| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2013: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Outline of Final Research Achievements |
In this study, we found that HTLV-1 bZIP factor (HBZ) induced unstable expression of Foxp3, which is associated with overproduction of interferon-γ (IFN-γ). IFN-γ production is likend with oncogenesis and inflammation. In addition, HBZ induced GATA3 transcription, which promoted CCR4 gene transcription. Enhanced CCR4 expression is associated with enhanced migration and proliferation. Furthermore, HBZ induced expression of TIGIT, which suppressed host immune response through increased IL-10 production from dendritic cells and T cells. HBZ causes inflammation through increased interferon gamma production.
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