ミッドカインによる内皮細胞由来の血管作動因子を介した血圧調整のメカニズムの解明

• Project/Area Number: 25293195
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Nagoya University
• Principal Investigator: 松尾 清一 名古屋大学, 医学(系)研究科(研究院), 教授 (70190410)
• Co-Investigator(Kenkyū-buntansha): 湯澤 由紀夫 藤田保健衛生大学, 医学部, 教授 (00191479) ; 丸山 彰一 名古屋大学, 医学(系)研究科(研究院), 准教授 (10362253) ; 佐藤 和一 藤田保健衛生大学, 医学部, 准教授 (90508920)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Adopted (Fiscal Year 2015)
• Budget Amount: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2013: ¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000)
• Keywords: 高血圧症 / ミッドカイン / 血管内皮障害 / 内皮由来血管拡張因子 / 高血圧 / 内皮細胞障害 / メタボローム解析

Outline of Annual Research Achievements

最近、高血圧症には血管拡張作用を持つ液性因子を血管内皮細胞が分泌し、Vascular toneが制御されている事が明らかにされている。血管拡張作用を有するものとして、プロスタグランジンI2、一酸化窒素（NO）、内皮細胞依存性過分極因子（EDHF）でCYP450由来のepoxyeicosatrienoic acids (EETs）が報告されているが、どうのように血管に関与しているかは明らかではない。
本研究では、ミッドカイン（MK）が内皮細胞由来の血管作動性因子を介して血圧を上昇させるメカニズムを解明し、MKを制御する事で高血圧症や血管内皮細胞障害に対する新たな治療法を開発する事を目的とした。これまでに、MK遺伝子欠損マウス（MKKO)と野生型（WT）マウスを用いて片腎摘マウスを作成し、NO合成酵素阻害剤L-NAMEを投与したところWTマウスではMKKOマウスと比べ、高血圧、腎機能障害をより強く呈したことを示した。その際、RAASやエンドセリンでは優位な差を認めなかった。一方で、血管拡張因子であるEETsの代謝産物の14, 15-DHETはMKKOマウスにて優位な上昇を認めていた。その後、EETsカスケード阻害剤をMKKOマウスに投与すると、血圧の上昇を認めた。また、血清ノルアドレナリン濃度の上昇を認めた。上記の結果を基とし、EETs阻害剤の投与により腎微小血管循環の変化を検証した。生体顕微鏡によりperitubular capilaryを観察し、阻害剤により循環流量の４０％程度の減少を示した。血管内皮障害を軽減させる事により高血圧や臓器障害を治療するための前臨床試験を動物実験によって行い、血管作動性因子や血管平滑筋細胞との相互作用の検証やメタボローム解析を使用したメカニズムの解明と新規関連因子の同定を今後もさらなる検討が必要であると考えられた。

Research Progress Status

26年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

26年度が最終年度であるため、記入しない。

Expenditure Plan for Carryover Budget

26年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Clinicopathological characteristics of M-type phospholipase A2 receptor (PLA2R)-related membranous nephropathy in Japanese. (2014)
  • Author(s): Hayashi N, Akiyama S, Okuyama H, Matsui Y, Adachi H, Yamaya H, Maruyama S, Imai E, Matsuo S, Yokoyama H.
  • Journal Title: Clin Exp Nephrol Volume: Epub
• [Journal Article] Prevalence of anti-phospholipase A2 receptor antibodies in Japanese patients with membranous nephropathy. (2014)
  • Author(s): Akiyama S, Akiyama M, Imai E, Ozaki T, Matsuo S, Maruyama S.
  • Journal Title: Clin Exp Nephrol Volume: Epub
  • Peer Reviewed
• [Journal Article] Midkine Regulates BP through Cytochrome P450-Derived Eicosanoids. (2014)
  • Author(s): Sato Y, Sato W, Maruyama S, Wilcox CS, Falck JR, Masuda T, Kosugi T, Kojima H, Maeda K, Furuhashi K, Ando M, Imai E, Matsuo S, Kadomatsu K.
  • Journal Title: J Am Soc Nephrol Volume: Epub
  • Peer Reviewed
• [Journal Article] Neutrophil/lymphocyte ratio as a predictor of cardiovascular events in incident dialysis patients: a Japanese prospective cohort study. (2014)
  • Author(s): Abe T, Kato S, Tsuruta Y, Sugiura S, Katsuno T, Kosugi T, Tsuboi N, Matsuo S, Maruyama S.
  • Journal Title: Clin Exp Nephrol. Volume: Epub
  • Peer Reviewed
• [Journal Article] Patient age and the prognosis of idiopathic membranous nephropathy. (2014)
  • Author(s): Yamaguchi M, Ando M, Yamamoto R, Akiyama S, Kato S, Katsuno T, Kosugi T, Sato W, Tsuboi N, Yasuda Y, Mizuno M, Ito Y, Matsuo S, Maruyama S.
  • Journal Title: PLoS One Volume: 9(10)
  • Peer Reviewed
• [Journal Article] Pristane-induced granulocyte recruitment promotes phenotypic conversion of macrophages and protects against diffuse pulmonary hemorrhage in Mac-1 deficiency. (2014)
  • Author(s): Shi Y, Tsuboi N, Furuhashi K, Du Q, Horinouchi A, Maeda K, Kosugi T, Matsuo S, Maruyama S.
  • Journal Title: J Immunol. Volume: 193 Issue: 10 Pages: 5129-39
  • DOI: 10.4049/jimmunol.1401051
  • Peer Reviewed
• [Journal Article] Effects of serum albumin and glycated albumin levels on performance of the Japanese GFR equation based on serum cystatin C. (2014)
  • Author(s): Horio M, Imai E, Yasuda Y, Watanabe T, Yokoyama H, Makino H, Matsuo S.
  • Journal Title: Clin Exp Nephrol. Volume: Epub
  • Peer Reviewed
• [Journal Article] Outcomes of primary nephrotic syndrome in elderly Japanese: retrospective analysis of the Japan Renal Biopsy Registry (J-RBR). (2014)
  • Author(s): Yokoyama H, Sugiyama H, Narita I, Saito T, Yamagata K, Nishio S, Fujimoto S, Mori N, Yuzawa Y, Okuda S, Maruyama S, Sato H, Ueda Y, Makino H, Matsuo S.
  • Journal Title: Clin Exp Nephrol Volume: Epub
  • Peer Reviewed
• [Journal Article] Impact of circulating cathepsin K on the coronary calcification and the clinical outcome in chronic kidney disease patients. (2014)
  • Author(s): Izumi Y, Hayashi M, Morimoto R, Cheng XW, Wu H, Ishii H, Yasuda Y, Yoshikawa D, Izawa H, Matsuo S, Oiso Y, Murohara T.
  • Journal Title: Heart Vessels Volume: Epub
  • Peer Reviewed
• [Journal Article] Efficacy and safety of fluoroscopic manipulation using the alpha-replacer for peritoneal catheter malposition. (2014)
  • Author(s): Saka Y, Ito Y, Iida Y, Maruyama S, Matsuo S.
  • Journal Title: Clin Exp Nephrol Volume: Epub
  • Peer Reviewed
• [Journal Article] The authors reply. (2014)
  • Author(s): Wada T, Nangaku M, Maruyama S, Matsuo S.
