connexin cytopathy in the pathogenesis of demyelinating disorders
| Project/Area Number |
25293204
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Kyushu University |
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Principal Investigator |
Kira Jun-ichi 九州大学, 医学(系)研究科(研究院), 教授 (40183305)
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| Co-Investigator(Kenkyū-buntansha) |
Matsushita Takuya 九州大学, 大学院医学研究院, 講師 (00533001)
Yamasaki Ryo 九州大学病院, 講師 (10467946)
Masaki Katsuhisa 九州大学, 大学院医学研究院, 助教 (90612903)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2015: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Keywords | 多発性硬化症 / 視神経脊髄炎 / Balo病 / コネキシン / アストロサイト / アクアポリン4 / グリアアセンブリ / グリアシンシチウム / オリゴデンドロサイト / エネルギー供給障害 / 脱髄性疾患 / グリア細胞 |
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| Outline of Final Research Achievements |
We found the extensive loss of connexins in active lesions of demyelinating disorders including multiple sclerosis, neuromyelitis optica and Balo's disease.Also we performed combined neuropathological and neuroradiological studies in spinal cord lesions from NMO patients. We showed all of isolated perivascular lesions, early lesion of NMO, were located in lateral and posterior columns in spinal cord. In addition, we examined whether T lymphocyte could influence cultured astrocytic Cx43 by using in vitro assay. We revealed that Th1-derived factor could downregulate the expression of astrocytic Cx43.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Efficacy of intravenous methylprednisolone pulse therapy in patients with multiple sclerosis and neuromyelitis optica2016
Author(s)
Yamasaki R, Matsushita T, Fukazawa T, Yokoyama K, Fujihara K, Ogino M, Yokota T, Miyamoto K, Niino M, Nomura K, Tomioka R, Tanaka M, Kawachi I, Ohashi T, Kaida KI, Matsui M, Nakatsuji Y, Ochi H, Fukaura H, Kanda T, Nagaishi A, Togo K, Mizusawa H, Murai H, Kira JI
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Journal Title
Multiple sclerosis
Volume: 印刷中
Issue: 10
Pages: 1337-1348
DOI
Related Report
Peer Reviewed
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[Journal Article] Japan Multiple Sclerosis Genetics Consortium Copy Number Variations in Multiple Sclerosis and Neuromyelitis Optica.2015
Author(s)
S. Sato, K. Yamamoto, T. Matsushita, N. Isobe, Y. Kawano, K, Iinuma, M. Niino, T. Fukazawa, Y. Nakamura, M. Watanabe, T. Yonekawa, K. Masaki, S. Yoshimura, H. Murai, R. Yamasaki, J. Kira
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Journal Title
Annals of Neurology
Volume: 78
Issue: 5
Pages: 762-774
DOI
Related Report
Peer Reviewed
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[Journal Article] Galectin-1 deficiency improves axonal swelling of motor neurons in SOD1 transgenic mice.2014
Author(s)
Kobayakawa, Y., Sakumi, K., Kajitani, K., Kadoya, T., Horie, H., Kira, J.I., and Nakabeppu, Y.
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Journal Title
Neuropathol Appl Neurobiol
Volume: N/A
Issue: 2
Pages: 227-244
DOI
Related Report
Peer Reviewed
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[Journal Article] A nationwide survey of hypertrophic pachymeningitis in Japan2013
Author(s)
Yonekawa T, Murai H, Utsuki S, Matsushita T, Masaki K, Isobe N, Yamasaki R, Yoshida M, Kusunoki S, Sakata K, Fujii K, Kira J
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Journal Title
J Neurol Neurosurg Psychiatry
Volume: 85
Issue: 7
Pages: 732-9
DOI
Related Report
Peer Reviewed
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