| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2015: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Outline of Final Research Achievements |
Rescue experiments using fragments of the (P)RR gene in (P)RR-deficient MEF showed the essential role of the (P)RR extracellular domain in maintenance of cell life. However, once V-ATPase is constructed, processing of the full length (P)RR to the extracellular (P)RR domain is not always necessary for the construction of V-ATPase. In addition, the mice overexpressed soluble (P)RR, that is almost extracellular domain of (P)RR, had no abnormal phenotype. Whereas, the mice overexpressed full-length (P)RR had fast muscle-dominant muscle atrophy mimicked human sarcopenia. The mechanism involved molecules contributing to autophagy, Wnt signals, and Sirt1.
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