Clarification of the mechanism of the chronicity of allergic diseases and establishment of the thrapeutic strategy against it

• Project/Area Number: 25293224
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Collagenous pathology/Allergology
• Research Institution: Saga University
• Principal Investigator: Izuhara Kenji 佐賀大学, 医学部, 教授 (00270463)
• Co-Investigator(Kenkyū-buntansha): ARIMA Kazuhiko 佐賀大学, 医学部, 准教授 (60336112) ; SUZUKI Shoichi 佐賀大学, 医学部, 助教 (40253695) ; OHTA Shoichiro 佐賀大学, 医学部, 助教 (20346886) ; OGAWA Masahiro 佐賀大学, 医学部, 助教 (90599317) ; NUNOMURA Satoshi 佐賀大学, 医学部, 助教 (70424728) ; YAMAMOTO Kenichi 佐賀大学, 医学部, 研究員 (00711798) ; INAMITSU Masako 佐賀大学, 医学部, 研究員 (10711814) ; NANRI Yasuhiro 佐賀大学, 医学部, 研究員 (00382218) ; 増岡 美穂 佐賀大学, 医学部, 非常勤博士研究員 (70588699)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000); Fiscal Year 2015: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000); Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2013: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
• Keywords: アレルギー / アトピー性皮膚炎 / アレルギー性結膜炎 / サイトカイン / 結膜炎 / 上皮細胞 / ペリオスチン / 気管支喘息

Outline of Final Research Achievements

Although it is known that type 2 immunity is the main body of allergic inflammation, the detailed mechanism of allergic inflammation evoked by IL-4 or IL-13, signature type 2 cytokines is unclear. We have focused on periostin, an IL-4- or IL-13-inducible product. We, in this study, found that periostin and IL-1alpha produced in fibroblasts and keratinocytes, respectively, co-operatively act on fibroblasts inducing production of IL-6. Moreover, we found that high concentration of periostin is detected in tears of allergic conjunctivitis patients correlated with their clinical severities, suggesting the usefulness of measurement of tear periostin for treatment of allergic conjunctivitis.

Research Products

• [Int'l Joint Research] Hanyang University College of Medicine(韓国)
• [Int'l Joint Research] Cincinnati Children's Hospital(米国)
• [Int'l Joint Research] Karolinska Institutet(スウェーデン)
• [Journal Article] Reduced vitreal concentration of periostin after vitrectomy in patients with proliferative diabetic retinopathy (2016)
  • Author(s): Tachibana T, Yoshida S, Kobayashi Y, Nakama T, Ishikawa K, Nakao S, Izuhara K, Kono T, Ishibashi T
  • Journal Title: Acta Ophthalmologica Volume: 94 Issue: 1
  • DOI: 10.1111/aos.12752
  • Peer Reviewed / Open Access
• [Journal Article] Periostin contributes to epidermal hyperplasia in psoriasis common to atopic dermatitis (2015)
  • Author(s): Arima K, Ohta S, Takagi A, Shiraishi H, Masuoka M, Ontsuka K, Suto H, Suzuki S, Yamamoto K-i, Ogawa M, Simmons O, Yamaguchi Y, Toda S, Aihara M, Conway SJ, Ikeda S, Izuhara K.
  • Journal Title: Allergology International Volume: 64 Issue: 1 Pages: 41-48
  • DOI: 10.1016/j.alit.2014.06.001
  • NAID: 130004873124
  • ISSN: 1323-8930, 1440-1592
  • URL: https://localhost/en/publications/ebff2209-6de7-4df0-ae52-61f40a94ecbd
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Serum level of periostin can predict long-term outcome of idiopathic pulmonary fibrosis (2015)
  • Author(s): Tajiri, M., Okamoto, M., Fujimoto, K., Johkoh, T., Ono, J., Tominaga, M., Azuma, K., Kawayama, T., Ohta, S., Izuhara, K. & Hoshino, T.
  • Journal Title: Respiratory investigation Volume: 53 Issue: 2 Pages: 73-81
  • DOI: 10.1016/j.resinv.2014.12.003
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Phenotype of asthma related with high serum periostin levels (2015)
  • Author(s): Matsusaka M, Kabata H, Fukunaga K, Suzuki Y, Masaki K, Mochimaru T, Sakamaki F, Oyamada Y, Inoue T, Oguma T, Sayama K, Koh H, Nakamura M, Umeda A, Ono J, Ohta S, Izuhara K, Asano K, Betsuyaku T.
  • Journal Title: Allergology International Volume: 64 Issue: 2 Pages: 175-180
  • DOI: 10.1016/j.alit.2014.07.003
  • NAID: 130005290305
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Journal Article] Overexpression of CD163 in vitreous and fibrovascular membranes of patients with proliferative diabetic retinopathy: possible involvement of periostin (2015)
  • Author(s): Kobayashi Y, Yoshida S, Nakama T, Zhou Y, Ishikawa K, Arita R, Nakao S, Miyazaki M, Sassa Y, Oshima Y, Izuhara K, Kono T, Ishibashi T
  • Journal Title: Brit J Ophthalmol Volume: ９９ Issue: 4 Pages: 451-456
  • DOI: 10.1136/bjophthalmol-2014-305321
  • Peer Reviewed / Open Access
• [Journal Article] Periostin in the bronchial lavage fluid of asthma patients (2015)
  • Author(s): akamura, Y., Nagashima, H., Ohta, S., Ono, J., Yamauchi, K. & Izuhara, K.
