Research and development of innovative cardioprotective modality by nanoparticle-mediated targeting to inflammatory monocytes and IR myocardium
Project/Area Number |
25293185
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Cardiovascular medicine
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Research Institution | Kyushu University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
MATOBA Tetsuya 九州大学病院, 循環器内科, 講師 (20448426)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2013: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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Keywords | 虚血再灌流傷害 / 急性心筋梗塞 / 再灌流療法 / ナノテクノロジー / ドラッグ・デリバリー・システム |
Outline of Final Research Achievements |
In rat and pig IR models, poly(lactic acid/glycolic acid) (PLGA) nanoparticle incorporating FITC accumulated in the IR myocardium through enhanced vascular permeability, and in CD11b-positive leukocytes in the IR myocardium and peripheral blood after intravenous treatment. Intravenous treatment with PLGA nanoparticle containing pitavastatin (Pitavastatin-NP, 1 mg/kg) at reperfusion reduced MI size after 24 hours and ameliorated left ventricular dysfunction 4-week after reperfusion; by contrast, pitavastatin alone (as high as 10 mg/kg) showed no therapeutic effects. In mouse model IR model, treatment with nanoparticles incorporated with CsA (CsA-NP) pioglitazone, irbesartan and etc at the onset of reperfusion enhanced cardioprotection against IR injury by those drugs alone. Therefore, this nanotechnology-based platform can be developed as an innovative cardioprotective modality that may advance currently unsatisfactory reperfusion therapy for AMI.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] A New Therapeutic Modality for Acute Myocardial Infarction: Nanoparticle-Mediated Delivery of Pitavastatin Induces Cardioprotection from Ischemia-Reperfusion Injury via Activation of PI3K/Akt Pathway and Anti-Inflammation in a Rat Model.2015
Author(s)
Nagaoka K, Matoba T, Mao Y, Nakano Y, Ikeda G, Egusa S, Tokutome M, Nagahama R, Nakano K, Sunagawa K, Egashira K.
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Journal Title
PLoS One.
Volume: 10(7)
Issue: 7
Pages: e0132451-e0132451
DOI
Related Report
Peer Reviewed / Open Access
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