| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2013: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
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| Outline of Final Research Achievements |
These three years, I have studied several aspects of quadripuls stimulation (QPS). I will mention three aspects. Interindividual stability or variability of QPS: We have shown more than the expected significant plasticity induction was accomplished in more than 80% of normal volunteers, which is much more stable than the other methods of stimulation. The voluntary contraction of the target muscle had no significant effects on the plasticity induced by QPS.
Anti-Parkinson’s disease drugs and plasticity: L-dopa enhanced the plasticity bidirectionally, and agonists had no influence on the plasticity. It may be explained by the plasticity enhancement should be produced by D1 function of dopamine. Zonisamide had a mild enhancing effect on the plasticity.
Gait induction by spinal plasticity: Repetitive TMS over the lumbar gait center induced gait-like rhythmical movements in leg muscles in normal subjects. It may help the gait in patients with paraparesis.
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