Identification of cardio protective factors secreted from growing skeletal muscle
| Project/Area Number |
25293186
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Kumamoto University |
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Principal Investigator |
Ogawa Hisao 熊本大学, 大学院生命科学研究部, 教授 (50177135)
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| Co-Investigator(Kenkyū-buntansha) |
IZUMIYA YASUHIRO 熊本大学, 大学院生命科学研究部, 助教 (10515414)
ARAKI SATOSHI 熊本大学, 医学部附属病院, 特任助教 (20706717)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2015: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2014: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2013: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
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| Keywords | 骨格筋 / 分泌因子 / 血管新生 / 腎臓病 / 心不全 / 心保護 |
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| Outline of Final Research Achievements |
It has been shown that skeletal muscle is not only a motor organ but also endocrine organ that secretes various cardio-renal protective factors. We demonstrated that skeletal muscle growth reduces renal damage in a mouse model of obstructive kidney disease. This improvement appears to be mediated by an increase in eNOS signaling in the kidney. Base on proteomic approach, we identified that several factors are secreted form growing skeletal muscle. We found that the Factor-1 served as a muscle-derived angiogenic factor, and Factor 2 and 3 could be a biomarker for the patients with heart failure. We also performed comprehensive analysis of muscle-derived miRNAs. We found that miR-215, miR-9, miR-96 are potential factors which secreted from growing muscle.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Sirt7 Contributes to Myocardial Tissue Repair by Maintaining Transforming Growth Factor-β Signaling Pathway2015
Author(s)
Araki S, Izumiya Y, Rokutanda T, Ianni A, Hanatani S, Kimura Y, Onoue Y, Senokuchi T, Yoshizawa T, Yasuda O, Koitabashi N, Kurabayashi M, Braun T, Bober E, Yamagata K, Ogawa H
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Journal Title
Circulation
Volume: 132(12)
Issue: 12
Pages: 1081-1093
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Growth differentiation factor-15 is a useful prognostic marker in patients with heart failure with preserved ejection fraction.2014
Author(s)
Izumiya Y, Hanatani S, Kimura Y, Takashio S, Yamamoto E, Kusaka H, Tokitsu T, Rokutanda T, Araki S, Tsujita K, Tanaka T, Yamamuro M, Kojima S, Tayama S, Kaikita K, Hokimoto S, Ogawa H.
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Journal Title
Can J Cardiol.
Volume: 30
Issue: 3
Pages: 338-344
DOI
Related Report
Peer Reviewed
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