  • Journal Title: Allergology International Volume: 64 Issue: 2 Pages: 209-210
  • DOI: 10.1016/j.alit.2015.01.001
  • NAID: 130005290284
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] No increase in the serum periostin level is detected in elementary school-age children with allergic diseases (2015)
  • Author(s): Inoue, Y., Izuhara, K., Ohta, S., Ono, J. & Shimojo, N.
  • Journal Title: Allergology International Volume: 64 Issue: 3 Pages: 289-290
  • DOI: 10.1016/j.alit.2015.04.001
  • NAID: 130005290276
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Periostin Is a Key Niche Component for Wound Metastasis of Melanoma. (2015)
  • Author(s): Fukuda K, Sugihara E, Ohta S, Izuhara K, Funakoshi T, Amagai M, Saya H.
  • Journal Title: PLoS One Volume: 10 Issue: 6 Pages: e0129704-e0129704
  • DOI: 10.1371/journal.pone.0129704
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Serum periostin levels correlate with airway hyperresponsiveness to methacholine and mannitol in children with asthma (2015)
  • Author(s): Song JS, You JS, Jeong SI, Yang S, Hwang IT, Im YG, Baek HS, Kim HY, Izuhara K
  • Journal Title: Allergy Volume: ７０ Issue: 6 Pages: 674-681
  • DOI: 10.1111/all.12599
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Recent developments regarding periostin in bronchial asthma (2015)
  • Author(s): Izuhara K, Matsumoto H, Ohta S, Ono J, Arima K, Ogawa M
  • Journal Title: Allergology International Volume: 64 Issue: Supplement.1 Pages: 3-10
  • DOI: 10.1016/j.alit.2015.04.012
  • NAID: 130005290263
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Predicting asthma morbidity in children using proposed markers of Th2-type inflammation (2015)
  • Author(s): Konradsen, J.R., Skantz, E., Nordlund, B., Lidegran, M., James, A., Ono, J., Ohta, S., Izuhara, K., Dahlen, S.E., Alving, K. & Hedlin, G.
  • Journal Title: Pediatric allergy and immunology Volume: 26 Issue: 8 Pages: 772-9
  • DOI: 10.1111/pai.12457
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] The Chitinase proteins YKL-40 and chitotriosidase are increased in both asthma and COPD (2015)
  • Author(s): James AJ, Reinius LE, Verhoek M, Gomes A, Kupczyk M, Hammar U, Ono J, Ohta S, Izuhara K, Bel E, Kere J, Söderhäll C, Dahlén B, Boot RG, Dahlén S
  • Journal Title: Am J Respir Crit Care Med Volume: １９３ Issue: 9 Pages: 131-142
  • DOI: 10.1371/journal.pone.0024399
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Increased expression of M-CSF and IL-13 in vitreous of patients with proliferative diabetic retinopathy: implications for M2 macrophage-involving fibrovascular membrane formation. (2014)
  • Author(s): Yoshida S, Kobayashi Y, Nakama T, Zhou Y, Ishikawa K, Arita R,Nakao S, Miyazaki M, Sassa Y, Oshima Y, Izuhara K, Kono T,Ishibashi T
  • Journal Title: Br J Ophthalmol Volume: 99 Issue: 5 Pages: 629-634
  • DOI: 10.1136/bjophthalmol-2014-305860
  • Peer Reviewed / Open Access
• [Journal Article] Periostin promotes the generation of fibrous membranes in proliferative vitreoretinopathy (2014)
  • Author(s): Ishikawa K, Yoshida S, Nakao S, Nakama T, Kita T, Asato R, Sassa Y, Arita R, Miyazaki M, Enaida H, Oshima Y, Murakami N, Niiro H, Ono J, Matsuda A, Goto Y, Akashi K, Izuhara K, Kudo A, Kono T, Hafezi-Moghadam A, Ishibashi T.
  • Journal Title: FASEB J Volume: 28 Issue: 1 Pages: 131-142
  • DOI: 10.1096/fj.13-229740
  • Peer Reviewed / Open Access
• [Journal Article] Periostin controls keratinocyte proliferation and differentiation by interacting with the paracrine IL-1a/IL-6 loop. (2014)
  • Author(s): Taniguchi K, Arima K, Masuoka M, Ohta S, Shiraishi H, Ontsuka K, Suzuki S, Inamitsu M, Yamamoto K-i, Simmons O, Toda S, Conway SJ, Hamasaki Y, Izuhara K.