  • Journal Title: Kidney Int Volume: 86(1) Issue: 1 Pages: 210-210
  • DOI: 10.1038/ki.2014.138
  • Peer Reviewed
• [Journal Article] Smoking is a risk factor for the progression of idiopathic membranous nephropathy. (2014)
  • Author(s): Yamaguchi M, Ando M, Yamamoto R, Akiyama S, Kato S, Katsuno T, Kosugi T, Sato W, Tsuboi N, Yasuda Y, Mizuno M, Ito Y, Matsuo S, Maruyama S.
  • Journal Title: PLoS One. Volume: 9 Issue: 6 Pages: e100835-e100835
  • DOI: 10.1371/journal.pone.0100835
  • Peer Reviewed / Open Access
• [Journal Article] Immediate therapeutic efficacy of low-density lipoprotein apheresis for drug-resistant nephrotic syndrome: evidence from the short-term results from the POLARIS Study. (2014)
  • Author(s): Muso E, Mune M, Hirano T, Hattori M, Kimura K, Watanabe T, Yokoyama H, Sato H, Uchida S, Wada T, Shoji T, Yuzawa Y, Takemura T, Sugiyama S, Nishizawa Y, Ogahara S, Yorioka N, Sakai S, Ogura Y, Yukawa S, Iino Y, Imai E, Matsuo S, Saito T.
  • Journal Title: Clin Exp Nephrol Volume: Epub
  • Peer Reviewed
• [Journal Article] Serum albumin, but not glycated albumin was a potent factor affecting the performance of GFR equation based on serum creatinine. (2014)
  • Author(s): Horio M, Imai E, Yasuda Y, Watanabe T, Yokoyama H, Makino H, Matsuo S.
  • Journal Title: Clin Exp Nephrol Volume: 19(2) Issue: 2 Pages: 284-92
  • DOI: 10.1007/s10157-014-0988-8
  • Peer Reviewed
• [Journal Article] Impact of albuminuria on the incidence of periprocedural myocardial injury in patients undergoing elective coronary stent implantation. (2014)
  • Author(s): Osugi N, Suzuki S, Ishii H, Yasuda Y, Shibata Y, Tatami Y, Ota T, Kawamura Y, Okumura S, Tanaka A, Inoue Y, Matsuo S, Murohara T.
  • Journal Title: Am J Cardiol Volume: 114(1) Issue: 1 Pages: 42-6
  • DOI: 10.1016/j.amjcard.2014.03.058
  • Peer Reviewed
• [Journal Article] Hyperbaric area index calculated from ABPM elucidates the condition of CKD patients: the CKD-JAC study. (2014)
  • Author(s): Iimuro S, Imai E, Watanabe T, Nitta K, Akizawa T, Matsuo S, Makino H, Ohashi Y, Hishida A.
  • Journal Title: Clin Exp Nephrol Volume: 19(1) Issue: 1 Pages: 114-24
  • DOI: 10.1007/s10157-014-0965-2
  • Peer Reviewed
• [Journal Article] A multicenter randomized controlled trial of tonsillectomy combined with steroid pulse therapy in patients with immunoglobulin A nephropathy. (2014)
  • Author(s): Kawamura T, Yoshimura M, Miyazaki Y, Okamoto H, Kimura K, Hirano K, Matsushima M, Utsunomiya Y, Ogura M, Yokoo T, Okonogi H, Ishii T, Hamaguchi A, Ueda H, Furusu A, Horikoshi S, Suzuki Y, Shibata T, Yasuda T, Shirai S, Imasawa T, Kanozawa K, Wada A, Matsuo S, Tomino Y(他6名)
  • Journal Title: Nephrol Dial Transplant Volume: 29(8) Issue: 8 Pages: 1546-53
  • DOI: 10.1093/ndt/gfu020
  • Peer Reviewed / Open Access
• [Journal Article] Novel preprocedural and acute-phase postprocedural predictive factors for contrast-induced kidney injury in CKD patients. (2014)
  • Author(s): Okumura N, Hayashi M, Ishii H, Yoshikawa D, Yasuda Y, Goto M, Matsuo S, Oiso Y, Murohara T.
  • Journal Title: Int J Cardiol Volume: 172(2) Issue: 2 Pages: e293-e296
  • DOI: 10.1016/j.ijcard.2013.12.193
  • Peer Reviewed
• [Journal Article] Anti-neutrophil cytoplasmic antibody-associated vasculitis associated with infectious mononucleosis due to primary Epstein-Barr virus infection: report of three cases. (2014)
  • Author(s): Yamaguchi M, Yoshioka T, Yamakawa T, Maeda M, Shimizu H, Fujita Y, Maruyama S, Ito Y, Matsuo S.
  • Journal Title: Clin Kidney J Volume: 7(1) Issue: 1 Pages: 45-8
  • DOI: 10.1093/ckj/sft140
  • Peer Reviewed
• [Journal Article] The effect of febuxostat to prevent a further reduction in renal function of patients with hyperuricemia who have never had gout and are complicated by chronic kidney disease stage 3: study protocol for a multicenter randomized controlled study. (2014)
  • Author(s): Hosoya T, Kimura K, Itoh S, Inaba M, Uchida S, Tomino Y, Makino H, Matsuo S, Yamamoto T, Ohno I, Shibagaki Y, Iimuro S, Imai N, Kuwabara M, Hayakawa H.
  • Journal Title: Trials Volume: 16 Issue: 1 Pages: 15-26
  • DOI: 10.1186/1745-6215-15-26
  • Peer Reviewed
• [Journal Article] A multicenter cross-sectional study of circulating soluble urokinase receptor in Japanese patients with glomerular disease (2014)
  • Author(s): Wada T, Nangaku M, Maruyama S, Imai E, Shoji K, Kato S, Endo T, Muso E, Kamata K, Yokoyama H, Fujimoto K, Obata Y, Nishino T, Kato H, Uchida S, Sasatomi Y, Saito T, Matsuo S.
  • Journal Title: Kidney Int Volume: 85 Issue: 3 Pages: 641-8
  • DOI: 10.1038/ki.2013.544
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of phenotype and outcome in microscopic polyangiitis between Europe and Japan. (2014)
  • Author(s): Furuta, S., Chaudhry, AN., Hamano, Y., Fujimoto, S., Nagafuchi, H., Makino, H., Matsuo, S., Ozaki, S., Endo, T., Muso, E., Ito, C., Kusano, E., Yamagata, M., Ikeda, K., Kashiwakuma, D., Iwamoto, I., Westman, K. and Jayne, D.
