Detection and functional analysis of the novel peptides regulating feeding and energy metabolic homeostasis
Project/Area Number |
25293216
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Endocrinology
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Research Institution | University of Miyazaki |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
Yamaguchi Hideki 宮崎大学, 医学部, 講師 (10305097)
Ueno Hiroaki 宮崎大学, 医学部, 助教 (00381062)
Toshinai Koji 宮崎大学, 医学部, 講師 (80381101)
Sakota Hideyuki 宮崎大学, 医学部, 講師 (50376464)
Tsuchimochi Wakaba 宮崎大学, 医学部, 医員 (90573303)
Tsubouchi Hironobu 宮崎大学, 医学部, 助教 (60573988)
Shimizu Kouichirou 宮崎大学, 医学部, 助教 (90711292)
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Research Collaborator |
Waise T. M. Zaved
Naznin Farhana
張 維東
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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Keywords | 摂食調節 / 視床下部 / ペプチド / 細胞内伝達情報 / エネルギー代謝 / 交感神経 / インスリン分泌 / 糖尿病 |
Outline of Final Research Achievements |
We identified two novel bioactive peptides and revealed their effects on feeding and energy homeostasis. Peptide A is expressed in the pancreatic beta cell with insulin and increased glucose stimulated insulin secretion from the islets and insulinoma-derived beta cell line MIN6. The peptide also increased glucose-induced intracellular calcium concentration. Glucose tolerant test showed the peptide increased insulin secretion in mice. The peptide is expected to be a candidate for diabetes treatment. Peptide B consists of 20 amino acids. Intraventriclular administration of peptide B suppressed food intake dose-dependently. This peptide decreased spontaneous movement, but increased the oxygen consumption. We studied the activities of sympathetic nerve and brown adipose tissue by the peptide B stimulation.
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Report
(4 results)
Research Products
(58 results)
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[Journal Article] Central insulin-action activates Kupffer cells by suppressing hepatic vagal activation through nicotinic alpha 7 acetylcholine receptor2016
Author(s)
Kimura K, Tanida M,Nagata N, Inaba Y, Watanabe H, Nagashimada M, Ota T, Asahara S, Kido Y, Matsumoto M, Toshinai K, Nakazato M, Shibamoto T, Kaneko S, Kasuga M, Inoue H
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Journal Title
Cell Rep
Volume: 14
Pages: 2362-2374
Related Report
Peer Reviewed / Open Access
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[Journal Article] Ghrelin administration for chronic respiratory failure: a randomized dose-comparison trial2015
Author(s)
Matsumoto N, Miki K, Tsubouchi H, Sakamoto A, Arimura Y, Yanagi S, Iiboshi H, Yoshida M, Souma R, Ishimoto H, Yamamoto Y, Yatera K, Yoshikawa M, Sagara H, Iwanaga T, Mukae H, Maekura R, Kimura H, Nakazato M, Kangawa K
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Journal Title
Lung
Volume: 193
Pages: 239-247
Related Report
Peer Reviewed / Open Access
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[Journal Article] Ghrelin2015
Author(s)
Muller TD, Nakazato M, Kojima M, Kangawa K, Smith RG, Tschop MH et al
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Journal Title
Mol Metab
Volume: 4
Pages: 437-460
Related Report
Open Access / Int'l Joint Research
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[Journal Article] Ghrelin administration suppresses inflammation-associated colorectal carcinogenesis in mice2015
Author(s)
Kawaguchi M, Kanemaru A, Fukushima T, Yamamoto K, Tanaka H, Haruyama Y, Itoh H, Matsumoto N, Kangawa K, Nakazato M, Kataoka H
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Journal Title
Cancer Sci.
Volume: 106
Issue: 9
Pages: 1130-1136
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Ghrelin Administration for Chronic Respiratory Failure: A Randomized Dose-Comparison Trial. Lung2015
Author(s)
Matsumoto N, Miki K, Tsubouchi H, Sakamoto A, Arimura Y, Yanagi S, Iiboshi H, Yoshida M, Souma R, Ishimoto H, Yamamoto Y, Yatera K, Yoshikawa M, Sagara H, Iwanaga T, Mukae H, Maekura R, Kimura H, Nakazato M, Kangawa K
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Journal Title
Lung
Volume: 193
Issue: 2
Pages: 239-247
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Ghrelin.2015
Author(s)
Muller T.D., Kojima M, Bloom S, Bowers C.Y, Casanueva F, Cowley M, Dickson S, Inui A, Nakazato M, Nass R, Perez-Tilve D, Pfluger, P.T., Schwartz T, Seeley R, Sleeman M, Smith R.G., Sun Y, Sussel L, Tong J, Thorner M.O., van der Lely A.J., van der Ploeg L, Zigman J, Kangawa K, Horvath T, Tschop M.H, et al
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Journal Title
Molecular Metabolism
Volume: 未定
Issue: 6
Pages: 437-460
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 2型糖尿病治療の新展開2015
Author(s)
中里雅光
Organizer
第88回日本内分泌学会学術集会
Place of Presentation
ホテルニューオータニ東京(東京都,千代田区)
Year and Date
2015-04-24
Related Report
Invited
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[Presentation] Neuroendocrine regulatory peptide-4(nerp-4): A Vgf derived peptide that expresses in pancreatic β- cells and stimulate glucose-induced insulin secretion.2014
Author(s)
Shimizu K, Moin AS Md, Ueno H, Toshinai K, Yamaguchi H, Yamasaki M, Hirako T, Shioda S, Sasaki K, Minamino N, Nakazato M
Organizer
American Diabetes Association 74th Scientific Sessions
Place of Presentation
San Francisco, California. USA
Year and Date
2014-06-13 – 2014-06-17
Related Report
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