| Project/Area Number |
25293227
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Infectious disease medicine
|
|---|
| Research Institution | National Institute of Infectious Diseases |
|---|
Principal Investigator |
ATO Manabu 国立感染症研究所, その他部局等, その他 (20392318)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
TAKAKI Satoshi 国立国際医療研究センター, 免疫制御研研究部, 部長 (10242116)
IKEBE Tadayoshi 国立感染症研究所, 細菌第一部, 主任研究官 (20333362)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
|
|---|
| Keywords | 感染症防御学 / 細菌感染 / 好中球減少 / サイトカイン |
|---|
| Outline of Final Research Achievements |
Streptococcus toxic shock syndrome (STSS) is a serious and fatal infectious disease and is characteristic for sudden onset, progressive septic shock, and multiple organ failure. Here we show that a novel immature myeloid cells with ring-shaped nuclear appear in the peripheral blood in a mouse model of STSS. They give rise under granulocytopenia accompanied with this severe infection and produce variety of cytokines, resulting in protection from this infection. In human clinical cases, the similar immature myeloid cells with ring-shaped nuclear are recognized in the peripheral blood and produce significant amount of cytokines. We further analyze differentiation mechanism of those immature myeloid cells in the bone marrow using mice model, and identify essential factors in differentiation of these immature myeloid cells in that infection model. We also find a novel bactericidal pathway with autophagy in neutrophils, which blockage bacterial escape from phagosomes to cytosol.
|
