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Transplantation of adipose tissue derived multilineage progenitor cells via portal vein improved serum levels of mucopolysaccharidosis model mice.

Research Project

Project/Area Number 25293229
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Pediatrics
Research InstitutionOsaka University

Principal Investigator

Matsuyama Akifumi  大阪大学, 国際医工情報センター, 招へい教授 (10423170)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2015: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2013: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Keywords再生医療 / ムコ多糖症 / ライソゾーム病 / 遺伝子疾患 / 脂肪組織由来多系統前駆細胞 / in situ reprogramming / 移植・再生医療 / 再生医学
Outline of Final Research Achievements

The mechanism of this study is in vivo engrafted reprogrammed-hepatocyte from adipse tisse derived multilinage progenitor cell, so called ‘ADMPC’ sustained secrete and supplied lysosomal hydrolase deficient in mucopolysaccharidosis to the whole body.Via the portal vein administration of ADMPC, β-galactosidase that are deficient GM1- gangliosidosis mouse, which is a mucopolysaccharidosis model animal had expressed in the blood, and the effect has been revealed that long-lasting. ADMPC have been induced to differentiate into hepatocytes in the liver, so we proposed the new concept of the "in situ reprogramming". The concept is defferent from "Reprogramming", reprogrammed terminal differentiated cell to pluripotent cells and "direct reprogramming", to differentiate directly to the target cells in vitro gene transfer, so far. We are going to deploy this as in situ stem cell therapy to the treatment.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (39 results)

All 2016 2015 2014 2013

All Journal Article (20 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 19 results,  Open Access: 2 results) Presentation (13 results) (of which Int'l Joint Research: 3 results,  Invited: 7 results) Book (6 results)

  • [Journal Article] Spermine Treated-Adipose Tissue-Derived Multi-Lineage Progenitor Cells Improve Left Ventricular Dysfunction in a Swine Model of Chronic Myocardial Infarction.2016

    • Author(s)
      Okura H., Morita M., Fujita M., Naba K., Hasebe-Takada N., Ichinose A., Matsuyama A.
    • Journal Title

      J Stem Cell Res Ther

      Volume: Epub

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Cell-surface MMP-9 protein is a novel functional marker to identify and separate pro-angiogenic cells from early endothelial progenitor cells derived from CD133+ cells.2016

    • Author(s)
      Kanayasu-Toyoda T., Tanaka T., Ishii-Watabe A., Kitagawa H., Matsuyama A., Uchida E., Yamaguchi T.
    • Journal Title

      Stem Cells

      Volume: Epub Issue: 5 Pages: 1251-1262

    • DOI

      10.1002/stem.2300

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Platelet-derived growth factor (PDGF)-AA/AB in human serum are potential indicators of the proliferative capacity of human synovial mesenchymal stem cells.2015

    • Author(s)
      Mizuno M, Katano H, Otabe K, Komori K, Matsumoto Y, Fujii S, Ozeki N, Tsuji K, Koga H, Muneta T, Matsuyama A, Sekiya
    • Journal Title

      Stem Cell Res Ther.

      Volume: 10 Issue: 1 Pages: 243-243

    • DOI

      10.1186/s13287-015-0239-2

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Report of the international conference on regulatory endeavors towards the sound development of human cell therapy products.2015

    • Author(s)
      Hayakawa T., Aoi T., Bravery C., Hoogendoorn K., Knezevic I., Koga J., Maeda D., Matsuyama A., McBlane J., Morio T., Petricciani J., Rao M., Ridgway A., Sato D., Sato Y., Stacey G., Sakamoto N., Trouvin J.H., Umezawa A., Yamato M., Yano K., Yokote H., Yoshimatsu K., Zorzi-Morre P.
    • Journal Title

      Biologicals

      Volume: 43(5) Pages: 283-97

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Trophic factors from adipose tissue-derived multi-lineage progenitor cells promote cytodifferentiation of periodontal ligament cells.2015

    • Author(s)
      Sawada K., Takedachi M., Yamamoto S., Morimoto C., Ozasa M., Iwayama T., Lee C.M., Okura H., Matsuyama A., Kitamura M., Murakami S.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: Aug 14;464(1) Issue: 1 Pages: 299-305