  • Journal Title: J Rheumatol. Volume: 41(2) Issue: 2 Pages: 325-33
  • DOI: 10.3899/jrheum.130602
  • Peer Reviewed / Open Access
• [Journal Article] Significance of combined cyclosporine-prednisolone therapy and cyclosporine blood concentration monitoring for idiopathic membranous nephropathy with steroid-resistant nephrotic syndrome: a randomized controlled multicenter trial. (2014)
  • Author(s): Saito T, Iwano M, Matsumoto K, Mitarai T, Yokoyama H, Yorioka N, Nishi S, Yoshimura A, Sato H, Ogahara S, Shuto H, Kataoka Y, Ueda S, Koyama A, Maruyama S, Nangaku M, Imai E, Matsuo S, Tomino
  • Journal Title: Clin Exp Nephrol Volume: 18(5) Issue: 5 Pages: 784-94
  • DOI: 10.1007/s10157-013-0925-2
  • Peer Reviewed / Open Access
• [Journal Article] Long-Term Effects of Spironolactone in Peritoneal Dialysis Patients. (2014)
  • Author(s): Ito Y, Mizuno M, Suzuki Y, Tamai H, Hiramatsu T, Ohashi H, Ito I, Kasuga H, Horie M, Maruyama S, Yuzawa Y, Matsubara T, Matsuo S; on behalf of the Nagoya Spiro Study Group.
  • Journal Title: Am Soc Nephrol. Volume: 25(5) Issue: 5 Pages: 1094-102
  • DOI: 10.1681/asn.2013030273
  • Peer Reviewed
• [Journal Article] CD147/basigin reflects renal dysfunction in patients with acute kidney injury. (2014)
  • Author(s): Nagaya H, Kosugi T, Maeda-Hori M, Maeda K, Sato Y, Kojima H, Hayashi H, Kato N, Ishimoto T, Sato W, Yuzawa Y, Matsuo S, Kadomatsu K, Maruyama S.
  • Journal Title: Clin Exp Nephrol. Volume: 18 Issue: 5 Pages: 746-54
  • DOI: 10.1007/s10157-013-0916-3
  • Peer Reviewed
• [Journal Article] Comparison of kidney disease: improving global outcomes and acute kidney injury network criteria for assessing patients in intensive care units. (2014)
  • Author(s): Shinjo H, Sato W, Imai E, Kosugi T, Hayashi H, Nishimura K, Nishiwaki K, Yuzawa Y, Matsuo S, Maruyama S.
  • Journal Title: Clin Exp Nephrol Volume: 18(5) Issue: 5 Pages: 737-45
  • DOI: 10.1007/s10157-013-0915-4
  • Peer Reviewed
• [Journal Article] Overestimation of the risk of progression to end-stage renal disease in the poor prognosis' group according to the 2002 Japanese histological classification for immunoglobulin A nephropathy. (2014)
  • Author(s): Miyazaki Y, Kawamura T, Joh K, Okonogi H, Koike K, Utsunomiya Y, Ogura M, Matsushima M, Yoshimura M, Horikoshi S, Suzuki Y, Furusu A, Yasuda T, Shirai S, Shibata T, Endoh M, Hattori M, Akioka Y, Katafuti R, Hashiguchi A, Kimura K, Matsuo S, Tomino Y.
  • Journal Title: Clin Exp Nephrol Volume: 18(3) Issue: 3 Pages: 475-80
  • DOI: 10.1007/s10157-013-0848-y
  • Peer Reviewed / Open Access
• [Journal Article] Proposal of remission criteria for IgA nephropathy. (2014)
  • Author(s): Suzuki Y, Matsuzaki K, Suzuki H, Sakamoto N, Joh K, Kawamura T, Tomino Y, Matsuo S.
  • Journal Title: Clin Exp Nephrol Volume: 18 Issue: 3 Pages: 481-486
  • DOI: 10.1007/s10157-013-0849-x
  • NAID: 40019847882
  • Peer Reviewed / Open Access
• [Journal Article] Lower serum albumin level is associated with higher fractional excretion of creatinine. (2014)
  • Author(s): Horio M, Imai E, Yasuda Y, Watanabe T, Matsuo S.
  • Journal Title: Clin Exp Nephrol Volume: 18(3) Issue: 3 Pages: 469-74
  • DOI: 10.1007/s10157-013-0841-5
  • Peer Reviewed
• [Journal Article] Geriatric nutritional risk index accurately predicts cardiovascular mortality in incident hemodialysis patients. (2013)
  • Author(s): Takahashi H, Ito Y, Ishii H, Aoyama T, Kamoi D, Kasuga H, Yasuda K, Maruyama S, Matsuo S, Murohara T, Yuzawa Y.
  • Journal Title: J Cardiol. Volume: S0914-5087(13) Issue: 1 Pages: 352-3
  • DOI: 10.1016/j.jjcc.2013.10.018
  • Peer Reviewed
• [Journal Article] Rat adipose tissue-derived stem cells attenuate peritoneal injuries in rat zymosan-induced peritonitis accompanied by complement activation. (2013)
  • Author(s): Kim H, Mizuno M, Furuhashi K, Katsuno T, Ozaki T, Yasuda K, Tsuboi N, Sato W, Suzuki Y, Matsuo S, Ito Y ,Maruyama S1.
  • Journal Title: Cytotherapy. Volume: 16(3) Issue: 3 Pages: 357-68
  • DOI: 10.1016/j.jcyt.2013.10.011
  • Peer Reviewed
• [Journal Article] A ray of light in the dark: alternative approaches to the assessment and treatment of ischemic nephropathy. (2013)
  • Author(s): Tsuboi N, Maruyama S, Matsuo S, Imai E.
  • Journal Title: Nephrol Dial Transplant. Volume: 29(2) Issue: 2 Pages: 228-31
  • DOI: 10.1093/ndt/gft463
  • Peer Reviewed
• [Journal Article] Clinical Correlates of Ambulatory BP Monitoring among Patients with CKD. (2013)
  • Author(s): Iimuro S, Imai E, Watanabe T, Nitta K, Akizawa T, Matsuo S, Makino H, Ohashi Y, Hishida A; for the Chronic Kidney Disease Japan Cohort Study Group.
  • Journal Title: Clin J Am Soc Nephrol. Volume: 8(5) Issue: 5 Pages: 721-30
  • DOI: 10.2215/cjn.06470612
  • Peer Reviewed
• [Journal Article] Japan Renal Biopsy Registry and Japan Kidney Disease Registry: Committee Report for 2009 and 2010. (2013)
  • Author(s): Sugiyama H, Yokoyama H, Sato H, Saito T, Kohda Y, Nishi S, Tsuruya K, Kiyomoto H, Iida H, Sasaki T, Higuchi M, Hattori M, Oka K, Kagami S, Kawamura T, Takeda T, Hataya H, Fukasawa Y, Fukatsu A, Morozumi K, Yoshikawa N, Shimizu A, Kitamura H, Yuzawa Y, Matsuo S, Kiyohara Y, Joh K, Nagata M, Taguchi T, Makino H
  • Journal Title: Clin Exp Nephrol. Volume: 17(2) Issue: 2 Pages: 155-73
  • DOI: 10.1007/s10157-012-0746-8
  • NAID: 10031169463
  • Peer Reviewed
• [Journal Article] Risk factors for increased left ventricular hypertrophy in patients with chronic kidney disease. (2013)
  • Author(s): Nitta K, Iimuro S, Imai E, Matsuo S, Makino H, Akizawa T, Watanabe T, Ohashi Y, Hishida A.