  • Journal Title: J Invest Dermatol Volume: 134 Issue: 5 Pages: 1295-1304
  • DOI: 10.1038/jid.2013.500
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The role of periostin in tissue remodeling across health and disease (2014)
  • Author(s): Conway SJ, Izuhara K, Kudo Y, Litvin J, Markwald R, Ouyang G, Arron JR, Holweg CT, Kudo A
  • Journal Title: Cell Mol Life Sci Volume: 71 Issue: 7 Pages: 1279-1288
  • DOI: 10.1007/s00018-013-1494-y
  • NAID: 120006714444
  • Peer Reviewed / Open Access
• [Journal Article] Periostin in Allergic Inflammation (2014)
  • Author(s): Kenji Izuhara, Kazuhiko Arima, Shoichiro Ohta, Shoichi Suzuki, Masako Inamitsu, and Ken-ichi Yamamoto
  • Journal Title: Allergology International Volume: 63 Issue: 2 Pages: 143-151
  • DOI: 10.2332/allergolint.13-RAI-0663
  • NAID: 130004477217
  • ISSN: 1323-8930, 1440-1592
  • URL: https://localhost/en/publications/0be4eabd-6b04-4ac1-acf3-c7228d162284
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Using exhaled nitric oxide and serum periostin as a composite marker to identify severe/steroid-insensitive asthma. (2014)
  • Author(s): Nagasaki T, Matsumoto H, Kanemitsu Y, Izuhara K, Tohda Y, Horiguchi T, Kita H, Tomii K, Fujimura M, Yokoyama A, Nakano Y, Hozawa S, Ito I, Oguma T, Izuhara Y, Tajiri T, Iwata T, Ono J, Ohta S, Yokoyama T, Niimi A, Mishima M.
  • Journal Title: Am J Respir Crit Care Med Volume: 190 Issue: 12 Pages: 1449-1452
  • DOI: 10.1164/rccm.201407-1290le
  • NAID: 40020962796
  • Peer Reviewed / Open Access
• [Journal Article] GLCCI1 variant accelerates pulmonary function decline in patients with asthma receiving inhaled corticosteroids. (2014)
  • Author(s): Izuhara Y, Matsumoto H, Kanemitsu Y, Izuhara K, Tohda Y, Horiguchi T, Kita H, Kuwabara K, Tomii K, Otsuka K, Fujimura M, Ohkura N, Tomita K, Yokoyama A, Ohnishi H, Nakano Y, Oguma T, Hozawa S, Nagasaki T, Ito I, Oguma T, Inoue H, Tajiri T, Iwata T, Ono J, Ohta S, Tamari M, Hirota T, Yokoyama T, Niimi A, Mishima M.
  • Journal Title: Allergy Volume: 69 Issue: 5 Pages: 668-73
  • DOI: 10.1111/all.12400
  • Peer Reviewed / Open Access
• [Journal Article] Periostin levels correlate disease severity and chronicity in patients with atopic dermatitis. (2014)
  • Author(s): Kenzen Kou, Tomoko Okawa, Yukie Yamaguchi, Junya Ono, Yusuke Inoue, Masumi Kohno, Setsuko Matsukura, Tsuyoshi Kambara, Shoichiro Ohta, Kenji Izuhara, and Michiko Aihara
  • Journal Title: British Journal of Dermatology Volume: 171 Issue: 2 Pages: 283-291
  • DOI: 10.1111/bjd.12943
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Periostin accelerates human malignant melanoma progression by modificating the melanoma microenvironment (2014)
  • Author(s): Kotobuki Y, Tanemura A, Serada S, Yang L, Nomura S, Kudo A, Izuhara K, Murota H, Fujimoto M, Katayama I, Naka T
  • Journal Title: Pigment Cell Melanoma Res Volume: 27 Issue: 4 Pages: 630-639
  • DOI: 10.1111/pcmr.12245
  • Peer Reviewed / Open Access
• [Journal Article] Expressions and Roles of Periostin in Otolaryngological Diseases (2014)
  • Author(s): Ohta N, Ishida A, Kurakami K, Kakehata S, Ono J, Okubo K, Ikeda H, Izuhara K
  • Journal Title: Allergology International Volume: 63 Issue: 2 Pages: 171-180
  • DOI: 10.2332/allergolint.13-RAI-0673
  • NAID: 130004477218
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Journal Article] Advancing the education in molecular diagnostics: The IFCC Initiative "Clinical Molecular Biology Curriculum" (C-CMBC); A ten-years experience (2014)
  • Author(s): Lianidou E, Ahmad-Nejad P, Izuhara K, Cremonesi L, Schröder M, Richter K, Neumaier M
  • Journal Title: Clinica Chimica Acta Volume: 436 Pages: 5-8
  • DOI: 10.1016/j.cca.2014.04.031
  • Peer Reviewed / Open Access
• [Journal Article] Osteopontin and periostin are associated with a 20-year decline of pulmonary function in patients with asthma. (2014)
  • Author(s): Kanemitsu Y, Ito I, Niimi A, Izuhara K, Ohta S, Ono J, Iwata T, Matsumoto H, Mishima M
  • Journal Title: Am J Respir Crit Care Med Volume: 190 Issue: 4 Pages: 472-474
  • DOI: 10.1164/rccm.201403-0562le
  • Peer Reviewed / Open Access
• [Journal Article] Association of serum periostin with aspirin-exacerbated respiratory disease. (2014)
  • Author(s): Mi-Ae Kim, Kenji Izuhara, Shoichiro Ohta, Junya Ono, Moon Kyung Yoon, MS, Ga Young Ban, Hye-Soo Yoo, Yoo Seob Shin, Young-Min Ye, Dong-Ho Nahm, and Hae-Sim Park
  • Journal Title: Annals of Allergy, Asthma & Immunology Volume: 113 Issue: 3 Pages: 314-320
  • DOI: 10.1016/j.anai.2014.06.014
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Critical role for mast-cell Stat5 activity in skin inflammation. (2013)
  • Author(s): Ando, T., Xiao, W., Gao, P., Namiranian, S., Matsumoto, K., Tomimori, Y., Hong, H., Yamashita, H., Kimura, M., Kashiwakura, J., Hata, T.R., Izuhara, K., Gurish, M.F., Roers, A., Rafaels, N.M., Barnes, K.C., Jamora, C., Kawakami, Y., and Kawakami, T.
