • Organizer
      第51回日本臨床分子医学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2014-04-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] アポE欠損マウスにおいてマイクロRNA-33欠損は動脈硬化進展を抑制する2014

    • Author(s)
      馬場 理
    • Organizer
      第51回日本臨床分子医学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2014-04-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Nardilysin is a critical regulator of insulin secretion and glucose metabolism2013

    • Author(s)
      Nishi K, Sato Y, Ohno M, Hiraoka Y, Saijyo S, Sakamoto J, Chen P, Kita T, Inagaki N, Kimura T, Nishi E.
    • Organizer
      American Heart Association Annual Scientific Sessions
    • Place of Presentation
      Dallas, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Critical roles of a metalloendopeptidase nardilysin in cold-induced adaptive thermogenesis2013

    • Author(s)
      Hiraoka Y, T. Matsuoka, M. Ohno, K. Nishi, K. Nakamura, K, Kita, T. Kimura and E. Nishi.
    • Organizer
      ASCB (American Society for Cell Biology)
    • Place of Presentation
      New Orleans, U.S.A.
    • Related Report
      2013 Annual Research Report
  • [Presentation] LincRNAs regulated by pressure-overload induce hypertrophy in neonatal mouse ventricular cardiomyocytes.2013

    • Author(s)
      Kuwabara Y.
    • Organizer
      American Heart Association Annual Scientific Sessions
    • Place of Presentation
      Dallas, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] MicroRNA-33 deficiency reduces atherosclerosis formation in vivo.2013

    • Author(s)
      Takahiro Horie, Osamu Baba, Masataka Nishiga, Koji Hasegawa, Masayuki Yokode, Takeshi Kimura, Koh Ono.
    • Organizer
      18th Annual Scientific Meeting of the International Society of Cardiovascular Pharmacotherapy
    • Place of Presentation
      Italy, Roma
    • Related Report
      2013 Annual Research Report
  • [Presentation] Branched-chain amino acids ameliorate heart failure in rats2013

    • Author(s)
      Tanada Y, Shioi T, Kawamoto A, Okuda J, Kimura T
    • Organizer
      American Heart Association Annual Scientific Sessions
    • Place of Presentation
      Dallas, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Branched–chain amino acids prevent heart failure in rats2013

    • Author(s)
      Tanada Y, Shioi T, Kawamoto A, Okuda J, Kimura T
    • Organizer
      Gordon Reseach Conferences, Biology of Aging
    • Place of Presentation
      Lucca, Italy
    • Related Report
      2013 Annual Research Report
  • [Presentation] Characteristics of Angiographic Peri-Stent Contrast Staining (PSS) on Very Late Stent Thrombosis After Sirolimus-Eluting Stent Implantation: Morphological Classification and Antiplatelet Therapy2013

    • Author(s)
      Imai-M.
    • Organizer
      European Society of Cardiology Annual Meeting
    • Place of Presentation
      Amsterdam, Netherland
    • Related Report
      2013 Annual Research Report
  • [Presentation] Modeling Catecholaminergic Polymorphic Ventricular Tachycardia using Human Induced Pluripotent Stem Cells: A Promising Tool for Drug Discovery2013

    • Author(s)
      Sasaki-K
    • Organizer
      American Heart Association Annual Scientific Sessions
    • Place of Presentation
      Dallas, USA
    • Related Report
      2013 Annual Research Report
  • [Book] Annual Review 循環器20142014

    • Author(s)
      尾野 亘
    • Total Pages
      315
    • Publisher
      中外医学社
    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
  • [Book] がん基盤生物学 -革新的シーズ育成に向けて-、第II部10章2013

    • Author(s)
      西 英一郎
    • Total Pages
      336
    • Publisher
      南山堂
    • Related Report
      2013 Annual Research Report
  • [Remarks] 京都大学医学部附属病院 循環器内科

    • URL

      http://kyoto-u-cardio.jp/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 京都大学医学部付属病院循環器内科

    • URL

      http://kyoto-u-cardio.jp/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 京都大学循環器内科

    • URL

      http://kyoto-u-cardio.jp/

    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] マイクロRNA溶出型ステント及びそれを用いた管腔治療2014

    • Inventor(s)
      尾野 亘、斉藤成達、出原正康、木村剛
    • Industrial Property Rights Holder
      尾野 亘、斉藤成達、出原正康、木村剛
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-044463
    • Filing Date
      2014-03-07
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-21   Modified: 2019-07-29  

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