  • Journal Title: Clin Exp Nephrol. Volume: 17(5) Issue: 5 Pages: 730-42
  • DOI: 10.1007/s10157-012-0758-4
  • Peer Reviewed
• [Journal Article] Deficiency of growth factor midkine exacerbates necrotizing glomerular injuries in progressive glomerulonephritis (2013)
  • Author(s): Kojima H, Kosugi T, Sato W, Sato Y, Maeda K, Kato N, Kato K, Inaba S, Ishimoto T, Tsuboi N, Matsuo S, Maruyama S, Yuzawa Y, Kadomatsu K
  • Journal Title: Am J Pathol Volume: 182(2) Issue: 2 Pages: 410-419
  • DOI: 10.1016/j.ajpath.2012.10.016
  • Peer Reviewed
• [Journal Article] Lower serum albumin level is associated with higher fractional excretion of creatinine. (2013)
  • Author(s): Horio M, Imai E, Yasuda Y, Watanabe T, Matsuo S.
  • Journal Title: Clin Exp Nephrol Volume: Epub
  • Peer Reviewed
• [Journal Article] Perforative peritonitis caused by appendicitis in a patient on peritoneal dialysis. (2013)
  • Author(s): Mizuno M, Suzuki Y, Nonaka K, Sei Y, Maruyama S, Matsuo S, Ito Y.
  • Journal Title: Intern Med. Volume: 52(11) Pages: 1177-81
  • NAID: 130003365636
  • Peer Reviewed
• [Journal Article] Significance of combined cyclosporine-prednisolone therapy and cyclosporine blood concentration monitoring for idiopathic membranous nephropathy with steroid-resistant nephrotic syndrome: a randomized controlled multicenter trial. (2013)
  • Author(s): Saito T, Iwano M, Matsumoto K, Mitarai T, Yokoyama H, Yorioka N, Nishi S, Yoshimura A, Sato H, Ogahara S, Shuto H, Kataoka Y, Ueda S, Koyama A, Maruyama S, Nangaku M, Imai E, Matsuo S, Tomino Y; The Refractory Nephrotic Syndrome Study Group.
  • Journal Title: Clin Exp Nephrol. Volume: Epub
  • Peer Reviewed
• [Journal Article] CD147/basigin reflects renal dysfunction in patients with acute kidney injury. (2013)
  • Author(s): Nagaya H, Kosugi T, Maeda-Hori M, Maeda K, Sato Y, Kojima H, Hayashi H, Kato N, Ishimoto T, Sato W, Yuzawa Y, Matsuo S, Kadomatsu K, Maruyama S.
  • Journal Title: Clin Exp Nephrol. Volume: Epub
  • Peer Reviewed
• [Journal Article] Long-Term Effects of Spironolactone in Peritoneal Dialysis Patients. (2013)
  • Author(s): Ito Y1, Mizuno M, Suzuki Y, Tamai H, Hiramatsu T, Ohashi H, Ito I, Kasuga H, Horie M, Maruyama S, Yuzawa Y, Matsubara T, Matsuo S; on behalf of the Nagoya Spiro Study Group.
  • Journal Title: J Am Soc Nephrol. Volume: Epub
  • Peer Reviewed
• [Journal Article] Comparison of Kidney Disease: Improving Global Outcomes and Acute Kidney Injury Network criteria for assessing patients in intensive care units. (2013)
  • Author(s): Shinjo H1, Sato W, Imai E, Kosugi T, Hayashi H, Nishimura K, Nishiwaki K, Yuzawa Y, Matsuo S, Maruyama S.
  • Journal Title: Clin Exp Nephrol Volume: Epub
  • Peer Reviewed
• [Presentation] Prevalence of anti-phospholipase A2 receptor antibodies in Japanese patients with membranous nephropathy. (2015)
  • Author(s): Shin’ichi Akiyama, Enyu Imai, Seiichi Matsuo, Shoichi Maruyama
  • Organizer: World Congress of Nephrology 2015
  • Place of Presentation: Cape Town（South Africa)
  • Year and Date: 2015-03-13 – 2015-03-17
• [Presentation] A RISE IN ANTI-NEUTROPHIL CYTOPLASMIC AUTOANTIBODY (ANCA) TITERS IS AN INDEPENDENT PREDICTOR OF RELAPSE IN ANCA-ASSOCIATED VASCULITIS (2015)
  • Author(s): M. Yamaguchi, S. Kato, T. Katsuno, N. Kato, T. Kosugi, N. Tsuboi, Y. Yasuda, Y. Ito, S. Matsuo, S. Maruyama
  • Organizer: World Congress of Nephrology 2015
  • Place of Presentation: Cape Town（South Africa)
  • Year and Date: 2015-03-13 – 2015-03-17
• [Presentation] Vascular Endothelial Growth Factor Receptor-3 Can Be a New Target to Improve Ultrafiltration Dysfunction in Methylglyoxal-Induced Peritoneal Injury (2014)
  • Author(s): Takeshi Terabayashi, MD, Yasuhiko Ito, MD, PhD, Masashi Mizuno, MD, PhD, Yasuhiro Suzuki, MD, Hiroshi Kinashi, MD, Fumiko Sakata, Shoichi Maruyama, MD, Yoshifumi Takei, PhD, Seiichi Matsuo, MD.
  • Organizer: Kidney Week 2014
  • Place of Presentation: フィラデルフィア (米国)
  • Year and Date: 2014-11-11 – 2014-11-16
• [Presentation] High Ferritin Level and Low Nutrition Status Predicts Higher Risk of Infection-Related Hospitalization in Incident Dialysis Patients: A Japanese Prospective Cohort Study (2014)
  • Author(s): Sawako Kato, MD, PhD, Shoichi Maruyama, MD, Bengt Lindholm, MD, PhD, Yukio Yuzawa, MD, Yoshinari Tsuruta, MD, Seiichi Matsuo, MD.
  • Organizer: Kidney Week 2014
  • Place of Presentation: フィラデルフィア (米国)
  • Year and Date: 2014-11-11 – 2014-11-16
• [Presentation] Aortic Calcification Was Accelerated After Radical Nephrectomy: Clinical Impact of GFR Decline for Vascular Calcification (2014)
  • Author(s): Yoshinari Yasuda, MD, PhD, Akitaka Suzuki, MD, Ryohei Hattori, MD, Yasuhito Funahashi, MD, PhD, Shoichi Maruyama, MD, Seiichi Matsuo, MD. CKD
  • Organizer: Kidney Week 2014
  • Place of Presentation: フィラデルフィア (米国)
  • Year and Date: 2014-11-11 – 2014-11-16
• [Presentation] The Growth Factor Midkine Reflect the Disease Activity in Lupus Nephritis (2014)
  • Author(s): Tomohiro Masuda, MD, Kayaho Maeda, MD, Waichi Sato, MD, PhD, Tomoki Kosugi, MD, PhD, Yuka Sato, MD, Takuji Ishimoto, MD, PhD, Seiichi Matsuo, MD, Shoichi Maruyama, MD.
  • Organizer: Kidney Week 2014
  • Place of Presentation: フィラデルフィア (米国)
  • Year and Date: 2014-11-11 – 2014-11-16
• [Presentation] Home Blood Pressure Telemonitoring System Among Patients with CKD: An Attempt to Achieve Optimal Blood Pressure Control with Real-Time Remote. (2014)
  • Author(s): Yoshinari Yasuda, MD, PhD, Misao Niwa, Kanako Shibata, Mayumi Kamiya, Imai Junko, Sawako Kato, MD, PhD, Shoichi Maruyama, MD, Seiichi Matsuo, MD.