  • Journal Title: Cell Reports Volume: 6 Issue: 2 Pages: 366-376
  • DOI: 10.1016/j.celrep.2013.12.029
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy of omalizumab in eosinophilic chronic rhinosinusitis patients with asthma. (2013)
  • Author(s): Tajiri T, Matsumoto H, Hiraumi H, Ikeda H, Morita K, Izuhara K, Ono J, Ohta S, Ito I, Oguma T, Nakaji H, Inoue H, Iwata T, Nagasaki T, Kanemitsu Y, Ito J, Niimi A, Mishima M.
  • Journal Title: Ann Allergy Asthma Immunol. Volume: 110 Issue: 5 Pages: 387-8
  • DOI: 10.1016/j.anai.2013.01.024
  • Peer Reviewed
• [Journal Article] Increased periostin associates with greater airflow limitation in patients receiving inhaled corticosteroids (2013)
  • Author(s): Kanemitsu Y, Mishima M,et al.
  • Journal Title: J Allergy Clin Immunol Volume: 132 Issue: 2 Pages: 305-312
  • DOI: 10.1016/j.jaci.2013.04.050
  • NAID: 120005342661
  • Peer Reviewed
• [Journal Article] Markers that can Reflect Asthmatic Activity before and after Reduction of Inhaled Corticosteroids: A Pilot Study (2013)
  • Author(s): Go Kato, Koichiro Takahashi, Kenji Izuhara, Kazutoshi Komiya, Shinya Kimura and Shinichiro Hayashi
  • Journal Title: Biomarker Insights Volume: 8 Pages: 97-105
  • DOI: 10.4137/bmi.s12537
  • Peer Reviewed
• [Journal Article] Clinical and pathological characteristics of organized hematoma. (2013)
  • Author(s): Ohta N, Watanabe T, Ito T, Kubota T, Suzuki Y, Ishida A, Kakehata S, Aoyagi M, Matsubara M, Izuhara K, Kakehata S.
  • Journal Title: International Journal of Otolaryngology Volume: 132 Pages: 305-312
  • DOI: 10.1155/2013/539642
  • Peer Reviewed
• [Presentation] アレルギー性炎症の慢性化機序 (2016)
  • Author(s): 出原賢治
  • Organizer: 第34回日本耳鼻咽喉科免疫アレルギー学会
  • Place of Presentation: 鳥羽
  • Year and Date: 2016-02-04
  • Invited
• [Presentation] 分子標的の探索 (2015)
  • Author(s): 出原賢治
  • Organizer: 第2回日本アレルギー学会総合アレルギー講習会
  • Place of Presentation: 横浜
  • Year and Date: 2015-12-12
  • Invited
• [Presentation] 気管支喘息治療における新時代の幕開け (2015)
  • Author(s): 出原賢治
  • Organizer: 第53回日本内科学会近畿支部生涯教育講演会
  • Place of Presentation: 神戸
  • Year and Date: 2015-11-28
  • Invited
• [Presentation] マトリセルラータンパク質であるペリオスチンによる炎症惹起機序とその臨床 (2015)
  • Author(s): 出原賢治
  • Organizer: 第19回日本内分泌病理学会学術総会
  • Place of Presentation: 佐賀
  • Year and Date: 2015-10-24
  • Invited
• [Presentation] Potential protein markers for asthma (2015)
  • Author(s): Izuhara K
  • Organizer: XXIV World Allergy Congress
  • Place of Presentation: ソウル
  • Year and Date: 2015-10-14
  • Int'l Joint Research / Invited
• [Presentation] Recent progress in the basic research of periostin in bronchial asthma (2015)
  • Author(s): 出原賢治
  • Organizer: 第25回国際喘息学会日本・北アジア部会
  • Place of Presentation: 横浜
  • Year and Date: 2015-09-03
  • Int'l Joint Research / Invited
• [Presentation] 喘息におけるバイオマーカー レビュートーク (2015)
  • Author(s): 出原賢治
  • Organizer: 第64回日本アレルギー学会
  • Place of Presentation: 東京
  • Year and Date: 2015-05-26
  • Invited
• [Presentation] 間質性肺炎特異的ペリオスチン測定キットの開発 (2015)
  • Author(s): 出原賢治
  • Organizer: 第55回日本呼吸器学会
  • Place of Presentation: 東京
  • Year and Date: 2015-04-17
  • Invited
• [Presentation] 特発性肺線維症と血清バイオマーカー (2015)
  • Author(s): 岡元昌樹、太田昭一郎、星野友昭、出原賢治
  • Organizer: 第55回日本呼吸器学会
  • Place of Presentation: 東京
  • Year and Date: 2015-04-17
  • Invited
• [Presentation] Injury promotes melanoma metastasis via wound healing process with periostin (2014)