    • DOI

      10.1016/j.bbrc.2015.06.147

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angiogenic Role of MMP-2/9 Expressed on the Cell Surface of Early Endothelial Progenitor Cells/Myeloid Angiogenic Cells.2015

    • Author(s)
      Kanayasu-Toyoda T., Tanaka T., Ishii-Watabe A., Kitagawa H., Matsuyama A., Uchida E., Yamaguchi T.
    • Journal Title

      J Cell Physiol

      Volume: 230(11) Pages: 2763-75

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of the cell growth analysis for detection of immortal cellular impurities in human mesenchymal stem cells. Biologicals.2015

    • Author(s)
      Kono K., Takada N., Yasuda S., Sawada R., Niimi S., Matsuyama A., Sato Y.
    • Journal Title

      Biologicals

      Volume: 43(2) Pages: 146-9

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Study on ensuring the quality and safety of pharmaceuticals and medical devices derived from processing of autologous human somatic stem cells.2015

    • Author(s)
      Hayakawa T., Aoi T., Umezaw A., Ozawa K., Sato Y., Sawa Y., Matsuyama A., Yamanaka S., Yamato M.
    • Journal Title

      Regenerative Therapy

      Volume: 1(2) Pages: 57-69

    • NAID

      120006471144

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Study on ensuring the quality and safety of pharmaceuticals and medical devices derived from processing of allogenic human somatic stem cells.2015

    • Author(s)
      Hayakawa T., Aoi T., Umezaw A., Ozawa K., Sato Y., Sawa Y., Matsuyama A., Yamanaka S., Yamato M.
    • Journal Title

      Regenerative Therapy

      Volume: 1(2) Pages: 70-80

    • NAID

      120006471143

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] tudy on ensuring the quality and safety of pharmaceuticals and medical devices derived from processing of autologous human induced pluripotent stem (-like) cells.2015

    • Author(s)
      Hayakawa T., Aoi T., Umezaw A., Ozawa K., Sato Y., Sawa Y., Matsuyama A., Yamanaka S., Yamato M.
    • Journal Title

      Regenerative Therapy

      Volume: 1(2) Pages: 81-94

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Study on ensuring the quality and safety of pharmaceuticals and medical devices derived from processing of allogenic human induced pluripotent stem (-like) cells.2015

    • Author(s)
      Hayakawa T., Aoi T., Umezaw A., Ozawa K., Sato Y., Sawa Y., Matsuyama A., Yamanaka S., Yamato M.
    • Journal Title

      Regenerative Therapy

      Volume: 1(2) Pages: 95-108

    • NAID

      120006469187

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Study on ensuring the quality and safety of pharmaceuticals and medical devices derived from processing of human embryonic stem (-like) cells.2015

    • Author(s)
      Hayakawa T., Aoi T., Umezaw A., Ozawa K., Sato Y., Sawa Y., Matsuyama A., Yamanaka S., Yamato M.
    • Journal Title

      Regenerative Therapy

      Volume: 1(2) Pages: 109-122

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of in vivo tumorigenicity tests using severe immunodeficient NOD/Shi-scid IL2Rγnull mice for detection of tumorigenic cellular impurities in human cell-processed therapeutic products.2015

    • Author(s)
      Kusakawa S., Machida K., Yasuda S., Takada N., Kuroda T., Sawada R., Okura H., Tsutsumi H., Kawamata S., Sato Y.
    • Journal Title

      Regenerative Therapy

      Volume: 1(4) Pages: 30-37

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Study on ensuring the quality and safety of pharmaceuticals and medical devices derived from processing of autologous human somatic stem cells.2015

    • Author(s)
      Hayakawa T, Aoi T, Umezaw A, Ozaw K, Yoji Sato, Sawa Y, Matsuyama A, Yamanaka S, Yamato M.
    • Journal Title

      Regenerative Therapy 1

      Volume: in press

    • NAID

      120006471144

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Study on ensuring the quality and safety of pharmaceuticals and medical devices derived from processing of allogenic human somatic stem cells.2015

