Plasticity induction by TMS using monophasic magnetic pulses (quadripulse stimulation) in human brain, spinal cord
| Project/Area Number |
25293206
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2013: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
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| Keywords | 長期増強 / 長期抑圧 / LTP / LTD / 磁気刺激 / 歩行誘導 / 対麻痺 / 脊髄 / 神経可塑性 / 反復磁気刺激 / 機能画像検査 / fMRI / QPS / dopamine / ドパミン |
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| Outline of Final Research Achievements |
These three years, I have studied several aspects of quadripuls stimulation (QPS). I will mention three aspects. Interindividual stability or variability of QPS: We have shown more than the expected significant plasticity induction was accomplished in more than 80% of normal volunteers, which is much more stable than the other methods of stimulation. The voluntary contraction of the target muscle had no significant effects on the plasticity induced by QPS.
Anti-Parkinson’s disease drugs and plasticity: L-dopa enhanced the plasticity bidirectionally, and agonists had no influence on the plasticity. It may be explained by the plasticity enhancement should be produced by D1 function of dopamine. Zonisamide had a mild enhancing effect on the plasticity.
Gait induction by spinal plasticity: Repetitive TMS over the lumbar gait center induced gait-like rhythmical movements in leg muscles in normal subjects. It may help the gait in patients with paraparesis.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] Variability in response to quadripulse stimulation of the motor cortex2016
Author(s)
Nakamura K, Groiss SF, Hamada M, Enomoto H, Kadowaki S, Murakami T, Wiratman W, Chang F, Kobayashi S, Hnajima R, Terao Y, Ugawa Y
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Journal Title
Brain Stimul
Volume: in press
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Somatosensory-evoked potential modulation by quadripulse transcranial magnetic stimulation in patients with benign myoclonus epilepsy.2016
Author(s)
Nakatani-Enomoto S, Hanajima R, Hamada M, Terao Y, Matsumoto H, Shirota Y, Ohminami S, Okabe S, Hirose M, Nakamura K, Furubayashi T, Groiss SJ, Kobayashi S, Mochizuki H, Enomoto H, Ugawa Y.
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Journal Title
Clin Neurophysiol
Volume: 127(2)
Issue: 2
Pages: 1560-7
DOI
Related Report
Peer Reviewed
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[Journal Article] Modulation of error-sensitivity during a prism adaptation task in people with cerebellar degeneration.2015
Author(s)
Hanajima R, Shadmehr R, Ohminami S, Tsutsumi R, Shirota Y, Shimizu T, Tanaka N, Terao Y, Tsuji S, Ugawa Y, Uchimura M, Inoue M, Kitazawa S.
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Journal Title
J Neurophysiol
Volume: 114(4)
Issue: 4
Pages: 2460-71
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Bidirectional effects on inter-hemispheric resting-state functional connectivity induced by excitatory and inhibitory repetitive transcranial magnetic stimulation.2013
Author(s)
Watanabe T, Abe O, Kuwabara H, Yahata N, Takano Y, Iwashiro N, Natsubori T, Aoki Y, Takao H, Kawakubo Y, Kamio Y, Kato N, Miyashita Y, Kasai K, and Yamasue H.
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Journal Title
Human Brain Mapping
Volume: 35
Issue: 5
Pages: 1896-1905
DOI
Related Report
Peer Reviewed / Open Access
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