  • Author(s): Fukuda K, Sugihara E, Ota S, Izuhara K, Saya H, Amagai M
  • Organizer: 日本研究皮膚科学会 第39回年次学術大会・総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-12-12 – 2014-12-14
• [Presentation] Periostin: Update on clinical use. (2014)
  • Author(s): Izuhara K
  • Organizer: WAO International scientific conference 2014
  • Place of Presentation: Rio de Janeiro, Brasil
  • Year and Date: 2014-12-06 – 2014-12-09
  • Invited
• [Presentation] 気管支喘息におけるペリオスチンに関する最新の話題 (2014)
  • Author(s): 出原賢治
  • Organizer: アレルギー・好酸球研究会2014
  • Place of Presentation: 東京
  • Year and Date: 2014-10-04
  • Invited
• [Presentation] 損傷は治癒過程に惹起されるペリオスチンを介してメラノーマの転移を促進する (2014)
  • Author(s): 福田桂太郎，杉原英志，太田昭一郎，出原賢治, 天谷雅行, 佐谷秀行
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] Serum periostin is a biomarker reflecting tissue remodeling in bronchial asthma. (2014)
  • Author(s): Izuhara K
  • Organizer: 30th symposium of the collegium internationale Allergologicum
  • Place of Presentation: St. Peterberg, Germany
  • Year and Date: 2014-09-13 – 2014-09-18
• [Presentation] The gender defference in the relationship between serum periostin and the indices of flow volume curve, and serum IgE. (2014)
  • Author(s): Odajima H, Tanaka Y, Izuhara K, Ono J
  • Organizer: ERS International Congress 2014
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 2014-09-06 – 2014-09-10
• [Presentation] Serum periostin in asthma: a potential biomarker for stratification in severe treatment-resistant asthma. (2014)
  • Author(s): Rupani H, Lau L, Ono J, Barber C, Elliot S, Brown T, Kurukulaaratchy R, Chauhan A, Izuhara K
  • Organizer: ERS International Congress 2014
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 2014-09-06 – 2014-09-10
• [Presentation] 呼吸器疾患マーカーとしてのペリオスチン測定試薬の開発 (2014)
  • Author(s): 出原賢治
  • Organizer: 第54回日本臨床化学会年次学術集会
  • Place of Presentation: 東京
  • Year and Date: 2014-09-05 – 2014-09-07
  • Invited
• [Presentation] Periostin: Its significance and clinical application to bronchial asthma. (2014)
  • Author(s): Izuhara K
  • Organizer: The 24th Congress of Interasma Japan/North Asia
  • Place of Presentation: Nagoya, Japan
  • Year and Date: 2014-07-18 – 2014-07-19
  • Invited
• [Presentation] ペリオスチンによるアレルギー性炎症の増幅 (2014)
  • Author(s): 有馬和彦，白石裕士，出原賢治
  • Organizer: 第24回日本サイトメトリー学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2014-06-28 – 2014-06-29
  • Invited
• [Presentation] 難治性喘息患者における血清ペリオスチン濃度と呼吸機能・副鼻腔陰影重症度の関連. (2014)
  • Author(s): 木村孔一，今野哲，中丸裕爾，牧田比呂仁，谷口菜津子，清水薫子，前田由起子，鈴木雅，長井桂，小野純也，太田昭一郎，出原賢治，西村正治
  • Organizer: 第79回日本インターフェロン・サイトカイン学会学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2014-06-19 – 2014-06-20
• [Presentation] Periostin: A useful biomarker for categorization of asthma endotypes. (2014)
  • Author(s): Izuhara K
  • Organizer: American Thoracic Society 2014 International Conference
  • Place of Presentation: San Diego, USA
  • Year and Date: 2014-05-16 – 2014-05-21
  • Invited
• [Presentation] Effect of allergen challenge on two novel ｂｉomarkars of aｉｒｗａｙ inflammation, periostin and YKL-40, in atopic asthmatic patients. (2014)
  • Author(s): James A, Gomes A, Daham K, Ono J, Ohta S, Dahlen B, Izuhara K, Dahlen S
  • Organizer: American Thoracic Society 2014 International Conference
  • Place of Presentation: San Diego, USA
  • Year and Date: 2014-05-16 – 2014-05-21
