Molecular mechanism of diabetes mellitus based on beta-cell transcription factor network
| Project/Area Number |
25293212
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Kumamoto University |
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Principal Investigator |
Yamagata Kazuya 熊本大学, 大学院生命科学研究部, 教授 (70324770)
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| Co-Investigator(Kenkyū-buntansha) |
Yoshizawa Tatsuya 熊本大学, 大学院生命科学研究部, 准教授 (40313530)
Sato Yoshifumi 熊本大学, 大学院生命科学研究部, 助教 (90622598)
門松 毅 熊本大学, 大学院生命科学研究部, 助教 (90555757)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Keywords | 糖尿病 / インスリン分泌 / 転写因子 / MODY / HNF / インスリン / グルコキナーゼ |
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| Outline of Final Research Achievements |
Mutations in the genes encoding hepatocyte nuclear factor (HNF) cause impaired insulin secretion and diabetes mellitus. However, the detailed molecular mechanisms are largely unknown. In the present work, we found that Crp is a direct target gene of HNF1 and high sensitive could be a biomarker for HNF1 diabetes. In addition, we found that Tmed6 is a target gene of HNF1. Furthermore, we identified that Anks4b, a direct target of HNF4, regulates insulin secretion by beta-cells.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] RNA interference-mediated knockdown of Smad1 inhibits receptor activator of nuclear factor κB ligand expression induced by BMP-2 in primary osteoblasts.2015
Author(s)
Yoshikawa Y, Yoshizawa T, Domae E, Hieda Y, Takeyama A, Hirota S, Kawamoto A, Goda S, Tamura I, Kamada A, Komasa Y, Morita S, Yamagata K, Ikeo T.
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Journal Title
Archives of Oral Biology
Volume: 60
Issue: 9
Pages: 1319-26
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Sirt7 Contributes to Myocardial Tissue Repair by Maintaining Transforming Growth Factor-β Signaling Pathway2015
Author(s)
Araki S, Izumiya Y, Rokutanda T, Ianni A, Hanatani S, Kimura Y, Onoue Y, Senokuchi T, Yoshizawa T, Yasuda O, Koitabashi N, Kurabayashi M, Braun T, Bober E, Yamagata K, Ogawa H
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Journal Title
Circulation
Volume: 132(12)
Issue: 12
Pages: 1081-1093
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway.2014
Author(s)
Yoshizawa T, Karim Md. F, Sato Y, Senokuchi T, Miyata K, Fukuda T, Go C, Tasaki M, Uchimura K, Kadomatsu T, Tian Z, Smolka C, Sawa T, Kakeya M, Tomizawa K, Ando Y, Araki E, Akaike T, Braun T, Oike Y, Bober E, Yamagata K.
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Journal Title
Cell Metab.
Volume: 9
Issue: 4
Pages: 712-721
DOI
Related Report
Peer Reviewed / Open Access
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