| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2015: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Outline of Final Research Achievements |
We developed ELISA to analyze the concentration of novel target molecule for malignant pleural mesothelioma diagnosis and found that a comparison between mesothelioma patients including 18 cases of stage I and the healthy controls revealed an area under the curve of 0.9 (sensitivity and specificity > 90.0%). Thus level of target molecule in serum can discriminate surgically resectable malignant pleural mesothelioma patients from healthy individuals.
We also identified another molecule, which is aberrantly up-regulated in malignant pleural mesothelioma, and conducted functional analyses of it. We identified downstream pathway of it including kinase and phosphatase. Our findings shed light on the underlying mechanisms how the tumor cells manage cellular stresses commonly cased from surrounding microenvironment at both primary and metastatic sites.
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