• [Presentation] Associations of serum periostin level with sinusitis severity and persistent airflow limitation in severe asthma. (2014)
  • Author(s): Kimura H, Konno S, Nakamaru Y, Makita H, Taniguchi N, Shimizu K, Maeda Y, Suzuki M, Nagai K, Ono J, Izuhara K, Nishimura M
  • Organizer: American Thoracic Society 2014 International Conference
  • Place of Presentation: San Diego, USA
  • Year and Date: 2014-05-16 – 2014-05-21
• [Presentation] 小児アレルギー疾患の新しいバイオマーカー（ペリオスチン,SCCA1,SCCA2）の検討 (2014)
  • Author(s): 平山淳也，山下敦士，貝沼圭吾，長尾みづほ，藤澤隆夫，出原賢治
  • Organizer: 第26回日本アレルギー学会春季臨床大会
  • Place of Presentation: 京都
  • Year and Date: 2014-05-09 – 2014-05-11
• [Presentation] 喘息バイオマーカーの現状 (2014)
  • Author(s): 出原賢治
  • Organizer: 第26回日本アレルギー学会春季臨床大会
  • Place of Presentation: 京都
  • Year and Date: 2014-05-09 – 2014-05-11
  • Invited
• [Presentation] アレルギー診療に役立つ免疫講座２：アレルギー疾患に対するこれからの治療 (2014)
  • Author(s): 出原賢治
  • Organizer: 第26回日本アレルギー学会春季臨床大会
  • Place of Presentation: 京都
  • Year and Date: 2014-05-09 – 2014-05-11
  • Invited
• [Presentation] 難治性喘息患者における血清ペリオスチン濃度と呼吸機能・副鼻腔陰影重症度との関連 (2014)
  • Author(s): 木村孔一，今野哲，中丸裕爾，牧田比呂仁，谷口菜津子，清水薫子，前田由起子，鈴木雅，長井桂，小野純也，太田昭一郎，出原賢治，西村正治
  • Organizer: 第26回日本アレルギー学会春季臨床大会
  • Place of Presentation: 京都
  • Year and Date: 2014-05-09 – 2014-05-11
• [Presentation] 気管支喘息におけるペリオスチン（PO)の役割の検討 (2014)
  • Author(s): 高橋健太郎，目黒和行，川島広稔，加々美新一郎，出原賢治，小野純也，岩本逸夫
  • Organizer: 第26回日本アレルギー学会春季臨床大会
  • Place of Presentation: 京都
  • Year and Date: 2014-05-09 – 2014-05-11
• [Presentation] アレルギー疾患の慢性化機序 (2014)
  • Author(s): 出原賢治
  • Organizer: 戦略的研究基盤形成支援事業「難治性“かゆみ”発症機構解明と予防・治療法開発の研究基盤構築」第1回公開シンポジウム 2014年
  • Place of Presentation: 東京
  • Year and Date: 2014-04-26
  • Invited
• [Presentation] ペリオスチンと呼吸器疾患 (2014)
  • Author(s): 出原賢治
  • Organizer: 第54回日本呼吸器学会学術講演会
  • Place of Presentation: 大阪
  • Year and Date: 2014-04-25 – 2014-04-27
  • Invited
• [Presentation] 吸入ステロイド治療下喘息患者におけるGLCCI1遺伝子多型と呼吸機能低下との関連についての検討． (2014)
  • Author(s): 出原裕美，松本久子，金光禎寛，出原賢治，東田有智，北英夫，堀口高彦，桑原和伸，富井啓介，大塚浩二郎，藤村政樹，大倉徳幸，富田桂公，横山彰仁，大西広志，中野恭幸，小熊 哲也，保澤総一郎，長崎 忠雄，伊藤功朗，小熊毅，田尻 智子，新実彰男，三嶋理晃
  • Organizer: 第54回日本呼吸器学会学術講演会
  • Place of Presentation: 大阪
  • Year and Date: 2014-04-25 – 2014-04-27
• [Presentation] オステオポンチンとペリオスチンは喘息患者の長期的な呼吸機能低下に寄与する (2014)
  • Author(s): 金光禎寛，伊藤功朗，新実彰男，松本久子，岩田敏之，出原賢治，太田昭一郎，小野純也，小熊毅，田尻智子，長崎忠雄，出原裕美，三嶋理晃
  • Organizer: 第54回日本呼吸器学会学術講演会
  • Place of Presentation: 大阪
  • Year and Date: 2014-04-25 – 2014-04-27
• [Presentation] 血清ペリオスチン値を用いた重症喘息クラスター解析（keio-SARP) (2014)
  • Author(s): 松坂雅子，加畑宏樹，福永興壱，坂巻 ，小山田吉孝，井上卓，小熊剛，浅野浩一郎，佐山宏一，黄英文，中村守，梅田啓，小野純也，出原賢治，浅野浩一郎，別役智子
  • Organizer: 第54回日本呼吸器学会学術講演会
  • Place of Presentation: 大阪
  • Year and Date: 2014-04-25 – 2014-04-27
• [Presentation] Expression of periostin in small peripheral lung adenocarcinoma: Correlation with CT findings, pathologic findings, and prognosis (2014)
  • Author(s): Iwamoto R, Fujimoto K, Sadohara J, Ikehara N, Abe T, Takamori S, Tabata K, Fukuoka J, Izuhara K
  • Organizer: 第73回日本医学放射線学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-04-10 – 2014-04-13
• [Presentation] Th2 signature selection strategies for CRTh2 antagonists: Baseline characteristics of a mild to moderate persistent asthma population. (2013)
  • Author(s): Chantry D, Ono J, Eberhardt C, Hayter L, Larsen P, Anderson P, Harmor R, Rhodes S, Brown S, Izuhara K, Bell S.