  • Organizer: Kidney Week 2014
  • Place of Presentation: フィラデルフィア (米国)
  • Year and Date: 2014-11-11 – 2014-11-16
• [Presentation] Effects of Educational Intervention on Renal Outcome of Early- to Moderate-Stage Chronic Kidney Disease: A Cluster-Randomized Trial (2014)
  • Author(s): Kunihiro Yamagata, MD, PhD, Hirofumi Makino, MD, PhD, Kunitoshi Iseki, MD, Sadayoshi Ito, MD, PhD, Kenjiro Kimura, MD, Eiji Kusano, MD, Kimio Tomita, MD, Ichiei Narita, MD, PhD, Tomoya Nishino, MD, PhD, Yoshihide Fujigaki, DrMed, Tsuyoshi Watanabe, MD, Takashi Wada, MD, PhD, Seiichi Matsuo, MD.
  • Organizer: Kidney Week 2014
  • Place of Presentation: フィラデルフィア (米国)
  • Year and Date: 2014-11-11 – 2014-11-16
• [Presentation] Association of Glomerular Macrophage Phenotypes and Urinary Soluble CD163 with Disease Activity in Human Lupus Nephritis (2014)
  • Author(s): Nobuhide Endo, DrMed, Naotake Tsuboi, MD, PhD, Kazuhiro Furuhashi, MD, PhD, Shoichi Maruyama, MD, Seiichi Matsuo, MD.
  • Organizer: Kidney Week 2014
  • Place of Presentation: フィラデルフィア (米国)
  • Year and Date: 2014-11-11 – 2014-11-16
• [Presentation] Smoking Is a Risk Factor for the Relapse of Antineutrophil Cytoplasmic Antibody (ANCA-Associated Vasculitis. (2014)
  • Author(s): Makoto Yamaguchi, MD, Sawako Kato, MD, PhD, Takuji Ishimoto, MD, PhD, Tomoki Kosugi, MD, PhD, Waichi Sato, MD, PhD, Naotake Tsuboi, MD, PhD, Masashi Mizuno, MD, PhD, Yasuhiko Ito, MD, PhD, Seiichi Matsuo, MD, Shoichi Maruyama, MD.
  • Organizer: Kidney Week 2014
  • Place of Presentation: フィラデルフィア (米国)
  • Year and Date: 2014-11-11 – 2014-11-16
• [Presentation] Plasma CD147/Basigin as a Promising Biomarker of the Kidney Diseases (2014)
  • Author(s): Kayaho Maeda, MD, Tomoki Kosugi, MD, PhD, Hiroshi Kojima, MD, Tomohiro Masuda, MD, Noritoshi Kato, MD, PhD, Waichi Sato, MD, PhD, Seiichi Matsuo, MD,
  • Organizer: Kidney Week 2014
  • Place of Presentation: フィラデルフィア (米国)
  • Year and Date: 2014-11-11 – 2014-11-16
• [Presentation] Low Prevalence of Anti-PLA2R Antibody in Patients with Idiopathic Membranous Nephropathy in Japan. (2014)
  • Author(s): Shin'ichi Akiyama, PhD, Enyu Imai, MD, PhD, Seiichi Matsuo, MD, Shoichi Maruyama, MD.
  • Organizer: Kidney Week 2014
  • Place of Presentation: フィラデルフィア (米国)
  • Year and Date: 2014-11-11 – 2014-11-16
• [Presentation] Low Awareness and Comprehension of Chronic Kidney Disease Among Japanese Health-Check Subjects (2014)
  • Author(s): Yoshinari Yasuda, MD, PhD, Mayumi Kamiya, Yohei Maeshima, MD, PhD, Tadao Akizawa, MD, Seiichi Matsuo, MD, Shoichi Maruyama, MD.
  • Organizer: Kidney Week 2014
  • Place of Presentation: フィラデルフィア (米国)
  • Year and Date: 2014-11-11 – 2014-11-16
• [Presentation] 膜型PhospholipaseA2受容体(PLA2R)関連膜性腎症の臨床病理学的検討 (2014)
  • Author(s): 林 憲史、松井 佑樹、藤本 圭司、渥美 浩克、足立 浩樹、奥山 宏、山谷 秀喜、横山 仁、秋山 真一、丸山 彰一、今井 圓裕、松尾 清一
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] ネフローゼ患者における抗PLA2R抗体測定の臨床的実用化の検討 (2014)
  • Author(s): 秋山 真一、武藤 玲子、松尾 清一、丸山 彰一
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] Transfused M2 macrophages ameliorate renal injury in murine nephrotoxic serum nephritis (2014)
  • Author(s): Du Qiuna、坪井 直毅、石 一沁、松尾 清一、丸山 彰一
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] 糖尿病患者における隠れ特発性膜性腎症の発見 (2014)
  • Author(s): 武藤 玲子、秋山 真一、松尾 清一、丸山 彰一
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] soluble Vascular Endotherial Growth Factor Receptor3（sVEGFR3）によるリンパ管新生抑制は、腹膜透析の除水不全を改善する (2014)
  • Author(s): 寺林 武、伊藤 恭彦、鬼無 洋、水野 正司、鈴木 康弘、坂田 史子、富田 貴子、清 祐実、井口 大旗、多和田 光洋、松尾 清一
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] 腹膜透析患者由来ヒト腹膜中皮細胞における膜補体制御因子の解析 (2014)
  • Author(s): 清 祐実、水野 正司、井口 大旗、東出 慶子、鈴木 康弘、今井 優樹、松尾 清一、伊藤 恭彦
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] CKD有病率の地域差には生活習慣病診療実態が関連する (2014)
  • Author(s): 安田 宜成、柴田 清、鈴木 貞夫、井関 邦敏、守山 敏樹、山縣 邦弘、鶴屋 和彦、吉田 英昭、藤元 昭一、旭 浩一、渡辺 毅、松尾 清一
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] メタボリックシンドロームは糸球体過剰ならびに過少濾過に関連する (2014)
  • Author(s): 岡田 理恵子、安田 宜成、津下 一代、若井 健志、浜島 信之、松尾 清一
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] IgA腎症後ろ向き研究コホートにおける免疫抑制療法や口蓋扁桃摘除術に伴う有害事象 (2014)
  • Author(s): 安田 宜成、安田 隆、大出 幸子、高橋 理、川村 哲也、松尾 清一
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] IgA腎症前向きコホート研究による我が国の予後分類の検証 (2014)
  • Author(s): 川村 哲也、鈴木 祐介、城 謙輔、横尾 隆、木村 健二郎、富野 康日己、松尾 清一