    • Author(s)
      Hayakawa T, Aoi T, Umezaw A, Ozaw K, Yoji Sato, Sawa Y, Matsuyama A, Yamanaka S, Yamato M.
    • Journal Title

      Regenerative Therapy 1

      Volume: in press

    • NAID

      120006471143

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Study on ensuring the quality and safety of pharmaceuticals and medical devices derived from processing of autologous human induced pluripotent stem (-like) cells.2015

    • Author(s)
      Hayakawa T, Aoi T, Umezaw A, Ozaw K, Yoji Sato, Sawa Y, Matsuyama A, Yamanaka S, Yamato M.
    • Journal Title

      Regenerative Therapy 1

      Volume: in press

    • NAID

      120006649574

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Study on ensuring the quality and safety of pharmaceuticals and medical devices derived from processing of allogenic human induced pluripotent stem (-like) cells.2015

    • Author(s)
      Hayakawa T, Aoi T, Umezaw A, Ozaw K, Yoji Sato, Sawa Y, Matsuyama A, Yamanaka S, Yamato M.
    • Journal Title

      Regenerative Therapy 1

      Volume: in press

    • NAID

      120006469187

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Study on ensuring the quality and safety of pharmaceuticals and medical devices derived from processing of human embryonic stem (-like) cells.2015

    • Author(s)
      Hayakawa T, Aoi T, Umezaw A, Ozaw K, Yoji Sato, Sawa Y, Matsuyama A, Yamanaka S, Yamato M.
    • Journal Title

      Regenerative Therapy 1

      Volume: in press

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic potential of human adipose tissue-derived multi-lineage progenitor cells in liver fibrosis.2015

    • Author(s)
      Okura H, Soeda M, Morita M, Fujita M, Naba K, Ito C, Ichinose A, Matsuyama A
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 24;456(4) Issue: 4 Pages: 860-865

    • DOI

      10.1016/j.bbrc.2014.11.122

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of the cell growth analysis for detection of immortal cellular impurities in human mesenchymal stem cells.2014

    • Author(s)
      Kono K, Takada N, Yasuda S, Sawada R, Niimi S, Matsuyama A, Sato Y.
    • Journal Title

      Biologicals

      Volume: 43(2) Issue: 2 Pages: 146-155

    • DOI

      10.1016/j.biologicals.2014.11.007

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 再生医療とOMICS2016

    • Author(s)
      松山晃文
    • Organizer
      第15回日本再生医療学会総会特別シンポジウム
    • Place of Presentation
      グランキューブ大阪
    • Year and Date
      2016-03-17
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] in situ reprogrammed spermine treated-adipose tissue–derived multi-lineage progenitor cells improve left ventricular dysfunction in a swine chronic myocardial infarction model.2016

    • Author(s)
      Okura H., Morita M., Fujita M., Naba K., Hasebe-Takada N., Ichinose A., Matsuyama A.
    • Organizer
      Clinical applications of stem cell
    • Place of Presentation
      Singapore
    • Year and Date
      2016-02-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 再生医療等製品の品質、有効性及び安全性の確保2015

    • Author(s)
      松山晃文
    • Organizer
      レギュラトリーサイエンス学会シンポジウム
    • Place of Presentation
      一橋大学一橋講堂
    • Year and Date
      2015-12-11
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 再生医療の実用化にむけて ―規制と知財の観点から―2015

    • Author(s)
      松山晃文
    • Organizer
      第6回先進医療コアシンポジウム
    • Place of Presentation
      東北大学未来科学技術共同研究センター
    • Year and Date
      2015-12-10
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Allogenic spermine treated-adipose tissue–derived multi-lineage progenitor cells improve left ventricular dysfunction in a swine chronic myocardial infarction model.2015

    • Author(s)
      Okura H., Morita M., Fujita M., Naba K., Hasebe-Takada N., Ichinose A., Matsuyama A.
    • Organizer
      ICCAD
    • Place of Presentation
      Florence, Italy.
    • Year and Date
      2015-11-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 再生医療新法実施で見えてきた課題2015

    • Author(s)
      松山晃文
    • Organizer
      再生医療倫理講習会
    • Place of Presentation
      東京大学
    • Year and Date
      2015-10-31
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 再生医療推進の課題2015