  • Organizer: ATS 2013 International Conference
  • Place of Presentation: フィラデルフィア, アメリカ
• [Presentation] TH2 specific biomarker profile determines steroid responsiveness in severe asthma. (2013)
  • Author(s): James A, Kupczyk M, Ono J, Ohta S, Izuhara K, Dahlen SE.
  • Organizer: ERS Annual Congress 2013
  • Place of Presentation: バルセロナ, スペイン
• [Presentation] Controlled oral steroid intervention decreases serum levels in asthmatic patients. (2013)
  • Author(s): James A, Ono J, Kupczyk M, Ohta S, Izuhara K, Dahlen SEK
  • Organizer: ATS 2013 International Conference
  • Place of Presentation: フィラデルフィア, アメリカ
• [Presentation] Periostin (2013)
  • Author(s): Izuhara K
  • Organizer: EAACI-WAO World Allergy & Asthma
  • Place of Presentation: ミラノ, イタリア
  • Invited
• [Presentation] Novel biomarkers for severe asthma. (2013)
  • Author(s): Izuhara K
  • Organizer: EAACI-WAO World Allergy & Asthma
  • Place of Presentation: ミラノ, イタリア
  • Invited
• [Presentation] Relationship between serum periostin levels and severity/phenotype of Asthma. (2013)
  • Author(s): Kabata H, Matsuoka M, Fukunaga K, Suzuki Y, Miyata J, Tanaka K, Masaki K, Mochimaru T, Ono J, Ohta S, Izuhara K, Asano K, Betsuyaku T
  • Organizer: ATS 2013 International Conference
  • Place of Presentation: フィラデルフィア, アメリカ
• [Presentation] Periostin associates with greater pulmonary function decline in asthmatic patients on treatment. (2013)
  • Author(s): Kanemitsu Y, Matsumoto H, Izuhara K, Ohta S, Tamari M, Hirota T, Yokoyama T, Niimi A, Mishima M
  • Organizer: ATS 2013 International Conference
  • Place of Presentation: フィラデルフィア, アメリカ
• [Presentation] 喘息患者における血清ペリオスチン値と臨床像の検討 (2013)
  • Author(s): 松坂 雅子，加畑 宏樹，福永 興壱，鈴木 雄介，正木 克宜，持丸 貴夫，小野 純也，出原 賢治，別役 智子，浅野 浩一郎
  • Organizer: The 23th Congress of Intreasma Japan/North Asia
  • Place of Presentation: 東京
• [Presentation] Asthma phenotypes with rapid decline in lung function. (2013)
  • Author(s): Nagasaki T, Matsumoto H, Kanemitsu Y, Izuhara K, Ohta S, Niimi A, Mishima M.
  • Organizer: ERS Annual Congress 2013
  • Place of Presentation: バルセロナ, スペイン
• [Presentation] Tajiri T, Matsumoto H, Hiraumi H, Ikeda H, Morita K, Izuhara K, Ono J, Ohta S, Ito I, Oguma T, Nakaji H, Inoue H, Iwata T, Nagasaki T, Kanemitsu Y, Ito J, Niimi A, Mishima M Efficacy of omalizumab in asthmatic patients with eosinophilic chronic rhinosinusitis or eosinophilic otitis media. (2013)
  • Author(s): Tajiri T, Matsumoto H, Hiraumi H, Ikeda H, Morita K, Izuhara K, Ono J, Ohta S, Ito I, Oguma T, Nakaji H, Inoue H, Iwata T, Nagasaki T, Kanemitsu Y, Ito J, Niimi A, Mishima M
  • Organizer: ATS 2013 International Conference
  • Place of Presentation: フィラデルフィア, アメリカ
• [Presentation] 表皮におけるアレルギー性炎症の増悪化メカニズム． (2013)
  • Author(s): 有馬 和彦，出原 賢治
  • Organizer: 第25回日本アレルギー学会春季臨床大会
  • Place of Presentation: 横浜
  • Invited
• [Presentation] アトピー性皮膚炎患者における血清ペリオスチン変動の臨床的意義． (2013)
  • Author(s): 侯 建全，大川 智子，山口 由衣，小野 純也，太田 昭一郎，出原 賢治，相原 道子
  • Organizer: 第25回日本アレルギー学会春季臨床大会
  • Place of Presentation: 横浜
• [Presentation] 臨床検査のガイドラインJSLM2012の活用法～改訂のポイントを一刀両断～呼吸器. (2013)
  • Author(s): 出原 賢治
  • Organizer: 第60回日本臨床検査医学会学術集会
  • Place of Presentation: 神戸
  • Invited
• [Presentation] アレルギー疾患における新規のバイオマーカー：ペリオスチン (2013)
  • Author(s): 出原 賢治
