| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2015: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2014: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2013: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
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| Outline of Final Research Achievements |
It has been shown that skeletal muscle is not only a motor organ but also endocrine organ that secretes various cardio-renal protective factors. We demonstrated that skeletal muscle growth reduces renal damage in a mouse model of obstructive kidney disease. This improvement appears to be mediated by an increase in eNOS signaling in the kidney. Base on proteomic approach, we identified that several factors are secreted form growing skeletal muscle. We found that the Factor-1 served as a muscle-derived angiogenic factor, and Factor 2 and 3 could be a biomarker for the patients with heart failure. We also performed comprehensive analysis of muscle-derived miRNAs. We found that miR-215, miR-9, miR-96 are potential factors which secreted from growing muscle.
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