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] 腎機能の比較的維持されたIgA腎症における蛋白尿の差異による治療効果 (2014)
  • Author(s): 安田 隆、安田 宣成、大出 幸子、高橋 理、川村 哲也、松尾 清一
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] CD147/basiginは急性期の腎機能障害を反映する (2014)
  • Author(s): 長屋 啓、小杉 智規、小島 博、前田 佳哉輔1、加藤 規利、石本 卓嗣、飯田 喜康、佐藤 和一、松尾 清一、丸山 彰一
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] 腎不全マウスにおいて食塩負荷は浸透圧刺激によって局所macrophage浸潤・炎症を惹起する (2014)
  • Author(s): 名倉 史子、伊藤 恭彦、水野 正司、鈴木 康弘、澤井 晶穂、鬼無 洋、寺林 武、清 祐実、富田 貴子、松尾 清一
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] 腎臓分野の新しいシーズの探索 (2014)
  • Author(s): 松尾 清一、丸山 彰一
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] 透析導入時の血清マグネシウム値と背景因子の関連についての検討 (2014)
  • Author(s): 田中 章仁、加藤 規利、勝野 敬之、尾崎 武徳、加藤 佐和子、小杉 智規、佐藤 和一、坪井 直毅、丸山 彰一、稲熊 大城、松尾 清一
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] 慢性腎臓病患者における心血管病スクリーニング検査法の検討 (2014)
  • Author(s): 鈴木 進、安田 宜成、室原 豊明、松尾 清一
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] 喫煙と特発性膜性腎症の腎予後との関連性について (2014)
  • Author(s): 山口 真、安藤 昌彦、秋山 真一、加藤 佐和子、勝野 敬之、小杉 智規、佐藤 和一、坪井 直毅、安田 宜成、水野 正司、伊藤 恭彦、松尾 清一、丸山 彰一
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] 原発性ネフローゼ症候群における免疫抑制療法抵抗性：日本ネフローゼ症候群コホート研究（JNSCS） (2014)
  • Author(s): 山本 陵平、丸山 彰一、横山 仁、松尾 清一、今井 圓裕
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] 腎疾患重症化予防のための戦略研究（FROM-J）参加患者の地域特性に関する検討 (2014)
  • Author(s): 甲斐 平康、斉藤 知栄、大久保 麗子、高橋 秀人、岡田 昌史、土井 麻理子、成田 一衛、渡辺 毅、菱田 明、槇野 博史、松尾 清一
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] かかりつけ医と腎臓専門医の連携の実際とCKD進展との関連について (2014)
  • Author(s): 斎藤 知栄、甲斐 平康、大久保 麗子、岡田 昌史、高橋 秀人、土井 麻里子、成田 一衛、渡辺 毅、菱田 明、槇野 博史、松尾 清一、山縣 邦弘
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] 慢性腎臓病を有する患者におけるトルバプタンの有効性 (2014)
  • Author(s): 丸山 彰一、松尾 清一
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] 進行性腎障害調査研究班の研究成果と課題 (2014)
  • Author(s): 丸山 彰一、松尾 清一
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] FROM-J「生活食事指導マニュアル」の有用性に対する検討 (2014)
  • Author(s): 石川 祐一、中川 幸恵、山田 康輔、甲斐 平康、齋藤 知栄、中村 丁次、成田 一衛、渡辺 毅、菱田 明、槙野 博史、松尾 清一、山縣 邦弘
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] アルブミン尿区分評価における早朝尿の重要性 (2014)
  • Author(s): 丹羽 操、安田 宜成、今井 順子、鈴木 進、加藤 佐和子、丸山 彰一、松尾 清一
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] 人間ドック受診者における血清シスタチンC検査の意義 (2014)
  • Author(s): 安田 宜成、大橋 功男、柘植 和子、大島 章、伊藤 和幸、松尾 清一
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] CD163陽性マクロファージ糸球体浸潤ならびに尿中可溶性CD163のループス腎炎活動性指標としての有用性 (2014)
  • Author(s): 遠藤 信英、坪井 直毅、松尾 清一、丸山 彰一
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] 膜性腎症とPLA2R (2014)
  • Author(s): 丸山 彰一、秋山 真一、松尾 清一
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] 腎移植ドナーにおける腎血漿流量と濾過率：健常者における基準値設定の試み (2014)
  • Author(s): 今井 順子、安田 宜成、丹羽 操、鈴木 進、加藤 佐和子、丸山 彰一、松尾 清一
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] 日本版PLA2R抗体研究2：PLA2R抗体の有無が日本人患者の腎機能予後に及ぼす影響 (2014)
  • Author(s): 武藤 玲子、秋山 真一、松尾 清一、丸山 彰一
  • Organizer: 第59回日本透析医学会学術総会・集会
  • Place of Presentation: 神戸ポートピアホテル (兵庫県神戸市)
  • Year and Date: 2014-06-12 – 2014-06-15
• [Presentation] 腹膜透析患者におけるC.E.R.A.投与量に関連する因子の検討 (2014)
  • Author(s): 鈴木 康弘、坂田 史子、勝野 敬之、加藤 規利、尾崎 武徳、小杉 智規、佐藤 和一、坪井 直毅、丸山 彰一、水野 正司、松尾 清一、伊藤 恭彦
  • Organizer: 第59回日本透析医学会学術総会・集会
  • Place of Presentation: 神戸ポートピアホテル (兵庫県神戸市)
  • Year and Date: 2014-06-12 – 2014-06-15
• [Presentation] 長期腹膜透析（PD）患者に生じた左房内calcified amorphous tumor（CAT）の1例 (2014)
  • Author(s): 田中 章仁、水野 正司、大島 英揮、筑紫 さおり、石川 英昭、坂田 史子、加藤 規利、鈴木 康弘、勝野 敬之、尾崎 武徳、小杉 智規、坪井 直毅、佐藤 和一、丸山 彰一、松尾 清一、伊藤 恭彦
  • Organizer: 第59回日本透析医学会学術総会・集会
  • Place of Presentation: 神戸国際会議場(兵庫県神戸市)
  • Year and Date: 2014-06-12 – 2014-06-15
• [Presentation] 東海腹膜透析（PD）レジストリ２ ～５年後の離脱と腹膜炎についての調査～ (2014)
  • Author(s): 水野 正司、伊藤 恭彦、鈴木 康弘、坂 洋祐、平松 武幸、玉井 宏史、水谷 真、成瀬 友彦、大橋 徳巳、春日 弘毅、志水 英明、倉田 久嗣、倉田 圭、鈴木 聡、鶴田 吉和、松岡 哲平、堀江 正宣、丸山 彰一、松尾 清一
  • Organizer: 第59回日本透析医学会学術総会・集会
  • Place of Presentation: 神戸国際会議場(兵庫県神戸市)
  • Year and Date: 2014-06-12 – 2014-06-15
• [Presentation] 高齢腹膜透析患者に発症したリウマチ性多発筋痛症の2症例 (2014)
  • Author(s): 天野 竜彰、坂田 史子、鈴木 康弘、佐藤 和一、坪井 直毅、水野 正司、丸山 彰一、伊藤 恭彦、松尾 清一
  • Organizer: 第59回日本透析医学会学術総会・集会
  • Place of Presentation: 神戸国際会議場(兵庫県神戸市)
  • Year and Date: 2014-06-12 – 2014-06-15
• [Presentation] IS TELOMERE ATTRITION LINKED TO INTERLEUKIN 6 LEVELS BUT NOT WHITE BLOOD CELL COUNTS IN JAPANESE DIALYSIS PATIENTS? (2014)
  • Author(s): Sawako Kato, Bengt Lindholm, Peter Stenvinkel, Paul G Shiels, Louise Nordfors, Yukio Yuzawa, Seiichi Matsuo, Shoichi Maruyama.
