Analysis of HTLV-1 bZIP factor induced inflammatory diseases
| Project/Area Number |
25293219
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Kyoto University |
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Principal Investigator |
Matsuoka Masao 京都大学, ウイルス・再生医科学研究所, 客員教授 (10244138)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2013: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Keywords | HTLV-1 / HBZ / 炎症 / TIGIT / CCR4 / Foxp3 / HTLV-1関連疾患 / Tax |
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| Outline of Final Research Achievements |
In this study, we found that HTLV-1 bZIP factor (HBZ) induced unstable expression of Foxp3, which is associated with overproduction of interferon-γ (IFN-γ). IFN-γ production is likend with oncogenesis and inflammation. In addition, HBZ induced GATA3 transcription, which promoted CCR4 gene transcription. Enhanced CCR4 expression is associated with enhanced migration and proliferation. Furthermore, HBZ induced expression of TIGIT, which suppressed host immune response through increased IL-10 production from dendritic cells and T cells. HBZ causes inflammation through increased interferon gamma production.
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Report
(5 results)
Research Products
(76 results)
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[Journal Article] Enhancement of anti-STLV-1/HTLV-1 immune responses through multimodal effects of anti-CCR4 antibody.2016
Author(s)
Sugata K, Yasunaga JI, Miura M, Akari H, Utsunomiya A, Nosaka K, Watanabe Y, Suzushima H, Koh KR, Nakagawa M, Kohara M, Matsuoka M.
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Journal Title
Scientific report
Volume: 6
Issue: 1
Pages: 27150-27150
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Integrated molecular analysis of adult T cell leukemia/lymphoma.2015
Author(s)
Kataoka K, Nagata Y, Kitanaka A, Shiraishi Y, Shimamura T, Yasunaga J, Totoki Y, Chiba K, Sato-Otsubo A, Nagae G, et al.
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Journal Title
Nat Genet.
Volume: 47(11)
Issue: 11
Pages: 1304-15
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Characterization of simian T-cell leukemia virus type 1 in naturally infected Japanese macaques as a model of HTLV-1 infection.2013
Author(s)
Miura M, Yasunaga J-I, Tanabe J, Sugata K, Zhao T, Ma G, Miyazato P, Ohshima K, Kaneko A, Watanabe A, Saito A, Akari H and Matsuoka M
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Journal Title
Retrovirology
Volume: 10
Issue: 1
Pages: 118-118
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Hematopoietic Stem Cell Infected with HTLV-1 Functions As a Viral Reservoir In Vivo.2016
Author(s)
Yasunaga, JI., Furuta, R., Miura, M., Sugata, K., Saito, A., Akari, H., Shimizu, M., Matsuda, F., Ueno, T., Takenouchi, N., Fujisawa, J., Melamede, A., Bangham, CR., Matsuoka, M.
Organizer
58th ASH Annual Meeting
Place of Presentation
San Diego
Year and Date
2016-12-03
Related Report
Int'l Joint Research
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