    • Author(s)
      松山晃文
    • Organizer
      第5回レギュラトリーサイエンス学会学術集会
    • Place of Presentation
      一橋大学一橋講堂
    • Year and Date
      2015-09-04
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] ヒト由来組織の産業化にむけた課題2015

    • Author(s)
      松山晃文
    • Organizer
      日本組織移植学会
    • Place of Presentation
      シティ プラザ大阪
    • Year and Date
      2015-08-29
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 平成24年5指針からみた品質について2015

    • Author(s)
      松山晃文
    • Organizer
      MCP策定会議
    • Place of Presentation
      東京・大阪 計6回
    • Year and Date
      2015-08-06
    • Related Report
      2015 Annual Research Report
  • [Presentation] Therapeutic potential of human adipose tissue-derived multi-lineage progenitor cells in non-alcoholic fatty liver disease Bridging the MOA and the POC for clinical application -in case study.2015

    • Author(s)
      Okura H., Morita M., Fujita M., Naba K., Hasebe-Takada N., Ichinose A., Matsuyama A.
    • Organizer
      ISSCR
    • Place of Presentation
      Stockholm Sweden
    • Year and Date
      2015-06-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 正しいモノを作る」から「正しくモノを作る」へ 再生医療が切り拓くバイオセーフティーの新規マーケット2015

    • Author(s)
      松山晃文
    • Organizer
      関西バイオセーフティー研究会
    • Place of Presentation
      神戸
    • Year and Date
      2015-06-12
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Transplantation of adipose tissue–derived multi-lineage progenitor cells via portal vein improved serum levels of beta-galactosidase in GM1-gangliosidosis model mice2013

    • Author(s)
      Mayumi Soeda, Hanayuki Okura, Junichiro Matsuda, Minako Koura, Mitsuko Morita, Junko Tani, Akihiro Ichinose and Akifumi Matsuyama
    • Organizer
      ISSCR 11th Annual Meeting
    • Place of Presentation
      米国ボストン
    • Related Report
      2013 Annual Research Report
  • [Presentation] Transplantation of adipose tissue–derived multi-lineage progenitor cells via portal vein improved serum levels of beta-galactosidase in GM1-gangliosidosis model mice2013

    • Author(s)
      Mayumi Soeda, Hanayuki Okura, Junichiro Matsuda, Minako Koura, Mitsuko Morita, Junko Tani, Akihiro Ichinose and Akifumi Matsuyama
    • Organizer
      Stem Cells in Translation - ISSCR Regional Forum Series 2013
    • Place of Presentation
      イタリア フィレンツェ
    • Related Report
      2013 Annual Research Report
  • [Book] 再生医療実現にむけた課題2016

    • Author(s)
      松山晃文
    • Total Pages
      4
    • Publisher
      BioClinica
    • Related Report
      2015 Annual Research Report
  • [Book] 『日本臨牀』 2015年6月増刊号「再生医療-新たな医療を求めて-」2016

    • Author(s)
      大倉華雪・松山晃文
    • Total Pages
      5
    • Publisher
      日本臨牀
    • Related Report
      2015 Annual Research Report
  • [Book] Gene Therapy and Cell Therapy Through the Liver.2015

    • Author(s)
      Okura H. and Matsuyama A.
    • Total Pages
      7
    • Publisher
      Springer Japan
    • Related Report
      2015 Annual Research Report
  • [Book] 年報医事法学2015

    • Author(s)
      松山晃文
    • Total Pages
      2
    • Publisher
      日本評論社
    • Related Report
      2015 Annual Research Report
  • [Book] 再生医療用語ハンドブック2015

    • Author(s)
      松山晃文
    • Total Pages
      10
    • Publisher
      メディカルトリビューン
    • Related Report
      2015 Annual Research Report
  • [Book] 先進医療NAVIGATOR II 再生医療・がん領域の実用化へのTOPICS2014

    • Author(s)
      大倉華雪・松山晃文
    • Total Pages
      4
    • Publisher
      先端医学社
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-21   Modified: 2019-07-29  

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