  • Organizer: 第63回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Invited
• [Presentation] 吸入ステロイド治療下喘息患者におけるGLCCI1遺伝子多型と呼吸機能低下との関連についての検討． (2013)
  • Author(s): 出原 裕美，松本 久子，金光 禎寛，出原 賢治，三嶋 理晃
  • Organizer: 第63回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
• [Presentation] osteopontinとperiostinは喘息患者の長期予後的な呼吸機能低下に寄与する (2013)
  • Author(s): 金光 禎寛，伊藤 功朗，新実 彰男，松本 久子，岩田 敏之，出原 賢治，太田 昭一郎，小野 純也，小熊 毅，田尻 智子，長崎 忠雄，出原 裕美，三嶋 理晃
  • Organizer: 第63回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
• [Presentation] ペリオスチンはTh2サイトカインを誘導して慢性アレルギー炎症を増悪させる． (2013)
  • Author(s): 増岡 美穂，白石 裕士，太田 昭一郎，出原 賢治，栗原 雄一，古江 増隆，成澤 寛
  • Organizer: 第112回日本皮膚科学会総会
  • Place of Presentation: 横浜
• [Presentation] アトピー性皮膚炎患者における血清ペリオスチンの値の検討 (2013)
  • Author(s): 大川 智子, 侯 建全，山口 由衣，河野 真純，松倉 節子，蒲原 毅，小野 純也，太田 昭一郎，出原 賢治，相原 道子
  • Organizer: 第43回日本皮膚アレルギー・接触皮膚炎学会総会学術大会
  • Place of Presentation: 金沢
• [Presentation] 好酸球前駆細胞におけるIL-25受容体シグナルの役割の解明. (2013)
  • Author(s): 続 啓史，有信 洋二郎，宮脇 恒太，太田 昭一郎，出原 賢治，大田 俊一郎，植木 直子，廣崎 友里，Siamak J，赤星 光輝，新納 宏昭，塚本 浩，堀内 孝彦，赤司 浩一
  • Organizer: 第63回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
• [Presentation] 免疫学・アレルギー学の基礎
  • Author(s): 出原 賢治
  • Organizer: 第43回日本アレルギー学会専門医教育セミナー
  • Place of Presentation: 横浜
  • Invited
• [Presentation] 新規ペリオスチンELISA測定試薬の開発：認識エピトープの解析と診断特性．
  • Author(s): 小野 純也，高井 雅之，東 義則，太田 昭一郎，出原 賢治
  • Organizer: 第53回日本臨床化学会年次学術集会
  • Place of Presentation: 徳島
• [Presentation] サイトカイン、ケモカインを中心に(ペリオスチンを含む) アレルギー疾患のバイオマーカー.
  • Author(s): 出原 賢治
  • Organizer: 第33回六甲カンファレンス
  • Place of Presentation: 京都
  • Invited
• [Book] Annual Review 2015 呼吸器 (2015)
  • Author(s): 出原賢治、有馬和彦、太田昭一郎
  • Total Pages: 252
  • Publisher: 中外医学社
• [Book] 中外医学社 (2015)
  • Author(s): 出原賢治、有馬和彦、太田昭一郎
  • Total Pages: 252
  • Publisher: Annual Review 2015 呼吸器
• [Book] 気管支喘息の分子バイオマーカー (2014)
  • Author(s): 出原賢治
  • Total Pages: 117
  • Publisher: Life Science Publishing
• [Book] Global Atlas of Allergy (2014)
  • Author(s): Izuhara K
  • Total Pages: 388
  • Publisher: The European Academy of Allergy and Clinical Immunology
• [Book] Metabolism of Human Diseases (2014)
  • Author(s): Izuhara K, Suzuki S, Arima K, Ohta S, Inamitsu M, Yamamoto K
  • Total Pages: 416
  • Publisher: Springer
• [Book] Allergic diseases: from Mechanisms to Cures (2014)
  • Author(s): Izuhara K, Matsumoto H, Kanemitsu Y, Ohta S, Ono J, Mishima M
  • Total Pages: 255
  • Publisher: Pacini Editore Medicina
• [Book] 病態の理解に向かうアレルギー疾患研究-なぜ、アレルギーが起こるのか? 発症・進展の新概念と臨床への展開 (2013)
  • Author(s): 有馬 和彦，出原 賢治
  • Total Pages: 207
  • Publisher: 羊土社
• [Remarks] 佐賀大学医学部分子生命科学講座分子医化学分野
  • URL: http://www.biomol.med.saga-u.ac.jp/medbiochem/index.php
• [Remarks] 佐賀大学分子医学部分子生命科学講座分子医化学分野
  • URL: http://www.biomol.med.saga-u.ac.jp/medbiochem/index.php
• [Remarks] 佐賀大学医学部分子生命科学講座分子医化学分野
  • URL: http://www.biomol.med.saga-u.ac.jp/medbiochem/index.php
• [Patent(Industrial Property Rights)] 眼科疾患を除くペリオスチン発現に起因する疾患用医療薬 (2013)
  • Inventor(s): 出原 賢治他
  • Industrial Property Rights Holder: 佐賀大学他
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-09-27
• [Patent(Industrial Property Rights)] アトピー性角結膜炎の検出法 (2013)
  • Inventor(s): 出原 賢治他
  • Industrial Property Rights Holder: 佐賀大学他
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-10-21