  • Organizer: the 51st ERA-EDTA Congress
  • Place of Presentation: the RAI congress center(The Netherlands,アムステルダム)
  • Year and Date: 2014-05-31 – 2014-06-03
• [Presentation] The Sun Yat-sen International Forum on Clinivakl Research and Translational (2014)
  • Author(s): Shoichi Maruyama, Ryohei Yamamoto, Hitoshi Yokoyama, Seiichi Matsuo, Enyu Imai
  • Organizer: The Ultimate Experience at Hilton Guangzhou Baiyun
  • Place of Presentation: （ Guangzhou , China）
  • Year and Date: 2014-05-23
• [Presentation] Spironolactone improving intrarenal renin-angiotensin system activation in type ２diabetic nephropathy patients with overt albuminuria. (2014)
  • Author(s): Sawako Kato, Shoichi Maruyama, Hirofumi Makino, Jun Wada, Takashi Uzu, Hisazumi Araki, Daisuke Koya,Keizo Kanasaki, Akira Nishiyama, Hiroyuki Kobori,Enyu Imai,Masahiko Ando, Yutaka Oiso, Seiichi Matsuo
  • Organizer: The 14th Asian Pacific Congress of Nephrology
  • Place of Presentation: 東京(港区,品川プリンスホテル)
  • Year and Date: 2014-05-14 – 2014-05-17
• [Presentation] Accuracy verification of cuffless automated sphygmomanometer for real-time blood pressure monitoring in hemodialysis patients. (2014)
  • Author(s): Naotake Tsuboi, Noritoshi Kato, Taiji Kawachi, Tsuyoshi Nakagawa, Seiichi Matsuo, Shoichi Maruyama
  • Organizer: Congress Secretariat of the 7th World Congress of the International Society for Hemodialysis (ISHD2014)
  • Place of Presentation: 沖縄コンベンションセンター（沖縄県宜野湾市）
  • Year and Date: 2014-04-25 – 2014-04-27
• [Presentation] ASSOCIATION OF GLOMERULAR MACROPHAGE PHENOTYPES AND URINE SOLUBLE CD163 WITH DISEASE ACTIVITY IN HUMAN LUPUS NEPHRITIS. (2014)
  • Author(s): N. Endo, N. Tsuboi, K. Furuhashi, S. Matsuo, S. Maruyama.
  • Organizer: 9th International Congress on Autoimmunity
  • Place of Presentation: Nice,France
• [Presentation] Expression of membrane complement regulators in end stage renal disease patients on peritoneal dialysis therapy. (2013)
  • Author(s): Yumi Sei, Masashi Mizuno, Yasuhiro Suzuki, Masaki Imai, Keiko Higashide, Claire L Harris, Seiichi Matsuo,Yasuhiko Ito
  • Organizer: 14th European Meeting on Complement in Human Disease
  • Place of Presentation: イエーナ,ドイツ
• [Presentation] The continuous erythropoietin receptor activator (C.E.R.A.) maintains renal anemia safely at extended administration intervals in CAPD patients. (2013)
  • Author(s): Takako Tomita, Yasuhiro Suzuki, Yasuhiko Ito, Masashi Mizuno, Hiroshi Kinashi, Humiko Sakata, Takeshi Terabayashi, Yumi Sei, Shoichi Maruyama and Seiichi Matsuo
  • Organizer: 6th International Society for Peritoneal Dialysis - Asia Pacific Chapter Meeting, ISPD-APCM
  • Place of Presentation: 台北,中国
• [Presentation] Performance of Japanese and CKD-EPI GFR Equations in Japanese Subjects. (2013)
  • Author(s): Yoshinari Yasuda, MD, PhD, Imai Junko, Shoichi Maruyama, MD, Seiichi Matsuo, MD
  • Organizer: Kidney Week 2013
  • Place of Presentation: Atlanta,USA
• [Presentation] Spironolactone Prevents Cardiac Hypertrophy in Peritoneal Dialysis Patients without Significant Adverse Effects. (2013)
  • Author(s): Yasuhiko Ito, MD, PhD, Masashi Mizuno, MD, PhD, Yasuhiro Suzuki, MD, Hirotake Kasuga, MD, PhD, Shoichi Maruyama, MD, Yukio Yuzawa, MD, Seiichi Matsuo, MD
  • Organizer: Kidney Week 2013
  • Place of Presentation: Atlanta,USA
• [Presentation] The Nationwide Retrospective Cohort Study in IgA Nephropathy in Japan. (2013)
  • Author(s): Takashi Yasuda, MD, PhD, Yoshinari Yasuda, MD, PhD, Sachiko Ohde, Osamu Takahashi, MD, PhD, Tetsuya Kawamura, MD, PhD, Seiichi Matsuo, MD
  • Organizer: Kidney Week 2013
  • Place of Presentation: Atlanta,USA
• [Presentation] Adverse Events Associated with Immunosuppressive Therapy and Tonsillectomy in IgAN: The Nationwide Retrospective Cohort Study in IgAN in Japan. (2013)
  • Author(s): Yoshinari Yasuda, MD, PhD, Takashi Yasuda, MD, PhD, Sachiko Ohde, Osamu Takahashi, MD, PhD, Tetsuya Kawamura, MD, PhD, Seiichi Matsuo, MD
  • Organizer: Kidney Week 2013
  • Place of Presentation: Atlanta,USA
• [Presentation] Neutrophil/Lymphocyte Ratio as a Predictor of Cardiovascular Events in Japanese Patients Starting Renal Replacement Therapy. (2013)
  • Author(s): Sawako Kato, MD, PhD, Bengt Lindholm, MD, PhD, Yukio Yuzawa, MD, Seiichi Matsuo, MD, Shoichi Maruyama, MD
  • Organizer: Kidney Week 2013
  • Place of Presentation: Atlanta,USA
• [Presentation] Serum Beta-2 Microglobulin Significantly Predicts Survival in Association with the Residual Renal Function in Japanese Patients on Peritoneal Dialysis- A Prospective Multicenter Cohort Study (PDR-CS). (2013)
  • Author(s): Hiroshi Morinaga, MD, Hitoshi Sugiyama, MD, PhD, Yasuhiko Ito, MD, PhD, Kazuhiko Tsuruya, MD, PhD, Hisako Yoshida, Hiroki Maruyama, MD, PhD, Shin Goto, MD, Tomoya Nishino, MD, PhD, Hiroyuki Terawaki, MD, PhD, Masaaki Nakayama, MD, PhD, Hidetomo Nakamoto, MD, PhD, Seiichi Matsuo, MD, Hirofumi Makino, MD, PhD
