| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
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| Outline of Final Research Achievements |
To clarify how the brain-gut peptide affects the cardiovascular regulatory system via the autonomic nerve, 1) we investigated the effect of ghrelin on myocardial infarction and cardiac hypertrophy models in ghrelin knockout mice, demonstrating that endogenous ghrelin suppresses sympathetic nerve activity and protects cardiac function after myocardial infarction and attenuates hypertrophy via a cholinergic anti-inflammatory pathway, 2) we developed selective agonists to neuromedin U receptors types 1 and 2 as tools for NMU/NMS-related research, 3) we selected orphan receptors expressed in the vagus nerve ganglion and searched for their endogenous ligands to find novel bioactive substances related to cardiovascular and autonomic nervous regulations.
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