| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2015: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2013: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Outline of Final Research Achievements |
We studied on target tissue injury in graft-versus-host disease (GVHD) following allogeneic hematopoietic stem cell transplantation and found that intestinal stem cells and their niche are targeted by alloreactive donor T cells. Intestinal ecology system is also distiubed and such a disruption of tissue homeostasis of intestinal microbial ecology is associated with clinical manifestation of GVHD. We found that Intestinal stem cell growth factor R-spondin1 promotes growth of both intestinal stem cells and Paneth cells. Brief administration of R-spondin1 to hosts protects the intestinal stem-niche system, ameliorates GVHD, prevents infection, and improves transplant outcome. Our study suggests that such novel strategies to maintain host homeostasis could improve transplant outcome.
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