  • Organizer: Kidney Week 2013
  • Place of Presentation: Atlanta,USA
• [Presentation] Mac-1 Deficiency Protects Mouse from Pulmonary Hemorrhage, whereas Exacerbates Glomerulonephritis in Experimental Model of Systemic Lupus Erythematosus. (2013)
  • Author(s): Yiqin Shi, Naotake Tsuboi, MD, PhD, Kazuhiro Furuhashi, MD, PhD, Shoichi Maruyama, MD, Seiichi Matsuo, MD
  • Organizer: Kidney Week 2013
  • Place of Presentation: Atlanta,USA
• [Presentation] GFR Distributions among Scheduled Contrast-Enhanced Computed Tomography before and after eGFR Self-Report. (2013)
  • Author(s): Yoshinari Yasuda, MD, PhD, Kanako Shibata, Shoichi Maruyama, MD, Seiichi Matsuo, MD
  • Organizer: Kidney Week 2013
  • Place of Presentation: Atlanta,USA
• [Presentation] Glycosylated Protein CD147 Reflects Renal Dysfunction in Patients with Acute Tubular Necrosis. (2013)
  • Author(s): Hiroshi Kojima, MD, Tomoki Kosugi, MD, PhD, Mayuko Maeda, MD, Kayaho Maeda, MD, Yuka Sato, MD, Hiroki Hayashi, MD, Waichi Sato, MD, PhD, Seiichi Matsuo, MD, Shoichi Maruyama, MD
  • Organizer: Kidney Week 2013
  • Place of Presentation: Atlanta,USA
• [Presentation] C-Reactive Protein Mediates the Association between Low Socioeconomic Status and Pulse Pressure in Japanese CKD Cohort (CKD-JAC). (2013)
  • Author(s): Naohiko Fujii, MD, PhD, Takayuki Hamano, MD, PhD, Yoshitaka Isaka, MD, PhD, Tsuyoshi Watanabe, MD, Kosaku Nitta, MD, PhD, Tadao Akizawa, MD, Seiichi Matsuo, MD, Enyu Imai, MD, PhD, Hirofumi Makino, MD, PhD
  • Organizer: Kidney Week 2013
  • Place of Presentation: Atlanta,USA
• [Presentation] Resistance to Immunosuppressive Therapy in Patients with Primary Nephrotic Syndrome: Japan Nephrotic Syndrome Cohort Study (JNSCS) (2013)
  • Author(s): Ryohei Yamamoto, MD, PhD, Shoichi Maruyama, MD, Hitoshi Yokoyama, MD, PhD, Seiichi Matsuo, MD, Enyu Imai, MD, PhD
  • Organizer: Kidney Week 2013
  • Place of Presentation: Atlanta,USA
• [Presentation] Molecular Characteristics of Anti-PLA2R IgG in Japanese Patients with Idiopathic Membranous Nephropathy. (2013)
  • Author(s): Shin' ichi Akiyama, PhD, Enyu Imai, MD, PhD, Seiichi Matsuo, MD, Shoichi Maruyama, MD
  • Organizer: Kidney Week 2013
  • Place of Presentation: Atlanta,USA
• [Presentation] Regional Differences in Chronic Kidney Disease Prevalence in Japan: A Japanese Nationwide Health-Check Study. (2013)
  • Author(s): Yoshinari Yasuda, MD, PhD, Kiyoshi Shibata, PhD, Kunitoshi Iseki, MD, Toshiki Moriyama, MD, PhD, Kunihiro Yamagata, MD, PhD, Kazuhiko Tsuruya, MD, PhD, Hideaki Yoshida, MD, PhD, Shouichi Fujimoto, MD, Koichi Asahi, MD, PhD, Tsuyoshi Watanabe, MD, Seiichi Matsuo, MD
  • Organizer: Kidney Week 2013
  • Place of Presentation: Atlanta,USA
• [Presentation] Serum-starved Adipose-derived Stromal Cells Ameliorate Rat Crescentic Glomerulonephritis By Promoting Immunoregulatory Macrophages. (2013)
  • Author(s): Naotake Tsuboi, Kazuhiro Furuhashi, Seiichi Matsuo, Shoichi Maruyama
  • Organizer: Kidney Week 2013
  • Place of Presentation: Atlanta,USA
• [Presentation] Low Serum Cultured Adipose Tissue-derived Stromal Cells Ameriorate Acute Kidney Injury In Rats. (2013)
  • Author(s): Takayuki Katsuno, Naotake Tsuboi, Seiichi Matsuo, Shoichi Maruyama
  • Organizer: Forefronts in Nephrology Florence
  • Place of Presentation: フィレンツェ、イタリア
• [Presentation] 脂肪由来間葉系幹細胞を用いた急性呼吸窮迫症候群への治療戦略 (2013)
  • Author(s): 三村哲史，坪井直毅，橋本直純，清水明日花，金恒秀，古橋和拡，松尾清一，丸山彰一
  • Organizer: 第34回日本炎症再生医学会
  • Place of Presentation: 国立京都国際会館(京都市)
• [Presentation] 低血清培養脂肪由来間葉系幹細胞の創傷治癒促進効果についての検討 (2013)
  • Author(s): 阿部 智子，尾崎 武徳，堀之内明日花，金 恒秀，古橋 和拡，秋山 真一，勝野 敬之， 安田 香，坪井 直毅，松尾 清一，丸山 彰一
  • Organizer: 第34回日本炎症再生医学会
  • Place of Presentation: 国立京都国際会館(京都市)
• [Presentation] Mac-1 deficiency protects mouse from pulmonary hemorrhage, whereas exacerbates glomerulonephritis in experimental model of systemic lupus erythematosus. (2013)
  • Author(s): 石 一沁，坪井 直毅，古橋 和拡，Mayadas Tanya，丸山 彰一，松尾 清一
  • Organizer: 第34回日本炎症再生医学会
  • Place of Presentation: 国立京都国際会館(京都市)
• [Presentation] PD患者由来ヒト腹膜中皮細胞における膜補体制御因子の解析 (2013)
  • Author(s): 清 祐実 、水野 正司 、今井 優樹 、Claire L. Harris、松尾 清一 、伊藤 恭彦
  • Organizer: 第50回補体シンポジウム
  • Place of Presentation: 旭川グランドホテル(旭川市)
• [Presentation] SLEに伴うPodocyte infoldingの1例 (2013)
  • Author(s): 田中 章仁、神谷 文隆、永原 靖子、鈴木 康弘、加藤 規利、勝野 敬之、尾崎 武徳、小杉 智規、佐藤 和一、坪井 直毅、水野 正司、丸山 彰一、伊藤 恭彦、松尾 清一
  • Organizer: 第43回日本腎臓学会西部学術大会
  • Place of Presentation: 松山全日空ホテル(愛媛県松山市)
• [Presentation] 視力障害で発症し多発性硬化症と診断した腹膜透析患者の一例 (2013)
  • Author(s): 永原 靖子、鈴木 康弘、加藤 規利、勝野 敬之、尾崎 武徳、小杉 智規、佐藤 和一、坪井 直毅、水野 正司、丸山 彰一、伊藤 恭彦、松尾 清一
  • Organizer: 第43回日本腎臓学会西部学術大会
  • Place of Presentation: 松山全日空ホテル(愛媛県松山市)
• [Presentation] CKD診療連携における多職種介入の効果 (2013)
  • Author(s): 濱田 昌実、加藤 佐和子、林 睦晴、後藤 資実、安田 宜成、丸山 彰一、松尾 清一
  • Organizer: 第43回日本腎臓学会西部学術大会
  • Place of Presentation: 松山全日空ホテル(愛媛県松山市)